المؤلفون: Cai C; School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China., Huang Y; School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China., Li L; School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China., Miu KK; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong SAR, China., Wang Z; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong SAR, China., Deng Y; Guangzhou National Laboratory, Guangzhou, China., Cai Y; School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China., Li J; BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China., Wu L; BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China., Zhu H; School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China., Gao Y; Department of Pharmacy & State Key Laboratory of Ophthalmology, Zhongshan Ophthalmological Center, Sun Yat-sen University, Guangzhou 510060, China., Chen J; School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China., Xiao W; Guangzhou First People's Hospital, Spine Surgery, Guangzhou 510180, China. Electronic address: eyxiaowende@scut.edu.cn., Lu L; School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address: luli@gdpu.edu.cn.

المصدر: International immunopharmacology [Int Immunopharmacol] 2024 May 30; Vol. 133, pp. 112040. Date of Electronic Publication: 2024 Apr 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Spondylitis, Ankylosing*/immunology , Spondylitis, Ankylosing*/genetics , Neovascularization, Pathologic*/immunology , Macaca fascicularis*, Animals ; Humans ; Monocytes/immunology ; Disease Models, Animal ; T Follicular Helper Cells/immunology ; Osteogenesis/immunology ; Male ; Dendritic Cells/immunology ; Angiogenesis

المؤلفون: Suen HC; Developmental and Regenerative Biology Program, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China., Ou F; Developmental and Regenerative Biology Program, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China., Miu KK; Developmental and Regenerative Biology Program, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China., Wang Z; Developmental and Regenerative Biology Program, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China., Chan WY; Developmental and Regenerative Biology Program, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China., Liao J; Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China. liaojinyue@link.cuhk.edu.hk.

المصدر: BMC genomics [BMC Genomics] 2024 May 13; Vol. 25 (1), pp. 464. Date of Electronic Publication: 2024 May 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100965258 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2164 (Electronic) Linking ISSN: 14712164 NLM ISO Abbreviation: BMC Genomics Subsets: MEDLINE

مواضيع طبية MeSH: Chromatin*/metabolism , Chromatin*/genetics , Cell Lineage*/genetics , Single-Cell Analysis* , SOX9 Transcription Factor*/genetics , SOX9 Transcription Factor*/metabolism , Gonads*/metabolism , Gonads*/cytology , Gonads*/embryology, Animals ; Mice ; Female ; Male ; Steroidogenic Factor 1/genetics ; Steroidogenic Factor 1/metabolism ; WT1 Proteins/genetics ; WT1 Proteins/metabolism ; Testis/metabolism ; Testis/cytology ; Epigenesis, Genetic ; Gene Expression Regulation, Developmental ; Ovary/metabolism ; Ovary/cytology

المؤلفون: Wang Z; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China., Chan SW; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China., Zhao H; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.; Kunming Institute of Zoology - The Chinese University of Hong Kong (KIZ-CUHK) Joint Laboratory of Bioresources and Molecular Research of Common Diseases, Hong Kong SAR, China.; Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China., Miu KK; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China. E-mail: kelvinmiu@gmail.com., Chan WY; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.; Kunming Institute of Zoology - The Chinese University of Hong Kong (KIZ-CUHK) Joint Laboratory of Bioresources and Molecular Research of Common Diseases, Hong Kong SAR, China.; Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.; Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. E-mail: chanwy@cuhk.edu.hk.

المصدر: Zoological research [Zool Res] 2023 May 18; Vol. 44 (3), pp. 559-576.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Science Press Country of Publication: China NLM ID: 101697192 Publication Model: Print Cited Medium: Internet ISSN: 2095-8137 (Print) Linking ISSN: 20958137 NLM ISO Abbreviation: Zool Res Subsets: MEDLINE

مواضيع طبية MeSH: Parkinson Disease*/genetics, Animals ; Rats ; Dopamine ; Inflammation ; Signal Transduction ; Ubiquitin-Protein Ligases/genetics

المؤلفون: Wang Z; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China., Miu KK; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China., Chan SW; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China., Ou F; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China., Wai-Nok Law P; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China., Chan WY; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.; Key Laboratory for Regenerative Medicine, Jinan University-The Chinese University of Hong Kong, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.

المصدر: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2022 Dec 22; Vol. 10, pp. 956604. Date of Electronic Publication: 2022 Dec 22 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101630250 Publication Model: eCollection Cited Medium: Print ISSN: 2296-634X (Print) Linking ISSN: 2296634X NLM ISO Abbreviation: Front Cell Dev Biol Subsets: PubMed not MEDLINE

المؤلفون: Zhu JY; Centre of Phase I Clinical Trial, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510000, China., Lyu AQ; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR 999077, China., Wang ZT; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR 999077, China., Chan WY; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR 999077, China., Qin T; Centre of Phase I Clinical Trial, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510000, China., Miu KK; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR 999077, China., Yao HR; Centre of Phase I Clinical Trial, Department of Medical Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510000, China.

المصدر: Journal of immunology research [J Immunol Res] 2022 Aug 18; Vol. 2022, pp. 3704798. Date of Electronic Publication: 2022 Aug 18 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Hindawi Publishing Corporation Country of Publication: Egypt NLM ID: 101627166 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-7156 (Electronic) Linking ISSN: 23147156 NLM ISO Abbreviation: J Immunol Res Subsets: MEDLINE

مواضيع طبية MeSH: Breast Neoplasms* , RNA, Long Noncoding*, Biomarkers, Tumor ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Machine Learning ; Prognosis

المؤلفون: Wang Z; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, 505A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, Hong Kong SAR, China., Ma J; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, 505A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, Hong Kong SAR, China; School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China., He Y; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, 505A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, Hong Kong SAR, China., Miu KK; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, 505A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, Hong Kong SAR, China., Yao S; State Key Laboratory of Drug Research and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Tang C; State Key Laboratory of Drug Research and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Ye Y; State Key Laboratory of Drug Research and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Lin G; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, 505A, Lo Kwee-Seong Integrated Biomedical Sciences Building, Area 39, Hong Kong SAR, China. Electronic address: linge@cuhk.edu.hk.

المصدر: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2022 Jul 20; Vol. 102, pp. 154162. Date of Electronic Publication: 2022 May 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

مواضيع طبية MeSH: Chemical and Drug Induced Liver Injury, Chronic*/pathology , Liver Diseases*/metabolism , Pyrrolizidine Alkaloids*/pharmacology, Animals ; Rats ; Antioxidants/metabolism ; Antioxidants/pharmacology ; Endothelial Cells/metabolism ; Glycogen Synthase Kinase 3 beta/metabolism ; Glycyrrhetinic Acid/analogs & derivatives ; Liver ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism

المؤلفون: Lee P; Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Yim R; Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Miu KK; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Fung SH; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Liao JJ; Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Wang Z; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China., Li J; Department of Infectious Diseases and Public Health, The City University of Hong Kong, Hong Kong, China., Yung Y; Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Chu HT; Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Yip PK; Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Lee E; Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Tse E; Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Kwong YL; Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Gill H; Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2022 May 18; Vol. 23 (10). Date of Electronic Publication: 2022 May 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/genetics , Myelodysplastic Syndromes*/drug therapy , Myelodysplastic Syndromes*/genetics , Neoplasms, Second Primary*/genetics , PTEN Phosphohydrolase*/genetics , Proto-Oncogene Proteins c-mdm2*/genetics, Azacitidine/pharmacology ; Azacitidine/therapeutic use ; Cell Line, Tumor ; DNA Methylation ; Decitabine/pharmacology ; Epigenesis, Genetic ; Gene Silencing ; Humans

المؤلفون: Lee P; Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China., Yim R; Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China., Fung SH; School of Biomedical Sciences, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China., Miu KK; School of Biomedical Sciences, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China., Wang Z; School of Biomedical Sciences, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China., Wu KC; Department of Clinical Oncology, School of Clinical Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China., Au L; Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China., Leung GM; Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China., Lee VH; Department of Clinical Oncology, School of Clinical Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China., Gill H; Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2022 Apr 22; Vol. 23 (9). Date of Electronic Publication: 2022 Apr 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Variation*/genetics , Leukemia, Myeloid, Acute*/genetics , Myelodysplastic Syndromes*/genetics , Myelodysplastic Syndromes*/pathology, DNA Copy Number Variations ; Disease Progression ; Humans ; Mutation ; Nucleotides ; Sequence Analysis, DNA ; Single-Cell Analysis/methods

المؤلفون: Wang Z; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China., Ma J; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China., Yao S; State Key Laboratory of Drug Research and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China., He Y; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China., Miu KK; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China., Xia Q; National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, United States., Fu PP; National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, United States., Ye Y; State Key Laboratory of Drug Research and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China., Lin G; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.

المصدر: Frontiers in pharmacology [Front Pharmacol] 2022 Mar 16; Vol. 13, pp. 850859. Date of Electronic Publication: 2022 Mar 16 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE

المؤلفون: Jia H; School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou, China.; Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China., Chen M; Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China., Cai Y; School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou, China., Luo X; School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou, China., Hou G; Department of Orthopedics, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Li Y; Guangzhou Blooming-Spring Biological Research Institute, Guangzhou, China., Cai C; School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou, China., Chen J; School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou, China., Li Q; School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou, China.; Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China., Miu KK; Developmental and Regenerative Biology Theme, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China., Fung SH; Developmental and Regenerative Biology Theme, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China., Wang Z; Developmental and Regenerative Biology Theme, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China., Huang R; Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China., Shen H; Department of Orthopedics, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, China., Lu L; School of Life Science and Biopharmacy, Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou, China. 541608180@qq.com.

المصدر: Arthritis research & therapy [Arthritis Res Ther] 2022 Jan 03; Vol. 24 (1), pp. 1. Date of Electronic Publication: 2022 Jan 03.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101154438 Publication Model: Electronic Cited Medium: Internet ISSN: 1478-6362 (Electronic) Linking ISSN: 14786354 NLM ISO Abbreviation: Arthritis Res Ther Subsets: MEDLINE

مواضيع طبية MeSH: Spondylitis, Ankylosing*/diagnostic imaging , Spondylitis, Ankylosing*/genetics, Animals ; Disease Progression ; Humans ; Macaca fascicularis ; Models, Animal ; Spine/pathology