المؤلفون: Gareth Jones, Jacques Richard, Simeon Ramsey, Rosalind Walley, Karl Richard Gibson, David C. Howe, Coralie S. Apfeldorfer, Natalie M. Mount, Amy N Brown, Nicholas Pullen, Tony Hawcock, Kirsty Bess, Alison McLeod, Peter M. Bungay, Sarah Tweedy

المصدر: Journal of Pharmacology and Experimental Therapeutics. 339:642-653

مصطلحات موضوعية: Adult, medicine.medical_specialty, Endometriosis, Biology, Pharmacology, Endometrium, Hormone antagonist, Translational Research, Biomedical, Young Adult, Hormone Antagonists, Double-Blind Method, Internal medicine, Follicular phase, Progesterone receptor, medicine, Animals, Humans, Estrogens, Non-Steroidal, Molecular Targeted Therapy, Sulfones, Receptor, Dose-Response Relationship, Drug, Estradiol, Antagonist, Mifepristone, Luteinizing Hormone, medicine.anatomical_structure, Endocrinology, Follicular Phase, Macaca, Pyrazoles, Molecular Medicine, Female, Receptors, Progesterone, Luteinizing hormone, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2424928f5d7c154555b10bc8fec040
https://doi.org/10.1124/jpet.111.183848

المؤلفون: Peter J. Bungay, Hannah M. Jones, David C. Howe, Natalie M. Mount, Sarah Tweedy, Karl Richard Gibson

المصدر: Drug Metabolism and Disposition. 39:1396-1405

مصطلحات موضوعية: Male, medicine.medical_specialty, Physiologically based pharmacokinetic modelling, Drug Evaluation, Preclinical, Pharmaceutical Science, Pharmacology, Models, Biological, Rats, Sprague-Dawley, Dogs, Double-Blind Method, Species Specificity, Pharmacokinetics, Predictive Value of Tests, Tandem Mass Spectrometry, Internal medicine, Progesterone receptor, medicine, Animals, Humans, Prospective Studies, Sulfones, Biotransformation, Chromatography, High Pressure Liquid, Dose-Response Relationship, Drug, Intestinal Secretions, Molecular Structure, biology, Chemistry, Antagonist, Cytochrome P450, Metabolism, In vitro, Rats, Endocrinology, Solubility, Injections, Intravenous, Hepatocytes, Microsomes, Liver, Microsome, biology.protein, Pyrazoles, Caco-2 Cells, Receptors, Progesterone, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92897838f58b38ea6fc96ef975e0d70a
https://doi.org/10.1124/dmd.110.037234

المؤلفون: Barber Christopher Gordon, David James Rawson, Maw Graham Nigel, Natalie M. Mount, David G. Brown, Charlotte Moira Norfor Allerton, Susan M. Cole, Charlotte Alice Louise Lane, David Ellis, Nicholas W. Summerhill, Colin Robinson, Kevin Beaumont, Street Stephen Derek Albert

المصدر: Journal of Medicinal Chemistry. 49:3581-3594

مصطلحات موضوعية: Male, Models, Molecular, Sildenafil, Cmax, Administration, Oral, Biological Availability, Pyrimidinones, Pharmacology, Crystallography, X-Ray, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Erectile Dysfunction, Pharmacokinetics, 3',5'-Cyclic-GMP Phosphodiesterases, In vivo, Oral administration, Drug Discovery, Animals, Humans, Cyclic Nucleotide Phosphodiesterases, Type 5, Dose-Response Relationship, Drug, Molecular Structure, biology, Ketones, Bioavailability, Pyrimidines, chemistry, Biochemistry, Enzyme inhibitor, cGMP-specific phosphodiesterase type 5, biology.protein, Azetidines, Molecular Medicine, Caco-2 Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabdec86ec361f6ee6391c958398a432
https://doi.org/10.1021/jm060113e

المؤلفون: Natalie M. Mount, Peter Stacey

المصدر: The Biochemist. 24:16-18

مصطلحات موضوعية: medicine.medical_specialty, business.industry, Urology, Medicine, Male erectile dysfunction, business, General Biochemistry, Genetics and Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b616e17a1e622feb60e5d51606799a0c
https://doi.org/10.1042/bio02402016

المؤلفون: Mark L. Lewis, Nick Edmunds, Stefan Sultana, Natalie M. Mount, Mark Ian Lansdell, Peter Wilson, Anne C. Heatherington, T. Bruce Brown, Alan Daniel Brown, Sarah Tweedy, David Hepworth, Julian Blagg, Cathryn Adams, Samantha Gaboardi, Kim Tang, Stevie Neal-Morgan, Andrew A. Calabrese, Neela Mistry, Maria Sudworth, David Sebastien Fradet, Neil Feeder, Val Gillon, Susan Cole, Steven W. Martin, Faye J. Quinton, Joanne Phipps, Scott Haughie, Denise J. Burring, Peter Stacey, Hugh Verrier, Chris Wayman

المصدر: Journal of medicinal chemistry. 53(8)

مصطلحات موضوعية: Agonist, Male, Models, Molecular, medicine.medical_specialty, Pyrrolidines, Sildenafil, medicine.drug_class, Administration, Sublingual, Administration, Oral, Biological Availability, Biology, Pharmacology, In Vitro Techniques, Crystallography, X-Ray, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, Erectile Dysfunction, Piperidines, Oral administration, Internal medicine, Drug Discovery, medicine, Animals, Humans, Receptor, Administration, Intranasal, Randomized Controlled Trials as Topic, Clinical Trials, Phase I as Topic, Stereoisomerism, Rats, Melanocortin 4 receptor, Sexual dysfunction, Endocrinology, chemistry, Hepatocytes, Microsomes, Liver, Molecular Medicine, Receptor, Melanocortin, Type 4, Nasal administration, Melanocortin, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b05a704b9e20c9d6ce95d234dd7627d0
https://pubmed.ncbi.nlm.nih.gov/20329799