المؤلفون: Burton, PR, Clayton, DG, Cardon, LR, Craddock, N, Deloukas, P, Duncanson, A, Kwiatkowski, DP, McCarthy, MI, Ouwehand, WH, Samani, NJ, Todd, JA, Donnelly, P, Barrett, JC, Davison, D, Easton, D, Evans, DM, Leung, HT, Marchini, JL, Morris, AP, Spencer, CC, Tobin, MD, Attwood, AP, Boorman, JP, Cant, B, Everson, U, Hussey, JM, Jolley, JD, Knight, AS, Koch, K, Meech, E, Nutland, S, Prowse, CV, Stevens, HE, Taylor, NC, Walters, GR, Walker, NM, Watkins, NA, Winzer, T, Jones, RW, McArdle, WL, Ring, SM, Strachan, DP, Pembrey, M, Breen, G, St Clair, D, Caesar, S, Gordon-Smith, K, Jones, L, Fraser, C, Green, EK, Grozeva, D, Hamshere, ML, Holmans, PA, Jones, IR, Kirov, G, Moskivina, V, Nikolov, I, O'Donovan, MC, Owen, MJ, Collier, DA, Elkin, A, Farmer, A, Williamson, R, McGuffin, P, Young, AH, Ferrier, IN, Ball, SG, Balmforth, AJ, Barrett, JH, Bishop, TD, Iles, MM, Maqbool, A, Yuldasheva, N, Hall, AS, Braund, PS, Dixon, RJ, Mangino, M, Stevens, S, Thompson, JR, Bredin, F, Tremelling, M, Parkes, M, Drummond, H, Lees, CW, Nimmo, ER, Satsangi, J, Fisher, SA, Forbes, A, Lewis, CM, Onnie, CM, Prescott, NJ, Sanderson, J, Matthew, CG, Barbour, J, Mohiuddin, MK, Todhunter, CE, Mansfield, JC, Ahmad, T, Cummings, FR, Jewell, DP, Webster, J, Brown, MJ, Lathrop, MG, Connell, J, Dominiczak, A, Marcano, CA, Burke, B, Dobson, R, Gungadoo, J, Lee, KL, Munroe, PB, Newhouse, SJ, Onipinla, A, Wallace, C, Xue, M, Caulfield, M, Farrall, M, Barton, A, Bruce, IN, Donovan, H, Eyre, S, Gilbert, PD, Hilder, SL, Hinks, AM, John, SL, Potter, C, Silman, AJ, Symmons, DP, Thomson, W, Worthington, J, Dunger, DB, Widmer, B, Frayling, TM, Freathy, RM, Lango, H, Perry, JR, Shields, BM, Weedon, MN, Hattersley, AT, Hitman, GA, Walker, M, Elliott, KS, Groves, CJ, Lindgren, CM, Rayner, NW, Timpson, NJ, Zeggini, E, Newport, M, Sirugo, G, Lyons, E, Vannberg, F, Hill, AV, Bradbury, LA, Farrar, C, Pointon, JJ, Wordsworth, P, Brown, MA, Franklyn, JA, Heward, JM, Simmonds, MJ, Gough, SC, Seal, S, Stratton, MR, Rahman, N, Ban, M, Goris, A, Sawcer, SJ, Compston, A, Conway, D, Jallow, M, Rockett, KA, Bumpstead, SJ, Chaney, A, Downes, K, Ghori, MJ, Gwilliam, R, Hunt, SE, Inouye, M, Keniry, A, King, E, McGinnis, R, Potter, S, Ravindrarajah, R, Whittaker, P, Widden, C, Withers, D, Cardin, NJ, Ferreira, T, Pereira-Gale, J, Hallgrimsdo'ttir, IB, Howie, BN, Su, Z, Teo, YY, Vukcevic, D, Bentley, D, Mitchell, SL, Newby, PR, Brand, OJ, Carr-Smith, J, Pearce, SH, Reveille, JD, Zhou, X, Sims, AM, Dowling, A, Taylor, J, Doan, T, Davis, JC, Savage, L, Ward, MM, Learch, TL, Weisman, MH, Brown, M

المصدر: Burton, P R, Clayton, D G, Cardon, L R, Craddock, N, Deloukas, P, Duncanson, A, Kwiatkowski, D P, McCarthy, M I, Ouwehand, W H, Samani, N J, Todd, J A, Donnelly, P, Barrett, J C, Davison, D, Easton, D, Evans, D M, Leung, H-T, Marchini, J L, Morris, A P, Spencer, C C A, Tobin, M D, Attwood, A P, Boorman, J P, Cant, B, Everson, U, Hussey, J M, Jolley, J D, Knight, A S, Koch, K, Meech, E, Nutland, S, Prowse, C V, Stevens, H E, Taylor, N C, Walters, G R, Walker, N M, Watkins, N A, Winzer, T, Jones, R W, McArdle, W L, Ring, S M, Strachan, D P, Pembrey, M, Breen, G, St Clair, D, Caesar, S, Drummond, H, Lees, C W & Nimmo, E R & Satsangi, J 2007, ' Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants ', Nature Genetics, vol. 39, no. 11, pp. 1329-37 . https://doi.org/10.1038/ng.2007.17

مصطلحات موضوعية: Linkage disequilibrium, Multiple Sclerosis, Genotype, Population, Single-nucleotide polymorphism, Genome-wide association study, Autoimmunity, Breast Neoplasms, Biology, medicine.disease_cause, Aminopeptidases, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Linkage Disequilibrium, Article, Minor Histocompatibility Antigens, Genetics, medicine, Humans, Spondylitis, Ankylosing, Receptors, Immunologic, education, Genetic association, education.field_of_study, Ankylosing spondylitis, Thyroiditis, Autoimmune, Chromosome Mapping, Receptors, Interleukin, medicine.disease, Endoplasmic reticulum aminopeptidase 2, Genetics, Population, Haplotypes, Case-Control Studies, Immunology, North America

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb0ae488030d93095bbd731921effd4
https://doi.org/10.1038/ng.2007.17

المؤلفون: Lodge KM; Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Vassallo A; Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom., Liu B; Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom., Long M; Department of Infection, Immunity, and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom; and., Tong Z; Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom., Newby PR; Institute of Inflammation and Ageing, University of Birmingham and., Agha-Jaffar D; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Paschalaki K; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Green CE; Institute of Inflammation and Ageing, University of Birmingham and., Belchamber KBR; Institute of Inflammation and Ageing, University of Birmingham and., Ridger VC; Department of Infection, Immunity, and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom; and., Stockley RA; University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom., Sapey E; Institute of Inflammation and Ageing, University of Birmingham and.; University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom., Summers C; Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom., Cowburn AS; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Chilvers ER; Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Li W; Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom., Condliffe AM; Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.; Department of Infection, Immunity, and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom; and.

المصدر: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2022 Apr 15; Vol. 205 (8), pp. 903-916.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Thoracic Society Country of Publication: United States NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE

مواضيع طبية MeSH: Pulmonary Disease, Chronic Obstructive*/metabolism , Vascular System Injuries*/metabolism, Endothelial Cells/metabolism ; Humans ; Hypoxia/metabolism ; Leukocyte Elastase/metabolism ; Neutrophils/metabolism

المؤلفون: Newby PR; Institute of Inflammation and Ageing, University of Birmingham, Queen Elizabeth Hospital Birmingham, Birmingham, UK., Crossley D; Institute of Inflammation and Ageing, University of Birmingham, Queen Elizabeth Hospital Birmingham, Birmingham, UK., Crisford H; Institute of Inflammation and Ageing, University of Birmingham, Queen Elizabeth Hospital Birmingham, Birmingham, UK., Stockley JA; University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, UK., Mumford RA; Mumford Pharma, Red Bank, NJ, USA., Carter RI; Dept of Respiratory Medicine, New Cross Hospital, Wolverhampton, UK., Bolton CE; Nottingham Respiratory Research Unit, Nottingham NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK.; Members of the NIHR Rare Diseases Translational Research Collaboration., Hopkinson NS; Respiratory NIHR Biomedical Research Centre, Royal Brompton and Harefield NHS Foundation Trust, London, UK.; Members of the NIHR Rare Diseases Translational Research Collaboration., Mahadeva R; Dept of Medicine, Cambridge NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.; Members of the NIHR Rare Diseases Translational Research Collaboration., Steiner MC; Institute for Lung Health, NIHR Leicester Biomedical Research Centre - Respiratory, University Hospitals of Leicester NHS Trust, Glenfield Hospital, Leicester, UK.; Members of the NIHR Rare Diseases Translational Research Collaboration., Wilkinson TMA; Respiratory NIHR Biomedical Research Centre, University of Southampton, Southampton, UK.; Members of the NIHR Rare Diseases Translational Research Collaboration., Sapey E; Institute of Inflammation and Ageing, University of Birmingham, Queen Elizabeth Hospital Birmingham, Birmingham, UK., Stockley RA; University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Birmingham, UK.; Members of the NIHR Rare Diseases Translational Research Collaboration.

المصدر: ERJ open research [ERJ Open Res] 2019 Aug 05; Vol. 5 (3). Date of Electronic Publication: 2019 Aug 05 (Print Publication: 2019).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: European Respiratory Society Country of Publication: England NLM ID: 101671641 Publication Model: eCollection Cited Medium: Print ISSN: 2312-0541 (Print) Linking ISSN: 23120541 NLM ISO Abbreviation: ERJ Open Res Subsets: PubMed not MEDLINE

المؤلفون: Campos MA; 1Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Miami School of Medicine, Miami, Florida., Geraghty P; 2Department of Medicine and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, New York., Holt G; 1Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Miami School of Medicine, Miami, Florida., Mendes E; 1Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Miami School of Medicine, Miami, Florida., Newby PR; 3University of Birmingham, Birmingham, United Kingdom., Ma S; 4Mount Sinai Icahn School of Medicine, New York, New York., Luna-Diaz LV; 5Jackson Memorial Hospital, Miami, Florida; and., Turino GM; 4Mount Sinai Icahn School of Medicine, New York, New York., Stockley RA; 6Lung Investigation Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom.

المصدر: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2019 Aug 01; Vol. 200 (3), pp. 318-326.

نوع المنشور: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Thoracic Society Country of Publication: United States NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE

مواضيع طبية MeSH: Trypsin Inhibitors/*administration & dosage , alpha 1-Antitrypsin/*administration & dosage , alpha 1-Antitrypsin Deficiency/*drug therapy, Adolescent ; Adult ; Aged ; Dose-Response Relationship, Drug ; Feasibility Studies ; Female ; Humans ; Male ; Middle Aged ; Pilot Projects ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/etiology ; Pulmonary Disease, Chronic Obstructive/therapy ; Young Adult ; alpha 1-Antitrypsin Deficiency/complications

المؤلفون: Hamilton A; Oxford Centre for Diabetes, Endocrinology, and Metabolism (A.H., J.A.H.W., S.C.L.G., M.J.S.), Department of Physiology, Anatomy, and Genetics (G.D., S.V.R.), and Oxford National Institute for Health Research Biomedical Research Centre (J.C.T.), Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7LE, United Kingdom; Centre for Endocrinology, Diabetes, and Metabolism (P.R.N., J.D.C.-S., J.A.F.), School of Clinical and Experimental Medicine, College of Medical and Dental Science, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TT, United Kingdom; Northern General Hospital (A.A.), Sheffield S5 7AU, United Kingdom; Royal Bournemouth Hospital (M.A.), Bournemouth BH7 7DW, United Kingdom; Department of Endocrinology and Metabolism (T.H.B., L.H.), Odense University Hospital, DK-5000 Odense, Denmark; Department of Medicine (K.C.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; School of Medicine (J.M.C.), University of Dundee, Dundee DD1 9SY, United Kingdom; Department of Medicine (P.J.H.), University of Otago, Dunedein 9016, New Zealand; Centre for Endocrine and Diabetes Sciences (J.H.L.), Cardiff University, Cardiff C14 4XN, United Kingdom; Institute of Genetic Medicine (S.H.P.), Newcastle University, Newcastle-upon-Tyne NE1 3BZ, Newcastle, United Kingdom; Kolling Institute (B.G.R.), Royal North Shore Hospital and The University of Sydney, Sydney NSW 2006, Australia; Royal Devon and Exeter Hospital (B.V.), Exeter EX2 5DW, United Kingdom; Department of Endocrinology and Metabolism (W.M.W.), University of Amsterdam, 1100 DE Amsterdam, The Netherlands; Department of Human Metabolism (A.P.W.), University of Sheffield, Sheffield S10 2RX, United Kingdom; and Oxford National Institute for Health Research Biomedical Research Centre (S.C.L.G.), Churchill Hospital, Oxford OX3 7LE, United Kingdom., Newby PR, Carr-Smith JD, Disanto G, Allahabadia A, Armitage M, Brix TH, Chatterjee K, Connell JM, Hegedüs L, Hunt PJ, Lazarus JH, Pearce SH, Robinson BG, Taylor JC, Vaidya B, Wass JA, Wiersinga WM, Weetman AP, Ramagopalan SV, Franklyn JA, Gough SC, Simmonds MJ

المصدر: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2014 Aug; Vol. 99 (8), pp. E1459-65. Date of Electronic Publication: 2014 May 19.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE

مواضيع طبية MeSH: Seasons*, Parturition/*immunology , Thyroiditis, Autoimmune/*epidemiology, Case-Control Studies ; Disease Susceptibility/epidemiology ; Europe/epidemiology ; Female ; Humans ; Male ; Risk Factors ; Siblings ; Time Factors ; United Kingdom/epidemiology ; White People

المؤلفون: Simmonds MJ; Oxford Centre for Diabetes, Endocrinology, and Metabolism (M.J.S., F.K.K., O.J.B., S.C.L.G.) and Oxford National Institute for Health Research Biomedical Research Centre (F.K.K., S.C.L.G.), Churchill Hospital, Headington, Oxford OX3 7LJ, United Kingdom; and Centre for Endocrinology, Diabetes, and Metabolism (P.R.N., L.E.J., C.E.H., J.A.F.), School of Clinical and Experimental Medicine, College of Medical and Dental Science, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom., Kavvoura FK, Brand OJ, Newby PR, Jackson LE, Hargreaves CE, Franklyn JA, Gough SC

المصدر: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2014 Jan; Vol. 99 (1), pp. E127-31. Date of Electronic Publication: 2013 Dec 20.

نوع المنشور: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE

مواضيع طبية MeSH: Thyroiditis, Autoimmune/*genetics , X Chromosome Inactivation/*genetics, Adult ; Case-Control Studies ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Male ; Middle Aged ; Pedigree ; Sex Factors ; Thyroiditis, Autoimmune/epidemiology ; United Kingdom/epidemiology ; White People/statistics & numerical data ; Young Adult

المؤلفون: Simmonds MJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Headington, Oxford, UK. matthew.simmonds@ocdem.ox.ac.uk, Brand OJ, Barrett JC, Newby PR, Franklyn JA, Gough SC

المصدر: Clinical endocrinology [Clin Endocrinol (Oxf)] 2010 Nov; Vol. 73 (5), pp. 654-60.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Blackwell Publishing Country of Publication: England NLM ID: 0346653 Publication Model: Print Cited Medium: Internet ISSN: 1365-2265 (Electronic) Linking ISSN: 03000664 NLM ISO Abbreviation: Clin Endocrinol (Oxf) Subsets: MEDLINE

مواضيع طبية MeSH: Graves Disease/*genetics , Receptors, Cell Surface/*genetics, Case-Control Studies ; Genetic Predisposition to Disease ; Humans ; Linkage Disequilibrium ; Logistic Models ; Middle Aged ; Polymorphism, Single Nucleotide ; Receptors, Fc ; Receptors, Immunologic/genetics ; White People/genetics

المؤلفون: Newby PR; Centre for Endocrinology, Diabetes and Metabolism, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham, West Midlands, UK., Pickles OJ, Mazumdar S, Brand OJ, Carr-Smith JD, Pearce SH, Franklyn JA, Evans DM, Simmonds MJ, Gough SC

مؤلفون مشاركون: Wellcome Trust Case-Control Consortium (WTCCC)

المصدر: European journal of human genetics : EJHG [Eur J Hum Genet] 2010 Sep; Vol. 18 (9), pp. 1021-6. Date of Electronic Publication: 2010 May 05.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9302235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5438 (Electronic) Linking ISSN: 10184813 NLM ISO Abbreviation: Eur J Hum Genet Subsets: MEDLINE

مواضيع طبية MeSH: Genome-Wide Association Study* , Polymorphism, Single Nucleotide*, Graves Disease/*genetics, Humans ; United Kingdom

المؤلفون: Yesmin K; Centre for Endocrinology, Diabetes and Metabolism, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, UK., Hargreaves C, Newby PR, Brand OJ, Heward JM, Franklyn JA, Gough SC, Simmonds MJ

المصدر: Clinical endocrinology [Clin Endocrinol (Oxf)] 2010 Jul; Vol. 73 (1), pp. 119-25. Date of Electronic Publication: 2010 Feb 10.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Blackwell Publishing Country of Publication: England NLM ID: 0346653 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2265 (Electronic) Linking ISSN: 03000664 NLM ISO Abbreviation: Clin Endocrinol (Oxf) Subsets: MEDLINE

مواضيع طبية MeSH: Autoantibodies/*metabolism , Graves Disease/*genetics , Receptors, IgG/*genetics, Case-Control Studies ; Disease Progression ; Genetic Predisposition to Disease ; Graves Disease/immunology ; Humans ; Middle Aged ; Polymorphism, Single Nucleotide

المؤلفون: Simmonds MJ; Institute of Biomedical Research, University of Birmingham , Edgbaston, Birmingham, UK ., Yesmin K, Newby PR, Brand OJ, Franklyn JA, Gough SC

المصدر: Thyroid : official journal of the American Thyroid Association [Thyroid] 2010 Apr; Vol. 20 (4), pp. 413-7.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Mary Ann Liebert Publishers Country of Publication: United States NLM ID: 9104317 Publication Model: Print Cited Medium: Internet ISSN: 1557-9077 (Electronic) Linking ISSN: 10507256 NLM ISO Abbreviation: Thyroid Subsets: MEDLINE

مواضيع طبية MeSH: Graves Disease/*genetics , Interleukin-3/*genetics , Uteroglobin/*genetics, Asian People/genetics ; Case-Control Studies ; Chromosomes, Human, Pair 5/genetics ; Genetic Linkage ; Genetic Predisposition to Disease ; Genotype ; Graves Disease/epidemiology ; Humans ; Polymorphism, Single Nucleotide ; Secretoglobins ; United Kingdom/epidemiology ; White People/genetics