المؤلفون: Morozko, EL, Smith-Geater, C, Monteys, AM, Pradhan, S, Lim, RG, Langfelder, P, Kachemov, M, Kulkarni, JA, Zaifman, J, Hill, A, Stocksdale, JT, Cullis, PR, Wu, J, Ochaba, J, Miramontes, R, Chakraborty, A, Hazral, TK, Laub, A, St-Cyrc, S, Orellanam, I, Kopan, L, Wang, KQ, Yeung, S, Leavitt, BR, Reidling, JC, Yang, XW, Steffan, JS, Davidson, BL, Sarkar, PS, Thompson, LM

المصدر: Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 32

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od_______325::09985a4ebf37235f513250eff78dfb8c
https://escholarship.org/uc/item/3qr022ts

المؤلفون: Morozko EL; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697., Smith-Geater C; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697., Monteys AM; Raymond G. Perelman Center for Cell and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Pradhan S; Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555., Lim RG; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697., Langfelder P; Department of Human Genetics, David Geffen School of Medicine at University of California, Los Angeles, CA 90095., Kachemov M; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697., Kulkarni JA; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3., Zaifman J; Department of Chemistry, University of British Columbia, Vancouver, BC, Canada V6T 1Z1., Hill A; Incisive Genetics Inc., Vancouver, BC, Canada V6A 0H9., Stocksdale JT; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697., Cullis PR; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.; NanoMedicines Innovation Network, University of British Columbia, Vancouver, BC, Canada V6T 1Z3., Wu J; Department of Biological Chemistry, University of California, Irvine, CA 92697., Ochaba J; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697., Miramontes R; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697., Chakraborty A; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555., Hazra TK; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555., Lau A; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697., St-Cyr S; Raymond G. Perelman Center for Cell and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Orellana I; Sue and Bill Gross Stem Cell Institute, University of California, Irvine, CA 92697., Kopan L; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697., Wang KQ; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697., Yeung S; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697., Leavitt BR; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada V5Z 4H4., Reidling JC; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697., Yang XW; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095., Steffan JS; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697.; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697., Davidson BL; Raymond G. Perelman Center for Cell and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104., Sarkar PS; Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555.; Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555., Thompson LM; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697; lmthomps@uci.edu.; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697.; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.; Department of Biological Chemistry, University of California, Irvine, CA 92697.; Sue and Bill Gross Stem Cell Institute, University of California, Irvine, CA 92697.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jan 26; Vol. 118 (4).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: DNA Repair* , Protein Processing, Post-Translational*, DNA/*genetics , DNA Repair Enzymes/*genetics , Huntingtin Protein/*genetics , Huntington Disease/*genetics , Phosphotransferases (Alcohol Group Acceptor)/*genetics , Protein Inhibitors of Activated STAT/*genetics , Small Ubiquitin-Related Modifier Proteins/*genetics, Animals ; Cell Differentiation ; DNA/metabolism ; DNA Damage ; DNA Repair Enzymes/metabolism ; Disease Models, Animal ; Female ; Humans ; Huntingtin Protein/metabolism ; Huntington Disease/metabolism ; Huntington Disease/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neurons/metabolism ; Neurons/pathology ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Pluripotent Stem Cells/metabolism ; Pluripotent Stem Cells/pathology ; Primary Cell Culture ; Protein Inhibitors of Activated STAT/antagonists & inhibitors ; Protein Inhibitors of Activated STAT/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Small Ubiquitin-Related Modifier Proteins/antagonists & inhibitors ; Small Ubiquitin-Related Modifier Proteins/metabolism ; Sumoylation ; Transcription, Genetic

المؤلفون: Ochaba J; Department of Psychiatry and Human Behavior, University of California Irvine; UCI MIND, University of California Irvine., Morozko EL; UCI MIND, University of California Irvine; Department of Neurobiology and Behavior, University of California Irvine., O'Rourke JG; Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center., Thompson LM; Department of Psychiatry and Human Behavior, University of California Irvine; UCI MIND, University of California Irvine; Department of Neurobiology and Behavior, University of California Irvine; lmthomps@uci.edu.

المصدر: Journal of visualized experiments : JoVE [J Vis Exp] 2018 Feb 27 (132). Date of Electronic Publication: 2018 Feb 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Video-Audio Media

بيانات الدورية: Publisher: MYJoVE Corporation Country of Publication: United States NLM ID: 101313252 Publication Model: Electronic Cited Medium: Internet ISSN: 1940-087X (Electronic) Linking ISSN: 1940087X NLM ISO Abbreviation: J Vis Exp Subsets: MEDLINE

مواضيع طبية MeSH: Dose Fractionation, Radiation*, Huntingtin Protein/*genetics , Huntington Disease/*drug therapy, Animals ; Humans ; Huntingtin Protein/metabolism ; Mice ; Models, Biological

المؤلفون: Morozko EL; University of California, Irvine, Neurobiology and Behavior, Irvine, CA, USA., Ochaba J; University of California, Irvine, Neurobiology and Behavior, Irvine, CA, USA.; University of California, Irvine, Psychiatry & Human Behavior, Irvine, CA, USA., Hernandez SJ; University of California, Irvine, Neurobiology and Behavior, Irvine, CA, USA., Lau A; University of California, Irvine, Psychiatry & Human Behavior, Irvine, CA, USA., Sanchez I; University of California, Irvine, Neurobiology and Behavior, Irvine, CA, USA., Orellana I; Institute for Memory Impairment and Neurological Disorders, University of California, Irvine, CA, USA., Kopan L; University of California, Irvine, Neurobiology and Behavior, Irvine, CA, USA., Crapser J; University of California, Irvine, Neurobiology and Behavior, Irvine, CA, USA., Duong JH; University of California, Irvine, Neurobiology and Behavior, Irvine, CA, USA., Overman J; University of California, Irvine, Neurobiology and Behavior, Irvine, CA, USA., Yeung S; Institute for Memory Impairment and Neurological Disorders, University of California, Irvine, CA, USA., Steffan JS; University of California, Irvine, Psychiatry & Human Behavior, Irvine, CA, USA.; Institute for Memory Impairment and Neurological Disorders, University of California, Irvine, CA, USA., Reidling J; Institute for Memory Impairment and Neurological Disorders, University of California, Irvine, CA, USA., Thompson LM; University of California, Irvine, Neurobiology and Behavior, Irvine, CA, USA.; University of California, Irvine, Psychiatry & Human Behavior, Irvine, CA, USA.; Institute for Memory Impairment and Neurological Disorders, University of California, Irvine, CA, USA.

المصدر: Journal of Huntington's disease [J Huntingtons Dis] 2018; Vol. 7 (4), pp. 321-335.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 101589965 Publication Model: Print Cited Medium: Internet ISSN: 1879-6400 (Electronic) Linking ISSN: 18796397 NLM ISO Abbreviation: J Huntingtons Dis Subsets: MEDLINE

مواضيع طبية MeSH: Brain/*metabolism , Huntingtin Protein/*metabolism , Protein Aggregation, Pathological/*metabolism, Animals ; Disease Models, Animal ; Electrophoresis, Agar Gel ; Electrophoresis, Polyacrylamide Gel ; Exons ; Humans ; Huntingtin Protein/genetics ; Huntington Disease/metabolism ; Longitudinal Studies ; Mice ; Mice, Inbred Strains ; Mice, Transgenic ; Specimen Handling

المؤلفون: Bird JE; Laboratory of Molecular Genetics, National Institutes of Health, Bethesda, MD 20814 jonathan.bird@nih.gov., Barzik M; Laboratory of Molecular Genetics, National Institutes of Health, Bethesda, MD 20814., Drummond MC; Laboratory of Molecular Genetics, National Institutes of Health, Bethesda, MD 20814., Sutton DC; Laboratory of Molecular Genetics, National Institutes of Health, Bethesda, MD 20814., Goodman SM; Laboratory of Molecular Genetics, National Institutes of Health, Bethesda, MD 20814., Morozko EL; Laboratory of Molecular Genetics, National Institutes of Health, Bethesda, MD 20814., Cole SM; Laboratory of Molecular Genetics, National Institutes of Health, Bethesda, MD 20814., Boukhvalova AK; Laboratory of Molecular Genetics, National Institutes of Health, Bethesda, MD 20814., Skidmore J; Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109., Syam D; Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109., Wilson EA; Laboratory of Molecular Genetics, National Institutes of Health, Bethesda, MD 20814., Fitzgerald T; Mouse Auditory Testing Core Facility, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20814., Rehman AU; Laboratory of Molecular Genetics, National Institutes of Health, Bethesda, MD 20814., Martin DM; Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109.; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109., Boger ET; Laboratory of Molecular Genetics, National Institutes of Health, Bethesda, MD 20814., Belyantseva IA; Laboratory of Molecular Genetics, National Institutes of Health, Bethesda, MD 20814., Friedman TB; Laboratory of Molecular Genetics, National Institutes of Health, Bethesda, MD 20814.

المصدر: Molecular biology of the cell [Mol Biol Cell] 2017 Feb 01; Vol. 28 (3), pp. 463-475. Date of Electronic Publication: 2016 Dec 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Cell Biology Country of Publication: United States NLM ID: 9201390 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-4586 (Electronic) Linking ISSN: 10591524 NLM ISO Abbreviation: Mol Biol Cell Subsets: MEDLINE

مواضيع طبية MeSH: Microscopy, Fluorescence/*methods , Molecular Imaging/*methods , Single-Cell Analysis/*methods, Actin Cytoskeleton/metabolism ; Cell Movement ; Green Fluorescent Proteins/metabolism ; Molecular Motor Proteins ; Myosins/metabolism ; Protein Interaction Domains and Motifs/physiology ; Protein Transport ; Pseudopodia/metabolism

المؤلفون: Morozko EL; National Institute on Deafness and Other Communication Disorders, Section on Human Genetics., Nishio A; National Institute on Deafness and Other Communication Disorders, Molecular Biology and Genetics Section., Ingham NJ; Wolfson Centre for Age-Related Diseases, King's College London, London SE1 1UL, UK., Chandra R; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Fitzgerald T; National Institute on Deafness and Other Communication Disorders, Mouse Auditory Testing Core Facility, National Institutes of Health, Bethesda, MD 20892-3729, USA., Martelletti E; Wolfson Centre for Age-Related Diseases, King's College London, London SE1 1UL, UK., Borck G; Institute of Human Genetics, University of Ulm, Ulm 89081, Germany., Wilson E; National Institute on Deafness and Other Communication Disorders, Section on Human Genetics., Riordan GP; National Institute on Deafness and Other Communication Disorders, Section on Human Genetics., Wangemann P; Anatomy and Physiology Department, Kansas State University, Manhattan, KS 66506-5802, USA and., Forge A; Centre for Auditory Research, University College London, London WC1X 8EE, UK., Steel KP; Wolfson Centre for Age-Related Diseases, King's College London, London SE1 1UL, UK., Liddle RA; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Friedman TB; National Institute on Deafness and Other Communication Disorders, Section on Human Genetics., Belyantseva IA; National Institute on Deafness and Other Communication Disorders, Section on Human Genetics belyants@nidcd.nih.gov.

المصدر: Human molecular genetics [Hum Mol Genet] 2015 Feb 01; Vol. 24 (3), pp. 609-24. Date of Electronic Publication: 2014 Sep 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE

مواضيع طبية MeSH: Hair Cells, Auditory/*pathology , Hearing Loss, Sensorineural/*pathology , Receptors, Cell Surface/*genetics , Tight Junctions/*pathology, Animals ; Disease Models, Animal ; Hair Cells, Auditory/metabolism ; Hearing Loss, Sensorineural/genetics ; Hearing Loss, Sensorineural/metabolism ; Humans ; MARVEL Domain Containing 2 Protein/metabolism ; Mice ; Mutation ; Receptors, Cell Surface/metabolism ; Tight Junctions/metabolism

SCR Disease Name: Deafness, Autosomal Recessive 42