المؤلفون: L. Lepescheux, R. Gosmini, F. De Ceuninck, Thierry Christophe, E. van der Aar, I. Botez, Nele Vandervoort, Pierre Deprez, D. Amantini, Roland Blanque, D. Merciris, Robert Touitou, Philippe Clément-Lacroix, C. Cottereaux, S. Meurisse, Patrick Mollat, F. Brebion, D. Comas, Christopher B. Little, Margaret M. Smith

المصدر: Osteoarthritis and Cartilage. 30:291-301

مصطلحات موضوعية: Metalloproteinase, biology, Chemistry, Cartilage, Biomedical Engineering, Osteoarthritis, Pharmacology, medicine.disease, Piperazines, Rats, Glycosaminoglycan, Mice, medicine.anatomical_structure, Rheumatology, Proteoglycan, In vivo, biology.protein, medicine, Animals, Humans, Orthopedics and Sports Medicine, ADAMTS5 Protein, Aggrecan, Aggrecanase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3703c4b9781633c63762275b997650
https://doi.org/10.1016/j.joca.2021.08.012

المؤلفون: Alain Monjardet, Thierry Christophe, Nicolas Triballeau, Helene Jary, Luke Jonathan Alvey, Romain Luc Marie Gosmini, Frédéric André De Ceuninck, Pierre Deprez, Robert Touitou, Roland Blanque, D. Amantini, Nele Vandervoort, Ellen van der Aar, Philip Leonard, F. Brebion, Patrick Mollat, Natacha Bienvenu, C. Cottereaux, I. Botez, Varin Marie Laurence Claire, Christophe Peixoto

المصدر: Journal of Medicinal Chemistry. 64:2937-2952

مصطلحات موضوعية: Cartilage, Articular, Models, Molecular, Osteoarthritis, Pharmacology, 01 natural sciences, law.invention, Glycosaminoglycan, Mice, 03 medical and health sciences, Dogs, law, Drug Discovery, medicine, Animals, Humans, IC50, Aggrecan, Glycosaminoglycans, 030304 developmental biology, Aggrecanase, 0303 health sciences, Chemistry, Cartilage, ADAMTS, medicine.disease, Rats, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, Recombinant DNA, Molecular Medicine, ADAMTS5 Protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63e1d09bcd2c3ffc719892459e89ab3
https://doi.org/10.1021/acs.jmedchem.0c02008

المؤلفون: Graeme Milligan, Luke Jonathan Alvey, Annick Hagers, Thierry Christophe, Emanuelle Wakselman, Luc Nelles, Line Oste, Steve De Vos, Ann Vandevelde, Katja Conrath, Laurent Saniere, Stephen Robert Fletcher, Laura Jenkins, Sandrine Le Tallec, D. Merciris, Pierre Deprez, Roland Blanque, C. Cottereaux, Romain Luc Marie Gosmini, Ellen van der Aar, Cécile da Costa, Sonia Dupont, Thi Thu Trang Mai, Vanessa Quenehen, Labeguere Frederic Gilbert, Philippe Clément-Lacroix, Florilène Soulas, Reginald Brys, Gregory John Robert Newsome, Nele Vandervoort, Amynata Tirera

المصدر: Journal of Medicinal Chemistry. 63:13526-13545

مصطلحات موضوعية: 0303 health sciences, Allosteric modulator, Drug discovery, Antagonist, Guanosine, Pharmacology, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, chemistry, Sulfasalazine, Drug Discovery, medicine, GPR84, Molecular Medicine, Potency, Receptor, 030304 developmental biology, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8f803bd9662806c89d70fe1a829f85
https://doi.org/10.1021/acs.jmedchem.0c00272

المؤلفون: Frédéric, Labéguère, Sonia, Dupont, Luke, Alvey, Florilène, Soulas, Gregory, Newsome, Amynata, Tirera, Vanessa, Quenehen, Thi Thu Trang, Mai, Pierre, Deprez, Roland, Blanqué, Line, Oste, Sandrine, Le Tallec, Steve, De Vos, Annick, Hagers, Ann, Vandevelde, Luc, Nelles, Nele, Vandervoort, Katja, Conrath, Thierry, Christophe, Ellen, van der Aar, Emanuelle, Wakselman, Didier, Merciris, Céline, Cottereaux, Cécile, da Costa, Laurent, Saniere, Philippe, Clement-Lacroix, Laura, Jenkins, Graeme, Milligan, Stephen, Fletcher, Reginald, Brys, Romain, Gosmini

المصدر: Journal of medicinal chemistry. 63(22)

مصطلحات موضوعية: Male, Mice, Inbred BALB C, Drug Evaluation, Preclinical, Acetates, Rats, Receptors, G-Protein-Coupled, Rats, Sprague-Dawley, Mice, Dogs, HEK293 Cells, Allosteric Regulation, Drug Discovery, Microsomes, Liver, Animals, Humans, Female, Caco-2 Cells, Cells, Cultured

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::dca817b6050468a00027ab8ce9b149c4
https://pubmed.ncbi.nlm.nih.gov/32902984

المؤلفون: Christelle David, Nele Vandervoort, Damien Fleury, Denis Annoot, Laëtitia Cherel, Willem Jan Hengeveld, Thierry Christophe, Sameh H. Soror, Agnès Marie Joncour, Christopher Gaëtan Housseman, Alain Monjardet, R Galien, Patrick Mollat, Reginald Brys, Veronique Roncoroni, Luce Lepissier, Natacha Bienvenu, Lionel Vercheval, Alexandre Wohlkonig, Christophe Peixoto, Jörg Heiermann, Katja Conrath, Mia Jans, Sandrine Le Tallec, Bertrand Heckmann, Robert Touitou, Nicolas Desroy, Jan Steyaert, Virginie Labeguere, Gregor Pilzak, Ellen van der Aar, Xavier Marie Bock, Nicolas Triballeau, Emanuelle Wakselman

المساهمون: Department of Bio-engineering Sciences, Structural Biology Brussels

المصدر: Journal of Medicinal Chemistry. 60:7371-7392

مصطلحات موضوعية: Male, 0301 basic medicine, Phosphodiesterase Inhibitors, Pyridines, Stereochemistry, Inflammation, 01 natural sciences, Cocrystal, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Lysophosphatidic acid, Hydrolase, medicine, Animals, Humans, Structure–activity relationship, chemistry.chemical_classification, Phosphoric Diester Hydrolases, 010405 organic chemistry, Chemistry, Drug discovery, Imidazoles, Lysophosphatidylcholines, Rats, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, Enzyme, Biochemistry, Molecular Medicine, lipids (amino acids, peptides, and proteins), Lysophospholipids, Autotaxin, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1bab957aedfbab6da364d90d0e33f16
https://doi.org/10.1021/acs.jmedchem.7b00647

المؤلفون: E. van der Aar, L. Lepescheux, I. Botez, Thierry Christophe, F. Brebion, Pierre Deprez, Roland Blanque, D. Merciris, S. Meurisse, Monica Borgonovi, R. Gosmini, F. De Ceuninck, Patrick Mollat, Philippe Clément-Lacroix, D. Comas, Nele Vandervoort, C. Cottereaux, D. Amantini

المصدر: FRIDAY, 15 JUNE 2018.

مصطلحات موضوعية: Fibrillation, medicine.medical_specialty, business.industry, ADAMTS, Cartilage, Arthritis, Hindlimb, Osteoarthritis, medicine.disease, medicine.anatomical_structure, Endocrinology, Internal medicine, medicine, medicine.symptom, business, Aggrecan, Aggrecanase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::740fa263bcd0d73ca8948c97a8e26acf
https://doi.org/10.1136/annrheumdis-2018-eular.2610

المؤلفون: R. Gosmini, E. van der Aar, Pierre Deprez, Roland Blanque, Thierry Christophe, L. Lepescheux, Christopher B. Little, Philippe Clément-Lacroix, F. Brebion, C. Cottereaux, D. Amantini, I. Botez, Patrick Mollat, D. Comas, Nele Vandervoort, F. De Ceuninck, S. Meurisse

المصدر: Oral Presentations.

مصطلحات موضوعية: Metalloproteinase, business.industry, ADAMTS, Cartilage, Assay, Osteoarthritis, Matrix metalloproteinase, Pharmacology, medicine.disease, In vitro, medicine.anatomical_structure, In vivo, Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9202796e0b4780d3509f8d554349e78c
https://doi.org/10.1136/annrheumdis-2017-eular.3775

المؤلفون: Nele Vandervoort, Xavier Marie Bock, Patrick Mollat, Jovica Ralić, Alain Monjardet, Nicolas Triballeau, Thierry Christophe, Ellen van der Aar, Marieke Lamers, Boska Hrvacic, Nicolas Desroy, Bertrand Heckmann, Line Oste, Emilie Rondet, Virginie Labeguere, Roland Blanque, Veronique Roncoroni, Christopher Gaëtan Housseman, Sandrine Le Tallec, Natacha Bienvenu, C. Cottereaux, M. Auberval, Reginald Brys, Laëtitia Cherel, Emanuelle Wakselman, Picolet Olivier Laurent, Jean-Marie Grassot, Agnès Marie Joncour, Christophe Peixoto, Denis Annoot

مصطلحات موضوعية: 0301 basic medicine, hERG, Pharmacology, autoaxin inhibitor, LPA, pulmonary fibrosis, bleomycin-induced model in mice, 03 medical and health sciences, Idiopathic pulmonary fibrosis, chemistry.chemical_compound, Mice, 0302 clinical medicine, In vivo, Drug Discovery, Pulmonary fibrosis, medicine, Animals, Humans, Thiazole, Mice, Knockout, Lung, medicine.diagnostic_test, biology, Chemistry, Phosphoric Diester Hydrolases, Imidazoles, medicine.disease, Idiopathic Pulmonary Fibrosis, Rats, 030104 developmental biology, Bronchoalveolar lavage, medicine.anatomical_structure, Pyrimidines, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, lipids (amino acids, peptides, and proteins), Autotaxin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c6f6e80895c7ca93e77aad9243c383
https://www.bib.irb.hr/981523

المؤلفون: C. Cottereaux, R. Gosmini, E. van der Aar, D. Amantini, Nele Vandervoort, L. Lepescheux, Patrick Mollat, D. Comas, Pierre Deprez, Roland Blanque, Thierry Christophe, F. Brebion, Christopher B. Little, I. Botez, Philippe Clément-Lacroix, F. De Ceuninck, S. Meurisse

المصدر: Osteoarthritis and Cartilage. 25:S58-S59

مصطلحات موضوعية: 030203 arthritis & rheumatology, 0301 basic medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Rheumatology, business.industry, ADAMTS, Biomedical Engineering, Medicine, Orthopedics and Sports Medicine, Pharmacology, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2a6ea7e1f012cfa0b4d04832d440fb14
https://doi.org/10.1016/j.joca.2017.02.106

المؤلفون: Reginald Brys, Emanuelle Wakselman, Lionel Vercheval, Christelle David, Nele Vandervoort, Laëtitia Cherel, Christopher Gaëtan Housseman, Luce Lepissier, Natacha Bienvenu, Mia Jans, Alain Monjardet, Agnès Marie Joncour, Nicolas Desroy, Gregor Pilzak, Willem Jan Hengeveld, Sandrine Le Tallec, Ellen van der Aar, Bertrand Heckmann, Nicolas Triballeau, Jan Steyaert, Patrick Mollat, Veronique Roncoroni, Virginie Labeguere, Sameh H. Soror, Damien Fleury, Thierry Christophe, Christophe Peixoto, Xavier Marie Bock, Denis Annoot, Jörg Heiermann, Katja Conrath, R Galien, Robert Touitou, Alexandre Wohlkonig

المصدر: Journal of Medicinal Chemistry. 61:4270-4270

مصطلحات موضوعية: chemistry.chemical_compound, Series (mathematics), chemistry, Stereochemistry, Drug Discovery, Pyridine, Molecular Medicine, Structure–activity relationship, Autotaxin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93dee812f5866eca6cabf47d605a46ce
https://doi.org/10.1021/acs.jmedchem.8b00579