المؤلفون: Wei Zhang, Yilan Shen, Zongshu Xian, Tao Ding, Lei Han, Dianwen Ju, Zhiyong Guo, Jiajun Fan, Xiaobin Mei, Wei Chen, Qi Bian, Zhonglian Cao, Xin Jin

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 127-142 (2021)

مصطلحات موضوعية: BUN, blood urea nitrogen, SDS-PAGE, SDS-polyacrylamide gel electrophoresis, AGEs, advanced glycation end products, Diabetic nephropathy, AST, aspartate aminotransferase, Pharmacology, Interleukin-22, medicine.disease_cause, IL-22, interleukin-22, Interleukin 22, 0302 clinical medicine, GSEA, gene set enrichment analysis, ESRD, end-stage renal disease, β2-MG, β2 microglobulin, FATPs, fatty acid transport proteins, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, eGFR, estimated glomerular filtration rate, ECM, extracellular matrix, Vascular endothelial growth factor B, VEGFR, vascular endothelial growth factor receptor, Lipotoxicity, HbA1c%, glycosylated hemoglobin, 030220 oncology & carcinogenesis, Original Article, ACR, urine albumin-to-creatinine ratio, medicine.symptom, Fusion protein, GBM, glomerular basement membrane, Inflammation, Ccr, creatinine clearance rate, KEGG, Kyoto Encyclopedia of Genes and Genomes, DN, diabetic nephropathy, 03 medical and health sciences, ROS, reactive oxygen species, Downregulation and upregulation, ALT, alanine aminotransferase, medicine, TEM, transmission electron microscopy, NRP-1, neuropilin-1, 030304 developmental biology, ADFP, adipocyte differentiation-related protein, business.industry, VEGF-B, vascular endothelial growth factor B, lcsh:RM1-950, FA, fatty acid, NLRP3, NOD-like receptor family pyrin domain-containing protein 3, NAC, N-acetyl-l-cysteine, H&E, hematoxylin & eosin, medicine.disease, PAS, periodic acid-Schiff, lcsh:Therapeutics. Pharmacology, business, Oxidative stress

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f219822cc51b051f7ece0ce7f7e9b55
https://doi.org/10.1016/j.apsb.2020.07.002

المؤلفون: Rebecca C. Coll, Tamara L Allen, Mark A. Febbraio, Helene L. Kammoun, S. Barre, Graeme I. Lancaster, Darren C. Henstridge, Mark S. Butler, Saskia Reibe, Mark E. Cooper, Luke A. J. O'Neill, D. R. Laybutt, Jeng Yie Chan, Avril A. B. Robertson, Lena Cron, Mohammed Bensellam

المصدر: Molecular Metabolism, Vol 10, Iss, Pp 66-73 (2018)
Molecular Metabolism

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, Interleukin-1beta, Anti-Inflammatory Agents, db/db mice, Inflammasome, Pathogenesis, Mice, Insulin-Secreting Cells, Sulfones, MCC950, Cells, Cultured, Sulfonamides, geography.geographical_feature_category, Type 2 diabetes, NLRP3, Nod-like receptor family pyrin domain-containing protein 3, Islet, Interleukin-1β, medicine.anatomical_structure, Indenes, Original Article, medicine.symptom, Pancreas, medicine.drug, lcsh:Internal medicine, medicine.medical_specialty, Programmed cell death, IL-1β, interleukin-1β, Inflammation, Heterocyclic Compounds, 4 or More Rings, 03 medical and health sciences, Internal medicine, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Animals, Hypoglycemic Agents, Secretion, DAMPs, danger-associated molecular patterns, Furans, lcsh:RC31-1245, Molecular Biology, geography, business.industry, Insulin, Cell Biology, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, T2D, Type 2 Diabetes, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b8a68246153e72d6a35820ff8e2849d
https://doi.org/10.1016/j.molmet.2018.02.001

المؤلفون: Debdutta Bandyopadhyay, Sameer Agarwal, Vismit Vyas, Jignesh P. Pethani, Poonam Giri, Hardik A. Shah, Rajiv P. Sharma, Mukul R. Jain, Santosh Sasane, Kasinath Viswanathan, Harsh Bhavsar

المصدر: Bioorganic & Medicinal Chemistry Letters

مصطلحات موضوعية: Inflammasomes, Interleukin-1beta, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Pharmacology, 01 natural sciences, Biochemistry, Sulfonylurea, Drug Stability, Drug Discovery, NCE, new chemical entity, Acute respiratory distress syndrome (ARDS), PAMP, pathogen‐associated molecular pattern, LPS, Lipopolysaccharide, Molecular Structure, integumentary system, Chemistry, Inflammasome, tPSA, total polar surface area, LDA, lithium diisopropylamide, Cytochrome P-450 CYP2C8 Inhibitors, Microsomes, Liver, Molecular Medicine, medicine.symptom, NLRP3, NOD-like receptor family, pyrin domain-containing protein 3, Coronavirus Infections, Interleukin-1β (IL-1β), medicine.drug, AIM2, absent in melanoma 2, 2019-20 coronavirus outbreak, Cytochrome P-450 CYP2C9 Inhibitors, Coronavirus disease 2019 (COVID-19), medicine.drug_class, Pneumonia, Viral, Inflammation, ATP, adenosinetriphosphate, PK, pharmacokinetic, Article, TFA, trifluoroacetic acid, Betacoronavirus, Structure-Activity Relationship, Dogs, NLRP3, Pharmacokinetics, Cell Line, Tumor, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Animals, Humans, Structure–activity relationship, Pandemics, Molecular Biology, ComputingMethodologies_COMPUTERGRAPHICS, SARS-CoV-2, 010405 organic chemistry, Organic Chemistry, COVID-19, DAMP, damage‐associated molecular pattern, NLRP3 inflammasome, Rats, 0104 chemical sciences, Bioavailability, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Sulfonylurea Compounds

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dbcadeb80c232f7df9847260e9af18c
https://doi.org/10.1016/j.bmcl.2020.127571

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المؤلفون: Shen Y; Department of Nephrology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China., Chen W; Department of Biological Medicines, Fudan University School of Pharmacy, Shanghai 201203, China.; Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA 94304, USA., Han L; Department of Biological Medicines, Fudan University School of Pharmacy, Shanghai 201203, China., Bian Q; Department of Nephrology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China., Fan J; Department of Biological Medicines, Fudan University School of Pharmacy, Shanghai 201203, China., Cao Z; Department of Biological Medicines, Fudan University School of Pharmacy, Shanghai 201203, China., Jin X; Department of Biological Medicines, Fudan University School of Pharmacy, Shanghai 201203, China., Ding T; Department of Nephrology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China., Xian Z; Department of Biological Medicines, Fudan University School of Pharmacy, Shanghai 201203, China., Guo Z; Department of Nephrology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China., Zhang W; Department of Nephrology, Shanghai Yangpu Hospital of TCM, Shanghai 200090, China., Ju D; Department of Biological Medicines, Fudan University School of Pharmacy, Shanghai 201203, China., Mei X; Department of Nephrology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.

المصدر: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 Jan; Vol. 11 (1), pp. 127-142. Date of Electronic Publication: 2020 Jul 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101600560 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2211-3835 (Print) Linking ISSN: 22113835 NLM ISO Abbreviation: Acta Pharm Sin B Subsets: PubMed not MEDLINE