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المؤلفون: L. Lepescheux, R. Gosmini, F. De Ceuninck, Thierry Christophe, E. van der Aar, I. Botez, Nele Vandervoort, Pierre Deprez, D. Amantini, Roland Blanque, D. Merciris, Robert Touitou, Philippe Clément-Lacroix, C. Cottereaux, S. Meurisse, Patrick Mollat, F. Brebion, D. Comas, Christopher B. Little, Margaret M. Smith
المصدر: Osteoarthritis and Cartilage. 30:291-301
مصطلحات موضوعية: Metalloproteinase, biology, Chemistry, Cartilage, Biomedical Engineering, Osteoarthritis, Pharmacology, medicine.disease, Piperazines, Rats, Glycosaminoglycan, Mice, medicine.anatomical_structure, Rheumatology, Proteoglycan, In vivo, biology.protein, medicine, Animals, Humans, Orthopedics and Sports Medicine, ADAMTS5 Protein, Aggrecan, Aggrecanase
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المؤلفون: Alain Monjardet, Thierry Christophe, Nicolas Triballeau, Helene Jary, Luke Jonathan Alvey, Romain Luc Marie Gosmini, Frédéric André De Ceuninck, Pierre Deprez, Robert Touitou, Roland Blanque, D. Amantini, Nele Vandervoort, Ellen van der Aar, Philip Leonard, F. Brebion, Patrick Mollat, Natacha Bienvenu, C. Cottereaux, I. Botez, Varin Marie Laurence Claire, Christophe Peixoto
المصدر: Journal of Medicinal Chemistry. 64:2937-2952
مصطلحات موضوعية: Cartilage, Articular, Models, Molecular, Osteoarthritis, Pharmacology, 01 natural sciences, law.invention, Glycosaminoglycan, Mice, 03 medical and health sciences, Dogs, law, Drug Discovery, medicine, Animals, Humans, IC50, Aggrecan, Glycosaminoglycans, 030304 developmental biology, Aggrecanase, 0303 health sciences, Chemistry, Cartilage, ADAMTS, medicine.disease, Rats, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, Recombinant DNA, Molecular Medicine, ADAMTS5 Protein
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المؤلفون: Graeme Milligan, Luke Jonathan Alvey, Annick Hagers, Thierry Christophe, Emanuelle Wakselman, Luc Nelles, Line Oste, Steve De Vos, Ann Vandevelde, Katja Conrath, Laurent Saniere, Stephen Robert Fletcher, Laura Jenkins, Sandrine Le Tallec, D. Merciris, Pierre Deprez, Roland Blanque, C. Cottereaux, Romain Luc Marie Gosmini, Ellen van der Aar, Cécile da Costa, Sonia Dupont, Thi Thu Trang Mai, Vanessa Quenehen, Labeguere Frederic Gilbert, Philippe Clément-Lacroix, Florilène Soulas, Reginald Brys, Gregory John Robert Newsome, Nele Vandervoort, Amynata Tirera
المصدر: Journal of Medicinal Chemistry. 63:13526-13545
مصطلحات موضوعية: 0303 health sciences, Allosteric modulator, Drug discovery, Antagonist, Guanosine, Pharmacology, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, chemistry, Sulfasalazine, Drug Discovery, medicine, GPR84, Molecular Medicine, Potency, Receptor, 030304 developmental biology, medicine.drug
وصف الملف: application/pdf
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المؤلفون: Frédéric, Labéguère, Sonia, Dupont, Luke, Alvey, Florilène, Soulas, Gregory, Newsome, Amynata, Tirera, Vanessa, Quenehen, Thi Thu Trang, Mai, Pierre, Deprez, Roland, Blanqué, Line, Oste, Sandrine, Le Tallec, Steve, De Vos, Annick, Hagers, Ann, Vandevelde, Luc, Nelles, Nele, Vandervoort, Katja, Conrath, Thierry, Christophe, Ellen, van der Aar, Emanuelle, Wakselman, Didier, Merciris, Céline, Cottereaux, Cécile, da Costa, Laurent, Saniere, Philippe, Clement-Lacroix, Laura, Jenkins, Graeme, Milligan, Stephen, Fletcher, Reginald, Brys, Romain, Gosmini
المصدر: Journal of medicinal chemistry. 63(22)
مصطلحات موضوعية: Male, Mice, Inbred BALB C, Drug Evaluation, Preclinical, Acetates, Rats, Receptors, G-Protein-Coupled, Rats, Sprague-Dawley, Mice, Dogs, HEK293 Cells, Allosteric Regulation, Drug Discovery, Microsomes, Liver, Animals, Humans, Female, Caco-2 Cells, Cells, Cultured
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المؤلفون: Christelle David, Nele Vandervoort, Damien Fleury, Denis Annoot, Laëtitia Cherel, Willem Jan Hengeveld, Thierry Christophe, Sameh H. Soror, Agnès Marie Joncour, Christopher Gaëtan Housseman, Alain Monjardet, R Galien, Patrick Mollat, Reginald Brys, Veronique Roncoroni, Luce Lepissier, Natacha Bienvenu, Lionel Vercheval, Alexandre Wohlkonig, Christophe Peixoto, Jörg Heiermann, Katja Conrath, Mia Jans, Sandrine Le Tallec, Bertrand Heckmann, Robert Touitou, Nicolas Desroy, Jan Steyaert, Virginie Labeguere, Gregor Pilzak, Ellen van der Aar, Xavier Marie Bock, Nicolas Triballeau, Emanuelle Wakselman
المساهمون: Department of Bio-engineering Sciences, Structural Biology Brussels
المصدر: Journal of Medicinal Chemistry. 60:7371-7392
مصطلحات موضوعية: Male, 0301 basic medicine, Phosphodiesterase Inhibitors, Pyridines, Stereochemistry, Inflammation, 01 natural sciences, Cocrystal, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Lysophosphatidic acid, Hydrolase, medicine, Animals, Humans, Structure–activity relationship, chemistry.chemical_classification, Phosphoric Diester Hydrolases, 010405 organic chemistry, Chemistry, Drug discovery, Imidazoles, Lysophosphatidylcholines, Rats, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, Enzyme, Biochemistry, Molecular Medicine, lipids (amino acids, peptides, and proteins), Lysophospholipids, Autotaxin, medicine.symptom
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المؤلفون: E. van der Aar, L. Lepescheux, I. Botez, Thierry Christophe, F. Brebion, Pierre Deprez, Roland Blanque, D. Merciris, S. Meurisse, Monica Borgonovi, R. Gosmini, F. De Ceuninck, Patrick Mollat, Philippe Clément-Lacroix, D. Comas, Nele Vandervoort, C. Cottereaux, D. Amantini
المصدر: FRIDAY, 15 JUNE 2018.
مصطلحات موضوعية: Fibrillation, medicine.medical_specialty, business.industry, ADAMTS, Cartilage, Arthritis, Hindlimb, Osteoarthritis, medicine.disease, medicine.anatomical_structure, Endocrinology, Internal medicine, medicine, medicine.symptom, business, Aggrecan, Aggrecanase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::740fa263bcd0d73ca8948c97a8e26acf
https://doi.org/10.1136/annrheumdis-2018-eular.2610 -
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المؤلفون: R. Gosmini, E. van der Aar, Pierre Deprez, Roland Blanque, Thierry Christophe, L. Lepescheux, Christopher B. Little, Philippe Clément-Lacroix, F. Brebion, C. Cottereaux, D. Amantini, I. Botez, Patrick Mollat, D. Comas, Nele Vandervoort, F. De Ceuninck, S. Meurisse
المصدر: Oral Presentations.
مصطلحات موضوعية: Metalloproteinase, business.industry, ADAMTS, Cartilage, Assay, Osteoarthritis, Matrix metalloproteinase, Pharmacology, medicine.disease, In vitro, medicine.anatomical_structure, In vivo, Medicine, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9202796e0b4780d3509f8d554349e78c
https://doi.org/10.1136/annrheumdis-2017-eular.3775 -
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المؤلفون: Nele Vandervoort, Xavier Marie Bock, Patrick Mollat, Jovica Ralić, Alain Monjardet, Nicolas Triballeau, Thierry Christophe, Ellen van der Aar, Marieke Lamers, Boska Hrvacic, Nicolas Desroy, Bertrand Heckmann, Line Oste, Emilie Rondet, Virginie Labeguere, Roland Blanque, Veronique Roncoroni, Christopher Gaëtan Housseman, Sandrine Le Tallec, Natacha Bienvenu, C. Cottereaux, M. Auberval, Reginald Brys, Laëtitia Cherel, Emanuelle Wakselman, Picolet Olivier Laurent, Jean-Marie Grassot, Agnès Marie Joncour, Christophe Peixoto, Denis Annoot
مصطلحات موضوعية: 0301 basic medicine, hERG, Pharmacology, autoaxin inhibitor, LPA, pulmonary fibrosis, bleomycin-induced model in mice, 03 medical and health sciences, Idiopathic pulmonary fibrosis, chemistry.chemical_compound, Mice, 0302 clinical medicine, In vivo, Drug Discovery, Pulmonary fibrosis, medicine, Animals, Humans, Thiazole, Mice, Knockout, Lung, medicine.diagnostic_test, biology, Chemistry, Phosphoric Diester Hydrolases, Imidazoles, medicine.disease, Idiopathic Pulmonary Fibrosis, Rats, 030104 developmental biology, Bronchoalveolar lavage, medicine.anatomical_structure, Pyrimidines, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, lipids (amino acids, peptides, and proteins), Autotaxin
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c6f6e80895c7ca93e77aad9243c383
https://www.bib.irb.hr/981523 -
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المؤلفون: C. Cottereaux, R. Gosmini, E. van der Aar, D. Amantini, Nele Vandervoort, L. Lepescheux, Patrick Mollat, D. Comas, Pierre Deprez, Roland Blanque, Thierry Christophe, F. Brebion, Christopher B. Little, I. Botez, Philippe Clément-Lacroix, F. De Ceuninck, S. Meurisse
المصدر: Osteoarthritis and Cartilage. 25:S58-S59
مصطلحات موضوعية: 030203 arthritis & rheumatology, 0301 basic medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Rheumatology, business.industry, ADAMTS, Biomedical Engineering, Medicine, Orthopedics and Sports Medicine, Pharmacology, business
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المؤلفون: Reginald Brys, Emanuelle Wakselman, Lionel Vercheval, Christelle David, Nele Vandervoort, Laëtitia Cherel, Christopher Gaëtan Housseman, Luce Lepissier, Natacha Bienvenu, Mia Jans, Alain Monjardet, Agnès Marie Joncour, Nicolas Desroy, Gregor Pilzak, Willem Jan Hengeveld, Sandrine Le Tallec, Ellen van der Aar, Bertrand Heckmann, Nicolas Triballeau, Jan Steyaert, Patrick Mollat, Veronique Roncoroni, Virginie Labeguere, Sameh H. Soror, Damien Fleury, Thierry Christophe, Christophe Peixoto, Xavier Marie Bock, Denis Annoot, Jörg Heiermann, Katja Conrath, R Galien, Robert Touitou, Alexandre Wohlkonig
المصدر: Journal of Medicinal Chemistry. 61:4270-4270
مصطلحات موضوعية: chemistry.chemical_compound, Series (mathematics), chemistry, Stereochemistry, Drug Discovery, Pyridine, Molecular Medicine, Structure–activity relationship, Autotaxin