المؤلفون: Miriam N. Jacobs, Jan M. Bult, Kevin Cavanagh, Christophe Chesne, Nathalie Delrue, Jianan Fu, Emma Grange, Ingrid Langezaal, Dominika Misztela, Jenny Murray, Martin Paparella, Gilly Stoddart, Torsten Tonn, Carol Treasure, Masaaki Tsukano, Rosemary Versteegen

المصدر: Frontiers in Toxicology, Vol 5 (2023)

مصطلحات موضوعية: human serum, in vitro test methods, human derived reagents, animal-free, xenofree, ethics, Toxicology. Poisons, RA1190-1270

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/ftox.2023.1140698/full; https://doaj.org/toc/2673-3080

URL الوصول: https://doaj.org/article/64e648c9e6894018be64557ad5a4ea22

المؤلفون: Shihori Tanabe, Jason O’Brien, Knut Erik Tollefsen, Youngjun Kim, Vinita Chauhan, Carole Yauk, Elizabeth Huliganga, Ruthann A. Rudel, Jennifer E. Kay, Jessica S. Helm, Danielle Beaton, Julija Filipovska, Iva Sovadinova, Natalia Garcia-Reyero, Angela Mally, Sarah Søs Poulsen, Nathalie Delrue, Ellen Fritsche, Karsta Luettich, Cinzia La Rocca, Hasmik Yepiskoposyan, Jördis Klose, Pernille Høgh Danielsen, Maranda Esterhuizen, Nicklas Raun Jacobsen, Ulla Vogel, Timothy W. Gant, Ian Choi, Rex FitzGerald

المصدر: Frontiers in Toxicology, Vol 4 (2022)

مصطلحات موضوعية: adverse outcome pathway (AOP), oxidative stress, reactive nitrogen species (RNS), disease, reactive oxygen species (ROS), Toxicology. Poisons, RA1190-1270

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/ftox.2022.887135/full; https://doaj.org/toc/2673-3080

URL الوصول: https://doaj.org/article/6e4603ffc4664fc2936ec3f4a2a4f907

المؤلفون: Edward J. Perkins, Julie Leblanc, Dominique Laurier, Michael A. Boyd, Vinita Chauhan, Holly Laakso, Sabina Halappanavar, Nathalie Delrue, Ruth C. Wilkins, Jason M. O'Brien, Bette Meek, Russell S. Thomas, Catalina Anghel, Barber Christopher Gordon, Crina Heghes, Julie Burtt, Ted Lazo, Tara S. Barton-Maclaren, Carole L. Yauk, Danielle Beaton, Francesco Marchetti, Donald Cool, Magdalini Sachana, Maurice Whelan, Daniel L. Villeneuve

المساهمون: Health Canada, Canadian Nuclear Laboratories (CNL), Organisation for Economic Co-operation and Development (OECD), Univesity of Ottawa, Environment and Climate Change Canada, U.S. Environmental Protection Agency (EPA), University of Ottawa, Lhasa Limited, US Army Engineer Research and Development Center, Canadian Nuclear Safety Commission (CNSC), PSE-SANTE/SESANE, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Nuclear Energy Agency (OECD NEA), European Commission, Electric Power Research Institute (EPRI)

المصدر: International Journal of Radiation Biology
International Journal of Radiation Biology, Informa Healthcare, 2021, 97 (4), pp.431-441. ⟨10.1080/09553002.2021.1884314⟩

مصطلحات موضوعية: Internationality, Adverse Outcome Pathways, Radiological and Ultrasound Technology, Adverse outcomes, Science, [SDV]Life Sciences [q-bio], Stressor, Low dose, Risk Assessment, 3. Good health, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Human health, 0302 clinical medicine, 13. Climate action, 030220 oncology & carcinogenesis, Adverse Outcome Pathway, Humans, Radiology, Nuclear Medicine and imaging, Engineering ethics, Psychology, Intersectoral Collaboration, Scientific disciplines

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6e0fc89815d0a52c9469f8301e1c31
https://doi.org/10.1080/09553002.2021.1884314

المؤلفون: Marco Corvaro, Paule Vasseur, Monica Vaccari, Annamaria Colacci, Federica Madia, Martin Paparella, Akiyoshi Nishikawa, Nathalie Delrue, Kumiko Ogawa, Norman Ertych, Raffaella Corvi, Miriam N. Jacobs, Kiyomi Ohmori, M. Cecilia Aguila, Mirjam Luijten, Daniel Desaulniers, Anoop Kumar Sharma, Abigail Jacobs

المساهمون: Centre for Radiation, Chemical and Environmental Hazards, Public Health England [London], ARPA Emilia-Romagna, Agenzia Regionale per la Protezione dell’Ambiente, European Commission - Joint Research Centre [Ispra] (JRC), U.S. Food and Drug Administration (FDA), Organisation de Coopération et de Développement Economiques (OCDE), German Federal Institute for Risk Assessment [Berlin] (BfR), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Innsbruck Medical University [Austria] (IMU), Technical University of Denmark [Lyngby] (DTU), Laboratoire Interdisciplinaire des Environnements Continentaux (LIEC), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Terre et Environnement de Lorraine (OTELo), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Jacobs, M N, Colacci, A, Corvi, R, Vaccari, M, Aguila, M C, Corvaro, M, Delrue, N, Desaulniers, D, Ertych, N, Jacobs, A, Luijten, M, Madia, F, Nishikawa, A, Ogawa, K, Ohmori, K, Paparella, M, Sharma, A K & Vasseur, P 2020, ' Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens ', Archives of Toxicology, vol. 94, no. 8, pp. 2899-2923 . https://doi.org/10.1007/s00204-020-02784-5
Archives of Toxicology
Archives of Toxicology, Springer Verlag, 2020, 94 (8), pp.2899-2923. ⟨10.1007/s00204-020-02784-5⟩

مصطلحات موضوعية: Cancer microenvironment, 0301 basic medicine, Consensus, Carcinogenicity Tests, [SDV]Life Sciences [q-bio], Cancer hallmarks, Health, Toxicology and Mutagenesis, [SDV.CAN]Life Sciences [q-bio]/Cancer, Context (language use), Toxicology, medicine.disease_cause, Risk Assessment, Cancer prevention, Meeting Reports, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Adverse Outcome Pathway, medicine, Animals, Humans, Cancer model, Integrated approaches to testing and assessment, Carcinogen, Non-genotoxic carcinogenicity, Reproducibility of Results, General Medicine, Integrated approach, Expert group, 3. Good health, Variety (cybernetics), 030104 developmental biology, Risk analysis (engineering), 030220 oncology & carcinogenesis, Carcinogens, Identification (biology), IATA, Business, Hazard assessment, Genotoxicity

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc056687031b8806f8cb63d08ebfaba
https://doi.org/10.1007/s00204-020-02784-5

المؤلفون: Nathalie Delrue, Anne Gourmelon, Patience Browne

المصدر: Current Opinion in Toxicology. 15:18-25

مصطلحات موضوعية: 0301 basic medicine, Alternative methods, Computer science, 010501 environmental sciences, Toxicology, 01 natural sciences, Chemical hazard, 03 medical and health sciences, Animal data, Human health, Identification (information), 030104 developmental biology, Risk analysis (engineering), 0105 earth and related environmental sciences

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c0737fa21c873d4fa279cd0c17be5292
https://doi.org/10.1016/j.cotox.2019.02.003

المؤلفون: Da-Woon Jung, Yooheon Park, Toine F.H. Bovee, Keith A. Houck, Patience Browne, Atsushi Ono, Yun Sook Kang, Masahiro Takeyoshi, Nathalie Delrue, Hee-Seok Lee, Miriam N. Jacobs, Anne Milcamps

المصدر: Food and Chemical Toxicology, 152
Food and Chemical Toxicology 152 (2021)

مصطلحات موضوعية: Agonist, Transcriptional Activation, medicine.drug_class, Drug Evaluation, Preclinical, Team Bioassays & Biosensors, Toxicology, 03 medical and health sciences, Transactivation, Gene Knockout Techniques, Mice, 0404 agricultural biotechnology, Glucocorticoid receptor, Receptors, Glucocorticoid, Cell Line, Tumor, Validation, medicine, Androgen Receptor Antagonists, Animals, Humans, 030304 developmental biology, OECD Test guideline, 0303 health sciences, Chemistry, Antagonist, Transcriptional activation assay, Reproducibility of Results, 04 agricultural and veterinary sciences, General Medicine, Transfection, 040401 food science, Molecular biology, In vitro, Androgen receptor, Mammary Tumor Virus, Mouse, Cell culture, Receptors, Androgen, Androgens, Glucocorticoid, Food Science, medicine.drug

وصف الملف: application/octet-stream; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7178b83e8e01ad510b330ffd60fca28a
https://research.wur.nl/en/publications/characterisation-and-validation-of-an-in-vitro-transactivation-as

المؤلفون: Nathalie Delrue, Yuki Sakuratani, Eeva Leinala, Anne Gourmelon, Robert Diderich, Magdalini Sachana

المصدر: Alternatives to Laboratory Animals. 44:417-429

مصطلحات موضوعية: 0301 basic medicine, In vitro test, Drug-Related Side Effects and Adverse Reactions, Integration testing, Computer science, Decision Making, 010501 environmental sciences, Toxicology, Bioinformatics, 01 natural sciences, Hazardous Substances, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Chemical safety, Adverse Outcome Pathway, Adverse Drug Reaction Reporting Systems, Animals, Humans, 0105 earth and related environmental sciences, Alternative methods, Mechanism (biology), business.industry, General Medicine, Toolbox, Medical Laboratory Technology, 030104 developmental biology, Risk analysis (engineering), Knowledge base, Environmental Pollutants, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5691011cd9cd7907bcf3060883f375ab
https://doi.org/10.1177/026119291604400504

المؤلفون: Silvia Vogl, Ibrahim Chahoud, Marlon R. Schneider, Weihua Li, Gilbert Schönfelder, Martina Rauch, Steffen Schneider, Frank Schulze, A. Gall, Rupert Kellner, Kohei Shiota, Francisco José Roma Paumgartten, Ruth Clark, Jochen Buschmann, Ellen Fritsche, Susan L. Makris, Nathalie Delrue, Anne Schmitt, Roland Solecki, Alberto Mantovani, Makiko Kuwagata, Nicole Kleinstreuer, Jingying Hu, Michio Fujiwara, Olena Kucheryavenko

المساهمون: Publica

المصدر: Reprod Toxicol

مصطلحات موضوعية: Test strategy, 0303 health sciences, Reproductive toxicology, Database, Alternatives to animal testing, Developmental toxicity, 010501 environmental sciences, Toxicology, computer.software_genre, 01 natural sciences, Article, Terminology, 03 medical and health sciences, Developmental toxicology, Relevance (information retrieval), Risk assessment, Psychology, computer, 030304 developmental biology, 0105 earth and related environmental sciences

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ea670d9cffa622d85024582e42acff
https://publica.fraunhofer.de/handle/publica/259248

المؤلفون: Zvonimir Zvonar, Susan P. Felter, Federica Madia, Katrin Schutte, Ruud A. Woutersen, Abigail Jacobs, Hedwig M. Braakhuis, Jan Willem van der Laan, Gerrit Wolterink, Marco Corvaro, Stephanie Melching-Kollmuss, Irene Manou, Douglas C. Wolf, Franz Lamplmair, Jyotigna Mehta, Raffaella Corvi, Mirjam Luijten, Thomas Holmes, Dick Lewis, Miriam N. Jacobs, Nathalie Delrue, Harm J. Heusinkveld, Bodo Haas, Nicola J. Hewitt, Gina M. Hilton, Frédéric Schorsch, Christian Strupp, Fiona Sewell

المصدر: Regulatory Toxicology and Pharmacology. 118:104789

مصطلحات موضوعية: Correctness, Carcinogenicity Tests, Agrochemical, Computer science, Alternative approaches to animal testing, 010501 environmental sciences, Animal Testing Alternatives, Toxicology, Risk Assessment, 030226 pharmacology & pharmacy, 01 natural sciences, 3Rs, Human health risk assessment, 03 medical and health sciences, Non-genotoxic carcinogens, 0302 clinical medicine, Neoplasms, Animals, Humans, Relevance (information retrieval), Animal testing, 0105 earth and related environmental sciences, Carcinogenicity, Mutagenicity Tests, business.industry, Toxicity Tests, Subchronic, General Medicine, Congresses as Topic, Toolbox, Toxicokinetics, Test (assessment), Cell Transformation, Neoplastic, New approach methodologies, Risk analysis (engineering), Mode of action, NAMs, General partnership, Predictive power, Agrochemicals, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0717bf3d457412cea1c5dee614fda577
https://doi.org/10.1016/j.yrtph.2020.104789

المؤلفون: Aldert H. Piersma, Rex E. FitzGerald, Manuela Tiramani, Florianne Monnet-Tschudi, Helena T. Hogberg, Gabriele Schmuck, Ellen Fritsche, Anna Bal-Price, Sandra Allen, Marcel Leist, Nathalie Delrue, Thomas Hartung, Martin Paparella, Daniela Maria Oggier, Timo Ylikomi, Timo Buetler, Eva Rached, Walter Lichtensteiger, Benoît Schilter, Susanne Hougaard Bennekou, Marta Axelstad, Michael Arand, Kevin M. Crofton, Martin F. Wilks, Tuula Heinonen, Luc Stoppini, Enrico Tongiorgi

المساهمون: Bal-Price, Anna, Crofton, Kevin M, Leist, Marcel, Allen, Sandra, Arand, Michael, Buetler, Timo, Delrue, Nathalie, Fitzgerald, Rex E, Hartung, Thoma, Heinonen, Tuula, Hogberg, Helena, Bennekou, Susanne Hougaard, Lichtensteiger, Walter, Oggier, Daniela, Paparella, Martin, Axelstad, Marta, Piersma, Aldert, Rached, Eva, Schilter, Benoît, Schmuck, Gabriele, Stoppini, Luc, Tongiorgi, Enrico, Tiramani, Manuela, Monnet-Tschudi, Florianne, Wilks, Martin F, Ylikomi, Timo, Fritsche, Ellen

المصدر: Bal-Price, A, Crofton, K M, Leist, M, Allen, S, Arand, M, Buetler, T, Delrue, N, FitzGerald, R E, Hartung, T, Heinonen, T, Hogberg, H, Bennekou, S H, Lichtensteiger, W, Oggier, D, Paparella, M, Petersen, M A, Piersma, A, Rached, E, Schilter, B, Schmuck, G, Stoppini, L, Tongiorgi, E, Tiramani, M, Monnet-Tschudi, F, Wilks, M F, Ylikomi, T & Fritsche, E 2015, ' International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes ', Archives of Toxicology, vol. 89, no. 2, pp. 269-287 . https://doi.org/10.1007/s00204-015-1464-2
Archives of Toxicology, vol. 89, no. 2, pp. 269-287
Archives of Toxicology

مصطلحات موضوعية: Matching (statistics), Process (engineering), Integration testing, Computer science, Health, Toxicology and Mutagenesis, Regulatory requirements, Guidelines as Topic, Meeting Report, Chemical screening, Developmental neurotoxicity, Adverse outcome pathway, Key event, Environmental hazard, Brain, Fetus, Humans, Neurotoxicity Syndromes, Risk Assessment, Toxicity Tests, Toxicology, Neurotoxicity Syndrome, ddc:570, Adverse Outcome Pathway, Regulatory requirement, Fetu, Road map, Chemical screening, Developmental neurotoxicity, Regulatory requirements, Adverse outcome pathway, Key event, Environmental hazard, SDG 8 - Decent Work and Economic Growth, General Medicine, Hazard, Risk analysis (engineering), Key (cryptography), Human

وصف الملف: application/pdf; STAMPA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5930c858834c129b367351d4e39bee46
https://doi.org/10.1007/s00204-015-1464-2