المؤلفون: Mitropoulou, Alkistis N., Bowen, Holly, Dodev, Tihomir S., Davies, Anna M., Bax, Heather J., Beavil, Rebecca L., Beavil, Andrew J., Gould, Hannah J., James, Louisa K., Sutton, Brian J.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2018 Sep 01. 115(37), E8707-E8716.

URL الوصول: https://www.jstor.org/stable/26531327

المؤلفون: Chen, Jiun-Bo^{Aff1, Aff2}, Ramadani, Faruk^{Aff2, Aff3}, Pang, Marie O. Y.^{Aff2, Aff3}, Beavil, Rebecca L.^{Aff2, Aff3, Aff4}, Holdom, Mary D.^{Aff2, Aff3}, Mitropoulou, Alkistis N.^{Aff2, Aff3}, Beavil, Andrew J.^{Aff2, Aff3}, Gould, Hannah J.^{Aff2, Aff3}, Chang, Tse Wen, Sutton, Brian J.^{Aff2, Aff3}, McDonnell, James M.^{Aff2, Aff3}, Davies, Anna M.^{Aff2, Aff3}

المصدر: Scientific Reports. 8(1)

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المؤلفون: Davies, Anna M., Allan, Elizabeth G., Keeble, Anthony H., Delgado, Jean, Cossins, Benjamin P., Mitropoulou, Alkistis N., Pang, Marie O. Y., Ceska, Tom, Beavil, Andrew J., Craggs, Graham, Westwood, Marta, Henry, Alistair J., McDonnell, James M., Sutton, Brian J.

المصدر: Davies, A M, Allan, E G, Keeble, A H, Delgado, J, Cossins, B P, Mitropoulou, A N, Pang, M O Y, Ceska, T, Beavil, A J, Craggs, G, Westwood, M, Henry, A J, McDonnell, J M & Sutton, B J 2017, ' Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab ', Journal of Biological Chemistry, vol. 292, no. 24, pp. 9975–9987 . https://doi.org/10.1074/jbc.M117.776476
The Journal of Biological Chemistry

مصطلحات موضوعية: Models, Molecular, Protein Conformation, Recombinant Fusion Proteins, Immunology, Omalizumab, Crystallography, X-Ray, Protein Refolding, Immunoglobulin Fab Fragments, antibody, Fluorescence Resonance Energy Transfer, Humans, Point Mutation, Protein Interaction Domains and Motifs, Anti-Asthmatic Agents, Pliability, X-ray crystallography, immunoglobulin E (IgE), Receptors, IgE, Immunoglobulin E, Surface Plasmon Resonance, allergy, allosteric regulation, Recombinant Proteins, Immunoglobulin Fc Fragments, Amino Acid Substitution, Solubility, Allosteric Site

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f1db23bdec5864c2332f1a27605a1219
https://kclpure.kcl.ac.uk/ws/files/72119846/Allosteric_mechanism_of_action_DAVIES_Publishedonline24April2017_GOLD_VoR_CC_BY_.pdf

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المؤلفون: Davies AM; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and., Allan EG; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and., Keeble AH; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and., Delgado J; UCB-Celltech, 208 Bath Road, Slough SL1 3WE, United Kingdom., Cossins BP; UCB-Celltech, 208 Bath Road, Slough SL1 3WE, United Kingdom., Mitropoulou AN; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and., Pang MOY; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and., Ceska T; UCB-Celltech, 208 Bath Road, Slough SL1 3WE, United Kingdom., Beavil AJ; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and., Craggs G; UCB-Celltech, 208 Bath Road, Slough SL1 3WE, United Kingdom., Westwood M; UCB-Celltech, 208 Bath Road, Slough SL1 3WE, United Kingdom., Henry AJ; UCB-Celltech, 208 Bath Road, Slough SL1 3WE, United Kingdom., McDonnell JM; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, james.mcdonnell@kcl.ac.uk.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and., Sutton BJ; From the Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London SE1 1UL, brian.sutton@kcl.ac.uk.; the Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 1UL, and.

المصدر: The Journal of biological chemistry [J Biol Chem] 2017 Jun 16; Vol. 292 (24), pp. 9975-9987. Date of Electronic Publication: 2017 Apr 24.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Models, Molecular*, Anti-Asthmatic Agents/*pharmacology , Immunoglobulin E/*metabolism , Omalizumab/*pharmacology , Receptors, IgE/*antagonists & inhibitors, Allosteric Site ; Amino Acid Substitution ; Crystallography, X-Ray ; Fluorescence Resonance Energy Transfer ; Humans ; Immunoglobulin E/chemistry ; Immunoglobulin E/genetics ; Immunoglobulin Fab Fragments/chemistry ; Immunoglobulin Fab Fragments/genetics ; Immunoglobulin Fab Fragments/metabolism ; Immunoglobulin Fab Fragments/pharmacology ; Immunoglobulin Fc Fragments/chemistry ; Immunoglobulin Fc Fragments/genetics ; Immunoglobulin Fc Fragments/metabolism ; Immunoglobulin Fc Fragments/pharmacology ; Omalizumab/chemistry ; Omalizumab/genetics ; Omalizumab/metabolism ; Pliability ; Point Mutation ; Protein Conformation ; Protein Interaction Domains and Motifs ; Protein Refolding ; Receptors, IgE/chemistry ; Receptors, IgE/metabolism ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/metabolism ; Recombinant Fusion Proteins/pharmacology ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Recombinant Proteins/pharmacology ; Solubility ; Surface Plasmon Resonance