المؤلفون: Johnson JL; Johnson & Johnson Innovative Medicine, Spring House, Pennsylvania, USA., Sargsyan D; Johnson & Johnson Innovative Medicine, Spring House, Pennsylvania, USA., Neiman EM; Johnson & Johnson Innovative Medicine, Spring House, Pennsylvania, USA., Hart A; Johnson & Johnson Innovative Medicine, Spring House, Pennsylvania, USA., Stojmirovic A; Johnson & Johnson Innovative Medicine, Spring House, Pennsylvania, USA., Kosoy R; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Icahn Institute for Data Science and Genomic Technology, New York, New York, USA., Irizar H; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Icahn Institute for Data Science and Genomic Technology, New York, New York, USA., Suárez-Fariñas M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Icahn Institute for Data Science and Genomic Technology, New York, New York, USA.; Center for Biostatistics, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Song WM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Icahn Institute for Data Science and Genomic Technology, New York, New York, USA., Argmann C; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Icahn Institute for Data Science and Genomic Technology, New York, New York, USA., Avey S; Johnson & Johnson Innovative Medicine, Spring House, Pennsylvania, USA., Shmuel-Galia L; Program in Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA., Vierbuchen T; Program in Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA., Bongers G; Johnson & Johnson Innovative Medicine, Spring House, Pennsylvania, USA., Sun Y; Johnson & Johnson Innovative Medicine, Spring House, Pennsylvania, USA., Edelstein L; Johnson & Johnson Innovative Medicine, Spring House, Pennsylvania, USA., Perrigoue J; Johnson & Johnson Innovative Medicine, Spring House, Pennsylvania, USA., Towne JE; Johnson & Johnson Innovative Medicine, Spring House, Pennsylvania, USA., Hall AO; Immunology Translational Early Development, Bristol Myers Squibb, Summit, New Jersey, USA., Fitzgerald KA; Program in Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA., Hoebe K; Johnson & Johnson Innovative Medicine, Spring House, Pennsylvania, USA.

المصدر: JCI insight [JCI Insight] 2024 Feb 08; Vol. 9 (3). Date of Electronic Publication: 2024 Feb 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE

مواضيع طبية MeSH: RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Colitis, Ulcerative*/genetics, Humans ; Gene Regulatory Networks ; Tumor Necrosis Factor-alpha/genetics ; Inflammation

المؤلفون: Peters LA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn Institute of Genomics and Multi-scale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Sema4, a Mount Sinai venture, Stamford, Connecticut, USA., Perrigoue J; Janssen Research and Development, LLC., Spring House, Pennsylvania, USA., Mortha A; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.; Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Iuga A; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, USA., Song WM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn Institute of Genomics and Multi-scale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Neiman EM; Janssen Research and Development, LLC., Spring House, Pennsylvania, USA., Llewellyn SR; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn Institute of Genomics and Multi-scale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Di Narzo A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn Institute of Genomics and Multi-scale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Kidd BA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn Institute of Genomics and Multi-scale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Telesco SE; Janssen Research and Development, LLC., Spring House, Pennsylvania, USA., Zhao Y; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn Institute of Genomics and Multi-scale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Stojmirovic A; Janssen Research and Development, LLC., Spring House, Pennsylvania, USA., Sendecki J; Janssen Research and Development, LLC., Spring House, Pennsylvania, USA., Shameer K; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn Institute of Genomics and Multi-scale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Miotto R; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn Institute of Genomics and Multi-scale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Institute for Next-Generation Healthcare, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Losic B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn Institute of Genomics and Multi-scale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Shah H; Icahn Institute of Genomics and Multi-scale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Lee E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn Institute of Genomics and Multi-scale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Wang M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn Institute of Genomics and Multi-scale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Faith JJ; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn Institute of Genomics and Multi-scale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Kasarskis A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn Institute of Genomics and Multi-scale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Brodmerkel C; Janssen Research and Development, LLC., Spring House, Pennsylvania, USA., Curran M; Janssen Research and Development, LLC., Spring House, Pennsylvania, USA., Das A; Janssen Research and Development, LLC., Spring House, Pennsylvania, USA., Friedman JR; Janssen Research and Development, LLC., Spring House, Pennsylvania, USA., Fukui Y; Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan., Humphrey MB; University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA., Iritani BM; Department of Comparative Medicine, University of Washington, Seattle, Washington, USA., Sibinga N; Department of Medicine (Cardiovascular Division), Albert Einstein College of Medicine, Bronx, New York, USA., Tarrant TK; Thurston Arthritis Research Center and Department of Medicine, Division of Rheumatology, Allergy, and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Argmann C; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn Institute of Genomics and Multi-scale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Hao K; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn Institute of Genomics and Multi-scale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Roussos P; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn Institute of Genomics and Multi-scale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Zhu J; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn Institute of Genomics and Multi-scale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Sema4, a Mount Sinai venture, Stamford, Connecticut, USA., Zhang B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn Institute of Genomics and Multi-scale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Dobrin R; Janssen Research and Development, LLC., Spring House, Pennsylvania, USA.; Bristol-Myers Squibb, Research &Development, Pennington, New Jersey, USA., Mayer LF; The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Division of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Schadt EE; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Icahn Institute of Genomics and Multi-scale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Sema4, a Mount Sinai venture, Stamford, Connecticut, USA.

المصدر: Nature genetics [Nat Genet] 2017 Oct; Vol. 49 (10), pp. 1437-1449. Date of Electronic Publication: 2017 Sep 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Gene Regulatory Networks* , Genes, Regulator* , Models, Genetic*, Genomics/*methods , Inflammatory Bowel Diseases/*genetics, Adoptive Transfer ; Animals ; Causality ; Cells, Cultured ; Colitis/chemically induced ; Colitis/genetics ; Datasets as Topic ; Disease Models, Animal ; Female ; Gene Knockdown Techniques ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Intestinal Mucosa/metabolism ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; RNA, Small Interfering/genetics ; T-Lymphocyte Subsets/transplantation ; Transcriptome

المؤلفون: Benetatos CA; Authors' Affiliations: TetraLogic Pharmaceuticals, 343 Phoenixville Pike, Malvern, Pennsylvania; and Tsinghua University School of Medicine, Beijing, China., Mitsuuchi Y, Burns JM, Neiman EM, Condon SM, Yu G, Seipel ME, Kapoor GS, Laporte MG, Rippin SR, Deng Y, Hendi MS, Tirunahari PK, Lee YH, Haimowitz T, Alexander MD, Graham MA, Weng D, Shi Y, McKinlay MA, Chunduru SK

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2014 Apr; Vol. 13 (4), pp. 867-79. Date of Electronic Publication: 2014 Feb 21.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Breast Neoplasms/*drug therapy , Dipeptides/*pharmacology , Gene Expression Regulation, Neoplastic/*drug effects , Indoles/*pharmacology, Animals ; Breast Neoplasms/pathology ; Caspase 8/metabolism ; Cell Line, Tumor ; Drug Synergism ; Female ; Humans ; Inhibitor of Apoptosis Proteins/metabolism ; Mice, Nude ; Mitochondrial Proteins/metabolism ; Receptors, Tumor Necrosis Factor ; Signal Transduction/drug effects ; TNF Receptor-Associated Factor 2/metabolism

المؤلفون: Krepler C; Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA., Chunduru SK, Halloran MB, He X, Xiao M, Vultur A, Villanueva J, Mitsuuchi Y, Neiman EM, Benetatos C, Nathanson KL, Amaravadi RK, Pehamberger H, McKinlay M, Herlyn M

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2013 Apr 01; Vol. 19 (7), pp. 1784-94. Date of Electronic Publication: 2013 Feb 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Molecular Mimicry*, Dipeptides/*pharmacology , Indoles/*pharmacology , Intracellular Signaling Peptides and Proteins/*metabolism , Melanoma/*metabolism , Mitochondrial Proteins/*metabolism, Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/pharmacology ; Apoptosis Regulatory Proteins ; Baculoviral IAP Repeat-Containing 3 Protein ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dipeptides/administration & dosage ; Disease Models, Animal ; Humans ; Indoles/administration & dosage ; Inhibitor of Apoptosis Proteins/metabolism ; Intracellular Signaling Peptides and Proteins/chemistry ; Melanoma/drug therapy ; Melanoma/pathology ; Mice ; Mitochondrial Proteins/chemistry ; Spheroids, Cellular ; Tumor Burden/drug effects ; Tumor Cells, Cultured ; Tumor Necrosis Factor-alpha/pharmacology ; Ubiquitin-Protein Ligases ; Xenograft Model Antitumor Assays