المؤلفون: Ivanchenko MV, Hathaway DM, Mulhall EM, Booth KT, Wang M, Peters CW, Klein AJ, Chen X, Li Y, György B, Corey DP

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 13. Date of Electronic Publication: 2023 Nov 13.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Mulhall EM; Howard Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA., Gharpure A; Howard Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA., Lee RM; Advanced Imaging Center, Howard Hughes Medical Institute Janelia Research Campus, Ashburn, VA, USA., Dubin AE; Howard Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA., Aaron JS; Advanced Imaging Center, Howard Hughes Medical Institute Janelia Research Campus, Ashburn, VA, USA., Marshall KL; Howard Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA.; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA., Spencer KR; Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA., Reiche MA; Advanced Imaging Center, Howard Hughes Medical Institute Janelia Research Campus, Ashburn, VA, USA., Henderson SC; Department of Molecular Medicine, Scripps Research, La Jolla, CA, USA., Chew TL; Advanced Imaging Center, Howard Hughes Medical Institute Janelia Research Campus, Ashburn, VA, USA., Patapoutian A; Howard Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA. ardem@scripps.edu.

المصدر: Nature [Nature] 2023 Aug; Vol. 620 (7976), pp. 1117-1125. Date of Electronic Publication: 2023 Aug 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Ion Channels*/chemistry , Ion Channels*/metabolism, Cell Membrane/metabolism ; Fluorescence ; Models, Molecular ; Movement ; Protein Conformation ; Single-Cell Analysis

المؤلفون: Ivanchenko MV; Department of Neurobiology, Harvard Medical School, Boston, MA, USA., Hathaway DM; Department of Neurobiology, Harvard Medical School, Boston, MA, USA.; Department of Otolaryngology - Head and Neck Surgery, Harvard Medical School and Massachusetts Eye and Ear, Boston, MA, USA., Klein AJ; Department of Neurobiology, Harvard Medical School, Boston, MA, USA., Pan B; Department of Neurobiology, Harvard Medical School, Boston, MA, USA., Strelkova O; Department of Otolaryngology - Head and Neck Surgery, Harvard Medical School and Massachusetts Eye and Ear, Boston, MA, USA., De-la-Torre P; Department of Otolaryngology - Head and Neck Surgery, Harvard Medical School and Massachusetts Eye and Ear, Boston, MA, USA., Wu X; Department of Neurobiology, Harvard Medical School, Boston, MA, USA., Peters CW; Department of Neurobiology, Harvard Medical School, Boston, MA, USA., Mulhall EM; Department of Neurobiology, Harvard Medical School, Boston, MA, USA., Booth KT; Department of Neurobiology, Harvard Medical School, Boston, MA, USA., Goldstein C; Department of Neurobiology, Harvard Medical School, Boston, MA, USA., Brower J; Department of Otolaryngology - Head and Neck Surgery, Harvard Medical School and Massachusetts Eye and Ear, Boston, MA, USA., Sotomayor M; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA., Indzhykulian AA; Department of Otolaryngology - Head and Neck Surgery, Harvard Medical School and Massachusetts Eye and Ear, Boston, MA, USA., Corey DP; Department of Neurobiology, Harvard Medical School, Boston, MA, USA. david_corey@hms.harvard.edu.

المصدر: Nature communications [Nat Commun] 2023 Apr 26; Vol. 14 (1), pp. 2400. Date of Electronic Publication: 2023 Apr 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Ear, Inner*/metabolism , Usher Syndromes*/genetics , Usher Syndromes*/therapy, Animals ; Mice ; Cadherins/metabolism ; Hair Cells, Auditory/metabolism ; Hearing/genetics ; Cadherin Related Proteins/metabolism

SCR Disease Name: Usher Syndrome, Type IF

المؤلفون: Mulhall EM; Department of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Program in Neuroscience, Harvard University, Cambridge, MA, USA., Ward A; Department of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA., Yang D; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA., Koussa MA; Department of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Program in Neuroscience, Harvard University, Cambridge, MA, USA., Corey DP; Department of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. dcorey@hms.harvard.edu., Wong WP; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. wesley.wong@childrens.harvard.edu.; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. wesley.wong@childrens.harvard.edu.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA. wesley.wong@childrens.harvard.edu.

المصدر: Nature communications [Nat Commun] 2021 Feb 08; Vol. 12 (1), pp. 849. Date of Electronic Publication: 2021 Feb 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Single Molecule Imaging*, Hair Cells, Auditory/*physiology , Proteins/*metabolism, Animals ; Biomechanical Phenomena ; Calcium/metabolism ; Deafness/genetics ; Dimerization ; Elasticity ; Extracellular Space/metabolism ; Mice ; Mutation/genetics ; Phenotype

المؤلفون: Tu YH; Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA., Cooper AJ; Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA., Teng B; Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA., Chang RB; Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA., Artiga DJ; Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA., Turner HN; Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA., Mulhall EM; Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA., Ye W; Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA. liman@usc.edu., Smith AD; Department of Biological Sciences, Section of Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA., Liman ER; Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA. liman@usc.edu.; Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA.

المصدر: Science (New York, N.Y.) [Science] 2018 Mar 02; Vol. 359 (6379), pp. 1047-1050. Date of Electronic Publication: 2018 Jan 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Ion Channels/*genetics , Ion Channels/*metabolism , Membrane Proteins/*genetics , Membrane Proteins/*metabolism , Taste Buds/*metabolism, Animals ; Conserved Sequence ; Drosophila melanogaster ; Evolution, Molecular ; HEK293 Cells ; Humans ; Ion Channels/classification ; Membrane Proteins/classification ; Mice ; Otolithic Membrane/growth & development ; Phylogeny ; Protons ; Tissue Distribution ; Transcriptome

المؤلفون: Ye W; Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089;, Chang RB; Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089;, Bushman JD; Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089;, Tu YH; Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089;, Mulhall EM; Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089;, Wilson CE; Department of Otolaryngology, University of Colorado Medical School, Aurora, CO 80045; Rocky Mountain Taste and Smell Center, University of Colorado Medical School, Aurora, CO 80045;, Cooper AJ; Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089;, Chick WS; Department of Cell and Developmental Biology, University of Colorado Medical School, Aurora, CO 80045;, Hill-Eubanks DC; Department of Pharmacology, University of Vermont, Burlington, VT 05405;, Nelson MT; Department of Pharmacology, University of Vermont, Burlington, VT 05405; Institute of Cardiovascular Sciences, University of Manchester, Manchester M13 9PT, United Kingdom., Kinnamon SC; Department of Otolaryngology, University of Colorado Medical School, Aurora, CO 80045; Rocky Mountain Taste and Smell Center, University of Colorado Medical School, Aurora, CO 80045;, Liman ER; Section of Neurobiology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089; liman@USC.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Jan 12; Vol. 113 (2), pp. E229-38. Date of Electronic Publication: 2015 Dec 01.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Protons* , Signal Transduction*/drug effects, Potassium Channels, Inwardly Rectifying/*metabolism , Taste/*physiology, Acids/pharmacology ; Action Potentials/drug effects ; Animals ; Calcium Channels/metabolism ; HEK293 Cells ; Humans ; Hydrogen-Ion Concentration ; Integrases/metabolism ; Intracellular Space/metabolism ; Ion Channel Gating/drug effects ; Mice, Knockout ; Models, Biological ; Organ Specificity/drug effects ; Receptors, Cell Surface/metabolism ; TRPM Cation Channels/metabolism ; Taste/drug effects ; Taste Buds/cytology ; Taste Buds/drug effects ; Taste Buds/metabolism ; Zinc/pharmacology