المؤلفون: Garcha HK; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, ON L5L 1C6, Canada.; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada., Nawar N; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, ON L5L 1C6, Canada.; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada., Sorger H; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210 Vienna, Austria., Erdogan F; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, ON L5L 1C6, Canada.; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada., Aung MMK; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210 Vienna, Austria., Sedighi A; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, ON L5L 1C6, Canada., Manaswiyoungkul P; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, ON L5L 1C6, Canada.; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada., Seo HS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA., Schönefeldt S; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210 Vienna, Austria., Pölöske D; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210 Vienna, Austria., Dhe-Paganon S; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA., Neubauer HA; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210 Vienna, Austria., Mustjoki SM; Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, 00014 Helsinki, Finland.; Hematology Research Unit, Helsinki University Hospital Comprehensive Cancer Center, 00290 Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, 00014 Helsinki, Finland., Herling M; Department of Hematology, Cellular Therapy, and Hemostaseology, University of Leipzig, 04109 Leipzig, Germany., de Araujo ED; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, ON L5L 1C6, Canada., Moriggl R; Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, 1210 Vienna, Austria., Gunning PT; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, ON L5L 1C6, Canada.; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada.

المصدر: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2022 Oct 26; Vol. 15 (11). Date of Electronic Publication: 2022 Oct 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE

المؤلفون: Erdogan F; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada.; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada., Radu TB; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada.; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada., Orlova A; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria., Qadree AK; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada.; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada., de Araujo ED; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada., Israelian J; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada.; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada., Valent P; Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria., Mustjoki SM; Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.; Hematology Research Unit, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland., Herling M; Department of Hematology, Cellular Therapy, and Hemostaseology, University of Leipzig, Leipzig, Germany., Moriggl R; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Vienna, Austria., Gunning PT; Department of Chemical and Physical Sciences, University of Toronto Mississauga, Mississauga, Ontario, Canada.; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada.

المصدر: Journal of cellular and molecular medicine [J Cell Mol Med] 2022 Apr; Vol. 26 (7), pp. 2049-2062. Date of Electronic Publication: 2022 Mar 01.

نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101083777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1582-4934 (Electronic) Linking ISSN: 15821838 NLM ISO Abbreviation: J Cell Mol Med Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms*/genetics , STAT Transcription Factors*/genetics , STAT Transcription Factors*/metabolism, Cytokines/metabolism ; ErbB Receptors/metabolism ; Humans

المؤلفون: Erdogan F; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Rd N., Mississauga, Canada; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Canada., Qadree AK; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Rd N., Mississauga, Canada; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Canada., Radu TB; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Rd N., Mississauga, Canada; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Canada., Orlova A; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, A-1210 Vienna, Austria., de Araujo ED; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Rd N., Mississauga, Canada., Israelian J; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Rd N., Mississauga, Canada; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Canada., Valent P; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria., Mustjoki SM; Hematology Research Unit, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland; Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland; iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland., Herling M; Department of Hematology, Cellular Therapy, and Hemostaseology, University of Leipzig, Leipzig, Germany., Moriggl R; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, A-1210 Vienna, Austria., Gunning PT; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Rd N., Mississauga, Canada; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Canada. Electronic address: patrick.gunning@utoronto.ca.

المصدر: Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2022 Mar; Vol. 1866 (3), pp. 130058. Date of Electronic Publication: 2021 Nov 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731726 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8006 (Electronic) Linking ISSN: 03044165 NLM ISO Abbreviation: Biochim Biophys Acta Gen Subj Subsets: MEDLINE

مواضيع طبية MeSH: STAT Transcription Factors*

المؤلفون: Toledo MAS; Institute for Biomedical Engineering, Department of Cell Biology, RWTH Aachen University Medical School, Aachen, Germany.; Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany.; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University Medical School, Aachen, Germany., Gatz M; Institute for Biomedical Engineering, Department of Cell Biology, RWTH Aachen University Medical School, Aachen, Germany.; Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany., Sontag S; Institute for Biomedical Engineering, Department of Cell Biology, RWTH Aachen University Medical School, Aachen, Germany.; Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany., Gleixner KV; Division of Hematology and Hemostaseology, Department of Internal Medicine I, and.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria., Eisenwort G; Division of Hematology and Hemostaseology, Department of Internal Medicine I, and.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria., Feldberg K; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University Medical School, Aachen, Germany., Hamouda AEI; Institute for Biomedical Engineering, Department of Cell Biology, RWTH Aachen University Medical School, Aachen, Germany.; Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany., Kluge F; Institute for Biomedical Engineering, Department of Cell Biology, RWTH Aachen University Medical School, Aachen, Germany.; Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany., Guareschi R; Institute of Neuroscience and Medicine, Institute for Advanced Simulation, Jülich, Germany., Rossetti G; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University Medical School, Aachen, Germany.; Institute of Neuroscience and Medicine, Institute for Advanced Simulation, Jülich, Germany.; Jülich Supercomputing Centre, Research Centre Jülich, Jülich, Germany., Sechi AS; Institute for Biomedical Engineering, Department of Cell Biology, RWTH Aachen University Medical School, Aachen, Germany.; Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany., Dufva OMJ; Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland., Mustjoki SM; Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland., Maurer A; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University Medical School, Aachen, Germany.; Institute of Pathology and., Schüler HM; Institute for Human Genetics, RWTH Aachen University Hospital, Aachen, Germany., Goetzke R; Institute for Biomedical Engineering, Department of Cell Biology, RWTH Aachen University Medical School, Aachen, Germany.; Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Aachen, Germany., Braunschweig T; Institute of Pathology and., Kaiser A; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University Medical School, Aachen, Germany., Panse J; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University Medical School, Aachen, Germany., Jawhar M; Department of Hematology and Oncology, University Medical Centre Mannheim, Heidelberg University, Mannheim, Germany; and., Reiter A; Department of Hematology and Oncology, University Medical Centre Mannheim, Heidelberg University, Mannheim, Germany; and., Hilberg F; Department of Pharmacology, Boehringer Ingelheim RCV, Vienna, Austria., Ettmayer P; Department of Pharmacology, Boehringer Ingelheim RCV, Vienna, Austria., Wagner W; Institute for Biomedical Engineering, Department of Cell Biology, RWTH Aachen University Medical School, Aachen, Germany.; Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Aachen, Germany., Koschmieder S; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University Medical School, Aachen, Germany., Brümmendorf TH; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University Medical School, Aachen, Germany., Valent P; Division of Hematology and Hemostaseology, Department of Internal Medicine I, and.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria., Chatain N; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University Medical School, Aachen, Germany., Zenke M; Institute for Biomedical Engineering, Department of Cell Biology, RWTH Aachen University Medical School, Aachen, Germany.; Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany.

المصدر: Blood [Blood] 2021 Apr 15; Vol. 137 (15), pp. 2070-2084.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Indoles/*pharmacology , Mastocytosis, Systemic/*drug therapy , Point Mutation/*drug effects , Proto-Oncogene Proteins c-kit/*genetics, Humans ; Induced Pluripotent Stem Cells/drug effects ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/pathology ; Mastocytosis, Systemic/genetics ; Mastocytosis, Systemic/pathology ; Tumor Cells, Cultured

المؤلفون: Brück OE; Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland.; Helsinki University Hospital Comprehensive Cancer Center, Department of Hematology, Helsinki, Finland., Lallukka-Brück SE; Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland., Hohtari HR; Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Translational Immunology Research Program, University of Helsinki, Helsinki, Finland., Ianevski A; Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland., Ebeling FT; Helsinki University Hospital Comprehensive Cancer Center, Department of Hematology, Helsinki, Finland., Kovanen PE; Department of Pathology, HUSLAB, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Kytölä SI; HUS Diagnostic Center, HUSLAB, Helsinki University Hospital, Helsinki, Finland., Aittokallio TA; iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland.; Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, and Oslo Centre for Biostatistics and Epidemiology, University of Oslo, Oslo, Norway., Ramos PM; Novartis Pharmaceuticals, Basel, Switzerland., Porkka KV; Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland.; Helsinki University Hospital Comprehensive Cancer Center, Department of Hematology, Helsinki, Finland., Mustjoki SM; Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.; Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland.; Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.

المصدر: Blood cancer discovery [Blood Cancer Discov] 2021 Mar 22; Vol. 2 (3), pp. 238-249. Date of Electronic Publication: 2021 Mar 22 (Print Publication: 2021).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Comment

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101764786 Publication Model: eCollection Cited Medium: Internet ISSN: 2643-3249 (Electronic) Linking ISSN: 26433230 NLM ISO Abbreviation: Blood Cancer Discov

مواضيع طبية MeSH: Myelodysplastic Syndromes*/diagnosis , Myelodysplastic-Myeloproliferative Diseases*/genetics, Bone Marrow/pathology ; Humans ; Machine Learning ; Mutation/genetics