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1
المؤلفون: Ching Kim Tye, Chunhong Yan, Sarah C. Traeger, Wayne Vaccaro, Yingru Zhang, Gerry Everlof, Jianqing Li, Henry Yip, Peng Li, John T. Hunt, Michael A. Poss, Gregory D. Vite, Mussari Christopher P, Steven Sheriff, Asoka Ranasinghe, Haiying Zhang, Richard A. Westhouse, Dharmpal S. Dodd, Richard Rampulla, Zheng Yang, Frank Marsilio, Derek J. Norris, Wen-Ching Han, Tram N. Huynh, Yufen Zhao, Patrice Gill, Nirmala Raghavan, Lalgudi S. Harikrishnan, Ashvinikumar V. Gavai, Susan Wee, John S. Tokarski, Dauh-Rurng Wu, Arvind Mathur, Mei-Li Wen, Huiping Zhang, David R. Tortolani, George V. Delucca, Krista Menard, Francis Y. Lee, Claude A. Quesnelle, Dawn Sun, Vijay T. Ahuja, Daniel O'malley, Christine Huang, Muthoni G. Kamau
المصدر: Journal of Medicinal Chemistry. 64:14247-14265
مصطلحات موضوعية: Drug, Proline, Phenylalanine, media_common.quotation_subject, Carbazoles, Administration, Oral, Antineoplastic Agents, Cell Cycle Proteins, Computational biology, BET inhibitor, Structure-Activity Relationship, Pharmacokinetics, In vivo, Drug Discovery, Transcriptional regulation, Humans, Potency, media_common, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Tryptophan, Signal transducing adaptor protein, Bromodomain, Molecular Medicine, Transcription Factors
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2
المؤلفون: Ji Jiang, Tammy C. Wang, Alice Ye A. Chen, Xiaohong Yin, Jennifer X. Qiao, Ming Chang, Muthoni G. Kamau, Julia Li, David S. Taylor, Leonard P. Adam, Lalgudi S. Harikrishnan, Xue-Qing Chen, Heather Finlay, R. Michael Lawrence, Richard Rampulla, Paul Levesque, Christine Huang, Paul G. Sleph, Carrie Xu, Ruth R. Wexler, Mark E. Salvati
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: biology, Chemistry, Organic Chemistry, Drug Discovery, Cholesterylester transfer protein, biology.protein, Pharmacology, Lead (electronics), Biochemistry, CETP inhibitor, Coronary heart disease
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3
المؤلفون: Yanling Huang, Jingwu Duan, Carolyn A. Weigelt, Cullen L. Cavallaro, Javed Khan, Brian E. Fink, Muthoni G. Kamau, Zheming Ruan, Lan-Ying Qin, Sylwia Stachura, Cliff Chen, Murali Gururajan, Lalgudi S. Harikrishnan, Tram N. Huynh, John S. Sack, Anwar Murtaza, Daniel O'malley, Zhuyin Li, Melissa Yarde, Max Ruzanov, Virna Borowski, Patrice Gill, Huadong Sun, Zhonghui Lu, Jessica J. Wong
المصدر: Bioorganicmedicinal chemistry letters. 30(12)
مصطلحات موضوعية: Agonist, Drug, medicine.drug_class, Receptors, Retinoic Acid, media_common.quotation_subject, Clinical Biochemistry, Retinoic acid, Pharmaceutical Science, Pharmacology, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Pharmacokinetics, RAR-related orphan receptor gamma, Heterocyclic Compounds, Drug Discovery, Benzyl Compounds, medicine, Animals, Molecular Biology, media_common, Orphan receptor, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, chemistry, Pharmacodynamics, Molecular Medicine, Female, Tricyclic
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4
المؤلفون: Leonard P. Adam, James A. Johnson, Paul G. Sleph, Ruth R. Wexler, Heather Finlay, Mark E. Salvati, Lalgudi S. Harikrishnan, David S. Taylor, Alice Ye A. Chen, Xiaohong Yin, Richard Yang, Muthoni G. Kamau, Jennifer X. Qiao, Tammy C. Wang, Ji Jiang
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:3278-3281
مصطلحات موضوعية: Genetically modified mouse, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Mice, Transgenic, 030204 cardiovascular system & hematology, 01 natural sciences, Biochemistry, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, Cholesterylester transfer protein, Animals, Humans, Potency, Amines, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Cholesterol, Organic Chemistry, In vitro, Cholesterol Ester Transfer Proteins, 0104 chemical sciences, chemistry, biology.protein, Molecular Medicine, lipids (amino acids, peptides, and proteins), Lead compound
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5
المؤلفون: Daniel Smith, Richard Rampulla, Xue-Qing Chen, Bilder Donna M, Xiaohong Yin, Ruth R. Wexler, Hong Shen, Yi-Xin Li, Richard Yang, Tammy C. Wang, Julia P. Li, David A. Gordon, Ming Chang, Leslie Leith, Carrie Xu, Lalgudi S. Harikrishnan, Paul G. Sleph, Dauh-Rurng Wu, R. Michael Lawrence, David S. Taylor, Christine Huang, Heather Finlay, Muthoni G. Kamau, Jianqing Li, Alice Ye A. Chen, Leonard P. Adam, Paul Levesque, Danshi Li, Mark E. Salvati, Shaobin Zhuang, Jennifer X. Qiao, Michael M. Miller, Michael A. Poss
المصدر: Journal of Medicinal Chemistry. 58:9010-9026
مصطلحات موضوعية: Aldosterone synthase, biology, Chemistry, Cholesterol, Stereochemistry, Reverse cholesterol transport, Torcetrapib, chemistry.chemical_compound, Drug Discovery, Cholesterylester transfer protein, biology.protein, Cholesteryl ester, Molecular Medicine, lipids (amino acids, peptides, and proteins), Benzamide, CETP inhibitor
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6
المؤلفون: Heather Finlay, Mark E. Salvati, R. Michael Lawrence, Muthoni G. Kamau, Michael A. Poss, Jennifer X. Qiao, Ji Jiang, Lalgudi S. Harikrishnan, Ruth R. Wexler
المصدر: Tetrahedron. 68:2696-2703
مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, chemistry, Scale (ratio), Organic Chemistry, Drug Discovery, Imine, Enantioselective synthesis, Organic chemistry, Salt (chemistry), Biochemistry
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7
المؤلفون: Dauh-Rurng Wu, Zheng Yang, Steven Sheriff, Muthoni G. Kamau, Lalgudi S. Harikrishnan, Dharmpal S. Dodd, Henry Yip, Christine Huang, Yingru Zhang, Yufen Zhao, Jianqing Li, Richard A. Westhouse, Richard Rampulla, Ashvinikumar V. Gavai, Haiying Zhang, Susan Wee, Dawn Sun, Gerry Everlof, Tram N. Huynh, Ching Su, Derek J. Norris, Arvind Mathur, Wayne Vaccaro, Peng Li, Huiping Zhang, Gregory D. Vite, Mussari Christopher P, John T. Hunt, Asoka Ranasinghe, David R. Tortolani, Nirmala Raghavan, Celia D’Arienzo, Daniel O'malley, Vijay T. Ahuja, Patrice Gill, Lisa Zhang, Claude A. Quesnelle, Tokarski John S, Michael A. Poss
المصدر: Cancer Research. 78:5789-5789
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Thermal shift assay, BRD4, Oncogene, Chemistry, Cancer, medicine.disease, Bromodomain, BET inhibitor, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, In vivo, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, medicine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ad3948219544cdcb29d5e3baea4000aa
https://doi.org/10.1158/1538-7445.am2018-5789 -
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المؤلفون: Jacques Y. Roberge, Muthoni G. Kamau, Sam T. Chao, Arvind Mathur, Michael A. Poss, Zheming Ruan, Lalgudi S. Harikrishnan, Dora M. Schnur, Mark S. Bednarz, John K. Dickson, Roy J. Vaz, Yalei Liu, R. Michael Lawrence, Ramesh Kakarla, Leslie Leith, Ashvinikumar V. Gavai, Christopher B. Cooper, Katy Van Kirk
المصدر: Journal of Combinatorial Chemistry. 11:72-82
مصطلحات موضوعية: Polymers, Chemistry, Stereochemistry, Acetal, Antagonist, General Chemistry, Combinatorial chemistry, Receptors, G-Protein-Coupled, Propanolamines, Small Molecule Libraries, chemistry.chemical_compound, Cross-Linking Reagents, Drug Design, Combinatorial Chemistry Techniques, Humans, Amines, Linker, Polymer supported, G protein-coupled receptor
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9
المؤلفون: Muthoni G. Kamau, Chunguang Wang, Rakesh K. Jain, Huiming Wang, Michael J. Sofia, Richard G. Dulina, Robert Ippolito, David Gange, Jan A. Anderson
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:2185-2189
مصطلحات موضوعية: Azides, Light, Stereochemistry, Carboxylic acid, Clinical Biochemistry, Carboxylic Acids, Pharmaceutical Science, Uronic acid, Hydroxylation, Biochemistry, Chemical synthesis, Mass Spectrometry, chemistry.chemical_compound, Drug Discovery, Combinatorial Chemistry Techniques, Scattering, Radiation, Monosaccharide, Glycosides, Molecular Biology, chemistry.chemical_classification, Fluorenes, Monosaccharides, Organic Chemistry, Glycoside, chemistry, Aldose, Molecular Medicine, Indicators and Reagents, Azide, Pharmacophore, Chromatography, Liquid
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10
المؤلفون: Heather Finlay, Mark E. Salvati, Leonard P. Adam, Ji Jiang, Ruth R. Wexler, Christine Huang, David S. Taylor, Xiaohong Yin, Alice Ye A. Chen, Paul G. Sleph, Yufeng Wang, Muthoni G. Kamau, Wu Yang, R. Michael Lawrence, David S. Nirschl, Lalgudi S. Harikrishnan, Katy Van Kirk, Richard Yang
المصدر: Bioorganicmedicinal chemistry letters. 24(3)
مصطلحات موضوعية: Stereochemistry, Pyridines, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, chemistry.chemical_compound, Transactivation, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Stability, Biomimetics, Heterocyclic Compounds, Drug Discovery, Cholesterylester transfer protein, Ethylamines, Humans, Urea, Molecular Biology, Pregnane X receptor, Chemotype, biology, Molecular Structure, Chemistry, Organic Chemistry, Biphenyl Compounds, Metabolic stability, Cholesterol Ester Transfer Proteins, biology.protein, Molecular Medicine