المؤلفون: Leslie, J, Macia, MG, Luli, S, Worrell, JC, Reilly, WJ, Paish, HL, Knox, A, Barksby, BS, Gee, LM, Zaki, MYW, Collins, AL, Burgoyne, RA, Cameron, R, Bragg, C, Xu, X, Chung, GW, Brown, CDA, Blanchard, AD, Nanthakumar, CB, Karsdal, M, Robinson, SM, Manas, DM, Sen, G, French, J, White, SA, Murphy, S, Trost, M, Zakrzewski, JL, Klein, U, Schwabe, RF, Mederacke, I, Nixon, C, Bird, T, Teuwen, L-A, Schoonjans, L, Carmeliet, P, Mann, J, Fisher, AJ, Sheerin, NS, Borthwick, LA, Mann, DA, Oakley, F

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المؤلفون: Khan MM; European Molecular Biology Laboratory, Heidelberg, Germany.; Discovery Biology, Cellzome GmbH, GSK, Heidelberg, Germany.; Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany., Poeckel D; Discovery Biology, Cellzome GmbH, GSK, Heidelberg, Germany., Halavatyi A; European Molecular Biology Laboratory, Heidelberg, Germany.; Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany., Zukowska-Kasprzyk J; European Molecular Biology Laboratory, Heidelberg, Germany., Stein F; European Molecular Biology Laboratory, Heidelberg, Germany., Vappiani J; Discovery Biology, Cellzome GmbH, GSK, Heidelberg, Germany., Sevin DC; Discovery Biology, Cellzome GmbH, GSK, Heidelberg, Germany., Tischer C; European Molecular Biology Laboratory, Heidelberg, Germany., Zinn N; Discovery Biology, Cellzome GmbH, GSK, Heidelberg, Germany., Eley JD; Novel Human Genetics Research Unit, GSK, Stevenage, UK., Gudmann NS; Nordic Bioscience, Herlev, Denmark., Muley T; Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.; Biobank Thoraxklinik, University Hospital Heidelberg, Heidelberg, Germany., Winter H; Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.; Biobank Thoraxklinik, University Hospital Heidelberg, Heidelberg, Germany., Fisher AJ; Newcastle University Translational and Clinical Research Institute and Institute of Transplantation, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, UK., Nanthakumar CB; Novel Human Genetics Research Unit, GSK, Stevenage, UK., Bergamini G; Discovery Biology, Cellzome GmbH, GSK, Heidelberg, Germany.; G. Bergamini and R. Pepperkok contributed equally to this article as lead authors and supervised the work., Pepperkok R; European Molecular Biology Laboratory, Heidelberg, Germany pepperko@embl.de.; Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.; G. Bergamini and R. Pepperkok contributed equally to this article as lead authors and supervised the work.

المصدر: The European respiratory journal [Eur Respir J] 2021 Jul 01; Vol. 58 (1). Date of Electronic Publication: 2021 Jul 01 (Print Publication: 2021).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: European Respiratory Society Country of Publication: England NLM ID: 8803460 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1399-3003 (Electronic) Linking ISSN: 09031936 NLM ISO Abbreviation: Eur Respir J Subsets: MEDLINE

مواضيع طبية MeSH: Microscopy* , Pulmonary Fibrosis*/pathology, Fibrosis ; Humans ; Lung/pathology ; Proteomics ; Transforming Growth Factor beta1

المؤلفون: Leslie J; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. jack.leslie@newcastle.ac.uk., Macia MG; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Luli S; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Worrell JC; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Reilly WJ; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Paish HL; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Knox A; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Barksby BS; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Gee LM; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Zaki MYW; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Biochemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt., Collins AL; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Burgoyne RA; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Cameron R; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Bragg C; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Xu X; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Chung GW; Newcells Biotech, The Biosphere, Newcastle Helix, Newcastle upon Tyne, UK., Brown CDA; Newcells Biotech, The Biosphere, Newcastle Helix, Newcastle upon Tyne, UK., Blanchard AD; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Stevenage, UK., Nanthakumar CB; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Stevenage, UK., Karsdal M; Nordic Bioscience A/S, Biomarkers & Research, Herlev, Denmark., Robinson SM; Department of Hepatobiliary Surgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Manas DM; Department of Hepatobiliary Surgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Sen G; Department of Hepatobiliary Surgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., French J; Department of Hepatobiliary Surgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., White SA; Department of Hepatobiliary Surgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Murphy S; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Trost M; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Zakrzewski JL; Center for Discovery and Innovation and John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ, USA., Klein U; Division of Haematology & Immunology, Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK., Schwabe RF; Department of Medicine, Columbia University, New York, NY, USA., Mederacke I; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany., Nixon C; Cancer Research UK Beatson Institute, Garscube Estate, Glasgow, UK., Bird T; Cancer Research UK Beatson Institute, Garscube Estate, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK.; MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Teuwen LA; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, Leuven, Belgium., Schoonjans L; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, Leuven, Belgium., Carmeliet P; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, Leuven, Belgium., Mann J; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Fibrofind, Medical School, Newcastle University, Newcastle upon Tyne, UK., Fisher AJ; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Institute of Transplantation, The Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Sheerin NS; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Borthwick LA; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Fibrofind, Medical School, Newcastle University, Newcastle upon Tyne, UK., Mann DA; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Fibrofind, Medical School, Newcastle University, Newcastle upon Tyne, UK., Oakley F; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. fiona.oakley@newcastle.ac.uk.; Fibrofind, Medical School, Newcastle University, Newcastle upon Tyne, UK. fiona.oakley@newcastle.ac.uk.

المصدر: Nature metabolism [Nat Metab] 2020 Nov; Vol. 2 (11), pp. 1350-1367. Date of Electronic Publication: 2020 Nov 09.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE

مواضيع طبية MeSH: Epithelium/*pathology , Liver Cirrhosis/*genetics , Liver Cirrhosis/*pathology , Macrophages/*pathology , Proto-Oncogene Proteins c-rel/*genetics, Animals ; Cell Polarity/genetics ; Gene Targeting ; Hepatocytes/pathology ; Hydroxyproline/metabolism ; Liver Cirrhosis/prevention & control ; Liver Regeneration/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mitosis/genetics ; Paracrine Communication/genetics ; Phosphofructokinase-2/genetics ; Proto-Oncogene Proteins c-rel/antagonists & inhibitors ; Proto-Oncogene Proteins c-rel/metabolism

المؤلفون: Woodcock HV; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK., Eley JD; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK., Guillotin D; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK., Platé M; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK., Nanthakumar CB; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Martufi M; Target Sciences, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Peace S; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Joberty G; Cellzome, a GSK Company, Meyershofstrasse 1, 69117, Heidelberg, Germany., Poeckel D; Cellzome, a GSK Company, Meyershofstrasse 1, 69117, Heidelberg, Germany., Good RB; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Taylor AR; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Zinn N; Cellzome, a GSK Company, Meyershofstrasse 1, 69117, Heidelberg, Germany., Redding M; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK., Forty EJ; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK., Hynds RE; CRUK Lung Cancer Centre of Excellence, UCL Cancer Institute, University College London, London, WC1E 6DD, UK.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, NW1 1AT, UK., Swanton C; CRUK Lung Cancer Centre of Excellence, UCL Cancer Institute, University College London, London, WC1E 6DD, UK.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, NW1 1AT, UK., Karsdal M; Nordic Bioscience, Herlev, 2730, Denmark., Maher TM; Fibrosis Research Group, Inflammation, Repair & Development Section, NHLI, Imperial College, London, SW3 6LY, UK., Fisher A; Newcastle Fibrosis Research Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Bergamini G; Cellzome, a GSK Company, Meyershofstrasse 1, 69117, Heidelberg, Germany., Marshall RP; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Blanchard AD; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Mercer PF; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK., Chambers RC; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK. r.chambers@ucl.ac.uk.

المصدر: Nature communications [Nat Commun] 2020 Sep 11; Vol. 11 (1), pp. 4680. Date of Electronic Publication: 2020 Sep 11.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Rønnow SR; Nordic Bioscience A/S, Herlev, Herlev Hovedgade 205-207, DK-2730, Herlev, Denmark.; Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Dabbagh RQ; Nordic Bioscience A/S, Herlev, Herlev Hovedgade 205-207, DK-2730, Herlev, Denmark., Genovese F; Nordic Bioscience A/S, Herlev, Herlev Hovedgade 205-207, DK-2730, Herlev, Denmark., Nanthakumar CB; Department of Fibrosis DPU, Respiratory TA, GlaxoSmithKline, Stevenage, UK., Barrett VJ; Department of Fibrosis DPU, Respiratory TA, GlaxoSmithKline, Stevenage, UK., Good RB; Department of Fibrosis DPU, Respiratory TA, GlaxoSmithKline, Stevenage, UK., Brockbank S; Innovative Medicines Unit, Grünenthal Innovation, Aachen, Germany.; Present Address: Medicines Discovery Catapult, Alderley Edge, Cheshire, UK., Cruwys S; Innovative Medicines Unit, Grünenthal Innovation, Aachen, Germany.; Present Address: TherapeutAix AG, Aachen, Germany., Jessen H; Nordic Bioscience A/S, Herlev, Herlev Hovedgade 205-207, DK-2730, Herlev, Denmark., Sorensen GL; Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Karsdal MA; Nordic Bioscience A/S, Herlev, Herlev Hovedgade 205-207, DK-2730, Herlev, Denmark., Leeming DJ; Nordic Bioscience A/S, Herlev, Herlev Hovedgade 205-207, DK-2730, Herlev, Denmark., Sand JMB; Nordic Bioscience A/S, Herlev, Herlev Hovedgade 205-207, DK-2730, Herlev, Denmark. jsa@nordicbio.com.

المصدر: Respiratory research [Respir Res] 2020 May 07; Vol. 21 (1), pp. 108. Date of Electronic Publication: 2020 May 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101090633 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-993X (Electronic) Linking ISSN: 14659921 NLM ISO Abbreviation: Respir Res Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Inflammatory Agents, Non-Steroidal/*pharmacology , Cicatrix/*chemically induced , Cicatrix/*metabolism , Extracellular Matrix/*metabolism , Fibroblasts/*metabolism , Protein Kinase Inhibitors/*pharmacology, Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Biomarkers/metabolism ; Cells, Cultured ; Cicatrix/drug therapy ; Collagen/antagonists & inhibitors ; Collagen/metabolism ; Drug Evaluation, Preclinical/methods ; Extracellular Matrix/drug effects ; Fibroblasts/drug effects ; Fibronectins/antagonists & inhibitors ; Fibronectins/metabolism ; Fibrosis/chemically induced ; Fibrosis/drug therapy ; Fibrosis/metabolism ; Humans ; Indoles/antagonists & inhibitors ; Indoles/metabolism ; Protein Kinase Inhibitors/therapeutic use ; Pyridones/antagonists & inhibitors ; Pyridones/metabolism ; Transforming Growth Factor beta1/toxicity

المؤلفون: Organ LA; Division of Respiratory Medicine, University of Nottingham, Nottingham, UK., Duggan AR; Fibrosis Discovery Performance Unit, GlaxoSmithKline R&D, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Oballa E; Fibrosis Discovery Performance Unit, GlaxoSmithKline R&D, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Taggart SC; Fibrosis Discovery Performance Unit, GlaxoSmithKline R&D, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Simpson JK; Fibrosis Discovery Performance Unit, GlaxoSmithKline R&D, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Kang'ombe AR; Fibrosis Discovery Performance Unit, GlaxoSmithKline R&D, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Braybrooke R; Division of Respiratory Medicine, University of Nottingham, Nottingham, UK., Molyneaux PL; NIHR Respiratory Clinical Research Facility, Royal Brompton Hospital, London, UK.; National Heart and Lung Institute, Imperial College, Sir Alexander Fleming Building, London, SW7 2AZ, UK., North B; Fibrosis Discovery Performance Unit, GlaxoSmithKline R&D, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Karkera Y; Fibrosis Discovery Performance Unit, GlaxoSmithKline R&D, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Leeming DJ; Nordic Bioscience A/S, Biomarkers and Research, Herlev Hovedgade 205-207, DK-2730, Herlev, Denmark., Karsdal MA; Nordic Bioscience A/S, Biomarkers and Research, Herlev Hovedgade 205-207, DK-2730, Herlev, Denmark., Nanthakumar CB; Fibrosis Discovery Performance Unit, GlaxoSmithKline R&D, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Fahy WA; Fibrosis Discovery Performance Unit, GlaxoSmithKline R&D, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Marshall RP; Fibrosis Discovery Performance Unit, GlaxoSmithKline R&D, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Jenkins RG; Division of Respiratory Medicine, University of Nottingham, Nottingham, UK. gisli.jenkins@nottingham.ac.uk.; Respiratory Research Unit, Nottingham University Hospitals NHS Trust, Nottingham, NG5 1PB, United Kingdom. gisli.jenkins@nottingham.ac.uk., Maher TM; NIHR Respiratory Clinical Research Facility, Royal Brompton Hospital, London, UK. t.maher@rbht.nhs.uk.; National Heart and Lung Institute, Imperial College, Sir Alexander Fleming Building, London, SW7 2AZ, UK. t.maher@rbht.nhs.uk.

المصدر: Respiratory research [Respir Res] 2019 Jul 12; Vol. 20 (1), pp. 148. Date of Electronic Publication: 2019 Jul 12.

نوع المنشور: Journal Article; Multicenter Study; Observational Study; Pragmatic Clinical Trial

بيانات الدورية: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101090633 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-993X (Electronic) Linking ISSN: 14659921 NLM ISO Abbreviation: Respir Res Subsets: MEDLINE

مواضيع طبية MeSH: Disease Progression*, Collagen/*biosynthesis , Collagen/*blood , Idiopathic Pulmonary Fibrosis/*blood , Idiopathic Pulmonary Fibrosis/*diagnosis, Aged ; Aged, 80 and over ; Biomarkers/blood ; Cohort Studies ; Humans ; Longitudinal Studies ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; Protein Biosynthesis/physiology

المؤلفون: Good RB; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY UK., Eley JD; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY UK., Gower E; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY UK., Butt G; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY UK., Blanchard AD; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY UK., Fisher AJ; Institute of Transplantation, Newcastle upon Tyne Hospitals NHS Trust and Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle, UK., Nanthakumar CB; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY UK.

المصدر: BMC biomedical engineering [BMC Biomed Eng] 2019 Jun 28; Vol. 1, pp. 14. Date of Electronic Publication: 2019 Jun 28 (Print Publication: 2019).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BMC Country of Publication: England NLM ID: 101756092 Publication Model: eCollection Cited Medium: Internet ISSN: 2524-4426 (Electronic) Linking ISSN: 25244426 NLM ISO Abbreviation: BMC Biomed Eng Subsets: PubMed not MEDLINE

المؤلفون: Martufi M; 1 Target Sciences Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Stevenage, United Kingdom., Good RB; 2 Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Stevenage, United Kingdom., Rapiteanu R; 1 Target Sciences Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Stevenage, United Kingdom., Schmidt T; 1 Target Sciences Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Stevenage, United Kingdom., Patili E; 1 Target Sciences Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Stevenage, United Kingdom., Tvermosegaard K; 1 Target Sciences Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Stevenage, United Kingdom., New M; 1 Target Sciences Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Stevenage, United Kingdom., Nanthakumar CB; 2 Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Stevenage, United Kingdom., Betts J; 1 Target Sciences Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Stevenage, United Kingdom., Blanchard AD; 2 Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Stevenage, United Kingdom., Maratou K; 1 Target Sciences Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Stevenage, United Kingdom.

المصدر: The CRISPR journal [CRISPR J] 2019 Feb; Vol. 2, pp. 31-40.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101738191 Publication Model: Print Cited Medium: Internet ISSN: 2573-1602 (Electronic) Linking ISSN: 25731599 NLM ISO Abbreviation: CRISPR J Subsets: MEDLINE

مواضيع طبية MeSH: Gene Editing/*methods , Gene Knockout Techniques/*methods , Primary Cell Culture/*methods, CRISPR-Cas Systems/genetics ; Cell Culture Techniques/methods ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; Fibroblasts/metabolism ; Genetic Engineering/methods ; Genetic Vectors ; Humans ; Lung/pathology ; Smad Proteins/genetics ; Smad Proteins/metabolism

المؤلفون: Woodcock HV; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK., Eley JD; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK., Guillotin D; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK., Platé M; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK., Nanthakumar CB; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Martufi M; Target Sciences, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Peace S; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Joberty G; Cellzome, a GSK Company, Meyershofstrasse 1, 69117, Heidelberg, Germany., Poeckel D; Cellzome, a GSK Company, Meyershofstrasse 1, 69117, Heidelberg, Germany., Good RB; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Taylor AR; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Zinn N; Cellzome, a GSK Company, Meyershofstrasse 1, 69117, Heidelberg, Germany., Redding M; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK., Forty EJ; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK., Hynds RE; CRUK Lung Cancer Centre of Excellence, UCL Cancer Institute, University College London, London, WC1E 6DD, UK.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, NW1 1AT, UK., Swanton C; CRUK Lung Cancer Centre of Excellence, UCL Cancer Institute, University College London, London, WC1E 6DD, UK.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, NW1 1AT, UK., Karsdal M; Nordic Bioscience, Herlev, 2730, Denmark., Maher TM; Fibrosis Research Group, Inflammation, Repair & Development Section, NHLI, Imperial College, London, SW3 6LY, UK., Fisher A; Newcastle Fibrosis Research Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Bergamini G; Cellzome, a GSK Company, Meyershofstrasse 1, 69117, Heidelberg, Germany., Marshall RP; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Blanchard AD; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Mercer PF; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK., Chambers RC; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK. r.chambers@ucl.ac.uk.

المصدر: Nature communications [Nat Commun] 2019 Jan 02; Vol. 10 (1), pp. 6. Date of Electronic Publication: 2019 Jan 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Adaptor Proteins, Signal Transducing/*metabolism , Collagen/*biosynthesis , Fibroblasts/*metabolism , Mechanistic Target of Rapamycin Complex 1/*metabolism , Phosphoproteins/*metabolism , Transforming Growth Factor beta1/*metabolism, Cell Cycle Proteins ; Cell Line ; Humans ; Idiopathic Pulmonary Fibrosis/etiology ; Phosphatidylinositol 3-Kinases/metabolism ; Signal Transduction ; Sirolimus ; TOR Serine-Threonine Kinases/metabolism