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1
المؤلفون: T. E. Mertz, Leslie M. Werbel, C. S. Stratton, S. Hastings, Milton L. Hoefle, T. J. Steffe, J. M. Hinkley, L. T. Blouin, R. W. Fleming
المصدر: ChemInform. 22
مصطلحات موضوعية: Chemistry, Organic chemistry, General Medicine
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2
المؤلفون: Bruce D. Roth, Milton L. Hoefle, A. W. Chucholowski, Roger S. Newton, C. D. Stratton, C. J. Blankley, Daniel F. Ortwine, Michael W. Wilson, C. S. Sekerke, E. Ferguson, Drago Robert Sliskovic
المصدر: ChemInform. 22
مصطلحات موضوعية: biology, Stereochemistry, General Medicine, Pyrrole derivatives, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Pyran, HMG-CoA reductase, medicine, biology.protein, Nucleus, Cholesterol biosynthesis, Pyrrole
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3
المؤلفون: Ann Holmes, Bruce D. Roth, C. J. Blankley, Essenburg Ad, K.A. Kieft, W. H. Roark, R. L. Stanfield, Bharat K. Trivedi, Brian R. Krause, Milton L. Hoefle
المصدر: Journal of Medicinal Chemistry. 35:1609-1617
مصطلحات موضوعية: Male, medicine.drug_class, Sterol O-acyltransferase, Alpha (ethology), Carboxamide, Cholesterol, Dietary, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Animals, Potency, IC50, Hypolipidemic Agents, chemistry.chemical_classification, Fatty acid, Rats, Inbred Strains, Rats, Cholesterol, Enzyme, chemistry, Biochemistry, Molecular Medicine, lipids (amino acids, peptides, and proteins), Rabbits, Sterol O-Acyltransferase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e850c63582d3658c596051af28b574
https://doi.org/10.1021/jm00087a016 -
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المؤلفون: Dirk A. Bornemeier, David T. Connor, Diane H. Boschelli, Milton L. Hoefle, Richard D. Dyer
المصدر: Bioorganic & Medicinal Chemistry Letters. 2:69-72
مصطلحات موضوعية: chemistry.chemical_classification, biology, Chemistry, Carboxylic acid, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Combinatorial chemistry, Drug Discovery, Arachidonate 5-lipoxygenase, biology.protein, Molecular Medicine, Cyclooxygenase, Molecular Biology
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5
المؤلفون: Michael William Wilson, Milton L. Hoefle, D. R. Sliskovic, Roger S. Newton, Bruce D. Roth, Charlotte D. Stratton, Daniel F. Ortwine
المصدر: Journal of Medicinal Chemistry. 33:21-31
مصطلحات موضوعية: Chemical Phenomena, Molecular model, Stereochemistry, Molecular Conformation, Reductase, Ring (chemistry), Lactones, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Structure–activity relationship, Pyrroles, Lovastatin, Ene reaction, Pyrans, Pyrrole, chemistry.chemical_classification, Molecular Structure, Chemistry, Physical, Rats, Chemistry, Cholesterol, Liver, chemistry, Molecular Medicine, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Pharmacophore, Lactone
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1694558173f4f71e10bcba1d30878f3
https://doi.org/10.1021/jm00163a005 -
6
المؤلفون: Leslie M. Werbel, T. E. Mertz, C. S. Stratton, R. W. Fleming, T. J. Steffe, Stephen G. Hastings, L. T. Blouin, Milton L. Hoefle, J. M. Hinkley
المصدر: Journal of medicinal chemistry. 34(1)
مصطلحات موضوعية: Tachycardia, Molecular Structure, Stereochemistry, Chemistry, Alpha (ethology), Biological activity, Pharmacology, Dog model, Coronary Vessels, Structure-Activity Relationship, Dogs, Piperidines, Heart Rate, Drug Discovery, Benzyl Compounds, medicine, Molecular Medicine, Animals, medicine.symptom, Short duration, Anti-Arrhythmia Agents
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2380bf40f1b914b1bfd0dfb905b675
https://pubmed.ncbi.nlm.nih.gov/1992154 -
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المؤلفون: Bruce D. Roth, C. J. Blankley, Catherine Sekerke, E. Ferguson, A. W. Chucholowski, Milton L. Hoefle, Roger S. Newton, Charlotte D. Stratton, Daniel F. Ortwine, D. R. Sliskovic
المصدر: Journal of medicinal chemistry. 34(1)
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Spectrophotometry, Infrared, Stereochemistry, medicine.drug_class, Carboxamide, Reductase, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, medicine, Structure–activity relationship, Animals, Pyrroles, Pyrrole, chemistry.chemical_classification, biology, Molecular Structure, Anticholesteremic Agents, Rats, Enzyme, chemistry, Liver, Pyran, Enzyme inhibitor, Pyrones, biology.protein, Molecular Medicine, Indicators and Reagents, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Lactone
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8cc1f80872bfb6e374a7d67e1aac12d
https://pubmed.ncbi.nlm.nih.gov/1992137 -
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المؤلفون: Milton L. Hoefle, R. W. Fleming, C. S. Stratton, T. E. Mertz, Stephen G. Hastings, T. J. Steffe, J. M. Hinkley, L. T. Blouin
المصدر: Journal of medicinal chemistry. 34(1)
مصطلحات موضوعية: Molecular Structure, Aryl, Alpha (ethology), Biological activity, Medicinal chemistry, Dog model, Coronary Vessels, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, chemistry, Piperidines, Heart Rate, Drug Discovery, Benzyl Compounds, Molecular Medicine, Animals, Indicators and Reagents, Methylene, Anti-Arrhythmia Agents
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323324628858f116ba17616191eeccb8
https://pubmed.ncbi.nlm.nih.gov/1992110 -
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المؤلفون: Michael W. Wilson, Milton L. Hoefle, Roger S. Newton, Charlotte D. Stratton, Bruce D. Roth, D. R. Sliskovic, Daniel F. Ortwine
المصدر: ChemInform. 21
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, biology, Stereochemistry, HMG-CoA reductase, biology.protein, General Medicine, Cholesterol biosynthesis, Pyrrole
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10
المصدر: ChemInform. 21
مصطلحات موضوعية: Stereochemistry, Chemistry, General Medicine, Cholesterol biosynthesis