المؤلفون: Veronica Aedo-Lopez, Bettina Bisig, Alexandre Wicky, Olivier Michielin, Mounir Trimech, Camille L. Gerard, Fanny S Krebs, Krisztian Homicsko, Edoardo Missiaglia, Vincent Zoete

المصدر: International Journal of Molecular Sciences, Vol 21, Iss 8021, p 8021 (2020)
International Journal of Molecular Sciences
International journal of molecular sciences, vol. 21, no. 21, pp. E8021
Volume 21
Issue 21

مصطلحات موضوعية: Models, Molecular, Uveal Neoplasms, Protein Conformation, Sequence Homology, medicine.disease_cause, lcsh:Chemistry, Melanoma, lcsh:QH301-705.5, Spectroscopy, Trametinib, Mutation, biology, Chemistry, Protein Stability, MEK inhibitor, General Medicine, Middle Aged, Computer Science Applications, molecular modelling, Gq alpha subunit, precision oncology, Female, Amino Acid Sequence, Antineoplastic Agents/therapeutic use, GTP-Binding Protein alpha Subunits, Gq-G11/chemistry, GTP-Binding Protein alpha Subunits, Gq-G11/genetics, GTP-Binding Protein alpha Subunits, Gq-G11/metabolism, Humans, Melanoma/drug therapy, Melanoma/genetics, Melanoma/metabolism, Melanoma/pathology, Mutant Proteins/chemistry, Mutant Proteins/genetics, Mutant Proteins/metabolism, Pyridones/therapeutic use, Pyrimidinones/therapeutic use, Receptor, Fibroblast Growth Factor, Type 4/chemistry, Receptor, Fibroblast Growth Factor, Type 4/genetics, Receptor, Fibroblast Growth Factor, Type 4/metabolism, Signal Transduction, Uveal Neoplasms/drug therapy, Uveal Neoplasms/genetics, Uveal Neoplasms/metabolism, Uveal Neoplasms/pathology, FGFR4, GNAQ, mutation, Pyridones, Antineoplastic Agents, Pyrimidinones, Catalysis, Article, Inorganic Chemistry, medicine, Receptor, Fibroblast Growth Factor, Type 4, Physical and Theoretical Chemistry, Molecular Biology, Organic Chemistry, Fibroblast growth factor receptor 4, medicine.disease, lcsh:Biology (General), lcsh:QD1-999, Personalized oncology, Cancer research, biology.protein, GTP-Binding Protein alpha Subunits, Gq-G11, Mutant Proteins

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a720d088a79814508b85a7b35f96730d
https://www.mdpi.com/1422-0067/21/21/8021

المؤلفون: Stéphanie Miserey-Lenkei, Patricia Bassereau, Feng-Ching Tsai, Laura Picas, Yosuke Senju, Aurélie Bertin, Emmanuel Lemichez, Pekka Lappalainen, John Manzi, Evelyne Coudrier, Hugo Bousquet, Meng Chen Tsai

المساهمون: Laboratoire Physico-Chimie Curie [Institut Curie] (PCC), Institut Curie [Paris]-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Compartimentation et dynamique cellulaires (CDC), Institut Curie [Paris]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Toxines bactériennes - Bacterial Toxins, Institut Pasteur [Paris] (IP), Institut de pharmacologie moléculaire et cellulaire (IPMC), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Université Paris Descartes - Paris 5 (UPD5), Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), This work was supported by Institut Curie, Centre National de la Recherche Scientifique (CNRS), the Agence Nationale pour la Recherche (grant ANR-15-CE18-0016 to F-CT, M-CT, EL and PB), the Investments for the Future’ LABEX SIGNALIFE (grant ANR-11-LABX-0028–01 for M-CT and EL), the European Research Council (EC and PB partners of the advanced grant, project 339847) and the Human Frontier Science Program Organization (RGP0005/2016 to YS, PL, F-CT, EC and PB). EC and PB groups belong to the CNRS consortium CellTiss, to the Labex CelTisPhyBio (ANR-11-LABX0038) and to Paris Sciences et Lettres (ANR-10-IDEX-0001–02). F-C Tsai was funded by the EMBO Long-Term fellowship (ALTF 1527–2014) and Marie Curie actions (H2020-MSCA-IF-2014, project membrane-ezrin-actin)., ANR-15-CE18-0016,TransEndotheliaTunnel,Vers la prévention de dysfonctions vasculaires et la délivrance de médicaments au travers des endothelia(2015), ANR-11-LABX-0028,SIGNALIFE,Réseau d'Innovation sur les Voies de Signalisation en Sciences de la Vie(2011), ANR-10-IDEX-0001,PSL,Paris Sciences et Lettres(2010), European Project: 339847,EC:FP7:ERC,ERC-2013-ADG,MYODYN(2014), European Project: 656442,H2020,H2020-MSCA-IF-2014,membrane-ezrin-actin(2016), Institute of Biotechnology, Doctoral Programme in Integrative Life Science, Pekka Lappalainen / Principal Investigator, University Management, University of Helsinki, Institut Pasteur [Paris], Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Picas, Laura, Vers la prévention de dysfonctions vasculaires et la délivrance de médicaments au travers des endothelia - - TransEndotheliaTunnel2015 - ANR-15-CE18-0016 - AAPG2015 - VALID, Centres d'excellences - Réseau d'Innovation sur les Voies de Signalisation en Sciences de la Vie - - SIGNALIFE2011 - ANR-11-LABX-0028 - LABX - VALID, Initiative d'excellence - Paris Sciences et Lettres - - PSL2010 - ANR-10-IDEX-0001 - IDEX - VALID, Myosins and the dynamics of intracellular membranes - MYODYN - - EC:FP7:ERC2014-02-01 - 2019-01-31 - 339847 - VALID, Membrane-ezrin-actin interactions mediated by ezrin binding proteins in reconstituted systems - membrane-ezrin-actin - - H20202016-01-01 - 2018-01-01 - 656442 - VALID

المصدر: eLife, Vol 7 (2018)
eLife
eLife, 2018, 7, pp.e37262. ⟨10.7554/eLife.37262⟩
eLife, eLife Sciences Publication, 2018, 7, pp.e37262. ⟨10.7554/eLife.37262⟩

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Lipid Bilayers, Mutant, [SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], Ezrin, MESH: Protein Conformation, physics of living systems, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], ezrin-membrane interaction, cellular protrusions, Biology (General), phosphorylation, General Neuroscience, CYTOSKELETAL LINKER, EPITHELIAL-CELLS, General Medicine, QUANTITATIVE-ANALYSIS, I-BAR domain proteins, [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, Membrane, Membrane curvature, C. elegans, Phosphorylation, Medicine, MESH: Actins/chemistrys, MESH: Lipid Bilayers/chemistry, Protein Binding, Research Article, MESH: Cell Membrane/genetics, GIANT UNILAMELLAR VESICLES, MESH: Mutant Proteins/chemistry, QH301-705.5, MESH: Cytoskeletal Proteins/chemistry, Science, PHYSIOLOGICAL CONDITIONS, MESH: Cytoskeletal Proteins/metabolism, [SDV.BBM.BP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, NATIVE MEMBRANES, macromolecular substances, PARIETAL-CELLS, Curvature, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Protein Domains, MESH: Cell Membrane/chemistry, MESH: Mutant Proteins/metabolism, Actin, MESH: Actins/geneticss, General Immunology and Microbiology, MESH: Phosphorylation, APICAL MEMBRANE, MESH: Mutant Proteins/genetics, Cell Membrane, MESH: Protein Binding/genetics, Apical membrane, Actins, F-ACTIN BINDING, In vitro, Protein enrichment, ezrin, Cytoskeletal Proteins, 030104 developmental biology, MESH: Lipid Bilayers/metabolisms, MESH: Protein Domains/genetics, membrane curvature, Biophysics, 1182 Biochemistry, cell and molecular biology, Mutant Proteins, ERM PROTEINS

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48bed8206767b2be9e516c247ec498bb
https://elifesciences.org/articles/37262

المؤلفون: Marta Grandal, Álvaro Mena, Manuel Delgado, Berta Pernas, Ana Mariño, Hortensia Álvarez, Nieves Valcarce, Ana B. Pérez, Eva Poveda, Andrés Tabernilla, Ángeles Castro-Iglesias

المساهمون: Pharmaceutical and Pharmacological Sciences

المصدر: RUC. Repositorio da Universidade da Coruña
instname

مصطلحات موضوعية: 0301 basic medicine, Male, Cirrhosis, viruses, Hepacivirus, Viral Nonstructural Proteins, medicine.disease_cause, NS5A, Gastroenterology, chemistry.chemical_compound, Genotype, Prevalence, education.field_of_study, Genotype 1a, virus diseases, Middle Aged, Genotype 3, Infectious Diseases, Cohort, Hepacivirus/classification, Adult, RASs, medicine.medical_specialty, Hepatitis C virus, Ribavirin/pharmacology, Population, Mutation, Missense, Antiviral Agents/pharmacology, Antiviral Agents, 03 medical and health sciences, Hepatitis C, Chronic/drug therapy, Virology, Internal medicine, Drug Resistance, Viral, Ribavirin, medicine, Humans, In patient, education, business.industry, Sequence Analysis, DNA, Hepatitis C, Chronic, medicine.disease, digestive system diseases, Viral Nonstructural Proteins/genetics, 030104 developmental biology, chemistry, Amino Acid Substitution, Mutant Proteins, Mutant Proteins/genetics, business, HCV-infection, Follow-Up Studies

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aad7b092ae15cd93d4287eb797adb38
https://hdl.handle.net/2183/20798

المؤلفون: Athanasiou, Dimitra, Aguila, Monica, Opefi, Chikwado A, South, Kieron, Bellingham, James, Bevilacqua, Dalila, Munro, Peter M, Kanuga, Naheed, Mackenzie, Francesca E, Dubis, Adam M, Georgiadis, Anastasios, Graca, Anna B, Pearson, Rachael A, Ali, Robin R, Sakami, Sanae, Palczewski, Krzysztof, Sherman, Michael Y, Reeves, Philip J, Cheetham, Michael E

المصدر: Athanasiou, D, Aguila, M, Opefi, C A, South, K, Bellingham, J, Bevilacqua, D, Munro, P M, Kanuga, N, Mackenzie, F E, Dubis, A M, Georgiadis, A, Graca, A B, Pearson, R A, Ali, R R, Sakami, S, Palczewski, K, Sherman, M Y, Reeves, P J & Cheetham, M E 2017, ' Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration ', Human Molecular Genetics, vol. 26, no. 2, pp. 305-319 . https://doi.org/10.1093/hmg/ddw387

مصطلحات موضوعية: Photoreceptor Cells/drug effects, genetic structures, Proteostasis Deficiencies/genetics, Protein Folding/drug effects, psychiatry, Rats, Disease Models, Animal, Mice, Retinal Rod Photoreceptor Cells/drug effects, Metformin/administration & dosage, Retinitis Pigmentosa/drug therapy, Animals, Humans, Rhodopsin/chemistry, Transcriptional Activation/drug effects, sense organs, Mutant Proteins/genetics, Rod Cell Outer Segment/drug effects, Retinal Degeneration/drug therapy, biological, AMP-Activated Protein Kinases/biosynthesis

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1be46c424e0267656e40252de0f66f7b
https://eprints.kingston.ac.uk/id/eprint/39938/1/McKenzie-F-39938-VoR.pdf

المؤلفون: Inoue, D., Kitaura, J., Togami, K., Nishimura, K., Enomoto, Y., Uchida, T., Kagiyama, Y., Kawabata, K. C., Nakahara, F., Izawa, K., Oki, T., Maehara, A., Isobe, M., Tsuchiya, A., Harada, Y., Harada, H., Ochiya, T., Aburatani, H., Kimura, Hiroshi, Thol, F., Heuser, M., Levine, R. L., Abdel-Wahab, O., Kitamura, T.

المصدر: Journal of Clinical Investigation. 123:4627-4640

مصطلحات موضوعية: Receptors, Cell Surface/genetics, Myeloid, Histones/metabolism, Chronic myelomonocytic leukemia, Receptors, Cell Surface, Lectins, C-Type/genetics, Biology, medicine.disease_cause, Methylation, Cell Line, Histones, Mice, hemic and lymphatic diseases, Histone methylation, medicine, Animals, Humans, Lectins, C-Type, Peptide Fragments/genetics, Homeodomain Proteins, Myelopoiesis, Mutation, Myelodysplastic syndromes, CLEC5A, Repressor Proteins/*genetics, General Medicine, medicine.disease, Peptide Fragments, Repressor Proteins, Mice, Inbred C57BL, MicroRNAs, Disease Models, Animal, MicroRNAs/genetics, homeobox A9, Leukemia, medicine.anatomical_structure, Mutant Proteins/*genetics, Myelodysplastic Syndromes/*genetics/metabolism/pathology, Myelodysplastic Syndromes, Immunology, Cancer research, Mutant Proteins, Myelopoiesis/genetics, Homeodomain Proteins/genetics, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55df7e4ea7cadbfc81c3a85ca2105bcc
https://doi.org/10.1172/jci70739

المؤلفون: Dicks, Matthew D. J., Goujon, Caroline, Pollpeter, Darja, Betancor, Gilberto, Apolonia, Luis, Bergeron, Julien, Malim, Michael H

المصدر: Dicks, M D J, Goujon, C, Pollpeter, D, Betancor, G, Apolonia, L, Bergeron, J & Malim, M H 2016, ' Oligomerization requirements for MX2 mediated suppression of HIV-1 infection ', Journal of Virology, vol. 90, no. 1, pp. 22-32 . https://doi.org/10.1128/JVI.02247-15

مصطلحات موضوعية: Models, Molecular, Myxovirus Resistance Proteins/genetics, Protein Conformation, viruses, DNA Mutational Analysis, Virus Replication, Immunity, Innate, Cell Line, Amino Acid Substitution, HIV-1/immunology, Host-Pathogen Interactions, Humans, Mutant Proteins/genetics, Protein Multimerization

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______2761::9f965cec13161390e25c7d35da229c01
https://kclpure.kcl.ac.uk/en/publications/0422b7c2-b6e0-405e-8260-ecf2a13932cc

المؤلفون: Andrew T. Watt, Michael E. Østergaard, Pawan Kumar, Pawan K. Sharma, Punit P. Seth, Josh G. Nichols, Poul Nielsen

المصدر: Østergaard, M E, Kumar, P, Nichols, J, Watt, A, Sharma, P K, Nielsen, P & Seth, P P 2015, ' Allele-Selective Inhibition of Mutant Huntingtin with 2-Thio-and C5-Triazolylphenyl-Deoxythymidine-Modified Antisense Oligonucleotides ', Nucleic Acid Therapeutics, vol. 25, no. 5, pp. 266-274 . https://doi.org/10.1089/nat.2015.0547

مصطلحات موضوعية: Thymidine/analogs & derivatives, Oligonucleotides, Antisense/genetics, Huntingtin, RNase P, Mutant, Ribonuclease H, Nerve Tissue Proteins, Biology, Biochemistry, Drug Discovery, Genetics, Huntingtin Protein, Nerve Tissue Proteins/genetics, Humans, RNase H, Molecular Biology, Base Pairing, Alleles, RNA Cleavage, Messenger RNA, DNA Repeat Expansion, Ribonuclease H/physiology, Base Sequence, Oligonucleotide, RNA, Oligonucleotides, Antisense, Molecular biology, biology.protein, Molecular Medicine, Mutant Proteins, Mutant Proteins/genetics, Thymidine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13b9c3fad6a832bc3a891027d83f039
https://pubmed.ncbi.nlm.nih.gov/26222265

المؤلفون: Romy Kronstein, Hans-Joachim Schnittler, Carsten Minten, Abdallah Abu Taha, Yvan Arsenijevic, Tatiana Afanasieva, Marek Drab, Jochen Seebach, Stefan Liebner, Sylvia Grossklaus, Britta Engelhardt

المصدر: Cardiovascular Research, vol. 93, no. 1, pp. 130-140
Kronstein, Romy; Seebach, Jochen; Grossklaus, Sylvia; Minten, Carsten; Engelhardt, Britta; Drab, Marek; Liebner, Stefan; Arsenijevic, Yvan; Taha, Abdallah Abu; Afanasieva, Tatiana; Schnittler, Hans-Joachim (2012). Caveolin-1 opens endothelial cell junctions by targeting catenins. Cardiovascular research, 93(1), pp. 130-40. Oxford: Oxford University Press 10.1093/cvr/cvr256 <http://dx.doi.org/10.1093/cvr/cvr256>

مصطلحات موضوعية: Physiology, Caveolin 1, CHO Cells, Biology, Cell junction, Cell Line, Mice, Cricetulus, Cell–cell interaction, Antigens, CD, Physiology (medical), Cricetinae, Human Umbilical Vein Endothelial Cells, Animals, Humans, Antigens, CD/metabolism, Base Sequence, Cadherins/metabolism, Catenins/metabolism, Caveolin 1/deficiency, Caveolin 1/genetics, DNA Primers/genetics, Endothelial Cells/drug effects, Endothelial Cells/metabolism, Intercellular Junctions/drug effects, Intercellular Junctions/metabolism, Mice, Knockout, Multiprotein Complexes/metabolism, Mutant Proteins/genetics, Mutant Proteins/metabolism, Thrombin/pharmacology, Cell adhesion, Barrier function, DNA Primers, Cadherin, Thrombin, Endothelial Cells, Catenins, Cadherins, Cell biology, Endothelial stem cell, Intercellular Junctions, Catenin, Multiprotein Complexes, Mutant Proteins, Catenin complex, Cardiology and Cardiovascular Medicine

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5659795732fad4950547b7c085aac6be
https://serval.unil.ch/notice/serval:BIB_CCF339084AD6

المؤلفون: Nicholas R. Lemoine, Joeri L. Aerts, Sarah K. Baird, Iain A. McNeish, Michelle Lockley, A Eddaoudi

المساهمون: Laboratory of Molecullar and Cellular Therapy, Physiology

مصطلحات موضوعية: Cancer Research, Programmed cell death, Cell Survival, Virus Replication/physiology, Apoptosis, Cell Survival/genetics, Biology, Cell Death/genetics, Virus Replication, medicine.disease_cause, Transfection, Article, Adenoviridae, Necrosis, Necrosis/genetics, Ovarian Neoplasms/genetics, Apoptosis/genetics, Autophagy, Genetics, medicine, Tumor Cells, Cultured, Humans, Mitochondria/physiology, Adenoviridae/genetics, Molecular Biology, Ovarian Neoplasms, Cell Death, Cancer, Adenovirus Death Protein, medicine.disease, Virology, Mitochondria, Oncolytic virus, Oncolytic Viruses, Adenovirus E1A Proteins/genetics, Lysosomes/physiology, Cancer research, Mutant Proteins, Female, Oncolytic Viruses/genetics, Adenovirus E1A Proteins, Autophagy/physiology, Mutant Proteins/genetics, Lysosomes, Carcinogenesis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ec6592658938d57547183a33dbcd54
https://hdl.handle.net/20.500.14017/0472a114-da41-41c7-b78a-129045e65399

المؤلفون: Martine Prévost, Paul M. Tulkens, Françoise Van Bambeke, Jean-Paul Becker, Grégoire Depret

المساهمون: UCL - MD/FARM - Ecole de pharmacie

المصدر: BMC Structural Biology
BMC Structural Biology, Vol. 9, no. 3, p. [1-18] (2009)
BMC structural biology, 9
BMC Structural Biology, Vol 9, Iss 1, p 3 (2009)

مصطلحات موضوعية: Models, Molecular, Bacterial Proteins -- genetics, Molecular model, Mutant Proteins -- metabolism, Protein Conformation, Plasma protein binding, P-Glycoprotein -- chemistry, Biology, Ligands, Structure-Activity Relationship, Protein structure, Bacterial Proteins, Structural Biology, Nucleotides -- metabolism, Bacterial Proteins -- metabolism, Chimie, Mutant Proteins -- genetics, Humans, Homology modeling, ATP Binding Cassette Transporter, Subfamily B, Member 1, Amino Acid Sequence, Binding site, lcsh:QH301-705.5, Mutant Proteins -- chemistry, Nucleotides, Bacterial Proteins -- chemistry, P-Glycoprotein, P-Glycoprotein -- genetics, Transmembrane domain, Biochemistry, Catalytic cycle, lcsh:Biology (General), Docking (molecular), P-Glycoprotein -- metabolism, Mutant Proteins, Nucleotides -- chemistry, Sequence Alignment, Research Article, Protein Binding, Signal Transduction

وصف الملف: 1 full-text file(s): application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453dc020e4b7055a6c80b5d821d7223b