نتائج البحث - "Nevena Mollova"

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Abstract 3696: GS-9716: A potent, selective and orally bioavailable small molecule inhibitor of MCL1 for the treatment of cancer

المؤلفون: Clinton K. Matson, Thomas Kenney, Bart H. Steiner, Chloe R. Deodato, Anella Yahiaoui, Claudia A. Rubio, Julie T. Chan, Nevena Mollova, Kathleen S. Keegan, Chandrasekar Venkataramani

المصدر: Cancer Research. 82:3696-3696

مصطلحات موضوعية: Cancer Research, Oncology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d5924c561235990b846e35b57d250718
https://doi.org/10.1158/1538-7445.am2022-3696

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Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia

المؤلفون: Marcel A.G. van der Heyden, Sridharan Rajamani, Alexandre Bossu, Veronique M.F. Meijborg, Rosanne Varkevisser, Albert Dunnink, Nevena Mollova, Marien J C Houtman, Luiz Belardinelli, Jacques M.T. de Bakker, H D M Beekman, Marc A. Vos

المصدر: British Journal of Pharmacology. 175:2470-2482

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Drug, business.industry, media_common.quotation_subject, Torsades de pointes, Phenethylamines, 030204 cardiovascular system & hematology, medicine.disease, Sodium current, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine, business, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5e08cf50eb144f833877c51eb689a311
https://doi.org/10.1111/bph.14217

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3

Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late INai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties

المصدر: Journal of Medicinal Chemistry. 59:9005-9017

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4d94b0c7942e17b573ee6f2bc8434003
https://doi.org/10.1021/acs.jmedchem.6b00939

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The novel late Na+current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations

المؤلفون: Donglin Guo, Nevena Mollova, Elfatih Elzein, Sridharan Rajamani, Nesrine El-Bizri, Gongxin Liu, Luiz Belardinelli, Kristopher M. Kahlig, Jeff Zablocki, Xiao-Liang Chen, Cindy Hong Li

المصدر: British Journal of Pharmacology. 173:3088-3098

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3f37746a20cc21acfbbbaa6363f39e04
https://doi.org/10.1111/bph.13563

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5

THU0017 IN VITRO MECHANISTIC STUDIES DEMONSTRATE FILGOTINIB ACTIVITY THAT HAS POTENTIAL IMPLICATIONS FOR DIFFERENTIATION AMONG JAK INHIBITORS

المؤلفون: Nevena Mollova, Julie Di Paolo, Amy Meng, Pei Han, Yuanjiang Yu

المصدر: Poster Presentations.

مصطلحات موضوعية: Tofacitinib, Filgotinib, biology, business.industry, Cell, Pharmacology, In vitro, Proinflammatory cytokine, medicine.anatomical_structure, Tyrosine kinase 2, Cholesterylester transfer protein, biology.protein, Medicine, business, Liver X receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::44bff10c4b5b0e72e8c57748a1125296
https://doi.org/10.1136/annrheumdis-2019-eular.3361

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Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late I Na i) of the cardiac Na v 1.5 channel with improved efficacy and potency relative to ranolazine

المؤلفون: Elfatih Elzein, Kobayashi Tetsuya, Brian Stafford, Ryoko Hirakawa, Nevena Mollova, Sridharan Rajamani, Belem Avila, Catherine Smith-Maxwell, Thao Perry, Lin Wu, Jennifer Tang, Jeff Zablocki, Xiaofen Li, Wei-Qun Wang, Dmitry Koltun, Parkhill Eric Q, Robert Jiang, Arvinder Dhalla, Luiz Belardinelli

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:3207-3211

مصطلحات موضوعية: Azoles, 0301 basic medicine, Gene isoform, Pyridines, Sodium, Clinical Biochemistry, hERG, Pharmaceutical Science, Ranolazine, chemistry.chemical_element, Nav1.5, Pharmacology, Biochemistry, NAV1.5 Voltage-Gated Sodium Channel, Structure-Activity Relationship, 03 medical and health sciences, Dogs, 0302 clinical medicine, Therapeutic index, Drug Discovery, medicine, Animals, Humans, Potency, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, biology, Organic Chemistry, Heart, Haplorhini, Ether-A-Go-Go Potassium Channels, Rats, 030104 developmental biology, medicine.anatomical_structure, chemistry, Peripheral nervous system, biology.protein, Molecular Medicine, Rabbits, 030217 neurology & neurosurgery, Sodium Channel Blockers, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98fe40fe24221536f142ea4df6dd02ec
https://doi.org/10.1016/j.bmcl.2016.03.096

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Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late I Na i) of the cardiac Na V 1.5 channel with improved efficacy and potency relative to ranolazine

المؤلفون: Dmitry O, Koltun, Eric Q, Parkhill, Elfatih, Elzein, Tetsuya, Kobayashi, Gregory T, Notte, Rao, Kalla, Robert H, Jiang, Xiaofen, Li, Thao D, Perry, Belem, Avila, Wei-Qun, Wang, Catherine, Smith-Maxwell, Arvinder K, Dhalla, Sridharan, Rajamani, Brian, Stafford, Jennifer, Tang, Nevena, Mollova, Luiz, Belardinelli, Jeff A, Zablocki

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:3202-3206

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef515260de6068eed1fe5a0177f0bb65
https://doi.org/10.1016/j.bmcl.2016.03.101

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8

Tu1903 EVALUATION OF POTENTIAL MECHANISMS UNDERLYING THE SAFETY OBSERVATIONS OF FILGOTINIB IN CLINICAL STUDIES IN RA

المؤلفون: Amy Meng, Pei Han, Astrid Clarke, Yuanjiang Yu, Bryan Downie, Julie Di Paolo, Nevena Mollova

المصدر: Gastroenterology. 158:S-1212

مصطلحات موضوعية: Safety observations, medicine.medical_specialty, Filgotinib, Hepatology, business.industry, Gastroenterology, medicine, Intensive care medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::47997d0a3a9304188d2c2aa72f78df40
https://doi.org/10.1016/s0016-5085(20)33690-8

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Full Text via ClinicalKey

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P460 Evaluation of potential mechanisms underlying the safety observations of filgotinib in clinical studies in rheumatoid arthritis

المؤلفون: Yuanjiang Yu, Pei Han, B Downie, Astrid S. Clarke, J Di Paolo, Amy Meng, Nevena Mollova

المصدر: Journal of Crohn's and Colitis. 14:S409-S409

مصطلحات موضوعية: Safety observations, medicine.medical_specialty, Filgotinib, Tofacitinib, business.industry, Baricitinib, Gastroenterology, General Medicine, medicine.disease, Plasma drug concentration, Rheumatoid arthritis, Medicine, Inhibitory concentration 50, Erythroid Progenitor Cells, business, Intensive care medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7ae28d4d3b4a5b62b0d9d6cb0c21053c
https://doi.org/10.1093/ecco-jcc/jjz203.589

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AB0484 Monotherapy with filgotinib, a jak1-selective inhibitor, reduces disease severity and alters immune cell subsets in the nzb/w f1 murine model of lupus

المؤلفون: C. Pohlmeyer, Z.-H. Cui, J. A. Di Paolo, S. Zaboli, A. Shauf, Nevena Mollova, Randall Mark Jones, Igor Mikaelian, Pei Han, Astrid S. Clarke

المصدر: Rheumatoid arthritis – non biologic treatment and small molecules.

مصطلحات موضوعية: 0301 basic medicine, Autoimmune disease, Systemic lupus erythematosus, Janus kinase 1, Cyclophosphamide, biology, business.industry, Autoantibody, Alpha interferon, medicine.disease, 03 medical and health sciences, 030104 developmental biology, Immune system, Immunology, biology.protein, Medicine, Antibody, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::253eec6a960895ab0b586085829bb095
https://doi.org/10.1136/annrheumdis-2018-eular.3367

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