المؤلفون: Nathan, WJ

المساهمون: McHugh, P, Wilson, D, Nussenzweig, A

مصطلحات موضوعية: Aging, Nervous system--Degeneration, DNA damage, DNA repair, Chemotherapy, Biochemistry, Cancer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______1064::5f48effef18517ab1babecb05e92cbdb
https://ora.ox.ac.uk/objects/uuid:71c4029b-4b0f-4347-b38f-5a1267b07dc8

المؤلفون: Saayman, X, Graham, E, Nathan, WJ, Nussenzweig, A, Esashi, F

المصدر: Molecular Cell. 83:523-538.e7

مصطلحات موضوعية: Cell Biology, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eef4ac109945f8cfdeb71710f9e3d9a
https://doi.org/10.1016/j.molcel.2023.01.004

المؤلفون: Wang D; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA., Wu W; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA.; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China., Callen E; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA., Pavani R; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA., Zolnerowich N; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA., Kodali S; Stem Cells and Regenerative Medicine, Center for Cell and Gene Therapy, Department of Molecular and Cellular Biology and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.; Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Zong D; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA., Wong N; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA., Noriega S; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA., Nathan WJ; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA., Matos-Rodrigues G; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA., Chari R; Genome Modification Core, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Kruhlak MJ; Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA., Livak F; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA., Ward M; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA., Caldecott K; Genome Damage and Stability Centre, University of Sussex, Falmer Brighton, UK., Di Stefano B; Stem Cells and Regenerative Medicine, Center for Cell and Gene Therapy, Department of Molecular and Cellular Biology and Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.; Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Nussenzweig A; Laboratory of Genome Integrity, National Cancer Institute NIH, Bethesda, MD, USA.

المصدر: Science (New York, N.Y.) [Science] 2022 Dec 02; Vol. 378 (6623), pp. 983-989. Date of Electronic Publication: 2022 Dec 01.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: DNA Demethylation* , Induced Pluripotent Stem Cells* , Neurons*/enzymology , DNA Breaks, Single-Stranded* , Enhancer Elements, Genetic* , Thymine DNA Glycosylase* , DNA Repair*, Cell Differentiation ; 5-Methylcytosine/metabolism ; Humans ; Cell Transdifferentiation

المؤلفون: Matos-Rodrigues G; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., van Wietmarschen N; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Wu W; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Tripathi V; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Koussa NC; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Pavani R; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Nathan WJ; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Callen E; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Belinky F; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Mohammed A; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Napierala M; Department of Neurology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390, USA., Usdin K; Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Ansari AZ; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA., Mirkin SM; Department of Biology, Tufts University, Medford, MA, USA. Electronic address: sergei.mirkin@tufts.edu., Nussenzweig A; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA. Electronic address: andre_nussenzweig@nih.gov.

المصدر: Molecular cell [Mol Cell] 2022 Oct 06; Vol. 82 (19), pp. 3538-3552.e5. Date of Electronic Publication: 2022 Sep 07.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: DNA, Cruciform* , Nylons*, DNA/metabolism ; DNA Breaks, Double-Stranded ; DNA Replication ; Humans ; Nucleic Acid Conformation

المؤلفون: van Wietmarschen N; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Nathan WJ; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Nussenzweig A; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA. Electronic address: andre_nussenzweig@nih.gov.

المصدر: Current opinion in genetics & development [Curr Opin Genet Dev] 2021 Dec; Vol. 71, pp. 34-38. Date of Electronic Publication: 2021 Jul 17.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 9111375 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0380 (Electronic) Linking ISSN: 0959437X NLM ISO Abbreviation: Curr Opin Genet Dev Subsets: MEDLINE

مواضيع طبية MeSH: Microsatellite Instability* , Neoplasms*/drug therapy , Neoplasms*/genetics, Exodeoxyribonucleases/genetics ; Humans ; Microsatellite Repeats ; RecQ Helicases/genetics ; RecQ Helicases/metabolism ; Werner Syndrome Helicase/genetics

المؤلفون: Wu W; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Hill SE; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA., Nathan WJ; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Paiano J; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Callen E; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Wang D; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Shinoda K; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., van Wietmarschen N; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Colón-Mercado JM; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA., Zong D; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., De Pace R; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA., Shih HY; National Eye Institute, NIH, Bethesda, MD, USA., Coon S; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA., Parsadanian M; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA., Pavani R; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Hanzlikova H; Department of Genome Dynamics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK., Park S; Lymphocyte Nuclear Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases and National Cancer Institute, NIH, Bethesda, MD, USA.; NIH Regulome Project, NIH, Bethesda, MD, USA., Jung SK; Lymphocyte Nuclear Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases and National Cancer Institute, NIH, Bethesda, MD, USA.; NIH Regulome Project, NIH, Bethesda, MD, USA., McHugh PJ; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Canela A; The Hakubi Center for Advanced Research and Radiation Biology Center, Graduate School of Biostudies, Kyoto University, Kyoto, Japan., Chen C; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, NIH, Bethesda, MD, USA., Casellas R; Lymphocyte Nuclear Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases and National Cancer Institute, NIH, Bethesda, MD, USA.; NIH Regulome Project, NIH, Bethesda, MD, USA., Caldecott KW; Department of Genome Dynamics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic. k.w.caldecott@sussex.ac.uk.; Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK. k.w.caldecott@sussex.ac.uk., Ward ME; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA. wardme@nih.gov., Nussenzweig A; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA. andre_nussenzweig@nih.gov.

المصدر: Nature [Nature] 2021 May; Vol. 593 (7859), pp. 440-444. Date of Electronic Publication: 2021 Mar 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: DNA Breaks, Single-Stranded* , DNA Repair*, Enhancer Elements, Genetic/*genetics , Neurons/*metabolism, 5-Methylcytosine/metabolism ; Cell Line ; DNA/biosynthesis ; DNA Replication ; Humans ; Male ; Methylation ; Poly(ADP-ribose) Polymerases/metabolism ; Sequence Analysis, DNA

المؤلفون: van Wietmarschen N; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Sridharan S; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Nathan WJ; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Tubbs A; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Chan EM; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Callen E; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Wu W; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Belinky F; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Tripathi V; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Wong N; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Foster K; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Noorbakhsh J; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Garimella K; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Cruz-Migoni A; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Sommers JA; Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD, USA., Huang Y; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Borah AA; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Smith JT; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Kalfon J; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Kesten N; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Harvard Medical School, Cambridge, MA, USA., Fugger K; DNA Recombination and Repair Laboratory, The Francis Crick Institute, London, UK., Walker RL; Genetics Branch, National Cancer Institute, NIH, Bethesda, MD, USA., Dolzhenko E; Illumina Inc., San Diego, CA, USA., Eberle MA; Illumina Inc., San Diego, CA, USA., Hayward BE; Laboratory of Cell and Molecular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD, USA., Usdin K; Laboratory of Cell and Molecular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD, USA., Freudenreich CH; Department of Biology, Tufts University, Medford, MA, USA., Brosh RM Jr; Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD, USA., West SC; DNA Recombination and Repair Laboratory, The Francis Crick Institute, London, UK., McHugh PJ; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Meltzer PS; Genetics Branch, National Cancer Institute, NIH, Bethesda, MD, USA., Bass AJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Nussenzweig A; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA. andre_nussenzweig@nih.gov.

المصدر: Nature [Nature] 2020 Oct; Vol. 586 (7828), pp. 292-298. Date of Electronic Publication: 2020 Sep 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: DNA Breaks, Double-Stranded*, DNA Repeat Expansion/*genetics , Dinucleotide Repeats/*genetics , Neoplasms/*genetics , Werner Syndrome Helicase/*metabolism, Ataxia Telangiectasia Mutated Proteins/metabolism ; Cell Line, Tumor ; Chromosomes, Human/genetics ; Chromosomes, Human/metabolism ; Chromothripsis ; DNA Cleavage ; DNA Replication ; DNA-Binding Proteins/metabolism ; Endodeoxyribonucleases/metabolism ; Endonucleases/metabolism ; Genomic Instability ; Humans ; Recombinases/metabolism

المؤلفون: Liu G; 1 Department of Radiation Oncology, Robert Lurie Cancer Center, Northwestern University Feinberg School of Medicine , Chicago, Illinois., Park SH; 1 Department of Radiation Oncology, Robert Lurie Cancer Center, Northwestern University Feinberg School of Medicine , Chicago, Illinois., Imbesi M; 1 Department of Radiation Oncology, Robert Lurie Cancer Center, Northwestern University Feinberg School of Medicine , Chicago, Illinois., Nathan WJ; 1 Department of Radiation Oncology, Robert Lurie Cancer Center, Northwestern University Feinberg School of Medicine , Chicago, Illinois., Zou X; 1 Department of Radiation Oncology, Robert Lurie Cancer Center, Northwestern University Feinberg School of Medicine , Chicago, Illinois.; 2 Driskill Graduate Program of Life Sciences, Northwestern University Feinberg School of Medicine , Chicago, Illinois., Zhu Y; 1 Department of Radiation Oncology, Robert Lurie Cancer Center, Northwestern University Feinberg School of Medicine , Chicago, Illinois., Jiang H; 1 Department of Radiation Oncology, Robert Lurie Cancer Center, Northwestern University Feinberg School of Medicine , Chicago, Illinois., Parisiadou L; 1 Department of Radiation Oncology, Robert Lurie Cancer Center, Northwestern University Feinberg School of Medicine , Chicago, Illinois., Gius D; 1 Department of Radiation Oncology, Robert Lurie Cancer Center, Northwestern University Feinberg School of Medicine , Chicago, Illinois.

المصدر: Antioxidants & redox signaling [Antioxid Redox Signal] 2017 May 20; Vol. 26 (15), pp. 849-863. Date of Electronic Publication: 2016 Sep 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 100888899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-7716 (Electronic) Linking ISSN: 15230864 NLM ISO Abbreviation: Antioxid Redox Signal Subsets: MEDLINE

مواضيع طبية MeSH: Mitophagy*, Mitochondria/*metabolism , Mitochondrial Proteins/*metabolism , Sirtuin 2/*deficiency, Acetylation ; Animals ; Cells, Cultured ; Humans ; Mice ; Mice, Knockout ; Sirtuin 2/genetics ; Sirtuin 2/metabolism