المؤلفون: Ma X; Department of Discovery Chemistry, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Sloman DL; Department of Discovery Chemistry, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Duggal R; Department of Pharmacokinetics, Dynamics, Metabolism and Bioanalytics, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Anderson KD; Department of Pharmacokinetics, Dynamics, Metabolism and Bioanalytics, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Ballard JE; Department of Pharmacokinetics, Dynamics, Metabolism and Bioanalytics, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Bharathan I; Department of Discovery Chemistry, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Brynczka C; Department of Nonclinical Drug Safety, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Gathiaka S; Department of Discovery Chemistry, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Henderson TJ; Department of Discovery Chemistry, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Lyons TW; Department of Process Research and Development, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Miller R; Department of Discovery Quantitative Biosciences, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Munsell EV; Department of Discovery Pharmaceutical Sciences, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Orth P; Department of Analytical Research and Development, Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, New Jersey 07065, United States., Otte RD; Department of Discovery Chemistry, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Palani A; Department of Discovery Chemistry, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Rankic DA; Department of Process Research and Development, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Robinson MR; Department of Pharmacokinetics, Dynamics, Metabolism and Bioanalytics, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States., Sather AC; Department of Process Research and Development, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Solban N; Department of Discovery Quantitative Biosciences, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Song XS; Department of Discovery Quantitative Biosciences, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Wen X; Department of Process Research and Development, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Xu Z; Department of Discovery Quantitative Biosciences, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Yang Y; Department of Discovery Quantitative Biosciences, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Yang R; Department of Discovery Quantitative Biosciences, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Day PJ; Department of Structural Biology, Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K., Stoeck A; Department of Discovery Biology, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Bennett DJ; Department of Discovery Chemistry, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States., Han Y; Department of Discovery Chemistry, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Jul 11; Vol. 67 (13), pp. 11024-11052. Date of Electronic Publication: 2024 Jun 26.

نوع المنشور: Clinical Trial, Phase I; Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery* , Proto-Oncogene Proteins p21(ras)*/antagonists & inhibitors , Proto-Oncogene Proteins p21(ras)*/genetics , Proto-Oncogene Proteins p21(ras)*/metabolism, Animals ; Dogs ; Humans ; Mice ; Rats ; Administration, Oral ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/chemistry ; Biological Availability ; Dose-Response Relationship, Drug ; Structure-Activity Relationship

المؤلفون: Forder JK; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware 19713, United States., Palakollu V; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware 19713, United States., Adhikari S; Analytical R&D, Digital & NMR Sciences, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Blanco MA; Discovery Pharmaceutical Sciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Derebe MG; Discovery Biologics, Protein Sciences, Merck & Co., Inc., South San Francisco, California 94080, United States., Ferguson HM; Discovery Pharmaceutical Sciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Luthra SA; Discovery Pharmaceutical Sciences, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Munsell EV; Discovery Pharmaceutical Sciences, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Roberts CJ; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware 19713, United States.

المصدر: Molecular pharmaceutics [Mol Pharm] 2024 Mar 04; Vol. 21 (3), pp. 1321-1333. Date of Electronic Publication: 2024 Feb 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal*/chemistry , Amino Acids*, Dynamic Light Scattering ; Osmolar Concentration ; Hydrogen-Ion Concentration

المؤلفون: Pirrone GF; Merck & Co., Inc., Analytical Research & Development, 33 Avenue Louis Pasteur, Boston, MA, USA. Electronic address: gregory.pirrone@merck.com., Munsell EV; Merck & Co., Inc., Discovery Pharmaceutical Sciences, 33 Avenue Louis Pasteur, Boston, MA, USA., Ferguson HM; Merck & Co., Inc., Discovery Pharmaceutical Sciences, 33 Avenue Louis Pasteur, Boston, MA, USA., Al-Sayah MA; Merck & Co., Inc., Analytical Research & Development, 33 Avenue Louis Pasteur, Boston, MA, USA., Luthra SA; Merck & Co., Inc., Discovery Pharmaceutical Sciences, 33 Avenue Louis Pasteur, Boston, MA, USA., Makarov AA; Merck & Co., Inc., Analytical Research & Development, 33 Avenue Louis Pasteur, Boston, MA, USA. Electronic address: alexey.makarov@merck.com.

المصدر: Journal of pharmaceutical sciences [J Pharm Sci] 2023 Nov; Vol. 112 (11), pp. 2778-2782. Date of Electronic Publication: 2023 Jul 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE

المؤلفون: Munsell EV; Department of Chemical and Biomolecular Engineering , University of Delaware , 150 Academy Street , Newark , Delaware 19716 , United States., Fang B; Department of Chemical and Biomolecular Engineering , University of Delaware , 150 Academy Street , Newark , Delaware 19716 , United States., Sullivan MO; Department of Chemical and Biomolecular Engineering , University of Delaware , 150 Academy Street , Newark , Delaware 19716 , United States.

المصدر: Bioconjugate chemistry [Bioconjug Chem] 2018 Nov 21; Vol. 29 (11), pp. 3691-3704. Date of Electronic Publication: 2018 Oct 29.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE

مواضيع طبية MeSH: Gene Transfer Techniques*, Biomimetic Materials/*chemistry , DNA/*administration & dosage , Gold/*chemistry , Histones/*chemistry , Metal Nanoparticles/*chemistry, Animals ; CHO Cells ; Chromatin/chemistry ; Cricetulus ; DNA/chemistry ; DNA/genetics ; Metal Nanoparticles/ultrastructure ; Plasmids/administration & dosage ; Plasmids/chemistry ; Plasmids/genetics ; Surface Properties ; Transfection/methods

المؤلفون: Munsell EV; Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy Street, Newark, DE 19716, United States. Electronic address: emunsell@udel.edu., Kurpad DS; Department of Orthopedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, United States. Electronic address: deepa.kurpad@jefferson.edu., Freeman TA; Department of Orthopedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, United States. Electronic address: theresa.freeman@jefferson.edu., Sullivan MO; Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy Street, Newark, DE 19716, United States. Electronic address: msullivan@udel.edu.

المصدر: Acta biomaterialia [Acta Biomater] 2018 Apr 15; Vol. 71, pp. 156-167. Date of Electronic Publication: 2018 Mar 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 101233144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7568 (Electronic) Linking ISSN: 17427061 NLM ISO Abbreviation: Acta Biomater Subsets: MEDLINE

مواضيع طبية MeSH: Bone Morphogenetic Protein 2*/biosynthesis , Bone Morphogenetic Protein 2*/genetics , Cell Differentiation*/drug effects , Cell Differentiation*/genetics , Chondrogenesis*/drug effects , Chondrogenesis*/genetics , Gene Transfer Techniques* , Histones*/chemistry , Histones*/pharmacology, Mesenchymal Stem Cells/*metabolism, Animals ; Mesenchymal Stem Cells/cytology ; Mice

المؤلفون: Munsell EV, Ross NL, Sullivan MO; Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy Street, Newark, DE 19716, Delaware. msullivan@udel.edu.

المصدر: Current pharmaceutical design [Curr Pharm Des] 2016; Vol. 22 (9), pp. 1227-44.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review

بيانات الدورية: Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9602487 Publication Model: Print Cited Medium: Internet ISSN: 1873-4286 (Electronic) Linking ISSN: 13816128 NLM ISO Abbreviation: Curr Pharm Des Subsets: MEDLINE

مواضيع طبية MeSH: Biopharmaceutics*, Cell Nucleus/*metabolism , Cytoplasm/*metabolism , Drug Carriers/*pharmacokinetics , Macromolecular Substances/*administration & dosage , Nanoparticles/*chemistry, Animals ; Biological Transport ; Humans ; Macromolecular Substances/chemistry

المؤلفون: Ross NL; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, USA., Munsell EV; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, USA., Sabanayagam C; Delaware Biotechnology Institute, University of Delaware, Newark, Delaware, USA., Sullivan MO; Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, USA.

المصدر: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2015 Feb 10; Vol. 4, pp. e226. Date of Electronic Publication: 2015 Feb 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101581621 Publication Model: Electronic Cited Medium: Print ISSN: 2162-2531 (Print) Linking ISSN: 21622531 NLM ISO Abbreviation: Mol Ther Nucleic Acids Subsets: PubMed not MEDLINE

المؤلفون: Sakowski EG; Department of Biological Sciences., Munsell EV; Department of Chemical and Biomolecular Engineering., Hyatt M; Department of Biological Sciences., Kress W; Department of Civil and Environmental Engineering, and., Williamson SJ; Lake Pend Oreille Waterkeeper, Sandpoint, ID 83864;, Nasko DJ; Center for Bioinformatics and Computational Biology, Delaware Biotechnology Institute, University of Delaware, Newark, DE 19716;, Polson SW; Department of Biological Sciences, Center for Bioinformatics and Computational Biology, Delaware Biotechnology Institute, University of Delaware, Newark, DE 19716; Department of Computer and Information Sciences, University of Delaware, Newark, DE 19716; Delaware Biotechnology Institute, University of Delaware, Newark, DE 19711., Wommack KE; Department of Biological Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, DE 19711 Department of Plant and Soil Sciences and College of Earth, Ocean, and Environment, University of Delaware, Newark, DE 19716; and wommack@dbi.udel.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2014 Nov 04; Vol. 111 (44), pp. 15786-91. Date of Electronic Publication: 2014 Oct 13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Genome, Viral* , Metagenome*, Aquatic Organisms/*genetics , DNA Viruses/*genetics , Ribonucleotide Reductases/*genetics , Viral Proteins/*genetics, Base Sequence ; Biodiversity ; DNA, Single-Stranded/genetics ; DNA, Viral/genetics ; Molecular Sequence Data