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المؤلفون: September Numata, Jeffrey P. McDermott, Gustavo Blanco

المصدر: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

مصطلحات موضوعية: sperm energetics, glycolysis, mitochondria, Na,K-ATPase, NAD/NADH, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.911056/full; https://doaj.org/toc/2296-634X

URL الوصول: https://doaj.org/article/d9fd618730ec4ff1bc04a9fce20c83a3

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المؤلفون: HuaJie He, YuZheng Zhang, BinBin Wen, XiangGuang Meng, Ning Wang, MingYun Sun, Rui Zhang, XueHui Zhao, QiuPing Tan, Wei Xiao, DongMei Li, XiLing Fu, XiuDe Chen, Ling Li

المصدر: Frontiers in Plant Science, Vol 12 (2022)

مصطلحات موضوعية: peach, NUDIX hydrolase, drought stress, ABA, NAD/NADH, Plant culture, SB1-1110

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fpls.2021.831883/full; https://doaj.org/toc/1664-462X

URL الوصول: https://doaj.org/article/d5041f1f8b454475b6cd7f6d5a3fd3eb

المؤلفون: Hohenschuh, William^{Aff1, Aff3}, Hector, Ronald E., Mertens, Jeffrey A., Murthy, Ganti S.^{Aff1, Aff4}

المصدر: Systems Microbiology and Biomanufacturing. 1(1):42-57

المؤلفون: M. M. Guzyk, T. M. Tykhonenko, K. O. Dyakun, L. V. Yanitska, I. B. Pryvrotska, T. M. Kuchmerovska

المصدر: The Ukrainian Biochemical Journal, Vol 91, Iss 1, Pp 21-29 (2019)

مصطلحات موضوعية: one of the serious complications of diabetes mellitus, is complex. In this study, we examined whether expression levels of SIRT1 and SIRT2 were the key for the development of brain dysfunctions and whether PARP-1 inhibitors could affect the expression of these proteins for prevention the development of DE in rats with type 1 diabetes. After 10 weeks of the streptozotocin-induced diabetes mellitus (70 mg/kg), Wistar male rats were treated by i.p. injection with PARP-1 inhibitors, 1.5-isoquinolinediol (ISO) or nicotinamide (NAm) (3 or 100 mg/kg/daily i.p., respectively) for 2 weeks. The rats with blood glucose levels over 19.7 ± 2.1 mmol/l were taken into experiments. Western blots were performed to evaluate effects of PAPR-1 inhibitors on the levels of sirtuins, SIRT1 and SIRT2 expression. Diabetes induced significant reduction of SIRT1 expression and SIRT2 overexpression in brain nuclear extracts of diabetic rats compared to non-diabetic control. In brain, NAm attenuated SIRT2 overexpression in nuclear extracts of diabetic rats and slightly elevated SIRT1 expression, while ISO didn’t affect expression of both sirtuins in diabetic rats. Furthermore, it was observed that in brain of diabetic rats, the ratio of free NAD/NADH couples decreased 3.1-fold compared to non-diabetic control. The administration of ISO increased only slightly the ratio of free NAD/NADH couples in the brain of diabetic rats while NAm increased this parameter 1.7-fold compared to diabetic rats. Therefore, 1.5-isoquinolinediol (ISO), diabetes mellitus, expression of sirtuins, nicotinamide (NAm), PARP-1 inhibitors, SIRT1, SIRT2, Biochemistry, QD415-436, Medicine, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://ukrbiochemjournal.org/wp-content/uploads/2019/01/Guzyk_1_19.pdf; https://doaj.org/toc/2409-4943; https://doaj.org/toc/2413-5003

URL الوصول: https://doaj.org/article/fd6d51925e7340a29387c4c2baa96588

المؤلفون: Witt, Emily A.^Aff1, Reissner, Kathryn J.

المصدر: Psychopharmacology. 237(3):669-680

المؤلفون: Wei Sun, Yongxiang Zou, Zheng Cai, Jinxiang Huang, Xinjie Hong, Qiang Liang, Weilin Jin

المصدر: Cancers, Vol 14, Iss 14, p 3538 (2022)

مصطلحات موضوعية: nicotinamide N-methyltransferase, glioma, GAP43, NAD/NADH ratio, SIRT1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2072-6694/14/14/3538; https://doaj.org/toc/2072-6694

URL الوصول: https://doaj.org/article/92c4f5fee78b42ceb0225bd010993f1a

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