المؤلفون: Craig P. Hersh, Andrew Lamb, James D. Crapo, Adel El Boueiz, P. Castaldi, Margaret M. Parker, Michael H. Cho, E.K. Silverman, Robert P. Chase, Sool Lee, Naing Zzc, Andrew B. Stergachis, Ruth Tal-Singer, D.L. DeMeo

مصطلحات موضوعية: Genetics, 0303 health sciences, Colocalization, Genomics, Genome-wide association study, Single-nucleotide polymorphism, Biology, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Expression quantitative trait loci, Gene, 030304 developmental biology, Epigenomics, Genetic association

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094be3984a436dceef9e6ddd1b767791
https://doi.org/10.1101/189100

المؤلفون: Polacco BJ; Quantitative Biosciences Institute (QBI), University of California, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA., Lobingier BT; Department of Chemical Physiology and Biochemistry, Oregon Health and Sciences University, Portland, OR, USA., Blythe EE; Quantitative Biosciences Institute (QBI), University of California, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA.; Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, USA., Abreu N; Department of Biochemistry, Weill Cornell Medicine, New York, NY, USA., Khare P; Quantitative Biosciences Institute (QBI), University of California, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA., Howard MK; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.; TETRAD Graduate Program, University of California San Francisco, San Francisco, CA, USA., Gonzalez-Hernandez AJ; Department of Biochemistry, Weill Cornell Medicine, New York, NY, USA., Xu J; Quantitative Biosciences Institute (QBI), University of California, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA., Li Q; Quantitative Biosciences Institute (QBI), University of California, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA., Novy B; Department of Chemical Physiology and Biochemistry, Oregon Health and Sciences University, Portland, OR, USA., Naing ZZC; Quantitative Biosciences Institute (QBI), University of California, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA., Shoichet BK; Quantitative Biosciences Institute (QBI), University of California, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA., Coyote-Maestas W; Quantitative Biosciences Institute (QBI), University of California, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA., Levitz J; Department of Biochemistry, Weill Cornell Medicine, New York, NY, USA., Krogan NJ; Quantitative Biosciences Institute (QBI), University of California, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA., Von Zastrow M; Quantitative Biosciences Institute (QBI), University of California, San Francisco, CA, USA. mark.vonzastrow@ucsf.edu.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA. mark.vonzastrow@ucsf.edu.; Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, USA. mark.vonzastrow@ucsf.edu., Hüttenhain R; Quantitative Biosciences Institute (QBI), University of California, San Francisco, CA, USA. ruthh@stanford.edu.; J. David Gladstone Institutes, San Francisco, CA, USA. ruthh@stanford.edu.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA. ruthh@stanford.edu.; Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA, USA. ruthh@stanford.edu.

المصدر: Nature chemical biology [Nat Chem Biol] 2024 Mar 25. Date of Electronic Publication: 2024 Mar 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

المؤلفون: Wang B, Vartak R, Zaltsman Y, Naing ZZC, Hennick KM, Polacco BJ, Bashir A, Eckhardt M, Bouhaddou M, Xu J, Sun N, Lasser MC, Zhou Y, McKetney J, Guiley KZ, Chan U, Kaye JA, Chadha N, Cakir M, Gordon M, Khare P, Drake S, Drury V, Burke DF, Gonzalez S, Alkhairy S, Thomas R, Lam S, Morris M, Bader E, Seyler M, Baum T, Krasnoff R, Wang S, Pham P, Arbalaez J, Pratt D, Chag S, Mahmood N, Rolland T, Bourgeron T, Finkbeiner S, Swaney DL, Bandyopadhay S, Ideker T, Beltrao P, Willsey HR, Obernier K, Nowakowski TJ, Hüttenhain R, State MW, Willsey AJ, Krogan NJ

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 08. Date of Electronic Publication: 2024 Feb 08.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Oskotsky T; Department of Pediatrics, UCSF, San Francisco, California, United States of America.; Bakar Computational Health Sciences Institute, UCSF, San Francisco, California, United States of America., Bajaj R; Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, California, United States of America., Burchard J; Cognitive Science and Computer Science Programs, UCLA, Los Angeles, California, United States of America., Cavazos T; Program in Biological and Medical Informatics, UCSF, San Francisco, California, United States of America., Chen I; Program in Biological and Medical Informatics, UCSF, San Francisco, California, United States of America., Connell WT; Department of Pharmaceutical Chemistry, UCSF, San Francisco, California, United States of America.; Institute for Neurodegenerative Diseases, UCSF, San Francisco, California, United States of America., Eaneff S; Bakar Computational Health Sciences Institute, UCSF, San Francisco, California, United States of America.; Berkeley Institute for Data Science, UC Berkeley, Berkeley, California, United States of America., Grant T; Program in Biological and Medical Informatics, UCSF, San Francisco, California, United States of America., Kanungo I; School of Medicine, UCSF, San Francisco, California, United States of America., Lindquist K; Department of Epidemiology & Biostatistics, UCSF, San Francisco, California, United States of America., Myers-Turnbull D; Department of Pharmaceutical Chemistry, UCSF, San Francisco, California, United States of America.; Quantitative Biosciences Consortium, UCSF, San Francisco, California, United States of America., Naing ZZC; Program in Biological and Medical Informatics, UCSF, San Francisco, California, United States of America.; QBI COVID-19 Research Group (QCRG), San Francisco, California, United States of America.; Quantitative Biosciences Institute (QBI), UCSF, San Francisco, California, United States of America.; J. David Gladstone Institutes, San Francisco, California, United States of America.; Department of Cellular and Molecular Pharmacology, UCSF, San Francisco, California, United States of America., Tang A; Bakar Computational Health Sciences Institute, UCSF, San Francisco, California, United States of America.; School of Medicine, UCSF, San Francisco, California, United States of America.; Department of Bioengineering, UC Berkeley, Berkeley, California, United States of America., Vora B; Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, California, United States of America., Wang J; School of Medicine, UCSF, San Francisco, California, United States of America., Karim I; Saint Francis High School, Mountain View, California, United States of America.; AI4ALL, Oakland, California, United States of America., Swadling C; AI4ALL, Oakland, California, United States of America.; Canton High School, Canton, Michigan, United States of America., Yang J; AI4ALL, Oakland, California, United States of America.; Department of Computer Science, Stanford University, Stanford, California, United States of America., Lindstaedt B; Office of Career and Professional Development, UCSF, San Francisco, California, United States of America.; Office for Postdoctoral Scholars, UCSF, San Francisco, California, United States of America., Sirota M; Department of Pediatrics, UCSF, San Francisco, California, United States of America.; Bakar Computational Health Sciences Institute, UCSF, San Francisco, California, United States of America.

مؤلفون مشاركون: AI4ALL Student Cohort 2020

المصدر: PLoS computational biology [PLoS Comput Biol] 2022 Jan 31; Vol. 18 (1), pp. e1009719. Date of Electronic Publication: 2022 Jan 31 (Print Publication: 2022).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7358 (Electronic) Linking ISSN: 1553734X NLM ISO Abbreviation: PLoS Comput Biol Subsets: MEDLINE

مواضيع طبية MeSH: Artificial Intelligence* , Biomedical Research*/education , Biomedical Research*/organization & administration , Computational Biology*/education , Computational Biology*/organization & administration , Cultural Diversity* , Mentoring*, Adolescent ; Female ; Humans ; Male ; Minority Groups ; Students

المؤلفون: Gordon DE; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Hiatt J; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA.; Medical Scientist Training Program, University of California, San Francisco, CA 94143, USA.; Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA., Bouhaddou M; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Rezelj VV; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724, Paris, cedex 15, France., Ulferts S; Institute for Clinical and Experimental Pharmacology and Toxicology I, University of Freiburg, 79104 Freiburg, Germany., Braberg H; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Jureka AS; Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA., Obernier K; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Guo JZ; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Batra J; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Kaake RM; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Weckstein AR; Aetion, Inc., New York, NY 10001, USA., Owens TW; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Gupta M; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Pourmal S; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Titus EW; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Cakir M; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Soucheray M; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., McGregor M; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Cakir Z; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Jang G; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., O'Meara MJ; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Tummino TA; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA., Zhang Z; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; Howard Hughes Medical Institute, San Francisco, CA 94158, USA., Foussard H; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Rojc A; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Zhou Y; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Kuchenov D; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Hüttenhain R; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Xu J; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Eckhardt M; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Swaney DL; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Fabius JM; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA., Ummadi M; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Tutuncuoglu B; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Rathore U; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Modak M; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Haas P; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Haas KM; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Naing ZZC; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Pulido EH; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Shi Y; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; Howard Hughes Medical Institute, San Francisco, CA 94158, USA., Barrio-Hernandez I; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Memon D; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Petsalaki E; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Dunham A; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Marrero MC; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Burke D; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Koh C; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724, Paris, cedex 15, France., Vallet T; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724, Paris, cedex 15, France., Silvas JA; Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA., Azumaya CM; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Billesbølle C; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Brilot AF; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Campbell MG; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Diallo A; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Dickinson MS; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Diwanji D; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Herrera N; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Hoppe N; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Kratochvil HT; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Liu Y; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Merz GE; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Moritz M; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Nguyen HC; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Nowotny C; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Puchades C; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Rizo AN; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Schulze-Gahmen U; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Smith AM; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Sun M; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Beam Therapeutics, Cambridge, MA 02139, USA., Young ID; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Zhao J; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Asarnow D; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Biel J; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Bowen A; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Braxton JR; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Chen J; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Chio CM; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Chio US; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Deshpande I; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Doan L; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Faust B; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Flores S; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Jin M; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Kim K; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Lam VL; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Li F; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Li J; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Li YL; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Li Y; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Liu X; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Lo M; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Lopez KE; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Melo AA; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Moss FR 3rd; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Nguyen P; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Paulino J; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Pawar KI; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Peters JK; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Pospiech TH Jr; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Safari M; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Sangwan S; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Schaefer K; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Thomas PV; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Thwin AC; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Trenker R; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Tse E; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Tsui TKM; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Wang F; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Whitis N; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Yu Z; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Zhang K; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Zhang Y; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Zhou F; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Saltzberg D; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA., Hodder AJ; Department of Biomedical Science, Centre for Membrane Interactions and Dynamics, University of Sheffield, Firth Court, Sheffield S10 2TN, UK., Shun-Shion AS; Department of Biomedical Science, Centre for Membrane Interactions and Dynamics, University of Sheffield, Firth Court, Sheffield S10 2TN, UK., Williams DM; Department of Biomedical Science, Centre for Membrane Interactions and Dynamics, University of Sheffield, Firth Court, Sheffield S10 2TN, UK., White KM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Rosales R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Kehrer T; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; 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David Gladstone Institutes, San Francisco, CA 94158, USA., Vallejo-Gracia A; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Fozouni P; J. David Gladstone Institutes, San Francisco, CA 94158, USA.; Medical Scientist Training Program, University of California, San Francisco, CA 94143, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA., Simoneau CR; J. David Gladstone Institutes, San Francisco, CA 94158, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA., Roth TL; Medical Scientist Training Program, University of California, San Francisco, CA 94143, USA.; Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA., Wu D; Medical Scientist Training Program, University of California, San Francisco, CA 94143, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA., Karim MA; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.; Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Ghoussaini M; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.; Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Dunham I; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.; Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Berardi F; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari 'ALDO MORO', Via Orabona, 4 70125, Bari, Italy., Weigang S; Institute of Virology, Medical Center-University of Freiburg, 79104 Freiburg, Germany., Chazal M; Département de Virologie, CNRS UMR 3569, Institut Pasteur, Paris 75015, France., Park J; Department of Medicine, University of California, San Diego, CA 92093, USA., Logue J; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA., McGrath M; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Weston S; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Haupt R; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Hastie CJ; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Elliott M; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Brown F; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Burness KA; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Reid E; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Dorward M; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Johnson C; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Wilkinson SG; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Geyer A; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Giesel DM; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Baillie C; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Raggett S; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Leech H; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Toth R; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Goodman N; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Keough KC; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Lind AL; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Klesh RJ; HealthVerity, Philadelphia, PA 19103, USA., Hemphill KR; Department of Neurology, University of California, San Francisco, CA 94143, USA., Carlson-Stevermer J; Synthego Corporation, Redwood City, CA 94063, USA., Oki J; Synthego Corporation, Redwood City, CA 94063, USA., Holden K; Synthego Corporation, Redwood City, CA 94063, USA., Maures T; Synthego Corporation, Redwood City, CA 94063, USA., Pollard KS; J. David Gladstone Institutes, San Francisco, CA 94158, USA.; Department of Epidemiology & Biostatistics, University of California, San Francisco, CA 94158, USA.; Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA., Sali A; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA., Agard DA; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA., Cheng Y; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Howard Hughes Medical Institute, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA., Fraser JS; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA., Frost A; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA., Jura N; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA., Kortemme T; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA.; The University of California, Berkeley-University of California, San Francisco Graduate Program in Bioengineering, University of California, San Francisco, CA 94158, USA., Manglik A; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA., Southworth DR; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA., Stroud RM; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA., Alessi DR; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Davies P; MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Frieman MB; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Ideker T; Department of Medicine, University of California, San Diego, CA 92093, USA.; Department to Bioengineering, University of California, San Diego, CA 92093, USA., Abate C; Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari 'ALDO MORO', Via Orabona, 4 70125, Bari, Italy., Jouvenet N; Institute of Virology, Medical Center-University of Freiburg, 79104 Freiburg, Germany.; Département de Virologie, CNRS UMR 3569, Institut Pasteur, Paris 75015, France., Kochs G; Institute of Virology, Medical Center-University of Freiburg, 79104 Freiburg, Germany., Shoichet B; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA., Ott M; J. David Gladstone Institutes, San Francisco, CA 94158, USA.; Department of Medicine, University of California, San Francisco, CA 94143, USA., Palmarini M; MRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, Scotland, UK., Shokat KM; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; Howard Hughes Medical Institute, San Francisco, CA 94158, USA., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Rassen JA; Aetion, Inc., New York, NY 10001, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu., Grosse R; Institute for Clinical and Experimental Pharmacology and Toxicology I, University of Freiburg, 79104 Freiburg, Germany. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.; Centre for Integrative Biological Signaling Studies (CIBSS), University of Freiburg, 79104 Freiburg, Germany., Rosenberg OS; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.; QBI, University of California, San Francisco, CA 94158, USA.; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.; Department of Medicine, University of California, San Francisco, CA 94143, USA., Verba KA; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.; QBI, University of California, San Francisco, CA 94158, USA.; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA., Basler CF; Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu., Vignuzzi M; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724, Paris, cedex 15, France. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu., Peden AA; Department of Biomedical Science, Centre for Membrane Interactions and Dynamics, University of Sheffield, Firth Court, Sheffield S10 2TN, UK. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu., Beltrao P; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu., Krogan NJ; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

مؤلفون مشاركون: QCRG Structural Biology Consortium, Zoonomia Consortium

المصدر: Science (New York, N.Y.) [Science] 2020 Dec 04; Vol. 370 (6521). Date of Electronic Publication: 2020 Oct 15.

نوع المنشور: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Host Microbial Interactions* , Protein Interaction Maps*, COVID-19/*metabolism , Coronavirus Nucleocapsid Proteins/*metabolism , Mitochondrial Membrane Transport Proteins/*metabolism , Severe acute respiratory syndrome-related coronavirus/*metabolism , SARS-CoV-2/*metabolism , Severe Acute Respiratory Syndrome/*metabolism, Conserved Sequence ; Coronavirus Nucleocapsid Proteins/genetics ; Cryoelectron Microscopy ; Humans ; Mitochondrial Membrane Transport Proteins/genetics ; Mitochondrial Precursor Protein Import Complex Proteins ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Protein Conformation

المؤلفون: Newberry RW; Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143, United States., Arhar T; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco, California 94143, United States., Costello J; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Hartoularos GC; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Maxwell AM; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco, California 94143, United States., Naing ZZC; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Pittman M; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Reddy NR; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Schwarz DMC; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco, California 94143, United States., Wassarman DR; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco, California 94143, United States., Wu TS; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco, California 94143, United States., Barrero D; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Caggiano C; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Catching A; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Cavazos TB; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Estes LS; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Faust B; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Fink EA; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Goldman MA; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Gomez YK; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Gordon MG; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Gunsalus LM; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Hoppe N; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Jaime-Garza M; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Johnson MC; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Jones MG; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Kung AF; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Lopez KE; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Lumpe J; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Martyn C; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., McCarthy EE; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Miller-Vedam LE; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Navarro EJ; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Palar A; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Pellegrino J; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Saylor W; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Stephens CA; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Strickland J; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Torosyan H; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Wankowicz SA; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Wong DR; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Wong G; Integrative Program in Quantitative Biology, University of California, San Francisco, California 94143, United States., Redding S; Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, United States., Chow ED; Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, United States., DeGrado WF; Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143, United States., Kampmann M; Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, United States.; Institute for Neurodegenerative Disease, University of California, San Francisco, California 94143, United States.; Chan Zuckerberg Biohub, San Francisco, California 94158, United States.

المصدر: ACS chemical biology [ACS Chem Biol] 2020 Aug 21; Vol. 15 (8), pp. 2137-2153. Date of Electronic Publication: 2020 Aug 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Saccharomyces cerevisiae/*drug effects , alpha-Synuclein/*toxicity, Amino Acid Sequence ; Humans ; Mutation ; Parkinson Disease/metabolism ; Protein Conformation ; Saccharomyces cerevisiae/metabolism ; alpha-Synuclein/chemistry ; alpha-Synuclein/genetics

المؤلفون: Gordon DE; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Jang GM; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Bouhaddou M; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Xu J; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Obernier K; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., White KM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., O'Meara MJ; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Rezelj VV; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, Paris, France., Guo JZ; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Swaney DL; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Tummino TA; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA., Hüttenhain R; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Kaake RM; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Richards AL; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. 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David Gladstone Institutes, San Francisco, CA, USA.; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Emerman M; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Jura N; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA., von Zastrow M; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA., Verdin E; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Buck Institute for Research on Aging, Novato, CA, USA., Ashworth A; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Schwartz O; Virus and Immunity Unit, Institut Pasteur, Paris, France., d'Enfert C; Direction Scientifique, Institut Pasteur, Paris, France., Mukherjee S; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; George William Hooper Foundation, Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA., Jacobson M; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA., Malik HS; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Fujimori DG; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA., Ideker T; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Division of Genetics, Department of Medicine, University of California San Diego, San Diego, CA, USA., Craik CS; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Floor SN; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Fraser JS; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA., Gross JD; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA., Sali A; 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Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Adolfo.Garcia-Sastre@mssm.edu.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Adolfo.Garcia-Sastre@mssm.edu.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Adolfo.Garcia-Sastre@mssm.edu.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Adolfo.Garcia-Sastre@mssm.edu., Shokat KM; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA. Kevan.Shokat@ucsf.edu.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA. Kevan.Shokat@ucsf.edu.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA. Kevan.Shokat@ucsf.edu.; Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA. Kevan.Shokat@ucsf.edu., Shoichet BK; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA. shoichet@cgl.ucsf.edu.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA. shoichet@cgl.ucsf.edu.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA. shoichet@cgl.ucsf.edu., Krogan NJ; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA. nevan.krogan@ucsf.edu.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA. nevan.krogan@ucsf.edu.; J. David Gladstone Institutes, San Francisco, CA, USA. nevan.krogan@ucsf.edu.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA. nevan.krogan@ucsf.edu.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. nevan.krogan@ucsf.edu.

المصدر: Nature [Nature] 2020 Jul; Vol. 583 (7816), pp. 459-468. Date of Electronic Publication: 2020 Apr 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Drug Repositioning* , Molecular Targeted Therapy* , Protein Interaction Maps*, Betacoronavirus/*drug effects , Coronavirus Infections/*drug therapy , Coronavirus Infections/*metabolism , Pneumonia, Viral/*drug therapy , Pneumonia, Viral/*metabolism , Viral Proteins/*metabolism, Animals ; Antiviral Agents/classification ; Antiviral Agents/pharmacology ; Betacoronavirus/genetics ; Betacoronavirus/metabolism ; Betacoronavirus/pathogenicity ; COVID-19 ; Chlorocebus aethiops ; Cloning, Molecular ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Drug Evaluation, Preclinical ; HEK293 Cells ; Host-Pathogen Interactions/drug effects ; Humans ; Immunity, Innate ; Mass Spectrometry ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; Protein Binding ; Protein Biosynthesis/drug effects ; Protein Domains ; Protein Interaction Mapping ; Receptors, sigma/metabolism ; SARS-CoV-2 ; SKP Cullin F-Box Protein Ligases/metabolism ; Vero Cells ; Viral Proteins/genetics ; COVID-19 Drug Treatment

المؤلفون: Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Naing ZZC, Zhou Y, Peng S, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Shen W, Shi Y, Zhang Z, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Ramachandran R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Lin Y, Wankowicz SA, Bohn M, Trenker R, Young JM, Cavero D, Hiatt J, Roth T, Rathore U, Subramanian A, Noack J, Hubert M, Roesch F, Vallet T, Meyer B, White KM, Miorin L, Agard D, Emerman M, Ruggero D, García-Sastre A, Jura N, von Zastrow M, Taunton J, Schwartz O, Vignuzzi M, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor S, Fraser JS, Gross J, Sali A, Kortemme T, Beltrao P, Shokat K, Shoichet BK, Krogan NJ

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2020 Mar 22. Date of Electronic Publication: 2020 Mar 22.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Boueiz A; 1 Channing Division of Network Medicine.; 2 Division of Pulmonary and Critical Care Medicine., Pham B; 1 Channing Division of Network Medicine., Chase R; 1 Channing Division of Network Medicine., Lamb A; 1 Channing Division of Network Medicine., Lee S; 1 Channing Division of Network Medicine., Naing ZZC; 1 Channing Division of Network Medicine., Cho MH; 1 Channing Division of Network Medicine.; 2 Division of Pulmonary and Critical Care Medicine., Parker MM; 1 Channing Division of Network Medicine., Sakornsakolpat P; 1 Channing Division of Network Medicine., Hersh CP; 1 Channing Division of Network Medicine.; 2 Division of Pulmonary and Critical Care Medicine., Crapo JD; 3 Pulmonary Medicine, National Jewish Health, Denver, Colorado; and., Stergachis AB; 4 Division of Genetics, and., Tal-Singer R; 5 GSK, King of Prussia, Pennsylvania., DeMeo DL; 1 Channing Division of Network Medicine.; 2 Division of Pulmonary and Critical Care Medicine., Silverman EK; 1 Channing Division of Network Medicine.; 2 Division of Pulmonary and Critical Care Medicine., Zhou X; 1 Channing Division of Network Medicine.; 2 Division of Pulmonary and Critical Care Medicine., Castaldi PJ; 1 Channing Division of Network Medicine.; 6 Division of General Medicine and Primary Care, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

مؤلفون مشاركون: COPDGene investigators, by Core Units:, ECLIPSE Investigators:, GenKOLS Investigators:

المصدر: American journal of respiratory cell and molecular biology [Am J Respir Cell Mol Biol] 2019 Apr; Vol. 60 (4), pp. 388-398.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Thoracic Society Country of Publication: United States NLM ID: 8917225 Publication Model: Print Cited Medium: Internet ISSN: 1535-4989 (Electronic) Linking ISSN: 10441549 NLM ISO Abbreviation: Am J Respir Cell Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Activin Receptors, Type I/*genetics , Genetic Predisposition to Disease/*genetics , Pulmonary Emphysema/*genetics , Transforming Growth Factor beta1/*metabolism, Cell Line, Tumor ; Genome-Wide Association Study ; Humans ; Jurkat Cells ; Lung/pathology ; Polymorphism, Single Nucleotide/genetics ; Proof of Concept Study ; Quantitative Trait Loci/genetics ; T-Lymphocyte Subsets/immunology

المؤلفون: Castaldi PJ; 1 Channing Division of Network Medicine and.; 2 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; and., Guo F; 1 Channing Division of Network Medicine and., Qiao D; 1 Channing Division of Network Medicine and., Du F; 1 Channing Division of Network Medicine and., Naing ZZC; 1 Channing Division of Network Medicine and., Li Y; 1 Channing Division of Network Medicine and., Pham B; 1 Channing Division of Network Medicine and., Mikkelsen TS; 3 Broad Institute, Cambridge, Massachusetts., Cho MH; 1 Channing Division of Network Medicine and.; 2 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; and., Silverman EK; 1 Channing Division of Network Medicine and.; 2 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; and., Zhou X; 1 Channing Division of Network Medicine and.; 2 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; and.

المصدر: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2019 Jan 01; Vol. 199 (1), pp. 52-61.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Thoracic Society Country of Publication: United States NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE

مواضيع طبية MeSH: GTPase-Activating Proteins/*genetics , Polymorphism, Single Nucleotide/*genetics , Pulmonary Disease, Chronic Obstructive/*genetics, CRISPR-Associated Protein 9 ; CRISPR-Cas Systems ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study ; High-Throughput Nucleotide Sequencing ; Humans ; Quantitative Trait Loci/genetics