-
1دورية أكاديمية
المؤلفون: Xiaohua Song, Ana Lopez-Campistrous, Lucy Sun, Nancy A Dower, Noemi Kedei, Jing Yang, Jessica S Kelsey, Nancy E Lewin, Tim E Esch, Peter M Blumberg, James C Stone
المصدر: PLoS ONE, Vol 8, Iss 8, p e72331 (2013)
وصف الملف: electronic resource
-
2
المؤلفون: Gary A. Mitchell, Jeewoo Lee, Nancy E. Lewin, Xiaoling Zhou, Amandeep S. Saini, Peter M. Blumberg, Agnes Czikora, Megan L. Peach, Jihyae Ann
المصدر: Journal of Medicinal Chemistry. 61:6261-6276
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Protein Kinase C-alpha, Guanine, Protein domain, Stimulation, Protein Kinase C-epsilon, Ligands, Substrate Specificity, Diglycerides, Lactones, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Protein Domains, Drug Discovery, Guanine Nucleotide Exchange Factors, Humans, Protein kinase C, Diacylglycerol kinase, HEK 293 cells, HEK293 Cells, 030104 developmental biology, Biochemistry, chemistry, Drug Design, 030220 oncology & carcinogenesis, Second messenger system, Molecular Medicine, Phosphorylation, ras Guanine Nucleotide Exchange Factors
-
3
المؤلفون: Gary A. Mitchell, Joydip Das, Satyabrata Pany, Adelle Abramovitz, Youngki You, Nancy E. Lewin, Amandeep S. Saini, Noemi Kedei, Agnes Czikora, Peter M. Blumberg
المصدر: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1860:1046-1056
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Biophysics, Chromosomal translocation, medicine.disease_cause, Biochemistry, Article, 03 medical and health sciences, chemistry.chemical_compound, Residue (chemistry), 0302 clinical medicine, Phorbol Esters, Tumor Cells, Cultured, medicine, Humans, Protein Interaction Domains and Motifs, Amino Acid Sequence, Diacylglycerol kinase, Mutation, Binding Sites, Chemistry, Cell Biology, Ligand (biochemistry), Cell biology, Molecular Docking Simulation, 030104 developmental biology, Membrane, Amino Acid Substitution, Protein Kinase C-theta, 030220 oncology & carcinogenesis, Second messenger system, Mutagenesis, Site-Directed, Phorbol, Mutant Proteins, Protein Binding
-
4
المؤلفون: Gary E. Keck, Aleksandra M. Michalowski, Xiguang Zhao, Noemi Kedei, Nancy E. Lewin, Peter M. Blumberg
المصدر: ChemBioChem. 19:1049-1059
مصطلحات موضوعية: Bryostatin 1, Stereochemistry, Substituent, 010402 general chemistry, Methylation, 01 natural sciences, Biochemistry, Article, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Animals, Humans, Potency, Bryostatin, Protein kinase A, Protein Kinase Inhibitors, Molecular Biology, Protein Kinase C, Protein kinase C, 010405 organic chemistry, Chemistry, Organic Chemistry, Biological activity, Bryostatins, 0104 chemical sciences, Drug Design, Molecular Medicine, Signal transduction
-
5
المؤلفون: Ryosuke Kobayashi, Agnes Czikora, Takuya Kobayakawa, Peter M. Blumberg, Nancy E. Lewin, Hirokazu Tamamura, Nami Ohashi, Brienna K. A. Herold, Wataru Nomura
المصدر: Bioconjugate Chemistry. 28:2135-2144
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Gene isoform, Stereochemistry, Protein domain, Biomedical Engineering, Pharmaceutical Science, Bioengineering, CHO Cells, Chemistry Techniques, Synthetic, Ligands, 010402 general chemistry, 01 natural sciences, Article, Diglycerides, Lactones, 03 medical and health sciences, Cricetulus, Protein Domains, Cricetinae, Animals, Protein kinase C, Diacylglycerol kinase, C1 domain, Pharmacology, Ligand, Chemistry, Organic Chemistry, 0104 chemical sciences, Transport protein, Protein Kinase C-delta, Protein Transport, 030104 developmental biology, Biochemistry, Second messenger system, lipids (amino acids, peptides, and proteins), Dimerization, Biotechnology
-
6
المؤلفون: Lucía Gandolfi Donadío, James A. Kelley, Xiaoling Zhou, Lia Cynthia Garcia, Christopher C. Lai, Megan L. Peach, Nancy E. Lewin, Maria Julieta Comin, Peter M. Blumberg, Eleonora Elhalem
المصدر: Bioorganic & Medicinal Chemistry. 25:2971-2980
مصطلحات موضوعية: 0301 basic medicine, Indoles, Protein Kinase C-alpha, Protein family, Stereochemistry, Guanine, Clinical Biochemistry, Pharmaceutical Science, Protein Kinase C-epsilon, Biochemistry, Article, Lactones, Structure-Activity Relationship, 03 medical and health sciences, Bryostatins, chemistry.chemical_compound, Protein Domains, indololactone, Drug Discovery, cancer, Guanine Nucleotide Exchange Factors, Humans, RasGRP, C1 domain, Molecular Biology, Protein kinase C, Diacylglycerol kinase, Indole test, Chemistry, Ligand, Otras Ciencias Químicas, Organic Chemistry, Ciencias Químicas, Small molecule, DNA-Binding Proteins, Molecular Docking Simulation, 030104 developmental biology, Molecular Medicine, CIENCIAS NATURALES Y EXACTAS, Protein Binding
وصف الملف: application/pdf
-
7
المؤلفون: Noemi Kedei, Ivan Volchkov, Michael J. Krische, Peter M. Blumberg, Nancy E. Lewin, John M. Ketcham, Te-Yu Chen
المصدر: Journal of the American Chemical Society. 138:13415-13423
مصطلحات موضوعية: Hydrogen, Stereochemistry, Diol, chemistry.chemical_element, Antineoplastic Agents, 010402 general chemistry, 01 natural sciences, Biochemistry, Article, Catalysis, chemistry.chemical_compound, Colloid and Surface Chemistry, Cell Line, Tumor, Humans, Potency, Chromans, Bryostatin, Cell Proliferation, Tumor Necrosis Factor-alpha, 010405 organic chemistry, Enantioselective synthesis, General Chemistry, Bryostatins, 0104 chemical sciences, Gene Expression Regulation, Neoplastic, chemistry, Phorbol, Chromane, Proto-Oncogene Proteins c-akt, Binding domain
-
8
المؤلفون: Elizabeth A. Craft, Derek C. Braun, Nancy E. Lewin, Agnes Czikora, Raymond C. Merritt, Noemi Kedei, Peter M. Blumberg, Adelle Abramovitz, Xiaoling Zhou, Daniel J. Lundberg, Megan L. Peach
المصدر: Journal of Biological Chemistry. 291:11133-11147
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Plasma protein binding, Molecular Dynamics Simulation, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Guanine Nucleotide Exchange Factors, Humans, Binding site, Molecular Biology, Phorbol 12,13-Dibutyrate, Protein kinase C, C1 domain, Diacylglycerol kinase, Binding Sites, 030102 biochemistry & molecular biology, Cell Biology, Molecular biology, Recombinant Proteins, Protein Structure, Tertiary, Molecular Docking Simulation, Kinetics, HEK293 Cells, 030104 developmental biology, Amino Acid Substitution, chemistry, Protein Structure and Folding, Phorbol, Mutant Proteins, Rap1, Guanine nucleotide exchange factor, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81d9da9843ecec84a349a7bdd8c37de
https://doi.org/10.1074/jbc.m116.725333 -
9
المؤلفون: Hobin Lee, Young Ho Kim, Timothy E. Esch, Kwang-Hyun Hur, Songyeon Ahn, Nancy E. Lewin, Jihyae Ann, Young Dong Yoo, Larry V. Pearce, Choon-Gon Jang, Jeewoo Lee, Peter M. Blumberg, Hee-Jin Ha, Ji-Young Hwang
المصدر: Eur J Med Chem
مصطلحات موضوعية: Male, Agonist, medicine.drug_class, Analgesic, TRPV1, Pain, TRPV Cation Channels, CHO Cells, Pharmacology, Ligands, 01 natural sciences, Article, Mice, Structure-Activity Relationship, 03 medical and health sciences, Cricetulus, Drug Discovery, medicine, Animals, Humans, Receptor, Cells, Cultured, 030304 developmental biology, Mice, Inbred ICR, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Antagonist, General Medicine, 0104 chemical sciences, Analgesics, Opioid, Opioid, Receptors, Opioid, μ-opioid receptor, Antagonism, medicine.drug
-
10
المؤلفون: Noemi Kedei, Youngki You, Gary A. Mitchell, Nancy E. Lewin, Peter M. Blumberg, Joydip Das, Satyabrata Pany, Jessica S. Kelsey
مصطلحات موضوعية: 0301 basic medicine, Scaffold protein, Models, Molecular, Protein Conformation, Protein domain, Nerve Tissue Proteins, Plasma protein binding, Molecular Dynamics Simulation, Ligands, Biochemistry, Article, 03 medical and health sciences, chemistry.chemical_compound, Mice, Neuroblastoma, Protein Domains, Cell Line, Tumor, Animals, Protein kinase C, Phorbol 12,13-Dibutyrate, Diacylglycerol kinase, C1 domain, Activator (genetics), Cell Membrane, Tryptophan, Phosphatidylserine, Recombinant Proteins, Rats, Protein Transport, 030104 developmental biology, chemistry, Amino Acid Substitution, Biophysics, Mutagenesis, Site-Directed, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9daa9f1c87929f753f733ea3b23c8f6d
https://europepmc.org/articles/PMC6008642/