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المؤلفون: Tiantian Qi, Letian Zhang, Tingyuan Yang, Yating Luo, Shiliang Li, Fanxun Zeng, Lili Zhu, Guantian Yang, Yingfan Liang, Honglin Li, Rui Wang, Xiaoyong Xu
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 795-809 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: EA, ethyl acetate, Molecular model, PhMe, toluene, RA, rheumatoid arthritis, DMF, N,N-dimethylformamide, DMSO, dimethyl sulfoxide, Pharmacology, DCE, 1,2-dichloroethane, chemistry.chemical_compound, 0302 clinical medicine, DMARDs, disease-modifying antirheumatic drugs, TsCl, tosyl chloride, HRMS, high-resolution mass spectrometry, DMAP, 4-dimethylaminopyridine, TEA, triethylamine, CIA, collagen-induced arthritis, NBS, N-bromosuccinimide, DHODH, dihydroorotate dehydrogenase, LCMS, liquid chromatography mass spectrometry, General Pharmacology, Toxicology and Pharmaceutics, AML, acute myeloid leukemia, Benzoic acid, 0303 health sciences, IBD, inflammatory bowel disease, Chemistry, NSAIDs, non-steroidal anti-inflammatory drugs, DCM, dichloromethane, PE, petroleum ether, HPLC, high performance liquid chromatography, 030220 oncology & carcinogenesis, Acrylamide, Original Article, PDA, photodiode array detector, Lead compound, NCS, N-chlorosuccinimide, THF, tetrahydrofuran, De novo pyrimidine biosynthesis, PK, pharmacokinetic, MS, multiple sclerosis, TFA, trifluoroacetic acid, 03 medical and health sciences, BPO, benzoyl peroxide, Pharmacokinetics, In vivo, LAH, lithium aluminium hydride, Potency, Rheumatoid arthritis, DHODH inhibitors, 030304 developmental biology, Acrylamide derivatives, lcsh:RM1-950, DHODH, SEL, systemic lupus erythematosus, FMN, flavin mononucleotide, lcsh:Therapeutics. Pharmacology, Dihydroorotate dehydrogenase, MeOH, methanol
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المؤلفون: Punniyakoti Veeraveedu Thanikachalam, Pooja Chawla, Rahul K. Maurya, Srinivasan Ramamurthy, Garima Bansal
المصدر: Journal of Advanced Research, Vol 23, Iss, Pp 163-205 (2020)
Journal of Advanced Researchمصطلحات موضوعية: NFκB, nuclear factor kappa-B, 0301 basic medicine, HFD, high-fat diet, Scaffold, mCPBA, meta-chloroperoxybenzoic acid, endocrine system diseases, IL-β, interlukin-beta, OGTT, oral glucose tolerance test, medicine.medical_treatment, Type 2 diabetes, Boc, Butyloxycarbonyl, DMSO, dimethyl sulfoxide, Pharmacology, GPT, glutamic pyruvic transaminase, TFAA, trifluoroacetic anhydride, DNA, deoxyribonucleic acid, LBD, ligand-binding domain, 0302 clinical medicine, AST, aspartate transaminase, DM, diabetes mellitus, LDL, low-density lipoprotein, NBS, N-bromosuccinimide, Thiazolidine-2,4-diones, PDB, protein data bank, TZD, thiazolidine-2,4-dione, AF, activation factor, lcsh:R5-920, Multidisciplinary, E, Entgegen, GLUT4, glucose transporter type 4, Drug discovery, Diabetes, WAT, white adipose tissue, TG, triglycerides, DCM, dichloromethane, PTP1B, protein-tyrosine phosphatase 1B, 030220 oncology & carcinogenesis, DMF, dimethylformamide, Rosiglitazone, lcsh:Medicine (General), THF, tetrahydrofuran, medicine.drug, KOH, potassium hydroxide, PPAR-γ, HEp-2, Human epithelial type 2, ALT, alanine transaminase, RXR, retinoid X receptor, HDL, high-density lipoprotein, PPAR, peroxisome-proliferator activated receptor, STZ, streptozotocin, SAR, structure-activity relationship, Article, ADDP, 1,1′-(Azodicarbonyl)dipiperidine, TFA, trifluoroacetic acid, HEK, human embryonic kidney, 03 medical and health sciences, Diabetes mellitus, FFA, free fatty acid, INS-1, insulin-secreting cells, medicine, lcsh:Science (General), HCl, Hydrochloric Acid, ComputingMethodologies_COMPUTERGRAPHICS, Thiazolidine 2 4 dione, GAL4, Galactose transporter type, MDA, malondialdehyde, PPRE, peroxisome proliferator response element, NO, nitric oxide, Pioglitazone, ALP, alkaline phosphatase, Z, Zusammen, business.industry, Pd, Palladium, Insulin, TNF-α, tumor necrosis factor-alpha, T2DM, type 2 diabetes mellitus, K2CO3, Potassium carbonate, medicine.disease, NaH, Sodium Hydride, QSAR, quantitative structure-activity relationship, 030104 developmental biology, FDA, food and drug administration, DBD, DNA-binding domain, NA, nicotinamide, ECG, electrocardiogram, IDF, international diabetes federation, i.m, Intramuscular, business, lcsh:Q1-390
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المؤلفون: Barbora Holubová, Petra Mikšátková, Lucie Fojtíková, Martin Kuchař, Ladislav Fukal, Oldřich Lapčík, Martina Blažková, Anna Šuláková
المصدر: Toxicology Reports, Vol 5, Iss, Pp 65-75 (2018)
Toxicology Reportsمصطلحات موضوعية: Drugs of abuse, GAR, goat anti-rabbit antibody, Health, Toxicology and Mutagenesis, medicine.medical_treatment, RSD, relative standard deviation, DCC, N,N’-dicyclohexylcarbodiimide, DMF, N,N-dimethylformamide, Toxicology, 01 natural sciences, Article, Immunomethods, JWH-200, lcsh:RA1190-1270, Synthetic cannabinoids, medicine, NPS, new psychoactive substances, NBS, N-bromosuccinimide, ComputingMethodologies_COMPUTERGRAPHICS, PEG, polyethylene glycol, lcsh:Toxicology. Poisons, chemistry.chemical_classification, Chromatography, LOD, limit of detection, 010405 organic chemistry, DIBAH, diisobutylaluminium hydride, 010401 analytical chemistry, THC, thin layer chromatography, Hapten synthesis, ELISA, enzyme-linked immunosorbent assay, LFIA, lateral flow immunoassay, NHS, N-hydroxysuccinimide, LFIA, 0104 chemical sciences, Highly sensitive, Enzyme, chemistry, BSA, bovine serum albumin, ELISA, Cannabinoid, Hapten, SCs, synthetic cannabinoids, Synthetic cannabinoid, GAR-Po, peroxidase labelled goat anti-rabbit antibody, RSA, rabbit serum albumin, medicine.drug, Lateral flow immunoassay
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المؤلفون: Ángel T. Martínez, Rebecca Pogni, Francisco J. Medrano, Marina Cañellas, Dolores Linde, Victor Guallar, Verónica Sáez-Jiménez, Francisco J. Ruiz-Dueñas, Adalgisa Sinicropi, Antonio A. Romero, Cristina Coscolín, Maria Camilla Baratto, Fátima Lucas
المساهمون: Barcelona Supercomputing Center
المصدر: UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Recercat. Dipósit de la Recerca de Catalunya
instname
Biochemical Journalمصطلحات موضوعية: Models, Molecular, Protein Conformation, ABTS, 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid), VP, versatile peroxidase, dye-decolorizing peroxidase, site-directed mutagenesis, EPR spectroscopy, molecular docking, QM/MM, catalytic protein radicals, QM, quantum mechanics, VA, veratryl alcohol, Multifrequency EPR, Biochemistry, Protein structure, catalytic protein radicals, Auricularia auricula-judae, NBS, N-bromosuccinimide, Coloring Agents, Site-directed mutagenesis, Dye decolorizing peroxidase, chemistry.chemical_classification, Fungal protein, biology, Chemistry, Enginyeria mecànica::Impacte ambiental [Àrees temàtiques de la UPC], Tryptophan, PELE, Protein Energy Landscape Exploration, Recombinant Proteins, hfcc, hyperfine coupling constant, Molecular Docking Simulation, Peroxidases, catalytic protein radical, Molecular docking, site-directed mutagenesis, Oxidation-Reduction, Research Article, EPR spectroscopy, RB19, Reactive Blue 19, Peroxidase, Hemeproteins, Free Radicals, Surface Properties, Stereochemistry, LRET, long-range electron transfer, DyP, dye-decolorizing peroxidase, Molecular Dynamics Simulation, QM/MM, Fungal Proteins, RB5, Reactive Black 5, Oxidoreductase, dye-decolorizing peroxidase, Enzyme kinetics, LiP, lignin peroxidase, Catalytic protein radicals, Molecular Biology, Dye-decolorizing peroxidase, Binding Sites, Basidiomycota, Protein, DMP, 2,6-dimethoxyphenol, MM, molecular mechanics, molecular docking, Cell Biology, WT, wild-type, TNM, tetranitromethane, Amino Acid Substitution, Biocatalysis, Mutagenesis, Site-Directed, biology.protein, Tyrosine, Mutant Proteins, Proteïnes
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10bb99b56025a9789d53e0fef7b90dbb
https://hdl.handle.net/2117/84134 -
5دورية أكاديمية
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6دورية أكاديمية
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7دورية أكاديمية
المؤلفون: Zeng F; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China., Li S; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China., Yang G; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China., Luo Y; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China., Qi T; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China., Liang Y; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China., Yang T; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China., Zhang L; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China., Wang R; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China., Zhu L; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China., Li H; Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China., Xu X; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China.
المصدر: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2020 Oct 15. Date of Electronic Publication: 2020 Oct 15.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101600560 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2211-3835 (Print) Linking ISSN: 22113835 NLM ISO Abbreviation: Acta Pharm Sin B
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8دورية أكاديمية
المؤلفون: Bansal G; Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ghal Kalan, Moga, Punjab 142001, India., Thanikachalam PV; Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ghal Kalan, Moga, Punjab 142001, India.; GRT Institute of Pharmaceutical Education and Research, GRT Mahalakshmi Nagar, Tiruttani, India., Maurya RK; Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ghal Kalan, Moga, Punjab 142001, India.; Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus, India., Chawla P; Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ghal Kalan, Moga, Punjab 142001, India., Ramamurthy S; College of Pharmacy and Health Sciences, University of Science and Technology of Fujairah, United Arab Emirates.
المصدر: Journal of advanced research [J Adv Res] 2020 Jan 22; Vol. 23, pp. 163-205. Date of Electronic Publication: 2020 Jan 22 (Print Publication: 2020).
نوع المنشور: Journal Article; Review
بيانات الدورية: Publisher: Cairo University, production and hosting by Elsevier B. V Country of Publication: Egypt NLM ID: 101546952 Publication Model: eCollection Cited Medium: Print ISSN: 2090-1232 (Print) Linking ISSN: 20901224 NLM ISO Abbreviation: J Adv Res Subsets: PubMed not MEDLINE
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9دورية أكاديمية
المؤلفون: Fojtíková L; Department of Biochemistry and Microbiology, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Technická 3, 166 28 Prague, Czech Republic., Šuláková A; Department of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Technická 3, 166 28 Prague, Czech Republic., Blažková M; Department of Biochemistry and Microbiology, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Technická 3, 166 28 Prague, Czech Republic., Holubová B; Department of Biochemistry and Microbiology, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Technická 3, 166 28 Prague, Czech Republic., Kuchař M; Department of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Technická 3, 166 28 Prague, Czech Republic., Mikšátková P; Department of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Technická 3, 166 28 Prague, Czech Republic., Lapčík O; Department of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Technická 3, 166 28 Prague, Czech Republic., Fukal L; Department of Biochemistry and Microbiology, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Technická 3, 166 28 Prague, Czech Republic.
المصدر: Toxicology reports [Toxicol Rep] 2017 Dec 06; Vol. 5, pp. 65-75. Date of Electronic Publication: 2017 Dec 06 (Print Publication: 2018).
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Elsevier Ireland Ltd Country of Publication: Ireland NLM ID: 101630272 Publication Model: eCollection Cited Medium: Internet ISSN: 2214-7500 (Electronic) Linking ISSN: 22147500 NLM ISO Abbreviation: Toxicol Rep Subsets: PubMed not MEDLINE