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المؤلفون: Eng JW; Division of Gastroenterology and Hepatology, Department of Medicine, College of Medicine, University of Illinois Chicago, Chicago, Illinois.; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, Illinois., Kato Y; Eisai Co., Ltd, Tsukuba, Japan., Adachi Y; Eisai Co., Ltd, Tsukuba, Japan., Swaminathan B; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, Illinois., Naiche LA; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, Illinois., Vadakath R; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, Illinois., Sakamoto Y; KAN Research Institute, Inc., Kobe, Japan., Nakazawa Y; Eisai Co., Ltd, Tsukuba, Japan., Tachino S; Eisai Co., Ltd, Tsukuba, Japan., Ito K; Eisai Co., Ltd, Tsukuba, Japan., Abe T; Eisai Co., Ltd, Tsukuba, Japan., Minoshima Y; Eisai Co., Ltd, Tsukuba, Japan., Hoshino-Negishi K; KAN Research Institute, Inc., Kobe, Japan., Ogasawara H; KAN Research Institute, Inc., Kobe, Japan., Kawakatsu T; KAN Research Institute, Inc., Kobe, Japan., Nishimura M; KAN Research Institute, Inc., Kobe, Japan., Katayama M; Eisai Co., Ltd, Tsukuba, Japan., Shimizu M; Eisai Co., Ltd, Tsukuba, Japan., Tahara K; Eisai Co., Ltd, Tsukuba, Japan., Sato T; Eisai Co., Ltd, Tsukuba, Japan., Suzuki K; Eisai Co., Ltd, Tsukuba, Japan., Agarwala K; Eisai Co., Ltd, Tsukuba, Japan., Iwata M; Eisai Co., Ltd, Tsukuba, Japan., Nomoto K; Eisai Inc., Woodcliff, New Jersey., Ozawa Y; Eisai Co., Ltd, Tsukuba, Japan., Imai T; KAN Research Institute, Inc., Kobe, Japan., Funahashi Y; Eisai Co., Ltd, Tsukuba, Japan., Matsui J; Eisai Inc., Woodcliff, New Jersey., Kitajewski J; Department of Physiology and Biophysics, College of Medicine, University of Illinois Chicago, Chicago, Illinois.; University of Illinois Cancer Center, Chicago, Illinois.

المصدر: Cancer research communications [Cancer Res Commun] 2024 Jul 01; Vol. 4 (7), pp. 1881-1893.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9918281580506676 Publication Model: Print Cited Medium: Internet ISSN: 2767-9764 (Electronic) Linking ISSN: 27679764 NLM ISO Abbreviation: Cancer Res Commun Subsets: MEDLINE

مواضيع طبية MeSH: Receptor, Notch4*/metabolism , Neovascularization, Pathologic*/drug therapy , Neovascularization, Pathologic*/pathology , Neovascularization, Pathologic*/metabolism , Antibodies, Neutralizing*/pharmacology , Antibodies, Neutralizing*/therapeutic use, Animals ; Mice ; Humans ; Female ; Cell Line, Tumor ; Signal Transduction/drug effects ; Xenograft Model Antitumor Assays ; Disease Models, Animal ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Cell Proliferation/drug effects ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Breast Neoplasms/metabolism

المؤلفون: Raza Q; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 1853 W Polk St, Rm 522 (MC 901), Chicago, IL, 60612, USA., Nadeem T; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 1853 W Polk St, Rm 522 (MC 901), Chicago, IL, 60612, USA., Youn SW; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 1853 W Polk St, Rm 522 (MC 901), Chicago, IL, 60612, USA., Swaminathan B; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 1853 W Polk St, Rm 522 (MC 901), Chicago, IL, 60612, USA., Gupta A; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 1853 W Polk St, Rm 522 (MC 901), Chicago, IL, 60612, USA., Sargis T; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 1853 W Polk St, Rm 522 (MC 901), Chicago, IL, 60612, USA., Du J; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 1853 W Polk St, Rm 522 (MC 901), Chicago, IL, 60612, USA., Cuervo H; Centro Nacional de Investigaciones Cardiovasculares Carlos III- CNIC- (F.S.P), Madrid, Spain., Eichmann A; Yale School of Medicine, New Haven, CT, USA., Ackerman SL; University of San Diego, San Diego, CA, USA., Naiche LA; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 1853 W Polk St, Rm 522 (MC 901), Chicago, IL, 60612, USA. naiche@uic.edu., Kitajewski J; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 1853 W Polk St, Rm 522 (MC 901), Chicago, IL, 60612, USA.; University of Illinois Cancer Center, Chicago, USA.

المصدر: Scientific reports [Sci Rep] 2024 Jun 13; Vol. 14 (1), pp. 13603. Date of Electronic Publication: 2024 Jun 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Netrin Receptors*/metabolism , Receptors, Notch*/metabolism , Cell Proliferation* , Signal Transduction* , Cell Movement* , Endothelial Cells*/metabolism , Retina*/metabolism, Animals ; Mice ; Humans ; Retinal Vessels/metabolism ; Neovascularization, Physiologic

المؤلفون: Kleinjan ML; Department of Physiology and Biophysics (M.L.K., D.Y.M., L.A.N., A.G., J.J.J., D.D.S., J.K.), University of Illinois at Chicago., Mao Y; Department of Physiology and Biophysics (M.L.K., D.Y.M., L.A.N., A.G., J.J.J., D.D.S., J.K.), University of Illinois at Chicago., Naiche LA; Department of Physiology and Biophysics (M.L.K., D.Y.M., L.A.N., A.G., J.J.J., D.D.S., J.K.), University of Illinois at Chicago., Joshi JC; Department of Pharmacology (J.C.J., D.M.), University of Illinois at Chicago., Gupta A; Department of Physiology and Biophysics (M.L.K., D.Y.M., L.A.N., A.G., J.J.J., D.D.S., J.K.), University of Illinois at Chicago., Jesse JJ; Department of Physiology and Biophysics (M.L.K., D.Y.M., L.A.N., A.G., J.J.J., D.D.S., J.K.), University of Illinois at Chicago., Shaye DD; Department of Physiology and Biophysics (M.L.K., D.Y.M., L.A.N., A.G., J.J.J., D.D.S., J.K.), University of Illinois at Chicago., Mehta D; Department of Pharmacology (J.C.J., D.M.), University of Illinois at Chicago., Kitajewski J; Department of Physiology and Biophysics (M.L.K., D.Y.M., L.A.N., A.G., J.J.J., D.D.S., J.K.), University of Illinois at Chicago.; University of Illinois Cancer Center, Chicago (J.K.).

المصدر: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2023 Aug; Vol. 43 (8), pp. 1441-1454. Date of Electronic Publication: 2023 Jun 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505803 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4636 (Electronic) Linking ISSN: 10795642 NLM ISO Abbreviation: Arterioscler Thromb Vasc Biol Subsets: MEDLINE

مواضيع طبية MeSH: Receptor, PAR-1*/genetics , Receptor, PAR-1*/metabolism , rhoA GTP-Binding Protein*/metabolism, Humans ; Mice ; Animals ; Thrombin/pharmacology ; Thrombin/metabolism ; Endothelium/metabolism ; Human Umbilical Vein Endothelial Cells/metabolism ; Cells, Cultured ; Chloride Channels/genetics ; Chloride Channels/metabolism ; Mitochondrial Proteins/metabolism

المؤلفون: Sargis T; Department of Physiology and Biophysics, University of Illinois College of Medicine, Chicago, IL, 60612, USA., Youn SW; Department of Physiology and Biophysics, University of Illinois College of Medicine, Chicago, IL, 60612, USA., Thakkar K; Department of Physiology and Biophysics, University of Illinois College of Medicine, Chicago, IL, 60612, USA., Naiche LA; Department of Physiology and Biophysics, University of Illinois College of Medicine, Chicago, IL, 60612, USA., Paik NY; Department of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL, 60612, USA., Pajcini KV; Department of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL, 60612, USA.; University of Illinois Cancer Center, University of Illinois Chicago, Chicago, IL, 60612, USA., Kitajewski JK; Department of Physiology and Biophysics, University of Illinois College of Medicine, Chicago, IL, 60612, USA. kitaj@uic.edu.; University of Illinois Cancer Center, University of Illinois Chicago, Chicago, IL, 60612, USA. kitaj@uic.edu.

المصدر: Angiogenesis [Angiogenesis] 2023 May; Vol. 26 (2), pp. 249-263. Date of Electronic Publication: 2022 Nov 15.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 9814575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7209 (Electronic) Linking ISSN: 09696970 NLM ISO Abbreviation: Angiogenesis Subsets: MEDLINE

مواضيع طبية MeSH: Angiogenesis Inhibitors*/genetics , Angiogenesis Inhibitors*/metabolism , Angiogenesis Inhibitors*/pharmacology , Endothelial Cells*/drug effects , Endothelial Cells*/metabolism , Receptor, Notch1*/antagonists & inhibitors , Receptor, Notch1*/genetics , Receptor, Notch1*/metabolism , Receptor, Notch4*/genetics , Receptor, Notch4*/metabolism, Animals ; Mice ; Epidermal Growth Factor/metabolism ; Immunoprecipitation ; Inflammation/drug therapy ; Inflammation/genetics ; Inflammation/metabolism ; Ligands ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Retinal Vessels/drug effects ; Surface Plasmon Resonance

المؤلفون: Naiche LA; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, Illinois 60612, USA., Villa SR; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, Illinois 60612, USA., Kitajewski JK; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, Illinois 60612, USA.; University of Illinois Cancer Center, Chicago, Illinois 60612, USA.

المصدر: Cold Spring Harbor perspectives in medicine [Cold Spring Harb Perspect Med] 2022 Nov 01; Vol. 12 (11). Date of Electronic Publication: 2022 Nov 01.

نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 101571139 Publication Model: Electronic Cited Medium: Internet ISSN: 2157-1422 (Electronic) Linking ISSN: 21571422 NLM ISO Abbreviation: Cold Spring Harb Perspect Med Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Notch* , Endothelial Cells*, Humans ; Signal Transduction ; Cell Differentiation ; Morphogenesis ; Neovascularization, Physiologic

المؤلفون: Swaminathan B; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, 60612, USA., Youn SW; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, 60612, USA., Naiche LA; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, 60612, USA., Du J; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, 60612, USA., Villa SR; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, 60612, USA., Metz JB; Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, 10032, USA., Feng H; Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, 10032, USA., Zhang C; Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, 10032, USA., Kopan R; Division of Developmental Biology, Department of Pediatrics, University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Sims PA; Department of Systems Biology, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, 10032, USA., Kitajewski JK; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, 60612, USA. kitaj@uic.edu.

المصدر: Scientific reports [Sci Rep] 2022 Jan 31; Vol. 12 (1), pp. 1655. Date of Electronic Publication: 2022 Jan 31.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Cell Movement* , Neovascularization, Physiologic*, Brain/*blood supply , Endothelial Cells/*enzymology , Receptors, Notch/*metabolism , rho GTP-Binding Proteins/*metabolism, Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; Cell Proliferation ; Gene Expression Regulation, Enzymologic ; HEK293 Cells ; Human Umbilical Vein Endothelial Cells/enzymology ; Humans ; Mice, Inbred C57BL ; Mice, Transgenic ; Receptors, Notch/genetics ; Signal Transduction ; Time Factors ; Transcription, Genetic ; ras Proteins/genetics ; ras Proteins/metabolism ; rho GTP-Binding Proteins/genetics ; Mice

المؤلفون: Treffy RW; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA., Rajan SG; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA., Jiang X; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA., Nacke LM; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA., Malkana UA; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA., Naiche LA; Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA., Bergey DE; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA., Santana D; Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA., Rajagopalan V; Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA., Kitajewski JK; Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA., O'Bryan JP; Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA; Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA; Jesse Brown VA Medical Center, Chicago, IL 60612, USA; Ralph H. Johnson VA Medical Center, Charleston, SC 29401, USA., Saxena A; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA. Electronic address: saxenaa@uic.edu.

المصدر: Developmental cell [Dev Cell] 2021 Oct 11; Vol. 56 (19), pp. 2752-2764.e6. Date of Electronic Publication: 2021 Oct 04.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101120028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1551 (Electronic) Linking ISSN: 15345807 NLM ISO Abbreviation: Dev Cell Subsets: MEDLINE

مواضيع طبية MeSH: Cell Differentiation/*physiology , Neuroblastoma/*metabolism, Animals ; Brain-Derived Neurotrophic Factor/metabolism ; Cell Line, Tumor ; Cell Movement/physiology ; Female ; Humans ; Male ; Mice ; Neural Crest/metabolism ; Neurons/cytology ; Neurons/physiology ; Signal Transduction ; Transplantation, Heterologous/methods ; Tretinoin/metabolism ; Tretinoin/pharmacology ; Tumor Microenvironment ; Zebrafish/metabolism

المؤلفون: Price JC; Integrated Program in Cellular Molecular and Biomedical Studies, Columbia University, New York, NY, United States of America., Azizi E; Program for Computational and Systems Biology, Parker Institute for Cancer Immunotherapy, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, United States of America., Naiche LA; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, United States of America., Parvani JG; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, United States of America., Shukla P; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, United States of America., Kim S; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, United States of America., Slack-Davis JK; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, United States of America., Pe'er D; Program for Computational and Systems Biology, Parker Institute for Cancer Immunotherapy, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, United States of America., Kitajewski JK; Department of Physiology and Biophysics, University of Illinois Chicago, Chicago, IL, United States of America.

المصدر: PloS one [PLoS One] 2020 Jun 11; Vol. 15 (6), pp. e0233962. Date of Electronic Publication: 2020 Jun 11 (Print Publication: 2020).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Ovarian Epithelial/*secondary , Cystadenocarcinoma, Serous/*secondary , Ovarian Neoplasms/*pathology , Peritoneal Neoplasms/*secondary , Receptor, Notch3/*metabolism, Animals ; Carcinogenesis/metabolism ; Carcinoma, Ovarian Epithelial/metabolism ; Cell Adhesion ; Cell Line, Tumor ; Cystadenocarcinoma, Serous/metabolism ; Disease Progression ; Extracellular Matrix Proteins/metabolism ; Female ; Humans ; Mice ; Mice, Nude ; Ovarian Neoplasms/metabolism ; Peritoneal Neoplasms/metabolism ; Receptor, Notch3/genetics