المؤلفون: Lambert K; Center for Translational Immunology, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA., Moo KG; Center for Translational Immunology, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA., Arnett A; Center for Translational Immunology, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA., Goel G; Center for Systems Immunology, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA., Hu A; Center for Systems Immunology, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA., Flynn KJ; Center for Systems Immunology, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA., Speake C; Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA., Wiedeman AE; Center for Translational Immunology, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA., Gersuk VH; Center for Systems Immunology, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA., Linsley PS; Center for Systems Immunology, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA., Greenbaum CJ; Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA., Long SA; Center for Translational Immunology, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA., Partridge R; Center for Translational Immunology, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA.; Department of Pediatrics, Virginia Mason Medical Center, 100 N.E. Gilman Blvd., Issaquah, WA 98027, USA., Buckner JH; Center for Translational Immunology, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA., Khor B; Center for Translational Immunology, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA.

المصدر: Science translational medicine [Sci Transl Med] 2022 Jan 12; Vol. 14 (627), pp. eabi4888. Date of Electronic Publication: 2022 Jan 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Autoimmune Diseases* , Diabetes Mellitus, Type 1* , Down Syndrome*/genetics, Aging ; Autoimmunity/genetics ; CD8-Positive T-Lymphocytes ; Humans ; Immunophenotyping

المؤلفون: Arnett A; Benaroya Research Institute, Seattle, Washington, USA., Moo KG; Benaroya Research Institute, Seattle, Washington, USA., Flynn KJ; Benaroya Research Institute, Seattle, Washington, USA., Sundberg TB; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA., Johannessen L; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA., Shamji AF; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA., Gray NS; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA., Decker T; Max Perutz Labs, University of Viennagrid.10420.37, Vienna, Austria., Zheng Y; NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studiesgrid.250671.7, La Jolla, California, USA., Gersuk VH; Benaroya Research Institute, Seattle, Washington, USA., Rahman ZS; Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA., Levy DE; Department of Pathology, New York University School of Medicine, New York, New York, USA., Marié IJ; Department of Pathology, New York University School of Medicine, New York, New York, USA., Linsley PS; Benaroya Research Institute, Seattle, Washington, USA., Xavier RJ; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.; The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA., Khor B; Benaroya Research Institute, Seattle, Washington, USA.

المصدر: Molecular and cellular biology [Mol Cell Biol] 2021 Aug 24; Vol. 41 (9), pp. e0008521. Date of Electronic Publication: 2021 Aug 24.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 8109087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5549 (Electronic) Linking ISSN: 02707306 NLM ISO Abbreviation: Mol Cell Biol Subsets: MEDLINE

مواضيع طبية MeSH: Immunophenotyping*, CD4-Positive T-Lymphocytes/*immunology , Cyclin-Dependent Kinase 8/*antagonists & inhibitors , Forkhead Transcription Factors/*metabolism , GATA3 Transcription Factor/*metabolism , Heterocyclic Compounds, 4 or More Rings/*pharmacology , Immune Tolerance/*drug effects , Isoquinolines/*pharmacology, Adolescent ; Adult ; Animals ; CD4-Positive T-Lymphocytes/drug effects ; Cell Differentiation/drug effects ; Cyclin-Dependent Kinase 8/metabolism ; Humans ; Immunity, Innate/drug effects ; Mice, Inbred BALB C ; Middle Aged ; Phosphorylation/drug effects ; Proto-Oncogene Proteins c-jun/metabolism ; STAT Transcription Factors/metabolism ; Signal Transduction/drug effects ; Young Adult ; Mice