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المؤلفون: Jimmy D. Ballard, Adam S Duerfeldt, Tyler M. Shadid, Catherine E Bishop, Megan L. Kempher, Nathan P. Lavey
المصدر: J Bacteriol
مصطلحات موضوعية: medicine.medical_treatment, Mutant, Druggability, Virulence, Biology, Microbiology, Bortezomib, Bacterial Proteins, Genome editing, medicine, Humans, Protein Isoforms, Coding region, Molecular Biology, Gene Editing, Spores, Bacterial, Protease, Clostridioides difficile, Gene Expression Regulation, Bacterial, Phenotype, Stop codon, Mutation, Clostridium Infections, Research Article
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d89e26f317c6077b2567f28c48fbb15
https://doi.org/10.1128/jb.00411-21 -
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المؤلفون: Tyler M. Shadid, Jimmy D. Ballard, Adam S. Duerfeldt, Nathan P. Lavey
المصدر: ACS Infectious Diseases. 5:79-89
مصطلحات موضوعية: Proteomics, 0301 basic medicine, Gene isoform, Proteases, medicine.medical_treatment, 030106 microbiology, Virulence, Context (language use), Article, 03 medical and health sciences, Depsipeptides, medicine, Pathogen, Serine protease, Protease, Sequence Homology, Amino Acid, biology, Clostridioides difficile, Endopeptidase Clp, Gene Expression Regulation, Bacterial, Cell biology, Isoenzymes, 030104 developmental biology, Infectious Diseases, Proteolysis, biology.protein, Function (biology)
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المؤلفون: Adam S. Duerfeldt, Jimmy D. Ballard, Bishop Ce, Tyler M. Shadid, Nathan P. Lavey, Nagib Ahsan, Megan L. Kempher
مصطلحات موضوعية: Genetics, Protease, Genome editing, medicine.medical_treatment, Mutant, medicine, Coding region, Virulence, Biology, Phenotype, Function (biology), Stop codon
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a32a074964ca2f525095c02fe32f81e2
https://doi.org/10.1101/2021.02.05.429978 -
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المؤلفون: Jessica E. Knobbe, Yu-Shan Lin, Jesse A. Coker, Yangxiong Li, Adam S. Duerfeldt, Hongtao Yu, Susan L. Nimmo, Dat C. Truong, Nathan P. Lavey
المصدر: ACS medicinal chemistry letters. 8(11)
مصطلحات موضوعية: 0301 basic medicine, Depsipeptide, Stereochemistry, Organic Chemistry, Target engagement, Biological activity, Biology, 010402 general chemistry, 01 natural sciences, Biochemistry, Molecular conformation, 0104 chemical sciences, 03 medical and health sciences, 030104 developmental biology, Mechanism of action, Drug Discovery, medicine, medicine.symptom, Antibacterial activity
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المؤلفون: Nathan P. Lavey, Adam S. Duerfeldt, Eliza A. Ruben, Jesse A. Coker
المصدر: Journal of natural products. 79(4)
مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, medicine.medical_treatment, Pharmaceutical Science, Biology, Bioinformatics, 01 natural sciences, Non peptide, Catalysis, Article, Analytical Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Sclerotiamide, Structure-Activity Relationship, Drug Discovery, Endopeptidases, medicine, Spiro Compounds, Antibacterial drug, Nuclear Magnetic Resonance, Biomolecular, Pharmacology, chemistry.chemical_classification, Biological Products, Natural product, Protease, Chemotype, Molecular Structure, 010405 organic chemistry, Activator (genetics), Organic Chemistry, Indolizines, 0104 chemical sciences, Anti-Bacterial Agents, 030104 developmental biology, Enzyme, Complementary and alternative medicine, Biochemistry, chemistry, Molecular Medicine