المؤلفون: Yang K; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Material Science, Northwest University, Xi'an, Shaanxi, 710127, PR China., Kang Y; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Material Science, Northwest University, Xi'an, Shaanxi, 710127, PR China., Zhang Q; Shaanxi Environmental Monitoring Centre, Shaanxi Key Laboratory for Environmental Monitoring and Forewarning of Trace Pollutants, Xi'an, Shaanxi, 710054, PR China., Wu D; Sunresin New Materials Co., Ltd., Xi'an, Shaanxi, 710076, PR China., Shen J; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Material Science, Northwest University, Xi'an, Shaanxi, 710127, PR China., Wei Y; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Material Science, Northwest University, Xi'an, Shaanxi, 710127, PR China., Wang C; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Material Science, Northwest University, Xi'an, Shaanxi, 710127, PR China. Electronic address: czwang@nwu.edu.cn.

المصدر: Talanta [Talanta] 2024 Aug 15; Vol. 276, pp. 126235. Date of Electronic Publication: 2024 May 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE

مواضيع طبية MeSH: Nitrogen*/chemistry , Gas Chromatography-Mass Spectrometry*/methods , Nanospheres*/chemistry , Carbon*/chemistry , Polymers*/chemistry , Nitrosamines*/analysis , Nitrosamines*/isolation & purification , Indoles*/chemistry , Solid Phase Extraction*/methods, Porosity ; Adsorption ; Ferrosoferric Oxide/chemistry

المؤلفون: Li MX; State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan 430074, China., Chen YJ; School of Environmental Studies, China University of Geosciences, Wuhan 430074, China., Chen WW; College of Environmental Science and Engineering, Guilin University of Technology, Guilin 541006, China., Huang HF; State Environmental Protection Key Laboratory of Water Environmental Simulation and Pollution Control, South China Institute of Environmental Sciences, Ministry of Ecology and Environment, Guangzhou 510535, China., Ding Y; Key Laboratory of Land Resources Evaluation and Monitoring in Southwest, Ministry of Education, Sichuan Normal University, Chengdu 610066, China., Xing XL; State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan 430074, China., Lu YQ; College of Environmental Science and Engineering, Guilin University of Technology, Guilin 541006, China., Qi SH; State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan 430074, China.; School of Environmental Studies, China University of Geosciences, Wuhan 430074, China.

المصدر: Huan jing ke xue= Huanjing kexue [Huan Jing Ke Xue] 2024 Jul 08; Vol. 45 (7), pp. 3930-3940.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Ke xue zhu ban she Country of Publication: China NLM ID: 8405344 Publication Model: Print Cited Medium: Print ISSN: 0250-3301 (Print) Linking ISSN: 02503301 NLM ISO Abbreviation: Huan Jing Ke Xue Subsets: MEDLINE

مواضيع طبية MeSH: Nitrosamines*/analysis , Water Pollution, Chemical*/statistics & numerical data , Water Pollutants, Chemical*/analysis , Environmental Monitoring*, Risk Assessment ; China ; Environmental Exposure/statistics & numerical data ; Drinking Water/analysis ; Rivers

المؤلفون: Li X; Research Institute for Environmental Innovation (Suzhou), Tsinghua, Suzhou, Jiangsu 215163, China; Shenzhen Key Laboratory of Organic Pollution Prevention and Control, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Shenzhen 518055, China., Ye Z; State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China., Wang J; Research Institute for Environmental Innovation (Suzhou), Tsinghua, Suzhou, Jiangsu 215163, China; State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China., Lin P; Research Institute for Environmental Innovation (Suzhou), Tsinghua, Suzhou, Jiangsu 215163, China., Zhang X; State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China., Xie S; State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Science and Engineering, Peking University, Beijing 100871, China., Chen C; Research Institute for Environmental Innovation (Suzhou), Tsinghua, Suzhou, Jiangsu 215163, China; State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China. Electronic address: chen_water@tsinghua.edu.cn.

المصدر: Journal of environmental sciences (China) [J Environ Sci (China)] 2024 Jul; Vol. 141, pp. 249-260. Date of Electronic Publication: 2023 May 23.

نوع المنشور: Meta-Analysis; Journal Article

بيانات الدورية: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 100967627 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1001-0742 (Print) Linking ISSN: 10010742 NLM ISO Abbreviation: J Environ Sci (China) Subsets: MEDLINE

مواضيع طبية MeSH: Tobacco Smoke Pollution*/adverse effects , Nitrosamines*/analysis , Neoplasms*/epidemiology, Adult ; Humans ; Smokers ; Carcinogens/analysis ; Smoke/analysis ; Dimethylnitrosamine ; China/epidemiology ; Tobacco Products

المؤلفون: Yan X; Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Guilin University of Technology, Guilin, 541004, China., Huang H; State Environmental Protection Key Laboratory of Water Environmental Simulation and Pollution ControlSouth China Institute of Environmental Sciences, Ministry of Ecology and Environment, Guangzhou, 510535, China., Chen W; Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Guilin University of Technology, Guilin, 541004, China., Li H; Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Guilin University of Technology, Guilin, 541004, China.; Collaborative Innovation Center for Water Pollution Control and Water Safety in Karst Area, Guilin University of Technology, Guilin, 541004, China., Chen Y; State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan, 430074, China., Liang Y; Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Guilin University of Technology, Guilin, 541004, China.; Collaborative Innovation Center for Water Pollution Control and Water Safety in Karst Area, Guilin University of Technology, Guilin, 541004, China., Zeng H; Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Guilin University of Technology, Guilin, 541004, China. zenghonghu@glut.edu.cn.; Collaborative Innovation Center for Water Pollution Control and Water Safety in Karst Area, Guilin University of Technology, Guilin, 541004, China. zenghonghu@glut.edu.cn.

المصدر: Environmental geochemistry and health [Environ Geochem Health] 2024 Jun 17; Vol. 46 (7), pp. 255. Date of Electronic Publication: 2024 Jun 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 8903118 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-2983 (Electronic) Linking ISSN: 02694042 NLM ISO Abbreviation: Environ Geochem Health Subsets: MEDLINE

مواضيع طبية MeSH: Nitrosamines*/analysis , Water Pollutants, Chemical*/analysis , Groundwater*/chemistry , Environmental Monitoring* , Rivers*/chemistry, China ; Wastewater/chemistry ; Industrial Waste/analysis ; Electroplating ; Animals ; Ecosystem

المؤلفون: Kruhlak NL; US Food and Drug Administration (US FDA), Silver Spring, MD, USA. Electronic address: Naomi.Kruhlak@fda.hhs.gov., Schmidt M; Danish Medicines Agency (DKMA), Copenhagen, Denmark., Froetschl R; Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany., Graber S; Swiss Agency for Therapeutic Products (Swissmedic), Bern, Switzerland., Haas B; Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany., Horne I; Therapeutic Goods Administration (TGA), Canberra, Australia., Horne S; Pharmaceutical Drugs Directorate, Health Canada, Ottawa, Ontario, Canada., King ST; US Food and Drug Administration (US FDA), Silver Spring, MD, USA., Koval IA; Medicines Evaluation Board (MEB), Utrecht, Netherlands., Kumaran G; US Food and Drug Administration (US FDA), Silver Spring, MD, USA., Langenkamp A; Swiss Agency for Therapeutic Products (Swissmedic), Bern, Switzerland., McGovern TJ; US Food and Drug Administration (US FDA), Silver Spring, MD, USA., Peryea T; US Food and Drug Administration (US FDA), Silver Spring, MD, USA., Sanh A; French National Agency for Medicines and Health Products Safety (ANSM), Saint-Denis, France., Siqueira Ferreira A; Agência Nacional de Vigilância Sanitária (ANVISA), Brasilia, Brazil., van Aerts L; Medicines Evaluation Board (MEB), Utrecht, Netherlands., Vespa A; Pharmaceutical Drugs Directorate, Health Canada, Ottawa, Ontario, Canada., Whomsley R; European Medicines Agency (EMA), Amsterdam, Netherlands.

المصدر: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2024 Jun; Vol. 150, pp. 105640. Date of Electronic Publication: 2024 May 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8214983 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0295 (Electronic) Linking ISSN: 02732300 NLM ISO Abbreviation: Regul Toxicol Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Nitrosamines*/analysis , Nitrosamines*/toxicity , Carcinogens*/analysis , Carcinogens*/toxicity , Drug Contamination*/prevention & control, Humans ; Animals ; Structure-Activity Relationship ; Risk Assessment ; Carcinogenicity Tests

المؤلفون: Nabizadeh S; Department of Food Science and Technology, Faculty of Nutrition Science, Food Science and Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Aeini K; Department of Food Hygiene and Aquaculture, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran., Barzegar F; Department of Food Science and Technology, Faculty of Nutrition Science, Food Science and Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Arabameri M; Food Safety Research Center (salt), Semnan University of Medical Sciences, Semnan, Iran., Hosseini H; Department of Food Science and Technology, Faculty of Nutrition Science, Food Science and Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Kamankesh M; Food Safety Research Center (salt), Semnan University of Medical Sciences, Semnan, Iran; School of Pharmacy, Semnan University of Medical Sciences, Semnan, Iran., Mohammadi A; Department of Food Science and Technology, Faculty of Nutrition Science, Food Science and Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Food Safety Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: ab.mohammadi@sbmu.ac.ir.

المصدر: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2024 Jun; Vol. 188, pp. 114649. Date of Electronic Publication: 2024 Apr 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8207483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6351 (Electronic) Linking ISSN: 02786915 NLM ISO Abbreviation: Food Chem Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Nitrosamines*/analysis , Meat Products*/analysis , Dietary Exposure*/analysis , Principal Component Analysis*, Humans ; Adult ; Risk Assessment ; Adolescent ; Child ; Middle Aged ; Young Adult ; Child, Preschool ; Iran ; Food Contamination/analysis ; Aged ; Gas Chromatography-Mass Spectrometry/methods

المؤلفون: Kartop RA; World Medicine İlaç San. Tic. A.Ş, 15 Temmuz Mah. Camiyolu Cd. No:50, K.4, 34212, Bağcılar, İstanbul, Türkiye., Güleli M; World Medicine İlaç San. Tic. A.Ş, 15 Temmuz Mah. Camiyolu Cd. No:50, K.4, 34212, Bağcılar, İstanbul, Türkiye., Faruzlu FA; World Medicine İlaç San. Tic. A.Ş, 15 Temmuz Mah. Camiyolu Cd. No:50, K.4, 34212, Bağcılar, İstanbul, Türkiye., Çalışkan C; World Medicine İlaç San. Tic. A.Ş, 15 Temmuz Mah. Camiyolu Cd. No:50, K.4, 34212, Bağcılar, İstanbul, Türkiye. Electronic address: cem.caliskan@worldmedicine.com.tr.

المصدر: Journal of pharmaceutical sciences [J Pharm Sci] 2024 Jun; Vol. 113 (6), pp. 1597-1606. Date of Electronic Publication: 2024 Jan 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE

مواضيع طبية MeSH: Drug Contamination*/prevention & control , Drug Packaging*/methods , Nitrosamines*/analysis , Tandem Mass Spectrometry*/methods, Liquid Chromatography-Mass Spectrometry ; Pharmaceutical Preparations/analysis ; Pharmaceutical Preparations/chemistry ; Reproducibility of Results ; Risk Assessment/methods

المؤلفون: Eisenbrand G; Kühler Grund 48/1, 69126, Heidelberg, Germany., Buettner A; Chair of Aroma and Smell Research, Friedrich-Alexander-Universität Erlangen-Nürnberg, Henkestrasse 9, 91054, Erlangen, Germany.; Fraunhofer Institute for Process Engineering and Packaging IVV, Giggenhauser Strasse 35, 85354, Freising, Germany., Diel P; Department of Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany., Epe B; Institute of Pharmaceutical and Biomedical Sciences, University of Mainz, Staudingerweg, 55128, Mainz, Germany., Först P; Food Process Engineering, TUM School of Life Sciences, Technical University of Munich, Weihenstephaner Berg 1, 85354, Freising, Germany., Grune T; German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany., Haller D; Chair of Nutrition and Immunology, Technical University of Munich, Gregor-Mendel-Strasse 2, 85354, Freising, Germany.; ZIEL Institute for Food and Health, Technical University of Munich, Weihenstephaner Berg 1, 85354, Freising, Germany., Heinz V; DIL German Institute of Food Technology, Professor-von-Klitzing-Strasse 7, 49610, Quakenbrück, Germany., Hellwig M; Chair of Special Food Chemistry, Technical University Dresden, Bergstrasse 66, 01062, Dresden, Germany., Humpf HU; Institute of Food Chemistry, University of Münster, Corrensstrasse 45, 48149, Münster, Germany., Jäger H; University of Natural Resources and Life Sciences, Gregor-Mendel-Strasse 33, 1180, Vienna, Austria., Kulling S; Department of Safety and Quality of Fruit and Vegetables, Max Rubner-Institut, Federal Research Institute of Nutrition and Food, Haid-und-Neu-Strasse 9, 76131, Karlsruhe, Germany., Lampen A; Risk Assessment Strategies, German Federal Institute for Risk Assessment (BfR), Max-Dohrn-Strasse 8-10, 10589, Berlin, Germany., Leist M; Division for In Vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, Universitaetsstrasse 10, 78464, Constance, Germany., Mally A; Department of Toxicology, University of Würzburg, Versbacher Strasse 9, 97078, Würzburg, Germany., Marko D; Department of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Währinger Strasse 38-40, 1090, Vienna, Austria., Nöthlings U; Institute for Nutrition Research and Food Science, Rheinische Friedrich-Wilhelms-University Bonn, Fiedrich-Hirzebruch-Allee 7, 53115, Bonn, Germany., Röhrdanz E; Unit Reproductive and Genetic Toxicology, Federal Institute for Drugs and Medical Devices (BfArM), Kurt-Georg-Kiesinger Allee 3, 53175, Bonn, Germany., Spranger J; Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany., Steinberg P; Max Rubner-Institut, Federal Research Institute of Nutrition and Food, Haid-Und-Neu-Straße 9, 76131, Karlsruhe, Germany., Vieths S; Paul-Ehrlich-Institut, Paul-Ehrlich-Strasse 51-59, 63225, Langen, Germany., Wätjen W; Institute of Agricultural and Nutritional Sciences, Martin-Luther-University Halle-Wittenberg, Weinbergweg 22, 06120, Halle (Saale), Germany., Hengstler JG; Department of Toxicology, Leibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystr. 67, 44139, Dortmund, Germany. hengstler@ifado.de.

المصدر: Archives of toxicology [Arch Toxicol] 2024 Jun; Vol. 98 (6), pp. 1573-1580. Date of Electronic Publication: 2024 Apr 04.

نوع المنشور: Journal Article; Editorial

بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Nitrosamines*/toxicity , Nitrosamines*/pharmacokinetics , Dietary Exposure*/adverse effects , Dimethylnitrosamine*/toxicity , DNA Adducts*, Humans ; Risk Assessment ; Food Contamination ; Food Safety ; Animals ; Nitrites/toxicity ; Nitrates/toxicity ; Nitrates/pharmacokinetics ; Reactive Nitrogen Species/metabolism

المؤلفون: Li B; School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning Province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang, China., Li X; Department of PIVAS, Yanbian University Hospital, Yanji, China., Jiang Z; Department of PIVAS, Yanbian University Hospital, Yanji, China., Zhou D; School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning Province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang, China., Feng Y; School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning Province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang, China., Chen G; School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning Province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang, China., Li N; School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning Province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang, China.

المصدر: British journal of pharmacology [Br J Pharmacol] 2024 Aug; Vol. 181 (15), pp. 2509-2527. Date of Electronic Publication: 2024 Apr 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Nitrosamines*/toxicity , MicroRNAs*/genetics , MicroRNAs*/metabolism , Carcinogens*/toxicity, Animals ; Mice ; Humans ; Lung Injury/chemically induced ; Lung Injury/metabolism ; Lung Injury/genetics ; Lung Neoplasms/chemically induced ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Male ; Nicotiana

المؤلفون: Sajid M; Division of Molecular Genetics and Biochemistry, Molecular Biology Group, ICMR-National Institute of Cancer Prevention and Research, Noida, India., Sharma U; Division of Molecular Genetics and Biochemistry, Molecular Biology Group, ICMR-National Institute of Cancer Prevention and Research, Noida, India., Srivastava S; Division of Molecular Genetics and Biochemistry, Molecular Biology Group, ICMR-National Institute of Cancer Prevention and Research, Noida, India., Yadav RK; Division of Molecular Genetics and Biochemistry, Molecular Biology Group, ICMR-National Institute of Cancer Prevention and Research, Noida, India., Bharadwaj M; Division of Molecular Genetics and Biochemistry, Molecular Biology Group, ICMR-National Institute of Cancer Prevention and Research, Noida, India. mausumi.bharadwaj@gov.in.

المصدر: Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2024 Jun 25; Vol. 108 (1), pp. 395. Date of Electronic Publication: 2024 Jun 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 8406612 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0614 (Electronic) Linking ISSN: 01757598 NLM ISO Abbreviation: Appl Microbiol Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: Tobacco, Smokeless* , Metagenomics* , Bacteria*/genetics , Bacteria*/classification , Bacteria*/metabolism , Bacteria*/isolation & purification , Microbiota* , Nitrosamines*/metabolism, India ; Nicotine/metabolism ; Humans