نتائج البحث - "Nadia Milech"

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دورية أكاديمية

β-Lactamase Tools for Establishing Cell Internalization and Cytosolic Delivery of Cell Penetrating Peptides

المؤلفون: Shane R. Stone, Tatjana Heinrich, Suzy M. Juraja, Jiulia N. Satiaputra, Clinton M. Hall, Mark Anastasas, Anna D. Mills, Christopher A. Chamberlain, Scott Winslow, Kristin Priebatsch, Paula T. Cunningham, Katrin Hoffmann, Nadia Milech

المصدر: Biomolecules, Vol 8, Iss 3, p 51 (2018)

مصطلحات موضوعية: cell penetrating peptide, high-throughput screening, functional validation, cell internalization, cytosolic delivery, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: http://www.mdpi.com/2218-273X/8/3/51; https://doaj.org/toc/2218-273X

URL الوصول: https://doaj.org/article/ca42dfa2a83b4d0c880a789631e2dd6c

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Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library

المصدر: Cell Chemical Biology

مصطلحات موضوعية: Phenotypic screening, Systems biology, Clinical Biochemistry, Peptide, Computational biology, Biology, medicine.disease_cause, 01 natural sciences, Biochemistry, Article, Protein–protein interaction, law.invention, Small Molecule Libraries, protein-protein interaction, Peptide Library, target identification, law, Drug Discovery, medicine, Humans, Genes, Tumor Suppressor, Phosphorylation, FOXO3a, lead discovery, Peptide library, Molecular Biology, Cells, Cultured, 14-3-3, Pharmacology, chemistry.chemical_classification, Mutation, 010405 organic chemistry, Forkhead Box Protein O3, phenotypic screening, Small molecule, 0104 chemical sciences, prokaryal genomes, target validation, chemistry, bioactive peptide, Molecular Medicine, Suppressor, Female, protein interference

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82261f81e78bea18e12f385b6c100941
https://doi.org/10.1016/j.chembiol.2021.05.009

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Structure-diverse Phylomer libraries as a rich source of bioactive hits from phenotypic and target directed screens against intracellular proteins

المؤلفون: Paul M. Watt, Nadia Milech, Shane R. Stone

المصدر: Current Opinion in Chemical Biology. 38:127-133

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f2db05d4eb66ae735caa4b9da1313b
https://doi.org/10.1016/j.cbpa.2017.03.016

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A platform for discovery of functional cell-penetrating peptides for efficient multi-cargo intracellular delivery

المصدر: Scientific reports, vol 8, iss 1
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)

مصطلحات موضوعية: 0301 basic medicine, Male, Cell, Druggability, Drug Evaluation, Preclinical, lcsh:Medicine, Cell-Penetrating Peptides, Inbred C57BL, Mice, 0302 clinical medicine, Drug Delivery Systems, Bacteriophage T7, Carbon-Nitrogen Ligases, Muscular Dystrophy, lcsh:Science, Microscopy, Multidisciplinary, Chemistry, Escherichia coli Proteins, Circular Dichroism, Preclinical, Other Physical Sciences, medicine.anatomical_structure, 5.1 Pharmaceuticals, 030220 oncology & carcinogenesis, Biotinylation, Development of treatments and therapeutic interventions, Intracellular, Endosome, Computational biology, CHO Cells, Article, Fluorescence, 03 medical and health sciences, Cricetulus, Rare Diseases, Peptide Library, medicine, Animals, Humans, Peptide library, Animal, HEK 293 cells, lcsh:R, Duchenne, Mice, Inbred C57BL, Muscular Dystrophy, Duchenne, Repressor Proteins, Disease Models, Animal, 030104 developmental biology, HEK293 Cells, Orphan Drug, Microscopy, Fluorescence, Cytoplasm, Disease Models, Drug Evaluation, lcsh:Q, Biochemistry and Cell Biology, Generic health relevance

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2982281cc58305b13bc410a28e61452e
https://escholarship.org/uc/item/9539k69b

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β-Lactamase Tools for Establishing Cell Internalization and Cytosolic Delivery of Cell Penetrating Peptides

المؤلفون: Nadia Milech, Katrin Hoffmann, Mark Anastasas, Shane R. Stone, Suzy M. Juraja, Anna D. Mills, Christopher Aled Chamberlain, Jiulia Satiaputra, Scott Winslow, Paula T. Cunningham, Clinton M. Hall, Kristin Priebatsch, Tatjana Heinrich

المصدر: Biomolecules, Vol 8, Iss 3, p 51 (2018)
Biomolecules
Volume 8
Issue 3

مصطلحات موضوعية: 0301 basic medicine, Cell type, cytosolic delivery, High-throughput screening, media_common.quotation_subject, Cell, lcsh:QR1-502, CHO Cells, Cell-Penetrating Peptides, 02 engineering and technology, cell internalization, Biochemistry, high-throughput screening, functional validation, beta-Lactamases, Article, lcsh:Microbiology, Cell Line, 03 medical and health sciences, Cricetulus, Cytosol, Drug Delivery Systems, medicine, Animals, Humans, Internalization, Molecular Biology, media_common, chemistry.chemical_classification, 021001 nanoscience & nanotechnology, High-Throughput Screening Assays, Cell biology, 030104 developmental biology, Enzyme, medicine.anatomical_structure, chemistry, cell penetrating peptide, Cytoplasm, Cell-penetrating peptide, 0210 nano-technology, Intracellular

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ed2871689eb2366d186e4de44e2c55
http://www.mdpi.com/2218-273X/8/3/51

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CHAPTER 17. Phylomer Libraries: A Rich Source of Peptide Hits in Phenotypic and Target-Directed Screens

المؤلفون: Tatjana Heinrich, Renae K. Barr, Richard W. Francis, Heique M. Bogdawa, Nadia Milech, Shane R. Stone, Robert E. Dewhurst, Paul M. Watt

مصطلحات موضوعية: chemistry.chemical_classification, Empirical data, Amino acid composition, chemistry, Peptide, Identification (biology), Computational biology, Biology, Combinatorial chemistry, Genome, Phenotype

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9f7cd2b256feed269730aa0148f5dbec
https://doi.org/10.1039/9781788011532-00497

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GFP-complementation assay to detect functional CPP and protein delivery into living cells

المؤلفون: Yew-Foon Tan, Mark Anastasas, Ferrer Ong, M. Scobie, Paul M. Watt, Tatjana Heinrich, Richard Hopkins, Maria Kerfoot, Scott Winslow, Wayne R. Thomas, Karen M. Kroeger, Nadia Milech, Paula T. Cunningham, Shane R. Stone, Brooke A. C. Longville, Theresa Connor, Katrin Hoffmann, Heique M. Bogdawa

المصدر: Scientific Reports

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3931f4fcfdf9f65101928a87029ea7c6

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8

Lack of Neuroprotection of Inhibitory Peptides Targeting Jun/JNK after Transient Focal Cerebral Ischemia in Spontaneously Hypertensive Rats

المؤلفون: Amanda J. Meade, Bruno P. Meloni, Paul M. Watt, Nadia Milech, Neville W. Knuckey, William R Gow, Kym Campbell

المصدر: Journal of Cerebral Blood Flow & Metabolism. 31:e1-e8

مصطلحات موضوعية: Male, medicine.medical_treatment, Oncogene Protein p65(gag-jun), Excitotoxicity, Ischemia, Neuropeptide, Blood Pressure, Pharmacology, medicine.disease_cause, Neuroprotection, Negative Result, Rats, Inbred SHR, Laser-Doppler Flowmetry, medicine, Animals, Mitogen-Activated Protein Kinase 8, Saline, Stroke, Dose-Response Relationship, Drug, business.industry, Neuropeptides, c-jun, JNK Mitogen-Activated Protein Kinases, Glutamate receptor, Infarction, Middle Cerebral Artery, Carbon Dioxide, medicine.disease, Rats, Oxygen, Neuroprotective Agents, Neurology, Ischemic Attack, Transient, Anesthesia, Neurology (clinical), Peptides, Cardiology and Cardiovascular Medicine, business, Psychomotor Performance

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838844a61dd88907db6f52ef0bd77160
https://doi.org/10.1038/jcbfm.2011.140

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9

Target validation of the inosine monophosphate dehydrogenase (IMPDH) gene in Cryptosporidium using Phylomer(®) peptides

المؤلفون: Paul M. Watt, Tanya Armstrong, A. Estcourt, C.K. Woh, Simon Reid, R. Jefferies, Anthony Armson, Rongchang Yang, Nadia Milech, T. Weldt, Richard Hopkins, Una Ryan

المصدر: Experimental parasitology. 148

مصطلحات موضوعية: 030231 tropical medicine, Immunology, Molecular Sequence Data, Cryptosporidium, Microbiology, 03 medical and health sciences, 0302 clinical medicine, IMP Dehydrogenase, IMP dehydrogenase, Peptide Library, Cell Line, Tumor, Two-Hybrid System Techniques, parasitic diseases, medicine, Animals, Humans, Amino Acid Sequence, Inosine-5′-monophosphate dehydrogenase, Inosine, Nucleotide salvage, 030304 developmental biology, 0303 health sciences, biology, Base Sequence, Dose-Response Relationship, Drug, Oocysts, Nitazoxanide, General Medicine, DNA, Protozoan, biology.organism_classification, 3. Good health, Infectious Diseases, Cryptosporidium parvum, Biochemistry, biology.protein, Parasitology, Cattle, Peptides, Cryptosporidium hominis, Genome, Bacterial, medicine.drug, Plasmids

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955ea63acd7df545075525ba7a6a008d
https://pubmed.ncbi.nlm.nih.gov/25447124

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Novel alternative PBX3 isoforms in leukemia cells with distinct interaction specificities

المؤلفون: Paul M. Watt, Ursula R. Kees, Nadia Milech

المصدر: Genes, Chromosomes and Cancer. 32:275-280

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318bfe1262e7f8aca388bd10e70d0cd9
https://doi.org/10.1002/gcc.1190

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