المؤلفون: Ian P. Street, Benjamin Cleary, Jonathan B. Baell, Jessica M. Strasser, Daniel L. Priebbenow, Hendrik Falk, Michael W. Parker, Susan A. Charman, H. Rachel Lagiakos, Brendon J. Monahan, Michael A. Walters, M.C. Chung, S.J. Hermans, Natalie L. Downer, Matthew E. Cuellar, Jayme L. Dahlin, Helene Jousset Sabroux, Tim Thomas, David J. Leaver, Swapna Varghese, Lian Xue, Karen L. White, Yuxin Sun, Prashant Mujumdar, Kasiram Katneni, Silvia Teguh, Anne K. Voss, Julie Sanchez, Kate E. Jarman, David M. Shackleford, Fei Huang, Ramesh Mudududdla, Nghi Nguyen

المصدر: Journal of Medicinal Chemistry. 63:4655-4684

مصطلحات موضوعية: Male, Lysine Acetyltransferases, Biological Availability, Antineoplastic Agents, 01 natural sciences, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, 03 medical and health sciences, Drug Stability, Histone Acetyltransferase KAT6A, Drug Discovery, Animals, Humans, Structure–activity relationship, Binding site, IC50, Histone Acetyltransferases, 030304 developmental biology, Sulfonamides, 0303 health sciences, Molecular Structure, Drug discovery, Chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Hydrazines, Biochemistry, Microsomes, Liver, Microsome, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eaf3a6eb34ac40b5b8c570155ff2a49
https://doi.org/10.1021/acs.jmedchem.9b02071

المؤلفون: Katie E. Frizzi, Maria R. Jones, Natalie L. Downer, Jeffrey M. Dale, Nigel A. Calcutt, Nathan Byers, Dan Landayan, Michael L. Garcia, Eric Villalón, Devin M. Barry

المصدر: Experimental Neurology. 306:158-168

مصطلحات موضوعية: Male, 0301 basic medicine, Neural Conduction, Neurodegenerative, Nerve conduction velocity, Serine, Mice, 0302 clinical medicine, Neurofilament Proteins, Ethidium, Site-Directed, Psychology, Phosphorylation, Axon, Myelin Sheath, Motor Neurons, Chemistry, Neurofilaments, Glutamate receptor, Sciatic Nerve, Cell biology, medicine.anatomical_structure, Neurology, Neurological, Sensory nerve, Nerve injury, Neurofilament, 1.1 Normal biological development and functioning, Clinical Sciences, Reduced nerve conduction, Article, 03 medical and health sciences, Developmental Neuroscience, Underpinning research, Reaction Time, medicine, Animals, Remyelination, Neurology & Neurosurgery, Neurosciences, Axons, 030104 developmental biology, nervous system, Mutagenesis, Mutagenesis, Site-Directed, Schwann Cells, 030217 neurology & neurosurgery, Demyelinating Diseases

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::665723f2ff535937106118e512dc01e2
https://doi.org/10.1016/j.expneurol.2018.05.009

المؤلفون: Helen M. McRae, Ian P. Street, John D. Bentley, Edwin D. Hawkins, Brandon J. Aubrey, Karen L. White, Bin Ren, Matthew L. Dennis, Meghan Hattarki, Stephen Mieruszynski, Natasha Zamudio, Gordon K. Smyth, M.C. Chung, Andrew J. Sealey, Maria I. Bergamasco, Guido Pacini, Natalie L. Downer, Jonathan B. Baell, Andreas Strasser, Jai Rautela, Ricky W. Johnstone, Nghi H. Nguyen, Alexandra L. Garnham, Bilal N. Sheikh, Andrea Newbold, Gemma L. Kelly, David J. Leaver, Pat Pilling, Rose E. May, Nicholas D. Huntington, Johannes Wichmann, Yuquing Yang, Tim Thomas, S.J. Hermans, Hannah K. Vanyai, Anne K. Voss, Beinan Wang, H. Rachel Lagiakos, Brendon J. Monahan, Bethany K. Davey, Stephen Wilcox, Melanie de Silva, Olan Dolezal, Michael W. Parker, Susan A. Charman, Margs S. Brennan, Kimberly J. Morgan, Karen Doggett, Joan K. Heath, Thomas S. Peat, Benjamin Cleary, Hendrik Falk

المصدر: Nature. 560:253-257

مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Senescence, Lysine Acetyltransferases, Lymphoma, Histones, Mice, 03 medical and health sciences, Drug Development, Animals, Epigenetics, Cells, Cultured, Cellular Senescence, Cell Proliferation, Histone Acetyltransferases, Regulation of gene expression, Sulfonamides, Multidisciplinary, biology, Lysine, Benzenesulfonates, Acetylation, Fibroblasts, Cell biology, Chromatin, Gene Expression Regulation, Neoplastic, Mice, Inbred C57BL, Hydrazines, 030104 developmental biology, Histone, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72783118ee7d6182bff8b36cfd55635
https://doi.org/10.1038/s41586-018-0387-5

المؤلفون: Jonathan B. Baell, David J. Leaver, Stefan J. Hermans, Gemma L. Kelly, Margs S. Brennan, Natalie L. Downer, Nghi Nguyen, Johannes Wichmann, Helen M. McRae, Yuqing Yang, Ben Cleary, H. Rache

المصدر: Nature, Nature. 560(7717):253-257

الإتاحة: https://ideas.repec.org/a/nat/nature/v560y2018i7717d10.1038_s41586-018-0387-5.html

المؤلفون: Didier Devys, Matthieu Stierle, Mathew P. Dixon, Farrah El-Saafin, Laszlo Tora, Luc Negroni, Imre Berger, Jean Marie Garnier, William B. Dobyns, Natalie L. Downer, Anne K. Voss, Tim Thomas, Isabelle Kolb-Cheynel, Cynthia J. Curry, Tao Ye

المساهمون: Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), European Molecular Biology Laboratory [Grenoble] (EMBL), Seattle Children's Research Institute

المصدر: Human Molecular Genetics
Human Molecular Genetics, Oxford University Press (OUP), 2018, 27 (12), pp.2171-2186. ⟨10.1093/hmg/ddy126⟩
El-Saafin, F, Curry, C, Ye, T, Garnier, J M, Kolb-Cheynel, I, Stierle, M, Downer, N L, Dixon, M P, Negroni, L, Berger, I, Thomas, T, Voss, A K, Dobyns, W, Devys, D & Tora, L 2018, ' Homozygous TAF8 mutation in a patient with intellectual disability results in undetectable TAF8 protein, but preserved RNA polymerase II transcription ', Human Molecular Genetics, vol. 27, no. 12, pp. 2171-2186 . https://doi.org/10.1093/hmg/ddy126

مصطلحات موضوعية: 0301 basic medicine, Transcription, Genetic, [SDV]Life Sciences [q-bio], BrisSynBio, RNA polymerase II, macromolecular substances, 03 medical and health sciences, Mice, 0302 clinical medicine, Transcription (biology), Intellectual Disability, Genetics, Animals, Humans, Molecular Biology, Genetics (clinical), ComputingMilieux_MISCELLANEOUS, [SDV.GEN]Life Sciences [q-bio]/Genetics, General transcription factor, biology, Cell Death, Bristol BioDesign Institute, Homozygote, Promoter, Mouse Embryonic Stem Cells, General Medicine, Articles, Molecular biology, Disease Models, Animal, 030104 developmental biology, Blastocyst, Transcription Factor TFIID, Transcription preinitiation complex, Mutation, biology.protein, Microcephaly, Synthetic Biology, Drosophila, RNA Polymerase II, Transcription factor II D, TATA-binding protein, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7d25e8f8087c6c928433a48e1d6ad4
https://hal.archives-ouvertes.fr/hal-02349579

المؤلفون: Gordon K. Smyth, Belinda Phipson, Anne K. Voss, Farrah El-Saafin, Bilal N. Sheikh, Natalie L. Downer, Rose E. May, Matthew Bird, Andrew J. Kueh, Tim Thomas, Hannah K. Vanyai

المصدر: Oncogene. 34:5807-5820

مصطلحات موضوعية: Senescence, Cancer Research, DNA damage, MYST3, Histones, Mice, Genetics, Animals, Molecular Biology, Cells, Cultured, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16, Histone Acetyltransferases, biology, EZH2, Acetylation, Histone acetyltransferase, Fibroblasts, Embryo, Mammalian, Histone, Cancer research, biology.protein, Chromatin immunoprecipitation, Cell aging, DNA Damage, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085651594ae08398e87504af084ef8bb
https://doi.org/10.1038/onc.2015.33

المؤلفون: Natalie L. Downer, Anne K. Voss, Andrew J. Kueh, Tim Thomas, Bilal N. Sheikh

المصدر: Stem Cells. 32:1451-1458

مصطلحات موضوعية: Mice, Inbred BALB C, animal structures, Cellular differentiation, Embryogenesis, Retinoic acid, Cell Differentiation, Mice, Transgenic, Tretinoin, Cell Biology, Biology, MYST3, Embryonic stem cell, Molecular biology, Mice, chemistry.chemical_compound, chemistry, embryonic structures, Animals, Molecular Medicine, Homeobox, Epigenetics, Hox gene, Cells, Cultured, Embryonic Stem Cells, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1723325d388fa0d6fe51a81d1234eeff
https://doi.org/10.1002/stem.1604

المؤلفون: Natalie L. Downer, Anne K. Voss, Gordon K. Smyth, Bilal N. Sheikh, Davis J. McCarthy, Tim Thomas, Hannah K. Vanyai, Andrew J. Kueh, Belinda Phipson

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 112(17)

مصطلحات موضوعية: animal structures, Retinoic acid, Repressor, macromolecular substances, Biology, chemistry.chemical_compound, Mice, Proto-Oncogene Proteins, Animals, Hox gene, Embryonic Stem Cells, Body Patterning, Histone Acetyltransferases, Genetics, Regulation of gene expression, Homeodomain Proteins, Mice, Knockout, Polycomb Repressive Complex 1, Mice, Inbred BALB C, Multidisciplinary, Gene Expression Regulation, Developmental, Histone acetyltransferase, Biological Sciences, Embryo, Mammalian, Chromatin, Gastrulation, chemistry, embryonic structures, biology.protein, Homeotic gene

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb821a46187eef46a0bbe1b7877f2d63
https://pubmed.ncbi.nlm.nih.gov/25922517

المؤلفون: Farrah El-Saafin, Stanley Chun-Wei Lee, Andreas Strasser, Stephanie Grabow, Warren S. Alexander, Gordon K. Smyth, Bilal N. Sheikh, Anne K. Voss, Tim Thomas, Natalie L. Downer, Belinda Phipson

المصدر: Experimental Hematology. 41:S54

مصطلحات موضوعية: Zinc finger, Cancer Research, medicine.medical_specialty, Hematology, Repressor, Cellular senescence, Cell Biology, Biology, medicine.disease, Lymphoma, Internal medicine, Genetics, Cancer research, medicine, Haploinsufficiency, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bde4aae23a2f5b259517442bd051c9bd
https://doi.org/10.1016/j.exphem.2013.05.211