المؤلفون: Fan Xie, Jernej Slak, Pedro Fardim, Guy Van den Mooter

المصدر: International journal of pharmaceutics: X. 5

مصطلحات موضوعية: Poorly water-soluble drugs, Amorphous state, DAC, Dialdehyde cellulose, AC, Acetone, XRPD, X-ray powder diffraction, Pharmaceutical Science, HPLC, High performance liquid chromatography, TBA, Tert-butanol, CBs, Cellulose beads, DCM, Dichloromethane, FNB, Fenofibrate, ITZ, Itraconazole, NCEs, New Chemical Entities, Swelling, FTIR, Fourier-transform infrared spectroscopy, IND, Indomethacin, Solubility improvement, Tg, Glass transition temperature, EtOH, Ethanol, ILs, Ionic liquids, DMSO, Dimethyl sulfoxide, SGF, Simulated gastric fluid, MeOH, Methanol, Supersaturation, EDA, Ethylenediamine, NMMO, N-methylmorpholine N –oxide, Cationic cellulose beads, mDSC, Modulated differential scanning calorimetry, NASDs, Amorphous solid dispersions

وصف الملف: Electronic-eCollection

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6579617d352b2ad2633f9809284cdcc5
https://pubmed.ncbi.nlm.nih.gov/36593986

المؤلفون: Xu Shen, Xiaoxia Qiu, Jiaying Wang, Wenwen Liu, Xiaokang Li, Fei Mao, Jian Lu, Baoli Li, Jin Zhu, Yixiang Xu, Jian Li, Lei Fan

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 4, Pp 646-666 (2020)

مصطلحات موضوعية: Original article, Nitazoxanide, Aβ, β-amyloid, Tau protein, mTOR, mammalian target of rapamycin, Pharmacology, CNS, central nervous system, PBL, porcine brain lipid, NFTs, neurofibrillary tangles, 03 medical and health sciences, 0302 clinical medicine, WORT, wortmannin, APP, amyloid precursor protein, Autophagy, medicine, NTZ, nitazoxanide, General Pharmacology, Toxicology and Pharmaceutics, BBB, blood–brain barrier, PI3K/AKT/mTOR pathway, 030304 developmental biology, 0303 health sciences, biology, β-amyloid, Activator (genetics), Drug discovery, business.industry, lcsh:RM1-950, NMDA, N-methyl-d-aspartate, Alzheimer's disease, PAMPA, parallel artificial membrane permeation assay, MWM, Morris Water Maze, Drug repositioning, lcsh:Therapeutics. Pharmacology, AChEIs, acetylcholinesterase inhibitors, SPs, senile plaques, 030220 oncology & carcinogenesis, biology.protein, Phosphorylation, AD, Alzheimer's disease, NCEs, new chemical entities, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe46f557fb401b09743b51fe8f97388
https://doi.org/10.1016/j.apsb.2019.07.006

المؤلفون: Jin Zhai, Mary Jo Wildey, Elisa Passini, John Imredy, Frederick Sannajust, Kevin Fitzgerald, Anne Chain, Sebastian Polak, Christopher P. Regan, Pierre Morissette, Patrick Fanelli, Jeffrey Travis, Blanca Rodriguez

المصدر: Toxicology and Applied Pharmacology

مصطلحات موضوعية: 0301 basic medicine, ICH, The International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use, TN, True Negative, PPV, Positive Predictive Value, Pharmacology, TdP, Torsade de Pointes, Toxicology, Membrane Potentials, 0302 clinical medicine, HTS, High Throughput Screening, QTcVdW, Van de Water's Heart Rate QT-corrected Interval, In Silico modeling, Medicine, Translational PKPD modeling, NCEs, New Chemical Entities, CTD90, Ca2+-Transient Duration at 90% repolarization, education.field_of_study, Anesthetized Cardiovascular Guinea Pig, HR, Heart Rate, PNV, Predictive Negative Value, Safety pharmacology, ECG, Electrocardiogram, FIH, First in Human, IKr, rapidly-activating delayed rectifier potassium current, AP, Action Potential, QTc, Heart Rate corrected QT Interval, PX, PatchXpress®, 030220 oncology & carcinogenesis, Electrophysiologic Techniques, Cardiac, FP, False Positive, LVP, Left Ventricular Pressure, Anti-Arrhythmia Agents, In silico, Population, Guinea Pigs, QT interval, Models, Biological, Article, Ventricular action potential, Cell Line, CVGP, Cardiovascular Anesthetized Guinea Pig, GP, Guinea Pig, 03 medical and health sciences, hERG, Human Ether-a-go-go Related Gene, Pharmacokinetics, In vivo, Animals, Humans, Computer Simulation, education, QT corrected interval, BP, Blood Pressure, business.industry, M5P, M5 trees automated pruning model, tPKPD, thranslational pharmacokinetic/pharmacodynamic, FLIPR, Fluorescent Imaging Plate Reader, Arrhythmias, Cardiac, ORd, O'Hara Rudy model, Electrophysiological Phenomena, 030104 developmental biology, HEK293 Cells, Models, Chemical, Pharmacodynamics, Torsade de Pointes, EMw, Electromechanical window, FN, False Negative, TP, True Positive, Calcium, Calcium Channels, LOO, Leave-One-Out, business, APD90, Action Potential Duration at 90% repolarization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291b9744f97d46ac0f6fd500ad2e1c0f
http://europepmc.org/articles/PMC7322544

المؤلفون: Noel Dybdal, Jason Cordes, Nick Edmunds, Gemma Ward, Helen Prior, Aileen Milne, Brian M. Roche, Michael Gerhard Hoffmann, Pascal Champéroux, Stéphane Milano, Mike Engwall, Ken Meecham, Rick Nelson, Jean-Pierre Valentin, Eric Delpy, Anna Bottomley, Mike Foley, Robert Kaiser, Kathryn Chapman

المصدر: Journal of Pharmacological and Toxicological Methods

مصطلحات موضوعية: Veterinary medicine, Swine, Applied psychology, Drug Evaluation, Preclinical, 030204 cardiovascular system & hematology, R&D, research and development, Social Environment, Toxicology, 030226 pharmacology & pharmacy, Toxicology studies, 0302 clinical medicine, ARRIVE, Animal Research: Reporting of In Vivo Experiments, Surveys and Questionnaires, Dog, Methods, Telemetry, Medicine, NC3Rs, National Centre for the Replacement, Refinement and Reduction of Animals in Research, NHP, non-human primate, Safety pharmacology, MTD, maximum tolerated dose, Housing, Animal, GLP, good laboratory practice, Minipig, 3Rs, Replacement, Refinement And Reduction, CCTV, closed circuit television, Swine, Miniature, NCEs, new chemical entities, Safety, Primates, Public housing, Best practice, Food consumption, CRO, contract research organisation, IACUC, Institutional Animal Care and Use Committee, Article, 3Rs, Outsourcing, ICH, International Conference on Harmonisation, 03 medical and health sciences, Dogs, AAALAC, Association for Assessment and Accreditation of Laboratory Animal Care International, Animals, Temperament, Pharmacology, Non human primate, business.industry, Hemodynamics, Social housing, Social environment, Non-human primate, SPS, Safety Pharmacology Society, AWERB, Animal Welfare and Ethical Review Body, ECG, electrocardiogram, Non-rodents, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30f4fae26b6268120ca6210c96d3958

المؤلفون: Xie F; Drug Delivery and Disposition, KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Campus Gasthuisberg ON2, Herestraat 49 b921, 3000 Leuven, Belgium., Slak J; Bio&Chemical Systems Technology, Reactor Engineering and Safety, Department of Chemical Engineering, KU Leuven, 3000 Leuven, Belgium., Fardim P; Bio&Chemical Systems Technology, Reactor Engineering and Safety, Department of Chemical Engineering, KU Leuven, 3000 Leuven, Belgium., Van den Mooter G; Drug Delivery and Disposition, KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Campus Gasthuisberg ON2, Herestraat 49 b921, 3000 Leuven, Belgium.

المصدر: International journal of pharmaceutics: X [Int J Pharm X] 2022 Dec 16; Vol. 5, pp. 100146. Date of Electronic Publication: 2022 Dec 16 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101753452 Publication Model: eCollection Cited Medium: Internet ISSN: 2590-1567 (Electronic) Linking ISSN: 25901567 NLM ISO Abbreviation: Int J Pharm X Subsets: PubMed not MEDLINE

المؤلفون: Li X; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China., Lu J; School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing 210023, China., Xu Y; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China., Wang J; School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing 210023, China., Qiu X; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China., Fan L; Center for Drug Safety Evaluation and Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Li B; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China., Liu W; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China., Mao F; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China., Zhu J; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China., Shen X; School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing 210023, China., Li J; State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.

المصدر: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2020 Apr; Vol. 10 (4), pp. 646-666. Date of Electronic Publication: 2019 Jul 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101600560 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2211-3835 (Print) Linking ISSN: 22113835 NLM ISO Abbreviation: Acta Pharm Sin B Subsets: PubMed not MEDLINE