المؤلفون: Emily I. Sparkes, Rachel A. Kettles, Chisom S. Egedeuzu, Natalie L. Stephenson, Stephanie A. Caslin, S. Yasin Tabatabaei Dakhili, Lu Shin Wong

المصدر: Biomolecules, Vol 10, Iss 9, p 1209 (2020)

مصطلحات موضوعية: silicatein, biocatalysis, biosilification, organosilicon, organosiloxane, hexahistidine tag, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2218-273X/10/9/1209; https://doaj.org/toc/2218-273X

URL الوصول: https://doaj.org/article/490a315e87ae4b82b8065adec2bc2654

المؤلفون: Natalie L. Stephenson, Johanna M. Avis

المصدر: FEBS Open Bio, Vol 5, Iss 1, Pp 625-633 (2015)

مصطلحات موضوعية: Notch, Negative regulatory region, Heterodimerization domain, HD domain, Atomic force microscopy, Molecular dynamics simulations, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2211-5463

URL الوصول: https://doaj.org/article/bbe65295cefc4552a0ebedf9141e41eb

المؤلفون: John Brognard, Owen J. Sansom, Tony Hunter, Crispin J. Miller, Ewelina Testoni, Matthew Collier, Ross Overman, Isabelle Green, Chris Phillips, Hannah K. Pollard, Claire Brassington, Jon A. Read, Lorena A. Puto, Phil Chapman, Susan Mason, Karen Blyth, Yaoyong Li, Eleanor W. Trotter, Hayeon Baik, Natalie L. Stephenson, Anna A. Marusiak

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0722c76c95b7bbc4901db1e2b3ae68
https://doi.org/10.1158/0008-5472.22409912

المؤلفون: Ewelina Testoni, Natalie L Stephenson, Pedro Torres‐Ayuso, Anna A Marusiak, Eleanor W Trotter, Andrew Hudson, Cassandra L Hodgkinson, Christopher J Morrow, Caroline Dive, John Brognard

المصدر: EMBO Molecular Medicine, Vol 8, Iss 2, Pp 105-116 (2016)

مصطلحات موضوعية: ABL1 mutations, dasatinib, imatinib, non‐small cell lung cancer, Medicine (General), R5-920, Genetics, QH426-470

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

URL الوصول: https://doaj.org/article/09b706bec30d4b42952219ab90a03b7c

المؤلفون: Stephanie A. Caslin, Emily I. Sparkes, Lu Shin Wong, Chisom S. Egedeuzu, Natalie L. Stephenson, S. Yasin Tabatabaei Dakhili, Rachel A. Kettles

المصدر: Sparkes, E I, Kettles, R A, Egedeuzu, C S, Stephenson, N L, Caslin, S A, Tabatabaei Dakhili, S Y & Wong, L S 2020, ' Improved Production and Biophysical Analysis of Recombinant Silicatein-α ', Biomolecules, vol. 10, no. 9, pp. 1209 . https://doi.org/10.3390/biom10091209
Biomolecules
Biomolecules, Vol 10, Iss 1209, p 1209 (2020)
Volume 10
Issue 9

مصطلحات موضوعية: biocatalysis, lcsh:QR1-502, Protein aggregation, 010402 general chemistry, 01 natural sciences, Biochemistry, lcsh:Microbiology, Article, protein aggregation, Hydrolase, Protein biosynthesis, Molecular Biology, chemistry.chemical_classification, organosilicon, 010405 organic chemistry, Chemistry, silicatein, biosilification, organosiloxane, hexahistidine tag, protein engineering, Protein engineering, Fusion protein, Cathepsins, Recombinant Proteins, 0104 chemical sciences, Enzyme, Biocatalysis, Yield (chemistry), Biophysics, protein production

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4d86f306fadaa171ae21d19d4faf7d
https://www.research.manchester.ac.uk/portal/en/publications/improved-production-and-biophysical-analysis-of-recombinant-silicatein(969c6674-34c4-4f95-9cc1-807599a659cf).html

المؤلفون: Ewelina Testoni, John Brognard, Cassandra L Hodgkinson, Anna A. Marusiak, Eleanor W. Trotter, Natalie L. Stephenson, Andrew M Hudson, Pedro Torres-Ayuso, Caroline Dive, Christopher J. Morrow

المصدر: Testoni, E, Stephenson, N L, Torres-Ayuso, P, Marusiak, A A, Trotter, E W, Hudson, A, Hodgkinson, C L, Morrow, C J, Dive, C & Brognard, J 2016, ' Somatically mutated ABL1 is an actionable and essential NSCLC survival gene ', EMBO Molecular Medicine, vol. 8, no. 2, pp. 105-16 . https://doi.org/10.15252/emmm.201505456
EMBO Molecular Medicine

مصطلحات موضوعية: 0301 basic medicine, Respiratory System, ABL1 mutations, Bioinformatics, medicine.disease_cause, Mice, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, hemic and lymphatic diseases, dasatinib, Proto-Oncogene Proteins c-abl, Cancer, Mutation, ABL, Manchester Cancer Research Centre, Kinase, Research Support, Non-U.S. Gov't, Dasatinib, Treatment Outcome, 030220 oncology & carcinogenesis, Imatinib Mesylate, Heterografts, Molecular Medicine, medicine.drug, non‐small cell lung cancer, Cell Survival, Antineoplastic Agents, 03 medical and health sciences, Report, Cell Line, Tumor, Journal Article, medicine, Animals, Humans, Lung cancer, neoplasms, business.industry, ResearchInstitutes_Networks_Beacons/mcrc, Imatinib, medicine.disease, respiratory tract diseases, Disease Models, Animal, 030104 developmental biology, Imatinib mesylate, imatinib, Cancer research, Mutant Proteins, business, Reports

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588373a0dd762246419e79d9a650f3e0
https://doi.org/10.15252/emmm.201505456

المؤلفون: Alexander Jones, John Brognard, Yimin Yang, Gema Lordén, Alexandra C. Newton, Natalie L. Stephenson, Julia A. Callender

المصدر: Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 24

مصطلحات موضوعية: 0301 basic medicine, Aging, Neurodegenerative, Inbred C57BL, Alzheimer's Disease, Mice, 0302 clinical medicine, Catalytic Domain, Chlorocebus aethiops, enzyme mutation, 2.1 Biological and endogenous factors, Phosphorylation, PKC, Aetiology, Multidisciplinary, Chemistry, Brain, Cell biology, Protein destabilization, PNAS Plus, Gain of Function Mutation, Second messenger system, COS Cells, Signal transduction, Alzheimer’s disease, signal transduction, Signal Transduction, Protein Kinase C-alpha, Allosteric regulation, Down-Regulation, Catalysis, Cell Line, 03 medical and health sciences, Alzheimer Disease, Acquired Cognitive Impairment, Animals, Humans, Protein kinase A, Protein kinase C, Diacylglycerol kinase, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, Mice, Inbred C57BL, Enzyme Activation, 030104 developmental biology, Protein kinase domain, Mutation, Calcium, Dementia, CRISPR-Cas Systems, 030217 neurology & neurosurgery, protein kinase C

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18276fc3e965284a0d17e12beae5ed5
https://escholarship.org/uc/item/3js1d9tn

المؤلفون: Cynthia Li, Christopher Wirth, John Brognard, Matthew Howell, Gitta Katona, S Furney, Natalie L. Stephenson, Eleanor W. Trotter, Andrew M Hudson, Patrycja Bieniasz-Krzywiec, Crispin J. Miller, Adam Fletcher

المصدر: Sci Signal

مصطلحات موضوعية: 0301 basic medicine, MAP Kinase Signaling System, MAP Kinase Kinase 7, Biology, Molecular Dynamics Simulation, Biochemistry, Article, law.invention, 03 medical and health sciences, law, Loss of Function Mutation, Stomach Neoplasms, Cell Line, Tumor, Humans, Kinome, Genes, Tumor Suppressor, Amino Acid Sequence, Kinase activity, Molecular Biology, Gene, Sequence Homology, Amino Acid, Kinase, Cell Biology, Genomics, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Protein kinase domain, Cancer cell, Cancer research, Suppressor, Functional genomics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab9ac2252ba0709b0016d5a7e4819f68
https://pubmed.ncbi.nlm.nih.gov/29666306

المؤلفون: Alexander M. Jones, Natalie L. Stephenson, Alexandra C. Newton, Yimin Yang, John Brognard, Julia Callender

المصدر: The FASEB Journal. 32

مصطلحات موضوعية: Gain of function, Downregulation and upregulation, Mechanism (biology), Chemistry, Genetics, Protein kinase A, Molecular Biology, Biochemistry, Biotechnology, Cell biology, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5c89f7fb7d497b20ffa82746db595ab0
https://doi.org/10.1096/fasebj.2018.32.1_supplement.662.7

المؤلفون: Andrew M. Hudson, Natalie L. Stephenson, Cynthia Li, Eleanor Trotter, Adam J. Fletcher, Gitta Katona, Patrycja Bieniasz-Krzywiec, Matthew Howell, Chris Wirth, Simon Furney, Crispin J. Miller, John Brognard

مصطلحات موضوعية: Protein kinase domain, Pan cancer, law, Kinase, Cancer genome, Suppressor, Genomics, Kinome, Motif (music), Computational biology, Biology, law.invention

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fa9cdde5a1fa64f5311a868fd3df9f
https://doi.org/10.1101/254813