نتائج البحث - "Nehal J. Patel"

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دورية أكاديمية

Spectrin-Based Regulation of Cardiac Fibroblast Cell-Cell Communication

المؤلفون: Drew M. Nassal, Rebecca Shaheen, Nehal J. Patel, Jane Yu, Nick Leahy, Dimitra Bibidakis, Narasimham L. Parinandi, Thomas J. Hund

المصدر: Cells, Vol 12, Iss 5, p 748 (2023)

مصطلحات موضوعية: cell-cell communication, cardiac fibroblast, spectrin, STAT3, exosomes, Cytology, QH573-671

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/5/748; https://doaj.org/toc/2073-4409

URL الوصول: https://doaj.org/article/a29e01bbb1b5463981044fe26df50d80

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CaMKII-dependent late Na+current increases electrical dispersion and arrhythmia in ischemia-reperfusion

المؤلفون: Amara Greer-Short, Thomas J. Hund, Peter J. Mohler, Drew M. Nassal, Tony Satroplus, Taylor Howard, Nehal J. Patel

المصدر: American Journal of Physiology-Heart and Circulatory Physiology. 315:H794-H801

مصطلحات موضوعية: Male, 0301 basic medicine, Time Factors, Physiology, Ischemia, Action Potentials, Mice, Transgenic, Myocardial Reperfusion Injury, 030204 cardiovascular system & hematology, Na current, NAV1.5 Voltage-Gated Sodium Channel, 03 medical and health sciences, 0302 clinical medicine, Heart Rate, Physiology (medical), Ca2+/calmodulin-dependent protein kinase, Dispersion (optics), Serine, medicine, Animals, Point Mutation, cardiovascular diseases, Phosphorylation, Chemistry, Sodium, Arrhythmias, Cardiac, Isolated Heart Preparation, medicine.disease, Protein kinase II, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, cardiovascular system, Biophysics, Action potential duration, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Cardiology and Cardiovascular Medicine, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17218bdd540d8ef19457cf809ce9977a
https://doi.org/10.1152/ajpheart.00197.2018

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المؤلفون: Drew M, Nassal, Nehal J, Patel, Sathya D, Unudurthi, Rebecca, Shaheen, Jane, Yu, Peter J, Mohler, Thomas J, Hund

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Male, βIVifKO, inducible fibroblast-specific βIV-spectrin knockout mouse, βIV-spectrin, FDR, false discovery rate, macromolecular substances, CF, cardiac fibroblast, STAT3, qv3J, mutant βIV-spectrin allele C-terminal region containing CaMKII interaction motif, Mice, βIV-S2254E, βIV-spectrin with glutamic acid substitution at serine 2254 (phosphomimetic), cDNA, complementary DNA, NIH, National Institutes of Health, CHX, cycloheximide, FBS, fetal bovine serum, Chlorocebus aethiops, Animals, Phosphorylation, Myofibroblasts, Cells, Cultured, Cell Proliferation, calmodulin kinase II, DMEM, Dulbecco's modified Eagle's medium, Myocardium, AngII, angiotensin II, fibrosis, qPCR, quantitative real-time PCR, Spectrin, cardiac fibroblast, Endomyocardial Fibrosis, Myocardial Contraction, ECM, extracellular matrix, Mice, Inbred C57BL, qv4J, mutant βIV-spectrin allele lacking repeats 10 through C terminus, CaMKII, Ca2+/calmodulin-dependent kinase II, Amino Acid Substitution, COS Cells, STAT3, signal transducer and activation of transcription 3, Female, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Research Article, DAPI, 4′,6-diamidino-2-phenylindole, HA, hemagglutinin, MS/MS, tandem MS/MS

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::489fe6d1e0962abf301fa87dc4345e10
https://pubmed.ncbi.nlm.nih.gov/34153319

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Emerging therapeutic targets for cardiac arrhythmias: role of STAT3 in regulating cardiac fibroblast function

المؤلفون: Nehal J. Patel, Drew M. Nassal, Thomas J. Hund, Daniel Gratz

المصدر: Expert Opin Ther Targets

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91cfede265ed21365696b5f4b4287e05

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Fibroblast growth factor-inducible 14 mediates macrophage infiltration in heart to promote pressure overload-induced cardiac dysfunction

المؤلفون: Drew M. Nassal, Curtis G. Pierson, Shyam S. Bansal, Evelyn Thomas, Nehal J. Patel, Peter J. Mohler, Thomas J. Hund, Jane Yu, Sathya D. Unudurthi

المصدر: Life Sci

مصطلحات موضوعية: 0301 basic medicine, Cardiac function curve, Male, Cardiac fibrosis, medicine.medical_treatment, Blood Pressure, Fibroblast growth factor, 030226 pharmacology & pharmacy, General Biochemistry, Genetics and Molecular Biology, Article, Cell Line, 03 medical and health sciences, Mice, 0302 clinical medicine, Fibrosis, medicine, Animals, Humans, General Pharmacology, Toxicology and Pharmaceutics, Chemokine CCL2, Pressure overload, Heart Failure, Inflammation, business.industry, Macrophages, NF-kappa B, Cytokine TWEAK, Heart, General Medicine, medicine.disease, Up-Regulation, Fibroblast Growth Factors, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Cytokine, TWEAK Receptor, Heart failure, Cancer research, Tumor necrosis factor alpha, Female, Tumor Necrosis Factor Inhibitors, business, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99865505b7757083d2a645eb6c117c2c
https://pubmed.ncbi.nlm.nih.gov/32070706

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βIV-Spectrin/STAT3 complex regulates fibroblast phenotype, fibrosis, and cardiac function

المؤلفون: Benjamin W Scandling, Drew M. Nassal, Sathya D. Unudurthi, Daniel Gratz, Xianyao Xu, Federica Accornero, Thomas J. Hund, Keith J. Gooch, Peter J. Mohler, Amara Greer-Short, Anuradha Kalyanasundaram, Vadim V. Fedorov, Nehal J. Patel

المصدر: JCI Insight. 4

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5223a42f2ff8021ccc70ec3d0e41b7f3
https://doi.org/10.1172/jci.insight.131046

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Spectrin-based pathways underlying electrical and mechanical dysfunction in cardiac disease

المؤلفون: Nehal J. Patel, Drew M. Nassal, Amara Greer-Short, Sathya D. Unudurthi, Thomas J. Hund

المصدر: Expert Review of Cardiovascular Therapy. 16:59-65

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2130074d8c00c72689486ff451deba
https://doi.org/10.1080/14779072.2018.1418664

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Ca2+/calmodulin kinase II–dependent regulation of βIV-spectrin modulates cardiac fibroblast gene expression, proliferation, and contractility

المؤلفون: Drew M. Nassal, Peter J. Mohler, Jane Yu, Sathya D. Unudurthi, Thomas J. Hund, Rebecca Shaheen, Nehal J. Patel

المصدر: Journal of Biological Chemistry. 297:100893

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::890dae6527adba4bc2f316cf93d966fe
https://doi.org/10.1016/j.jbc.2021.100893

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Abstract 229: TWEAK-Fn14 Axis: A Potential Therapeutic Target for Treating Heart Failure

المؤلفون: Nehal J. Patel, Evelyn Thomas, Thomas J. Hund, Alexander J. Winkle, Sathyadev Unudurthi, Daniel Gratz

المصدر: Circulation Research. 125

مصطلحات موضوعية: medicine.medical_specialty, Chemokine, biology, Physiology, business.industry, Complex disease, Inflammation, medicine.disease, Downregulation and upregulation, Fibrosis, Internal medicine, Heart failure, Cardiology, biology.protein, Medicine, Cardiac structure, medicine.symptom, Cardiology and Cardiovascular Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1850b94a5d0e9927fa0af8cbf43bd5d2
https://doi.org/10.1161/res.125.suppl_1.229

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Abstract 844: β IV -spectrin Regulates Cardiac Fibroblast Phenotype, Fibrosis, and Cardiac Function

المؤلفون: Benjamin W Scandling, Nehal J. Patel, Drew M. Nassal, Amara Greer-Short, Thomas J. Hund, Sathya D. Unudurthi, Xianyao Xu, Keith J. Gooch, Peter J. Mohler

المصدر: Circulation Research. 125

مصطلحات موضوعية: Cardiac function curve, Cell physiology, Pathology, medicine.medical_specialty, Physiology, business.industry, Increased fibrosis, medicine.disease, Phenotype, Cardiac fibroblast, Fibrosis, Heart failure, medicine, Spectrin, Cardiology and Cardiovascular Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::50c186aa07d7ec693fbca29aa6d453b7
https://doi.org/10.1161/res.125.suppl_1.844

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