المؤلفون: Ko Fujimori, Yusuke Iguchi, Yukiko Yamashita, Keigo Gohda, Naoki Teno

المصدر: Molecules, Vol 24, Iss 22, p 4155 (2019)

مصطلحات موضوعية: mesenchymal stem cells, fxr, agonist, osteoblast, bone, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/24/22/4155; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/61ac62be565e4b98b0703e5e1d8f2c69

المؤلفون: Yukiko Yamashita, Keigo Gohda, Yusuke Iguchi, Ko Fujimori, Keisuke Oda, Arisa Masuda, Mizuho Une, Naoki Teno

المصدر: Bioorganic & Medicinal Chemistry. 85:117238

مصطلحات موضوعية: Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d66c0cd0371d4982622092e72cfab0dd
https://doi.org/10.1016/j.bmc.2023.117238

المؤلفون: Takie Hiramoto, Tomoko Nishimaki-Mogami, Ko Fujimori, Yukiko Yamashita, Yusuke Iguchi, Keigo Gohda, Keisuke Oda, Arisa Masuda, Mizuho Une, Naoki Teno

المصدر: Bioorganic & Medicinal Chemistry. 27:2220-2227

مصطلحات موضوعية: Male, Clinical Biochemistry, Administration, Oral, Receptors, Cytoplasmic and Nuclear, Pharmaceutical Science, Ileum, Pharmacology, 01 natural sciences, Biochemistry, Rats, Sprague-Dawley, Structure-Activity Relationship, In vivo, Drug Discovery, Nonalcoholic fatty liver disease, medicine, Animals, Hypoglycemic Agents, Structure–activity relationship, Distribution (pharmacology), Molecular Biology, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Antagonist, medicine.disease, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, Liver, Molecular Medicine, Administration, Intravenous, Benzimidazoles, Farnesoid X receptor, Anti-Obesity Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b73b79c845ae66f62b7c603b48dde83
https://doi.org/10.1016/j.bmc.2019.04.029

المؤلفون: Arisa Masuda, Keigo Gohda, Naoki Teno, Yusuke Iguchi, Yukiko Yamashita, Keisuke Oda, Ko Fujimori, Mizuho Une

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: Nonsteroidal, 010405 organic chemistry, Chemistry, Drug discovery, Organic Chemistry, Antagonist, Ileum, Pharmacology, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Orally active, medicine.anatomical_structure, Drug Discovery, medicine, Distribution (pharmacology), Farnesoid X receptor, Mouse Ileum

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8ee33a6a092cadc2b8498bfe2e3759
https://pubmed.ncbi.nlm.nih.gov/33738070

المؤلفون: Yusuke Iguchi, Naoki Teno, Yukiko Yamashita, Ko Fujimori, Arisa Masuda, Keigo Gohda

المصدر: Bioorganicmedicinal chemistry letters. 41

مصطلحات موضوعية: Nonalcoholic steatohepatitis, Clinical Biochemistry, Pharmaceutical Science, Receptors, Cytoplasmic and Nuclear, Molecular Dynamics Simulation, Chenodeoxycholic Acid, Ligands, 01 natural sciences, Biochemistry, Partial agonist, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Humans, Molecular Biology, Binding Sites, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Ligand binding domain, Ligand (biochemistry), 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Drug Design, Helix, Biophysics, Blood cholesterol, Molecular Medicine, Farnesoid X receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365dc4070fe40d506af59352921352d2
https://pubmed.ncbi.nlm.nih.gov/33839252

المؤلفون: Arisa, Masuda, Keigo, Gohda, Yusuke, Iguchi, Ko, Fujimori, Yukiko, Yamashita, Keisuke, Oda, Mizuho, Une, Naoki, Teno

المصدر: Bioorganicmedicinal chemistry. 28(14)

مصطلحات موضوعية: Structure-Activity Relationship, Dose-Response Relationship, Drug, Molecular Structure, Humans, Receptors, Calcitriol, Receptors, Cytoplasmic and Nuclear, Benzimidazoles

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::e461dbe31fbdf873e0e30d85456dc966
https://pubmed.ncbi.nlm.nih.gov/32616182

المؤلفون: Naoki Teno, Ko Fujimori, Keigo Gohda, Yukiko Yamashita, Yusuke Iguchi

المصدر: Molecules, Vol 24, Iss 22, p 4155 (2019)
Molecules
Volume 24
Issue 22

مصطلحات موضوعية: Models, Molecular, Agonist, Cell Survival, medicine.drug_class, Fluoroimmunoassay, Receptors, Cytoplasmic and Nuclear, Pharmaceutical Science, Chemistry Techniques, Synthetic, bone, Article, Analytical Chemistry, lcsh:QD241-441, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, fxr, lcsh:Organic chemistry, Genes, Reporter, Chenodeoxycholic acid, Drug Discovery, medicine, Animals, Humans, Physical and Theoretical Chemistry, agonist, 030304 developmental biology, 0303 health sciences, mesenchymal stem cells, Osteoblasts, Organic Chemistry, Mesenchymal stem cell, Cell Differentiation, Osteoblast, Isoxazoles, G protein-coupled bile acid receptor, Cell biology, RUNX2, medicine.anatomical_structure, chemistry, Chemistry (miscellaneous), 030220 oncology & carcinogenesis, osteoblast, Molecular Medicine, Farnesoid X receptor, Bone marrow

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1e813af35d7366b615bf5ce724c8ac
https://www.mdpi.com/1420-3049/24/22/4155

المؤلفون: Keigo Gohda, Ko Fujimori, Yukiko Yamashita, Takie Hiramoto, Naoki Teno, Tomoko Nishimaki-Mogami, Yusuke Iguchi, Mizuho Une

المصدر: ACS Medicinal Chemistry Letters. 9:78-83

مصطلحات موضوعية: 0301 basic medicine, Transcriptional activity, Chemotype, Chemistry, Stereochemistry, Organic Chemistry, Antagonist, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, In vivo, 030220 oncology & carcinogenesis, Drug Discovery, Moiety, Farnesoid X receptor, Piperidine, Cholesterol metabolism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::46d871532d23f5739c5ff3bb81a92411
https://doi.org/10.1021/acsmedchemlett.7b00363

المؤلفون: Keigo Gohda, Nobuhiro Mori, Naoki Teno, Yusuke Iguchi, Tomoko Nishimaki-Mogami, Mizuho Une, Yukiko Yamashita

المصدر: Bioorganic & Medicinal Chemistry. 25:1787-1794

مصطلحات موضوعية: 0301 basic medicine, Benzimidazole, Stereochemistry, Proton Magnetic Resonance Spectroscopy, Clinical Biochemistry, Receptors, Cytoplasmic and Nuclear, Pharmaceutical Science, 01 natural sciences, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Fluorescence Resonance Energy Transfer, Humans, RNA, Messenger, Cholesterol 7-alpha-Hydroxylase, Molecular Biology, Nonsteroidal, Increased cholesterol, Chemotype, Organic Chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, chemistry, Small heterodimer partner, Molecular Medicine, Benzimidazoles, Farnesoid X receptor, Antagonism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c431e24ac722b3287454c58fe27fd3ca
https://doi.org/10.1016/j.bmc.2017.01.040

المؤلفون: Naoki Teno, Yukiko Yamashita, Mizuho Une, Keigo Gohda, Yusuke Iguchi, Keisuke Oda, Arisa Masuda, Ko Fujimori

المصدر: Bioorganic & Medicinal Chemistry. 28:115512

مصطلحات موضوعية: Agonist, Bile acid, 010405 organic chemistry, medicine.drug_class, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Osteoblast, 01 natural sciences, Biochemistry, G protein-coupled bile acid receptor, Calcitriol receptor, 0104 chemical sciences, Cell biology, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, Nuclear receptor, Drug Discovery, medicine, Molecular Medicine, Glucose homeostasis, Farnesoid X receptor, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3be6d9eb6adb62ec73a69a98557a6eca
https://doi.org/10.1016/j.bmc.2020.115512