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المؤلفون: Ester Gil Vazquez, Nadia Nasreddin, Gabriel N. Valbuena, Eoghan J. Mulholland, Hayley L. Belnoue-Davis, Holly R. Eggington, Ryan O. Schenck, Valérie M. Wouters, Pratyaksha Wirapati, Kathryn Gilroy, Tamsin R.M. Lannagan, Dustin J. Flanagan, Arafath K. Najumudeen, Sulochana Omwenga, Amy M.B. McCorry, Alistair Easton, Viktor H. Koelzer, James E. East, Dion Morton, Livio Trusolino, Timothy Maughan, Andrew D. Campbell, Maurice B. Loughrey, Philip D. Dunne, Petros Tsantoulis, David J. Huels, Sabine Tejpar, Owen J. Sansom, Simon J. Leedham
المساهمون: Center of Experimental and Molecular Medicine, CCA - Cancer biology and immunology
المصدر: Vasquez, E G, Nasreddin, N, Valbuena, G N, Mulholland, E J, Belnoue-Davis, H L, Eggington, H R, Schenck, R O, Wouters, V M, Wirapati, P, Gilroy, K, Lannagan, T R M, Flanagan, D J, Najumudeen, A K, Omwenga, S, McCorry, A M B, Easton, A, Koelzer, V H, East, J E, Morton, D, Trusolino, L, Maughan, T, Loughrey, M B, Dunne, P D, Tsantoulis, P, Huels, D J, Tejpar, S, Sansom, O J & Leedham, S J 2022, ' Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia ', Cell Stem Cell, vol. 29, no. 8, pp. 1213-1228.e8 . https://doi.org/10.1016/j.stem.2022.07.008
Cell stem cell, 29(8), 1213-1228.e8. Cell Pressمصطلحات موضوعية: EXPRESSION, colorectal cancer, Receptors, G-Protein-Coupled, Mice, G-Protein-Coupled, intestinal polyps, SDG 3 - Good Health and Well-being, Cell & Tissue Engineering, stem cells, COLON, cell plasticity, colorectal neoplasia, intestinal stem cells, molecular phenotyping, Animals, Homeostasis, Humans, Intestines, Neoplastic Stem Cells, Colorectal Neoplasms, Intestinal Mucosa, Receptors, TUMORIGENESIS, PROGRAM, Genetics, PLASTICITY, SIGNATURES, SMALL-INTESTINE, Science & Technology, IDENTIFICATION, IN-VITRO, Cell Biology, METASTASIS, Molecular Medicine, Life Sciences & Biomedicine
وصف الملف: application/pdf; Print
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e8ae6065d6af4d48e6bf14034d2918
https://pure.qub.ac.uk/en/publications/ebe1f6bb-dff1-49d2-b1ec-2dd3b998e338 -
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المؤلفون: Ester Gil Vazquez, Nadia Nasreddin, Gabriel N Valbuena, Eoghan J Mulholland, Hayley L Belnoue-Davis, Holly Eggington, Ryan O Schenck, Valérie M Wouters, Pratyaksha Wirapati, Kathryn Gilroy, Tamsin R M Lannagan, Dustin J Flanagan, Arafath K Najumudeen, Sulochana Omwenga, Amy M B McCorry, Alistair Easton, Viktor H Koelzer, James E East, Dion Morton, Livio Trusolino, Timothy Maughan, Andrew D Campbell, Maurice B Loughrey, Philip D Dunne, Petros Tsantoulis, David J Huels, Sabine Tejpar, Owen Sansom, Simon J Leedham
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bbefa25d12c76480d625ba52678c0be8
https://doi.org/10.1101/2022.06.11.495729 -
3دورية أكاديمية
المؤلفون: Dustin J. Flanagan, Nalle Pentinmikko, Kalle Luopajärvi, Nicky J. Willis, Kathryn Gilroy, Alexander P. Raven, Lynn Mcgarry, Johanna I. Englund, Anna T. Webb, Sandra Scharaw, Nadia Nasreddin
المصدر: Nature, Nature. 594(7863):430-435
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المؤلفون: Pirjo Nummela, Colin Nixon, William C. Clark, Ella Gilchrist, Simon J. Leedham, Michael C. Hodder, Nalle Pentinmikko, Arafath Kaja Najumudeen, Nathalie Sphyris, E. Yvonne Jones, Jean-Paul Vincent, Hans Clevers, Nicky J. Willis, Alexander Raven, Kristina Kirschner, Dustin J. Flanagan, Paul V. Fish, Emma Minnee, Pekka Katajisto, Ville Hietakangas, Owen J. Sansom, Christine Perret, Lynn McGarry, Nadia Nasreddin, Rachel A. Ridgway, Ann C. Williams, Kathryn Gilroy, Kalle Luopajärvi, Sandra Scharaw, Béatrice Romagnolo, Marianne Lähde, Ari Ristimäki, Johanna Englund, Anna Taylor Webb, Kari Alitalo, Ann Hedley
المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research, Institute of Biotechnology (-2009), University of Helsinki, CAN-PRO - Translational Cancer Medicine Program, Centre of Excellence in Stem Cell Metabolism, Helsinki Institute of Life Science HiLIFE, Institute of Biotechnology, Juha Klefström / Principal Investigator, Research Programs Unit, Department of Pathology, Doctoral Programme in Biomedicine, ATG - Applied Tumor Genomics, Doctoral Programme in Integrative Life Science, HUSLAB, Kari Alitalo / Principal Investigator, Molecular and Integrative Biosciences Research Programme, Biosciences, Nutrient sensing laboratory
المصدر: Nature, 594(7863), 430-435. Nature Publishing Group
Flanagan, D J, Williams, A C, Katajisto, P K, Sampson, O J & al., E 2021, ' NOTUM from Apc-mutant cells biases clonal competition to initiate cancer ', Nature, vol. 594, pp. 430–435 (2021) . https://doi.org/10.1038/s41586-021-03525-zمصطلحات موضوعية: 0301 basic medicine, Male, HOMEOSTASIS, Cell, medicine.disease_cause, Cell Transformation, Inbred C57BL, Ligands, BETA-CATENIN, ACTIVATION, PATHWAY, Mice, 0302 clinical medicine, Conditioned, INTESTINE, Stem Cells/cytology, Wnt Signaling Pathway, Cell Competition/genetics, Esterases/antagonists & inhibitors, Mutation, Multidisciplinary, biology, Stem Cells, Cell Transformation, Neoplastic/genetics, Wnt signaling pathway, Esterases, Cell Differentiation, Neoplastic/genetics, Cell biology, Organoids, POLYPOSIS, medicine.anatomical_structure, Cell Transformation, Neoplastic, 030220 oncology & carcinogenesis, Disease Progression, Organoids/cytology, Female, Stem cell, Colorectal Neoplasms, STEM-CELLS, BONE-FORMATION, Adenoma, Beta-catenin, Genes, APC, 3122 Cancers, Crypt, Adenomatous Polyposis Coli Protein, WNT, 03 medical and health sciences, Cancer stem cell, Wnt Proteins/metabolism, medicine, Animals, Humans, Adenomatous Polyposis Coli Protein/genetics, Cell Proliferation, Adenoma/genetics, Colorectal Neoplasms/genetics, Notum, Culture Media, APC, Wnt Proteins, Mice, Inbred C57BL, 030104 developmental biology, Genes, Cell Competition, Culture Media, Conditioned, biology.protein, 1182 Biochemistry, cell and molecular biology
وصف الملف: application/pdf
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المؤلفون: Viktor H. Koelzer, Mathilde Colombe, Alison Simmons, Douglas J. Winton, Lennard Y W Lee, James E. East, Eoghan J. Mulholland, H Davis, Matthias Friedrich, Oxford Ibd Cohort investigators, Simon J. Leedham, Nadia Nasreddin, Sujata Biswas, Koppens M, Lai Mun Wang, Agne Antanaviciute, Gabriel N. Valbuena
مصطلحات موضوعية: Stromal cell, Downregulation and upregulation, Chemistry, Regeneration (biology), Stem cell, Cell fate determination, Bone morphogenetic protein, Autocrine signalling, Reprogramming, Cell biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4c011c958343c160babb96fb54162220
https://doi.org/10.1101/2021.01.06.425570 -
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المؤلفون: Martijn A.J. Koppens, Hayley Davis, Gabriel N. Valbuena, Eoghan J. Mulholland, Nadia Nasreddin, Mathilde Colombe, Agne Antanaviciute, Sujata Biswas, Matthias Friedrich, Lennard Lee, Lai Mun Wang, Viktor H. Koelzer, James E. East, Alison Simmons, Douglas J. Winton, Simon J. Leedham
المصدر: Gastroenterology
مصطلحات موضوعية: Male, 0301 basic medicine, Colon, Bone Morphogenetic Protein 4, Cell fate determination, Biology, Bone morphogenetic protein, Article, 03 medical and health sciences, 0302 clinical medicine, Re-Epithelialization, Downregulation and upregulation, Intestine, Small, Animals, Humans, Regeneration, Intestinal Mucosa, Autocrine signalling, Cell Proliferation, Mice, Knockout, Hepatology, Regeneration (biology), Gastroenterology, Cell Differentiation, Epithelial Cells, Colitis, Cell biology, Mice, Inbred C57BL, Autocrine Communication, Radiation Injuries, Experimental, 030104 developmental biology, Intercellular Signaling Peptides and Proteins, Female, 030211 gastroenterology & hepatology, Stem cell, Signal transduction, Reprogramming, Signal Transduction
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المؤلفون: Ibrahim Al Bakir, Kane Smith, Morgan Moorghen, Maja Kopczynska, Manuel Rodriguez-Justo, Nadia Nasreddin, Ann-Marie Baker, Kit Curtius, Lai Mun Wang, Theo So Clarke, James E. East, Ailsa Hart, Marnix Jansen, Trevor A. Graham, Meghan Agnew
المصدر: Gastroenterology. 156:S-162
مصطلحات موضوعية: medicine.medical_specialty, Hepatology, Colorectal cancer, business.industry, Internal medicine, Gastroenterology, medicine, medicine.disease, business, Ulcerative colitis
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