يعرض 1 - 10 نتائج من 12 نتيجة بحث عن '"Nadine Michot"', وقت الاستعلام: 1.16s تنقيح النتائج
  1. 1
    Albumin binding Nanofitins, a new scaffold to extend half-life of biologics - a case study with exenatide peptide

    المؤلفون: Nadine Michot, Aurélia Guyochin, Mathieu Cinier, Chloé Savignard, Olivier Kitten, Marie-Hélène Pascual, Stéphanie Pouzieux, Marie-Laure Ozoux, Patrick Verdier, Pascale Vicat, Jacques Dumas

    المصدر: Peptides. 152

    مصطلحات موضوعية: Cellular and Molecular Neuroscience, Biological Products, Mice, Endocrinology, Physiology, Albumins, Animals, Exenatide, Peptides, Biochemistry, Half-Life

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a804de8b35f06e68686cdc1a4b5fec
    https://pubmed.ncbi.nlm.nih.gov/35150805

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  2. 2
    Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors

    المؤلفون: Benoit Pasquier, Youssef El-Ahmad, Bruno Filoche-Rommé, Christine Dureuil, Florence Fassy, Pierre-Yves Abecassis, Magali Mathieu, Thomas Bertrand, Tsiala Benard, Cédric Barrière, Samira El Batti, Jean-Philippe Letallec, Véronique Sonnefraud, Maurice Brollo, Laurence Delbarre, Véronique Loyau, Fabienne Pilorge, Luc Bertin, Patrick Richepin, Jérôme Arigon, Jean-Robert Labrosse, Jacques Clément, Florence Durand, Romain Combet, Pierre Perraut, Vincent Leroy, Frédéric Gay, Dominique Lefrançois, François Bretin, Jean-Pierre Marquette, Nadine Michot, Anne Caron, Christelle Castell, Laurent Schio, Gary McCort, Hélène Goulaouic, Carlos Garcia-Echeverria, Baptiste Ronan

    المصدر: Journal of Medicinal Chemistry. 58:376-400

    مصطلحات موضوعية: Male, Models, Molecular, Stereochemistry, Molecular Sequence Data, Antineoplastic Agents, Mice, SCID, Pyrimidinones, Plasma protein binding, Crystallography, X-Ray, Rats, Sprague-Dawley, chemistry.chemical_compound, In vivo, Cell Line, Tumor, Neoplasms, Morpholine, Drug Discovery, Animals, Humans, Transferase, Amino Acid Sequence, Enzyme Inhibitors, Trifluoromethyl, Molecular Structure, Sequence Homology, Amino Acid, Drug discovery, Kinase, fungi, Synthon, Bridged Bicyclo Compounds, Heterocyclic, Class III Phosphatidylinositol 3-Kinases, Xenograft Model Antitumor Assays, Protein Structure, Tertiary, Models, Chemical, chemistry, Area Under Curve, Thermodynamics, Molecular Medicine, Caco-2 Cells, HeLa Cells, Protein Binding

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f364d6dcf08b486db73cd403e73d3b1
    https://doi.org/10.1021/jm5013352

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  3. 3
    [P4–053]: TAU PATHOLOGY PROPAGATES THROUGH NEURAL NETWORKS IN TAU22 MICE AFTER INJECTION OF SYNTHETIC TRUNCATED TAU AGGREGATES IN DORSAL HIPPOCAMPUS

    المؤلفون: Pascal Chaillou, Mireille Meunier, Jean-Marie Miquet, Irène Mafhouz, Véronique Mary, Véronique Blanchard, Elisabeth Genet, Marie-Carmen Obinu, Agnès Hubert, Valérie Fauchey, Mati Lopez-Grancha, Nadine Michot, Stéphanie Eyquem

    المصدر: Alzheimer's & Dementia. 13

    مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Tau pathology, Dorsal hippocampus, Developmental Neuroscience, Artificial neural network, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology, Psychology, Neuroscience

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1cee6eced2a5563977c311e956677549
    https://doi.org/10.1016/j.jalz.2017.06.1918

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  4. 4
    Discovery and Optimization of Pyrimidone Indoline Amide PI3Kβ Inhibitors for the Treatment of Phosphatase and Tensin Homologue (PTEN)-Deficient Cancers

    المؤلفون: Jean Pierre Marquette, Andreas Karlsson, Sylvie Monget, Thomas Bertrand, Jean Christophe Carry, Frank Halley, Marc Antoine Perrin, Jean Paul Nicolas, Tsiala Benard, Angela Virone-Oddos, Luc Bertin, Céline Amara, Hélène Bonnevaux, Laurence Delbarre, Gilles Doerflinger, Pierre Yves Abecassis, Youssef El-Ahmad, Véronique Charrier, Victor Certal, Bruno Filoche-Romme, Florence Gruss-Leleu, Sébastien Perron, Alexey Rak, Patrick Richepin, Stephane Guerif, Carlos Garcia-Echeverria, Loic Vincent, Nadine Michot, Magali Mathieu, Véronique Loyau, Olivier Lemaitre, Maurice Brollo, Christoph Lengauer, Houlfa Guizani, Laurent Schio, Fabienne Thompson, Cécile Delorme

    المصدر: Journal of Medicinal Chemistry. 57:903-920

    مصطلحات موضوعية: Male, Cell Membrane Permeability, Indoles, Phosphatase, Molecular Conformation, Biological Availability, Antineoplastic Agents, Mice, SCID, Pyrimidinones, Crystallography, X-Ray, Mice, Rats, Nude, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, In vivo, Cell Line, Tumor, Neoplasms, Drug Discovery, Animals, Humans, PTEN, Tensin, Pyrimidone, Phosphoinositide-3 Kinase Inhibitors, Mice, Inbred BALB C, biology, PTEN Phosphohydrolase, Stereoisomerism, In vitro, Rats, Molecular Docking Simulation, Solubility, chemistry, Structural biology, Biochemistry, Indoline, Microsomes, Liver, biology.protein, Cancer research, Heterografts, Molecular Medicine, Female, Drug Screening Assays, Antitumor, Neoplasm Transplantation, Protein Binding

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c85553ea8c69d86eeaefddb3c7297b6
    https://doi.org/10.1021/jm401642q

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  5. 5
    Preparation and optimization of new 4-(morpholin-4-yl)-(6-oxo-1,6-dihydropyrimidin-2-yl)amide derivatives as PI3Kβ inhibitors

    المؤلفون: Cécile Delorme, Angela Virone-Oddos, Bernadette Tric, Audrey Louboutin, Fabienne Thompson, Christoph Lengauer, Loic Vincent, Nadine Michot, Isabelle Vade, Jean Paul Nicolas, Frank Halley, Youssef El-Ahmad, Bruno Filoche-Romme, Hélène Bonnevaux, Andreas Karlsson, Sylvie Monget, Renaud Morales, Victor Certal, Laurent Schio, Gilles Doerflinger, Sébastien Perron, Jean Christophe Carry, Pierre Yves Abecassis

    المصدر: Bioorganic & Medicinal Chemistry Letters. 22:6381-6384

    مصطلحات موضوعية: Male, Models, Molecular, Gene isoform, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Mice, SCID, Pyrimidinones, Crystallography, X-Ray, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Amide, Drug Discovery, Animals, Humans, Protein Isoforms, Anilides, Pyrimidone, Molecular Biology, Phosphoinositide-3 Kinase Inhibitors, Chemistry, Organic Chemistry, PTEN Phosphohydrolase, Prostate, Target engagement, Assay, Prostatic Neoplasms, In vitro, Bioavailability, Class Ia Phosphatidylinositol 3-Kinase, Prostate cancer cell line, Molecular Medicine, Female, Gene Deletion

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a7ad294cd6eed46f1ac36681f76724
    https://doi.org/10.1016/j.bmcl.2012.08.072

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  6. 6
    Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective PI3Kβ Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers

    المؤلفون: Jean Christophe Carry, Youssef El-Ahmad, Bruno Filoche-Romme, Frank Halley, Loic Vincent, Andreas Karlsson, Thomas Bertrand, Christoph Lengauer, Tsiala Benard, Pierre Yves Abecassis, Peter Below, Alexey Rak, Jean Paul Nicolas, Gilles Lebourg, Audrey Louboutin, Victor Certal, Laurent Schio, Cécile Delorme, Nadine Michot, Fabienne Pilorge, Fabienne Chatreaux, Pascale Lejeune, Fabienne Thompson, Angela Virone-Oddos, Isabelle Vade, Hélène Bonnevaux, Jean Pierre Marquette, Odile Angouillant-Boniface

    المصدر: Journal of Medicinal Chemistry. 55:4788-4805

    مصطلحات موضوعية: Models, Molecular, Gene isoform, Benzimidazole, Class I Phosphatidylinositol 3-Kinases, Antineoplastic Agents, Mice, SCID, Pyrimidinones, Pharmacology, Crystallography, X-Ray, medicine.disease_cause, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, PTEN, Tensin, Pyrimidone, Phosphorylation, PI3K/AKT/mTOR pathway, Benzoxazoles, Molecular Structure, biology, Kinase, Chemistry, Macrophages, PTEN Phosphohydrolase, Neoplasms, Experimental, Fibroblasts, Xenograft Model Antitumor Assays, Isoenzymes, biology.protein, Molecular Medicine, Benzimidazoles, Carcinogenesis, Proto-Oncogene Proteins c-akt, Protein Binding

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da44cb5e3b90d40fe34a0bb8a89c84d
    https://doi.org/10.1021/jm300241b

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  7. 7
    Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (PPAR) γ/δ Agonists with High Potency and in vivo Efficacy

    المؤلفون: Magali Mathieu, Stefanie Keil, Hans Matter, Wolfgang Wendler, Nadine Michot, Karl Schönafinger, Silke Haag-Diergarten, Matthias Urmann, Maike Glien, Jean-Pierre Marquette

    المصدر: ChemMedChem. 6:633-653

    مصطلحات موضوعية: Agonist, Stereochemistry, medicine.drug_class, Peroxisome proliferator-activated receptor, Pharmacology, Crystallography, X-Ray, Biochemistry, Partial agonist, Diabetes Mellitus, Experimental, Mice, Structure-Activity Relationship, In vivo, Thiadiazoles, Drug Discovery, medicine, Animals, PPAR delta, Sulfones, General Pharmacology, Toxicology and Pharmaceutics, Receptor, chemistry.chemical_classification, Binding Sites, Drug discovery, Chemistry, Organic Chemistry, PPAR gamma, Diabetes Mellitus, Type 2, Nuclear receptor, Molecular Medicine, Rosiglitazone, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f464493d9c6ed21e71a3f568c4a63a27
    https://doi.org/10.1002/cmdc.201100047

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  8. 8
    Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents

    المؤلفون: François Vallée, Mati Lopez-Grancha, Dominique Françon, Tatiana Tolstykh, Scott Brittain, Heike Arlt, Franck Augé, Michel Didier, Thibaud Leroy, Lionel Bert, Guy Griebel, Sandra Beeské, Fangxian Sun, Bailin Zhang, Nicolas Redon, Patrick Avenet, Vincent Mikol, Nadine Michot, Véronique Menet, Jacques Houtmann, Timothy He, Johanna Escoubet, Alexey Rak, Agnès Jacquet, Dmitri Wiederschain, Pascal George, Thomas Bertrand, Luc Even, Olivier Bergis, Philippe Pichat, Qunyan Yu

    المصدر: Scientific Reports
    'Scientific Reports ', vol: 5, pages: 7642-1-7642-16 (2015)

    مصطلحات موضوعية: Long-Term Potentiation, 2-Arachidonoylglycerol, Administration, Oral, Hippocampus, Mice, SCID, Pharmacology, Crystallography, X-Ray, Epileptogenesis, Mass Spectrometry, Mice, chemistry.chemical_compound, Piperidines, Enzyme Inhibitors, Chromatography, High Pressure Liquid, Analgesics, Sulfonamides, Multidisciplinary, Hydrolysis, Brain, Long-term potentiation, Endocannabinoid system, Memory, Short-Term, Rimonabant, medicine.symptom, Pain, Arachidonic Acids, In Vitro Techniques, Article, Glycerides, Seizures, medicine, Animals, Humans, Learning, Cannabinoid Receptor Antagonists, Binding Sites, Visceral pain, Acetylcholine, Electric Stimulation, Monoacylglycerol Lipases, Protein Structure, Tertiary, Mice, Inbred C57BL, Monoacylglycerol lipase, Disease Models, Animal, chemistry, Pyrazoles, Cannabinoid receptor antagonist, Carbamates, Endocannabinoids

    وصف الملف: application/pdf

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5a11c4d12b0bf96848fec09827b27a
    https://doi.org/10.1038/srep07642

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  9. 9
    PA700, the regulatory complex of the 26S proteasome, interferes with α-synuclein assembly

    المؤلفون: Ronald Melki, Jacques Mallet, Medeva Ghee, Nadine Michot

    المصدر: FEBS Journal. 272:4023-4033

    مصطلحات موضوعية: Alpha-synuclein, 0303 health sciences, animal diseases, Binding protein, Protein subunit, Cell Biology, Biology, Fibril, Biochemistry, nervous system diseases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Protein structure, nervous system, chemistry, Proteasome, mental disorders, Biophysics, Thioflavin, Protein folding, Molecular Biology, 030217 neurology & neurosurgery, 030304 developmental biology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::df1835e970447b85196a940cf0ec88ea
    https://doi.org/10.1111/j.1742-4658.2005.04776.x

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  10. 10
    PA700, the regulatory complex of the 26S proteasome, interferes with alpha-synuclein assembly

    المؤلفون: Medeva, Ghee, Ronald, Melki, Nadine, Michot, Jacques, Mallet

    المساهمون: Université Pierre et Marie Curie - Paris 6 (UPMC), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratoire d'Enzymologie et Biochimie Structurales (LEBS), Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

    المصدر: FEBS Journal
    FEBS Journal, 2005, 272 (16), pp.4023-33. ⟨10.1111/j.1742-4658.2005.04776.x⟩
    FEBS Journal, Wiley, 2005, 272 (16), pp.4023-33. ⟨10.1111/j.1742-4658.2005.04776.x⟩

    مصطلحات موضوعية: Proteasome Endopeptidase Complex, Protein Folding, animal diseases, [SDV]Life Sciences [q-bio], Synucleins, Nerve Tissue Proteins, Protein Structure, Secondary, Recombinant Proteins, nervous system diseases, Kinetics, Biopolymers, Microscopy, Electron, Transmission, nervous system, Spectroscopy, Fourier Transform Infrared, mental disorders, Chromatography, Gel, alpha-Synuclein, Electrophoresis, Polyacrylamide Gel

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8b6c1ebebf42b1d096c0c38695fd43b7
    https://hal.science/hal-01183842

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