المؤلفون: May, RD, Monk, PD, Cohen, ES, Manuel, D, Dempsey, F, Davis, NHE, Dodd, AJ, Corkill, DJ, Woods, J, Joberty-Candotti, C, Conroy, LA, Koentgen, F, Martin, EC, Wilson, R, Brennan, N, Powell, J, Anderson, IK

المصدر: British Journal of Pharmacology; May2012, Vol. 166 Issue 1, p177-193, 17p, 6 Graphs

مصطلحات موضوعية: INTERLEUKIN-13, ASTHMA treatment, IMMUNOGLOBULINS, CYTOKINES, MONOCLONAL antibodies, DRUG development, LABORATORY monkeys

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المؤلفون: Monk PD; Synairgen Research Ltd, Southampton, UK. phillip.monk@synairgen.com., Brookes JL; Synairgen Research Ltd, Southampton, UK., Tear VJ; Synairgen Research Ltd, Southampton, UK., Batten TN; Veramed, Twickenham, London, UK., Newall C; Veramed, Twickenham, London, UK., Mankowski M; Synairgen Research Ltd, Southampton, UK.; tranScrip Ltd, Wokingham, UK., Crooks MG; Respiratory Research Group, Hull York Medical School, University of Hull, Kingston Upon Hull, Hull, UK., Singh D; Medicines Evaluation Unit, The University of Manchester, Manchester University NHS Foundation Trust, Manchester, UK., Chaudhuri R; Gartnavel General Hospital, Glasgow, UK.; School of Infection and Immunity, University of Glasgow, Glasgow, UK., Leaker B; Respiratory Clinical Trials Ltd, Fitzrovia Hospital, London, UK., Lunn K; Synairgen Research Ltd, Southampton, UK., Reynolds S; Synairgen Research Ltd, Southampton, UK., Dudley S; Synairgen Research Ltd, Southampton, UK., Gabbay FJ; tranScrip Ltd, Wokingham, UK., Holgate ST; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, University of Southampton, Southampton, UK., Djukanovic R; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, University of Southampton, Southampton, UK., Wilkinson TM; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, University of Southampton, Southampton, UK.

المصدر: Respiratory research [Respir Res] 2024 May 29; Vol. 25 (1), pp. 228. Date of Electronic Publication: 2024 May 29.

نوع المنشور: Journal Article; Randomized Controlled Trial

بيانات الدورية: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101090633 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-993X (Electronic) Linking ISSN: 14659921 NLM ISO Abbreviation: Respir Res Subsets: MEDLINE

مواضيع طبية MeSH: Pulmonary Disease, Chronic Obstructive*/drug therapy , Pulmonary Disease, Chronic Obstructive*/diagnosis , Pulmonary Disease, Chronic Obstructive*/virology, Humans ; Male ; Female ; Middle Aged ; Aged ; Administration, Inhalation ; Double-Blind Method ; Nebulizers and Vaporizers ; Sputum/virology ; Sputum/metabolism ; Treatment Outcome ; Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; Disease Progression ; Interferon-beta/administration & dosage

المؤلفون: Francis NA; Primary Care Research Centre, Faculty of Medicine, University of Southampton, Aldermoor Health Centre, Southampton, UK nick.francis@soton.ac.uk., Monk PD; Synairgen Research Ltd, Southampton, UK., Nuttall J; Southampton Clinical Trials Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK., Oliver T; Southampton Clinical Trials Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK., Simpson C; Southampton Clinical Trials Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK., Brookes JL; Synairgen Research Ltd, Southampton, UK., Tear VJ; Synairgen Research Ltd, Southampton, UK., Thompson AG; Quinn Clinical Limited, Merseyside, UK., Batten TN; Veramed, Twickenham, London, UK., Mankowski M; tranScrip Ltd, Wokingham, UK., Wilkinson TM; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, University of Southampton, Southampton, UK.

المصدر: BJGP open [BJGP Open] 2023 Dec 19; Vol. 7 (4). Date of Electronic Publication: 2023 Dec 19 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal College of General Practitioners Country of Publication: England NLM ID: 101713531 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2398-3795 (Electronic) Linking ISSN: 23983795 NLM ISO Abbreviation: BJGP Open Subsets: PubMed not MEDLINE

المؤلفون: Jagannathan P; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Chew KW; Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA., Giganti MJ; Harvard T.H. Chan School of Public Health, Boston, MA, USA., Hughes MD; Harvard T.H. Chan School of Public Health, Boston, MA, USA., Moser C; Harvard T.H. Chan School of Public Health, Boston, MA, USA., Main MJ; Synairgen Research Ltd, Southampton, United Kingdom., Monk PD; Synairgen Research Ltd, Southampton, United Kingdom., Javan AC; National Institutes of Health, Bethesda, MD, USA., Li JZ; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Fletcher CV; University of Nebraska Medical Center, College of Pharmacy, USA., McCarthy C; Harvard T.H. Chan School of Public Health, Boston, MA, USA., Wohl DA; Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Daar ES; Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Eron JJ; Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Currier JS; Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA., Singh U; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Smith DM; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Fischer W; Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.

مؤلفون مشاركون: ACTIV-2/A5401 Study Team

المصدر: EClinicalMedicine [EClinicalMedicine] 2023 Oct 06; Vol. 65, pp. 102250. Date of Electronic Publication: 2023 Oct 06 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: The Lancet Country of Publication: England NLM ID: 101733727 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-5370 (Electronic) Linking ISSN: 25895370 NLM ISO Abbreviation: EClinicalMedicine Subsets: PubMed not MEDLINE

المؤلفون: Monk PD; Synairgen Research Ltd, Southampton, UK., Brookes JL; Synairgen Research Ltd, Southampton, UK., Tear VJ; Synairgen Research Ltd, Southampton, UK., Batten TN; Veramed, Twickenham, UK., Mankowski M; tranScrip Ltd, Wokingham, UK., Adzic-Vukicevic T; University Clinical Center of Serbia, COVID Hospital Batajnica, Belgrade, Serbia., Crooks MG; Respiratory Research Group, Hull York Medical School, University of Hull, Kingston upon Hull, UK., Dosanjh DPS; Birmingham and West Midlands Lung Research Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Kraft M; Department of Medicine, College of Medicine, Tucson, AZ, USA.; Asthma and Airway Disease Research Center, University of Arizona Health Sciences, Tucson, AZ, USA., Brightling CE; Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Gabbay FJ; tranScrip Ltd, Wokingham, UK., Holgate ST; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, University of Southampton, Southampton, UK., Djukanovic R; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, University of Southampton, Southampton, UK., Wilkinson TMA; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, University of Southampton, Southampton, UK.

المصدر: ERJ open research [ERJ Open Res] 2023 Mar 27; Vol. 9 (2). Date of Electronic Publication: 2023 Mar 27 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: European Respiratory Society Country of Publication: England NLM ID: 101671641 Publication Model: eCollection Cited Medium: Print ISSN: 2312-0541 (Print) Linking ISSN: 23120541 NLM ISO Abbreviation: ERJ Open Res Subsets: PubMed not MEDLINE

المؤلفون: Monk PD; Synairgen Research, Southampton General Hospital, Southampton, UK., Marsden RJ; Synairgen Research, Southampton General Hospital, Southampton, UK., Tear VJ; Synairgen Research, Southampton General Hospital, Southampton, UK., Brookes J; Synairgen Research, Southampton General Hospital, Southampton, UK., Batten TN; Veramed, Regal House, Twickenham, UK., Mankowski M; TranScrip Partners, Wokingham, UK., Gabbay FJ; TranScrip Partners, Wokingham, UK., Davies DE; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Sir Henry Wellcome Laboratories, Southampton, UK., Holgate ST; Synairgen Research, Southampton General Hospital, Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Sir Henry Wellcome Laboratories, Southampton, UK., Ho LP; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, UK., Clark T; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Sir Henry Wellcome Laboratories, Southampton, UK., Djukanovic R; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Sir Henry Wellcome Laboratories, Southampton, UK., Wilkinson TMA; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Sir Henry Wellcome Laboratories, Southampton, UK. Electronic address: t.wilkinson@soton.ac.uk.

مؤلفون مشاركون: Inhaled Interferon Beta COVID-19 Study Group

المصدر: The Lancet. Respiratory medicine [Lancet Respir Med] 2021 Feb; Vol. 9 (2), pp. 196-206. Date of Electronic Publication: 2020 Nov 12.

نوع المنشور: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 101605555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2619 (Electronic) Linking ISSN: 22132600 NLM ISO Abbreviation: Lancet Respir Med Subsets: MEDLINE

مواضيع طبية MeSH: COVID-19 Drug Treatment*, Antiviral Agents/*administration & dosage , Interferon beta-1a/*administration & dosage, Administration, Inhalation ; Adult ; Aged ; Antiviral Agents/adverse effects ; Double-Blind Method ; Female ; Humans ; Interferon beta-1a/adverse effects ; Male ; Middle Aged ; Nebulizers and Vaporizers ; Treatment Outcome

المؤلفون: Jones MG; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Andriotis OG; Institute for Lightweight Design and Structural Biomechanics, TU Wien, Getreidemarkt, Austria., Roberts JJ; Synairgen Research Ltd, Southampton, United Kingdom., Lunn K; Synairgen Research Ltd, Southampton, United Kingdom., Tear VJ; Synairgen Research Ltd, Southampton, United Kingdom., Cao L; Pharmaxis Ltd, Frenchs Forest, Australia., Ask K; Department of Medicine, Firestone Institute for Respiratory Health, McMaster University and The Research Institute of St. Joe's Hamilton, Hamilton, Canada., Smart DE; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Bonfanti A; Aeronautics, Astronautics and Computational Engineering, Faculty of Engineering and the Environment, University of Southampton, Southampton, United Kingdom., Johnson P; Department of Chemistry, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, United Kingdom.; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom., Alzetani A; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; University Hospital Southampton, Southampton, United Kingdom., Conforti F; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Doherty R; Biomedical Imaging Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Lai CY; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Johnson B; CRUK and NIHR Experimental Cancer Medicine Centre, Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Bourdakos KN; Department of Chemistry, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, United Kingdom.; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom., Fletcher SV; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; University Hospital Southampton, Southampton, United Kingdom., Marshall BG; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; University Hospital Southampton, Southampton, United Kingdom., Jogai S; University Hospital Southampton, Southampton, United Kingdom., Brereton CJ; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Chee SJ; University Hospital Southampton, Southampton, United Kingdom.; CRUK and NIHR Experimental Cancer Medicine Centre, Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Ottensmeier CH; CRUK and NIHR Experimental Cancer Medicine Centre, Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Sime P; Division of Pulmonary and Critical Care Medicine, University of Rochester School of Medicine and Dentistry, Rochester, United States., Gauldie J; Department of Medicine, Firestone Institute for Respiratory Health, McMaster University and The Research Institute of St. Joe's Hamilton, Hamilton, Canada., Kolb M; Department of Medicine, Firestone Institute for Respiratory Health, McMaster University and The Research Institute of St. Joe's Hamilton, Hamilton, Canada., Mahajan S; Department of Chemistry, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, United Kingdom.; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom., Fabre A; Department of Histopathology, St. Vincent's University Hospital & UCD School of Medicine, University College Dublin, Dublin, Ireland., Bhaskar A; Aeronautics, Astronautics and Computational Engineering, Faculty of Engineering and the Environment, University of Southampton, Southampton, United Kingdom., Jarolimek W; Pharmaxis Ltd, Frenchs Forest, Australia., Richeldi L; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., O'Reilly KM; Mater Misericordiae University Hospital, Dublin, Ireland.; School of Medicine and Medical Science, University College Dublin, Dublin, Ireland., Monk PD; Synairgen Research Ltd, Southampton, United Kingdom., Thurner PJ; Institute for Lightweight Design and Structural Biomechanics, TU Wien, Getreidemarkt, Austria., Davies DE; NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom.

المصدر: ELife [Elife] 2018 Jul 03; Vol. 7. Date of Electronic Publication: 2018 Jul 03.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

مواضيع طبية MeSH: Amino Acid Oxidoreductases/*antagonists & inhibitors , Collagen/*chemistry , Enzyme Inhibitors/*pharmacology , Extracellular Matrix/*chemistry , Pulmonary Fibrosis/*drug therapy , Reticulin/*chemistry, Amino Acid Oxidoreductases/genetics ; Amino Acid Oxidoreductases/metabolism ; Amino Acids/chemistry ; Animals ; Biomechanical Phenomena ; Case-Control Studies ; Collagen/metabolism ; Collagen/ultrastructure ; Cross-Linking Reagents/chemistry ; Disease Models, Animal ; Extracellular Matrix/metabolism ; Extracellular Matrix/ultrastructure ; Female ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Gene Expression ; Homeostasis/genetics ; Humans ; Lung/metabolism ; Lung/pathology ; Mechanotransduction, Cellular ; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase/antagonists & inhibitors ; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase/genetics ; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase/metabolism ; Protein-Lysine 6-Oxidase ; Pulmonary Fibrosis/genetics ; Pulmonary Fibrosis/metabolism ; Pulmonary Fibrosis/pathology ; Rats ; Rats, Sprague-Dawley ; Reticulin/metabolism ; Reticulin/ultrastructure ; Structure-Activity Relationship ; Transforming Growth Factor beta1/antagonists & inhibitors ; Transforming Growth Factor beta1/pharmacology

المؤلفون: Cohen ES; MedImmune Ltd; Cambridge, UK., Dobson CL; MedImmune Ltd; Cambridge, UK., Käck H; 2 AstraZeneca R&D; Mölndal, Sweden., Wang B; MedImmune LLC; Hayward, CA USA., Sims DA; MedImmune PLC; Gaithersburg, MD USA., Lloyd CO; MedImmune Ltd; Cambridge, UK., England E; MedImmune Ltd; Cambridge, UK., Rees DG; MedImmune Ltd; Cambridge, UK., Guo H; 2 AstraZeneca R&D; Mölndal, Sweden., Karagiannis SN; 5 Cutaneous Medicine and Immunotherapy Unit; St. John's Institute of Dermatology; Division of Genetics and Molecular Medicine; King's College London School of Medicine & NIHR Biomedical Research Centre at Guy's and St. Thomas's Hospitals and King's College London; Guy's Hospital; King's College London; London, UK., O'Brien S; MedImmune Ltd; Cambridge, UK., Persdotter S; 2 AstraZeneca R&D; Mölndal, Sweden., Ekdahl H; Labjoy; Lund, Sweeden., Butler R; MedImmune Ltd; Cambridge, UK., Keyes F; MedImmune Ltd; Cambridge, UK., Oakley S; MedImmune Ltd; Cambridge, UK., Carlsson M; 2 AstraZeneca R&D; Mölndal, Sweden., Briend E; MedImmune Ltd; Cambridge, UK., Wilkinson T; MedImmune Ltd; Cambridge, UK., Anderson IK; Johnson & Johnson Innovation; London, UK., Monk PD; Synairgen Research Ltd; Southampton General Hospital; Southampton, UK., von Wachenfeldt K; 9 Truly Translational Sweden AB; Lund, Sweden., Eriksson PO; Spago Imaging AB; Lund, Sweden., Gould HJ; Randall Division of Cell and Molecular Biophysics; Division of Asthma, Allergy and Lung Biology; MRC and Asthma UK Centre for Allergic Mechanisms of Asthma; King's College London; London, UK., Vaughan TJ; MedImmune Ltd; Cambridge, UK., May RD; MedImmune Ltd; Cambridge, UK.

المصدر: MAbs [MAbs] 2014 May-Jun; Vol. 6 (3), pp. 756-64. Date of Electronic Publication: 2014 Feb 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Anti-Idiotypic/*immunology , Antibodies, Anti-Idiotypic/*therapeutic use , Antibodies, Neutralizing/*immunology , Antibodies, Neutralizing/*therapeutic use , Asthma/*immunology , Asthma/*therapy , Immunoglobulin E/*immunology, Adolescent ; Adult ; Aged ; Antibodies, Anti-Idiotypic/genetics ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antibodies, Neutralizing/genetics ; Antibody Affinity ; Antibody Specificity ; Antigen-Antibody Complex/chemistry ; Antigen-Antibody Complex/immunology ; Antigen-Antibody Reactions ; Binding Sites ; Cohort Studies ; Humans ; Immunoglobulin E/chemistry ; Immunoglobulin E/metabolism ; Immunoglobulin G/genetics ; Immunoglobulin G/immunology ; Immunoglobulin G/therapeutic use ; Middle Aged ; Models, Molecular ; Omalizumab ; Peptide Library ; Receptors, IgE/metabolism ; Young Adult