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1
المؤلفون: Abbey L. Perl, Yiannis A. Ioannou, Avi Ma'ayan, Shen Yao, Analisa DiFeo, Rosalie C. Sears, Qiaonan Duan, Giridharan Gokulrangan, Zhizhi Wang, Caitlin M. O’Connor, Matthew D. Galsky, Jaya Sangodkar, Danica Wiredja, Eric Yuan, David L. Brautigan, Mark R. Chance, Manish Datt, Heather M. Giannini, Kimberly McClinch, Daniel McQuaid, Sahar Mazhar, Neil S. Dhawan, Elena Svenson, Michael Ohlmeyer, Caroline C. Farrington, Alice C. Levine, Rita Tohme, Lifu Wang, Janna Kiselar, Goutham Narla, Rita A. Avelar, Shozeb Haider, Agnes Stachnik, David B. Kastrinsky, Daniela Schlatzer, Divya Hoon, Wenqing Xu, Alain C. Borczuk, Neelesh Sharma, Nilesh Zaware, Vickram Gidwani, Edward Y. Chen, Sudeh Izadmehr, Blake E. Smith, Daniel Leonard
المصدر: Journal of Clinical Investigation. 127:2081-2090
مصطلحات موضوعية: Male, 0301 basic medicine, Cell Survival, Phosphatase, Enzyme Activators, Mice, Nude, Antineoplastic Agents, Mice, Transgenic, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, Enzyme activator, Cell Line, Tumor, medicine, Animals, Humans, Protein Phosphatase 2, Mice, Inbred BALB C, business.industry, Kinase, Cancer, General Medicine, Protein phosphatase 2, medicine.disease, Xenograft Model Antitumor Assays, Small molecule, Tumor Burden, Enzyme Activation, 030104 developmental biology, Drug Resistance, Neoplasm, Immunology, Cancer cell, Cancer research, Signal transduction, business, Protein Binding, Signal Transduction, Research Article
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2
المؤلفون: Goutham Narla, Jaya Sangodkar, Avi Ma'ayan, Rita Tohme, Neal Vasireddi, Sai Gandhe, Neil S. Dhawan, Michael Ohlmeyer, Sudeh Izadmehr, Matthew D. Galsky, Neelesh Sharma, Giancarlo Tabaro, Sanjay Vallabhaneni, Ava Thomas
المصدر: JCI Insight. 4
مصطلحات موضوعية: Male, 0301 basic medicine, MAPK/ERK pathway, Lung Neoplasms, MAP Kinase Signaling System, medicine.drug_class, Afatinib, Enzyme Activators, Adenocarcinoma of Lung, Apoptosis, Tyrosine-kinase inhibitor, Mice, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, Phosphoprotein Phosphatases, medicine, Animals, Humans, Lung cancer, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Cell Proliferation, Chemistry, General Medicine, Protein phosphatase 2, medicine.disease, Xenograft Model Antitumor Assays, respiratory tract diseases, ErbB Receptors, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer research, Female, Phosphatidylinositol 3-Kinase, Tyrosine kinase, Research Article, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de382d9af5070d2236b74d6ec74e25ff
https://doi.org/10.1172/jci.insight.125693 -
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المؤلفون: Alex P. Scopton, Arvin C. Dar, Neil S. Dhawan
المصدر: Nature. 537:112-116
مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Mutation, Multidisciplinary, Kinase, Allosteric regulation, Regulator, Plasma protein binding, Biology, medicine.disease_cause, 3. Good health, Cell biology, 03 medical and health sciences, 030104 developmental biology, Biochemistry, medicine, Phosphorylation, Protein kinase A
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4دورية أكاديمية
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المؤلفون: Jaya Sangodkar, Goutham Narla, Nilesh Zaware, Sudeh Izadmehr, David B. Kastrinsky, Michael Ohlmeyer, Neil S. Dhawan
المصدر: Bioorg Med Chem
مصطلحات موضوعية: Clomipramine, Side effect, Cell Survival, Transplantation, Heterologous, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Pharmacology, Biochemistry, Article, Mice, Phosphatidylinositol 3-Kinases, chemistry.chemical_compound, Dibenzazepines, Phenothiazines, In vivo, Cell Line, Tumor, Neoplasms, Phenothiazine, Drug Discovery, medicine, Animals, Humans, Potency, Molecular Biology, chemistry.chemical_classification, Organic Chemistry, Cancer, medicine.disease, In vitro, chemistry, Vesicular Monoamine Transport Proteins, Molecular Medicine, Heterocyclic Compounds, 3-Ring, Proto-Oncogene Proteins c-akt, Signal Transduction, medicine.drug, Tricyclic
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المؤلفون: Sudeh Izadmehr, Jaya Sangodkar, Nilesh Zaware, Caroline C. Farrington, Goutham Narla, Neil S. Dhawan, Heather M. Giannini, Michael Ohlmeyer, Kimberly McClinch, David B. Kastrinsky
المصدر: Bioorganicmedicinal chemistry. 23(23)
مصطلحات موضوعية: chemistry.chemical_classification, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Cancer, medicine.disease, Biochemistry, chemistry, Drug Discovery, Cancer research, medicine, Molecular Medicine, Molecular Biology, Tricyclic
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المؤلفون: Jaya Sangodkar, Sudeh Izadmehr, Caroline C. Farrington, Goutham Narla, Eric Yuan, Analisa DiFeo, Michael Ohlmeyer, Pearlann Arnovitz, Suzanna Katz, Neil S. Dhawan, Tara Albano, Matthew D. Galsky, David Burstein, Rachel Okrent, Katerina Politi, David Y. Zhang, Varan J. Singh, Sahar Mazhar, Huma Q. Rana, Heather Melville
المصدر: Journal of Clinical Investigation. 122:2637-2651
مصطلحات موضوعية: Lung Neoplasms, Transcription, Genetic, Active Transport, Cell Nucleus, Kruppel-Like Transcription Factors, Mice, Nude, Adenocarcinoma of Lung, Antineoplastic Agents, FOXO1, Adenocarcinoma, Biology, Real-Time Polymerase Chain Reaction, Erlotinib Hydrochloride, Mice, Cell Line, Tumor, Proto-Oncogene Proteins, Kruppel-Like Factor 6, medicine, Animals, Humans, Protein kinase B, Mice, Inbred BALB C, Forkhead Box Protein O1, Drug Synergism, Forkhead Transcription Factors, General Medicine, medicine.disease, Xenograft Model Antitumor Assays, Trifluoperazine, Tumor Burden, Enzyme Activation, ErbB Receptors, Gene Expression Regulation, Neoplastic, KLF6, Drug Resistance, Neoplasm, Cell culture, Mutation, Quinazolines, Cancer research, Female, Erlotinib, Signal transduction, Proto-Oncogene Proteins c-akt, Signal Transduction, Research Article, medicine.drug
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المؤلفون: Neil S. Dhawan, Arnab Chakravarti, Jeffrey J. Raizer, Paul J. Lukac, James P. Chandler, Jaclyn J. Renfrow, Griffith R. Harsh, Hannes Vogel, Markus Bredel, Adrienne C. Scheck
المصدر: Neuro-oncology. 13(8)
مصطلحات موضوعية: In situ, Proteomics, Cancer Research, medicine.diagnostic_test, Brain Neoplasms, Gene Amplification, In situ hybridization, Proximity ligation assay, Biology, Molecular biology, Cell biology, ErbB Receptors, Oncology, Gene duplication, Basic and Translational Investigations, medicine, Tumor Cells, Cultured, Humans, Neurology (clinical), Glioblastoma, Gene, Bradford protein assay, In Situ Hybridization, Fluorescence, Fluorescence in situ hybridization
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda345fae7652a2e5ec370e77639f36a
https://pubmed.ncbi.nlm.nih.gov/21798849 -
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المؤلفون: David Burstein, Goutham Narla, Huma Q. Rana, Vickram Gidwani, Heather Melville, Blake E. Smith, Varan J. Singh, Michael Ohlmeyer, Analisa DiFeo, Eric Yuan, Katerina Politi, Neil S. Dhawan, Jaya Sangodkar, Caroline C. Farrington, Rachel Okrent
المصدر: Cancer Research. 72:1885-1885
مصطلحات موضوعية: Cancer Research, biology, Tumor suppressor gene, FOXO1, medicine.disease_cause, Transactivation, Oncology, biology.protein, medicine, Cancer research, PTEN, Erlotinib, KRAS, Epidermal growth factor receptor, Protein kinase B, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fcc5080250dbedc7f196831c8d94d19b
https://doi.org/10.1158/1538-7445.am2012-1885 -
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المؤلفون: Neil S. Dhawan, Jaya Sangodkar, David B. Kastrinsky, Vickram Gidwani, Michael Ohlmeyer, Goutham Narla, Blake E. Smith
المصدر: Molecular Cancer Therapeutics. 10:A218-A218
مصطلحات موضوعية: MAPK/ERK pathway, Cancer Research, Chemistry, Trifluoperazine, Pharmacology, Small molecule, In vitro, Oncology, In vivo, medicine, Signal transduction, Protein kinase B, PI3K/AKT/mTOR pathway, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8239cc28c6586004902fdee0125898e0
https://doi.org/10.1158/1535-7163.targ-11-a218
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