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1دورية أكاديمية
المؤلفون: Naoki Kanegawa, Yasushi Kiyono, Taku Sugitaa, Yuji Kuge, Yasushisa Fujibayasi, Hideo Saji
المصدر: Molecular Imaging, Vol 11 (2012)
مصطلحات موضوعية: Biology (General), QH301-705.5, Medical technology, R855-855.5
وصف الملف: electronic resource
Relation: https://doaj.org/toc/1536-0121
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2
المؤلفون: Takuya Oguma, Shota Uehara, Kenji Nakahara, Yuya Okuyama, Kouki Fuchino, Naoyuki Suzuki, Yukiko Kan, Naoki Kanegawa, Yuki Ogata, Ken-ichi Kusakabe
المصدر: ACS Medicinal Chemistry Letters. 14:223-228
مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry
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3
المؤلفون: Naoya Asada, Tatsuhiko Ueno, Shiho Yamamoto, Ken-ichi Kusakabe, Diederik Moechars, Naoki Kanegawa, Harrie J.M. Gijsen, Frederik J. R. Rombouts, Mana Ito, Eriko Matsuoka, Hisanori Ito
المصدر: Journal of Medicinal Chemistry. 64:14165-14174
مصطلحات موضوعية: chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Amyloid, biology, Pyridines, Chemistry, Cocrystal, Loop (topology), Structure-Activity Relationship, chemistry.chemical_compound, Enzyme, In vivo, mental disorders, Drug Discovery, Pyridine, Amyloid precursor protein, biology.protein, Biophysics, Aspartic Acid Endopeptidases, Humans, Molecular Medicine, Amyloid Precursor Protein Secretases, Enzyme Inhibitors, Selectivity
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4
المؤلفون: Yasuyoshi Iso, Shigeru Ando, Harrie J.M. Gijsen, Yasuto Kido, Shinji Suzuki, Herman Borghys, Kenji Morimoto, Vijay Urmaliya, Deborah Dhuyvetter, Takahiko Yamamoto, Ard Teisman, Gaku Sakaguchi, Naoki Kanegawa, Nigel Austin, Eriko Matsuoka, An Van Den Bergh, Hisanori Ito, Takuya Oguma, Francois Paul Bischoff, Tamio Fukushima, Peter Verboven, Tomoyuki Kawachi, Kenji Nakahara, Yoshinori Yamano, Kosuke Anan, Ken-ichi Kusakabe
المصدر: ChemMedChem. 14:1894-1910
مصطلحات موضوعية: Male, Models, Molecular, hERG, Thiazines, Pharmacology, 01 natural sciences, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Oral administration, Oxazines, Drug Discovery, Hydrolase, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Humans, General Pharmacology, Toxicology and Pharmaceutics, Mice, Knockout, chemistry.chemical_classification, Mice, Inbred ICR, Amyloid beta-Peptides, Trifluoromethyl, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Rats, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Enzyme, Drug Design, Hepatocytes, Microsomes, Liver, biology.protein, Microsome, Molecular Medicine, Efflux, Amyloid Precursor Protein Secretases
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5
المؤلفون: Kazuki Fujimoto, Shigeru Ando, Yutaka Tonomura, Shuhei Yoshida, Harrie J.M. Gijsen, Shiho Yamamoto, Diederik Moechars, Naoki Kanegawa, Frederik J. R. Rombouts, Hisanori Ito, Kouki Fuchino, Shinji Suzuki, Takahiko Yamamoto, Eriko Matsuoka, Genta Tadano, Naoya Asada, Ken-ichi Kusakabe
المصدر: Journal of medicinal chemistry. 64(6)
مصطلحات موضوعية: Propynyl, 01 natural sciences, Cocrystal, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Alzheimer Disease, Drug Discovery, Oxazines, Molecule, Aspartic Acid Endopeptidases, Humans, Enzyme Inhibitors, 030304 developmental biology, 0303 health sciences, Chemistry, Water, Combinatorial chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Drug Design, β secretase, Molecular Medicine, Verubecestat, Structure based, Amyloid Precursor Protein Secretases, Selectivity, High homology
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6
المؤلفون: Igor Yakushev, Ryosuke Arakawa, Naoki Kanegawa, Lars Farde, Kai Chun Yang, Akihiro Takano, Junya Matsumoto
المصدر: Molecular Imaging and Biology. 20:183-187
مصطلحات موضوعية: Raclopride, Cancer Research, medicine.diagnostic_test, business.industry, Kinetics, Binding potential, Striatum, Sevoflurane, ddc, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Oncology, Positron emission tomography, Anesthesia, Anesthetic, medicine, Radioligand, Radiology, Nuclear Medicine and imaging, Nuclear medicine, business, 030217 neurology & neurosurgery, medicine.drug
وصف الملف: application/pdf
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7دورية أكاديمية
المؤلفون: Tatsuhiko Ueno, Eriko Matsuoka, Naoya Asada, Shiho Yamamoto, Naoki Kanegawa, Mana Ito, Hisanori Ito, Diederik Moechars, Rombouts, Frederik J. R., Gijsen, Harrie J. M., Ken-ichi Kusakabe
المصدر: Journal of Medicinal Chemistry; 10/14/2021, Vol. 64 Issue 19, p14165-14174, 10p
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8
المؤلفون: Yasuyoshi Iso, Naoki Kanegawa, Vijay Urmaliya, Kazuki Fujimoto, Kazuo Komano, Ard Teisman, An Van Den Bergh, Herman Borghys, Hisanori Ito, Shuhei Yoshida, Shigeru Ando, Yasuto Kido, Nigel E. Austin, Naoya Asada, Shinji Suzuki, Kenji Nakahara, Ken-ichi Kusakabe, Eriko Matsuoka, Harrie J.M. Gijsen, Gaku Sakaguchi, Genta Tadano, Yoshinori Yamano, Tamio Fukushima, Takahiko Yamamoto, Deborah Dhuyvetter, Kouki Fuchino
المصدر: Journal of medicinal chemistry. 62(20)
مصطلحات موضوعية: Male, Liver toxicity, Drug Evaluation, Preclinical, Thiazines, Pharmacology, 01 natural sciences, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Mice, Dogs, In vivo, Thiazine, Alzheimer Disease, mental disorders, Drug Discovery, Amyloid precursor protein, Animals, Humans, Protease Inhibitors, Volume concentration, 030304 developmental biology, Cytochrome P-450 CYP2C9, 0303 health sciences, Amyloid beta-Peptides, biology, Half-life, Brain, Heart, Haplorhini, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, chemistry, Liver, biology.protein, β secretase, Molecular Medicine, Trough level, Female, Amyloid Precursor Protein Secretases, Half-Life
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9
المؤلفون: Kenji Nakahara, Harrie J.M. Gijsen, Naoki Kanegawa, Genta Tadano, Naoya Asada, Hisanori Ito, Takahiko Yamamoto, Diederik Moechars, Ken-ichi Kusakabe, Eriko Matsuoka, Kouki Fuchino, Kazuki Fujimoto
المصدر: Journal of medicinal chemistry. 62(10)
مصطلحات موضوعية: Male, Models, Molecular, Melanocyte, 01 natural sciences, Substrate Specificity, Melanin, 03 medical and health sciences, Amyloid beta-Protein Precursor, Mice, Structure-Activity Relationship, Alzheimer Disease, Microsomes, mental disorders, Hydrolase, Drug Discovery, Amyloid precursor protein, medicine, Structure–activity relationship, Animals, Aspartic Acid Endopeptidases, Humans, Biotransformation, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Mice, Inbred ICR, biology, Drug discovery, 0104 chemical sciences, Cell biology, PMEL, 010404 medicinal & biomolecular chemistry, Enzyme, medicine.anatomical_structure, Neuroprotective Agents, chemistry, Drug Design, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases
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10
المؤلفون: Caroline Olgart Höglund, Naoki Kanegawa, Ryosuke Arakawa, Eva Kosek, Andrea Varrone, Anton Forsberg, K. Collste, Aurelija Jucaite, Christer Halldin, Lars Farde, Simon Cervenka, Martin Schain, Jon Lampa, Mats Lekander
المصدر: Brain, Behavior, and Immunity. 54:149-157
مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Immunology, Central nervous system, Blood–brain barrier, Cohort Studies, Leukocyte Count, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, Immune system, Receptors, GABA, In vivo, Internal medicine, medicine, Translocator protein, Radioligand, Humans, Carbon Radioisotopes, Microglia, biology, Endocrine and Autonomic Systems, Age Factors, Brain, Middle Aged, In vitro, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Blood-Brain Barrier, Positron-Emission Tomography, biology.protein, Female, Radiopharmaceuticals, Biomarkers, 030217 neurology & neurosurgery, Protein Binding