المؤلفون: Xiao X; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA., Kennelly JP; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA., Ferrari A; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA., Clifford BL; Department of Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA, USA., Whang E; Pediatric Gastroenterology, Hepatology and Nutrition, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Gao Y; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA., Qian K; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA., Sandhu J; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA., Jarrett KE; Department of Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA, USA., Brearley-Sholto MC; Department of Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA, USA., Nguyen A; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Nagari RT; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA., Lee MS; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA., Zhang S; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA., Weston TA; Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Young SG; Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA., Bensinger SJ; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA., Villanueva CJ; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA., de Aguiar Vallim TQ; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA, USA.; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center (JCCC), University of California, Los Angeles, Los Angeles, CA, USA., Tontonoz P; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA. ptontonoz@mednet.ucla.edu.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA. ptontonoz@mednet.ucla.edu.

المصدر: Nature metabolism [Nat Metab] 2023 Jan; Vol. 5 (1), pp. 165-181. Date of Electronic Publication: 2023 Jan 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE

مواضيع طبية MeSH: Cholesterol*/metabolism , Liver*/metabolism, Biological Transport/physiology ; Homeostasis ; Fatty Acids/metabolism

المؤلفون: Priest C; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095., Nagari RT; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095., Bideyan L; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095., Lee SD; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095., Nguyen A; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.; Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095., Xiao X; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095., Tontonoz P; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.; Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 May 03; Vol. 119 (18), pp. e2201859119. Date of Electronic Publication: 2022 Apr 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Hippo Signaling Pathway* , Signal Transduction*, Hepatocytes/metabolism ; Liver/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism

المؤلفون: Corsello SM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Nagari RT; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Spangler RD; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rossen J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kocak M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bryan JG; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Duke University, Durham, NC, USA., Humeidi R; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Peck D; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wu X; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Tang AA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wang VM; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bender SA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lemire E; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Narayan R; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Montgomery P; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ben-David U; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel., Garvie CW; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chen Y; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rees MG; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lyons NJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA., McFarland JM; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wong BT; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wang L; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; 10x Genomics, Pleasanton, CA, USA., Dumont N; Broad Institute of MIT and Harvard, Cambridge, MA, USA., O'Hearn PJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Relay Therapeutics, Cambridge, MA, USA., Stefan E; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Biogen, Cambridge, MA, USA., Doench JG; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Harrington CN; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Greulich H; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Meyerson M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Vazquez F; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Subramanian A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Roth JA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bittker JA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Vertex Pharmaceuticals, Boston, MA, USA., Boehm JS; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mader CC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Flatiron Health, New York, NY, USA., Tsherniak A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Golub TR; Broad Institute of MIT and Harvard, Cambridge, MA, USA. golub@broadinstitute.org.; Harvard Medical School, Boston, MA, USA. golub@broadinstitute.org.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. golub@broadinstitute.org.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. golub@broadinstitute.org.

المصدر: Nature cancer [Nat Cancer] 2020 Feb; Vol. 1 (2), pp. 235-248. Date of Electronic Publication: 2020 Jan 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer

مواضيع طبية MeSH: Neoplasms*/drug therapy, Cell Line ; Disulfiram ; Drug Repositioning ; Humans

المؤلفون: Compton CL; Department of Chemistry, Brown University, Providence, Rhode Island, USA., Fernandopulle MS; Department of Chemistry, Brown University, Providence, Rhode Island, USA., Nagari RT; Department of Chemistry, Brown University, Providence, Rhode Island, USA., Sello JK; Department of Chemistry, Brown University, Providence, Rhode Island, USA jason_sello@brown.edu.

المصدر: Journal of bacteriology [J Bacteriol] 2015 Sep; Vol. 197 (17), pp. 2747-53. Date of Electronic Publication: 2015 Jun 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 2985120R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5530 (Electronic) Linking ISSN: 00219193 NLM ISO Abbreviation: J Bacteriol Subsets: MEDLINE

مواضيع طبية MeSH: Bacterial Proteins/*metabolism , Protein Processing, Post-Translational/*physiology , Streptomyces coelicolor/*physiology , Ubiquitins/*metabolism, Amino Acid Sequence ; Animals ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Gene Expression Regulation, Bacterial ; Molecular Sequence Data ; Mutation ; Proteomics ; Pupa/genetics ; Pupa/metabolism ; Streptomyces coelicolor/genetics ; Streptomyces coelicolor/metabolism ; Ubiquitins/chemistry ; Ubiquitins/genetics