المؤلفون: Ng NHJ; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, 138673, Singapore., Ghosh S; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., Bok CM; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, 138673, Singapore., Ching C; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, 138673, Singapore., Low BSJ; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, 138673, Singapore., Chen JT; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, 138673, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.; Department of Biochemistry, National University of Singapore, Singapore, 117596, Singapore., Lim E; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, 138673, Singapore.; Department of Biochemistry, National University of Singapore, Singapore, 117596, Singapore., Miserendino MC; Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, X5000HUA, Córdoba, Argentina.; Bioinformatics Institute, A*STAR, Singapore, 138671, Singapore., Tan YS; Bioinformatics Institute, A*STAR, Singapore, 138671, Singapore., Hoon S; Molecular Engineering Laboratory, IMCB, A*STAR, Singapore, 138673, Singapore., Teo AKK; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, 138673, Singapore. ateo@imcb.a-star.edu.sg.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore. ateo@imcb.a-star.edu.sg.; Department of Biochemistry, National University of Singapore, Singapore, 117596, Singapore. ateo@imcb.a-star.edu.sg.; Precision Medicine Translational Research Programme (TRP), National University of Singapore, Singapore, 119228, Singapore. ateo@imcb.a-star.edu.sg.

المصدر: Nature communications [Nat Commun] 2024 Jun 22; Vol. 15 (1), pp. 4288. Date of Electronic Publication: 2024 Jun 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Hepatocyte Nuclear Factor 4*/metabolism , Hepatocyte Nuclear Factor 4*/genetics , Hepatocyte Nuclear Factor 1-alpha*/metabolism , Hepatocyte Nuclear Factor 1-alpha*/genetics , Insulin-Secreting Cells*/metabolism , Diabetes Mellitus, Type 2*/genetics , Diabetes Mellitus, Type 2*/metabolism , Hepatocytes*/metabolism , Gene Expression Regulation*, Humans ; Animals ; Mice ; A Kinase Anchor Proteins/metabolism ; A Kinase Anchor Proteins/genetics ; Organ Specificity/genetics

SCR Disease Name: Mason-Type Diabetes

المؤلفون: Ho BX; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; BetaLife Pte Ltd, Singapore, Singapore., Teo AKK; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Precision Medicine Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Ng NHJ; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

المصدر: Frontiers in immunology [Front Immunol] 2024 Apr 08; Vol. 15, pp. 1375177. Date of Electronic Publication: 2024 Apr 08 (Print Publication: 2024).

نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Islets of Langerhans Transplantation*/methods , Diabetes Mellitus, Type 1*/immunology , Diabetes Mellitus, Type 1*/therapy , Graft Rejection*/immunology , Graft Rejection*/prevention & control, Humans ; Animals ; Biomedical Engineering/methods ; Islets of Langerhans/immunology

المؤلفون: Tan WX; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Bok CM; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore., Ng NHJ; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore., Teo AKK; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore. ateo@imcb.a-star.edu.sg.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. ateo@imcb.a-star.edu.sg.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. ateo@imcb.a-star.edu.sg.

المصدر: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2429, pp. 215-232.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Organoids* , Pluripotent Stem Cells*, Cell Differentiation ; Chromatin Immunoprecipitation ; DNA ; Humans

المؤلفون: Low BSJ; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Lim CS; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore., Ding SSL; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Tan YS; Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Ng NHJ; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Krishnan VG; Molecular Engineering Lab (MEL), IMCB, A*STAR, Singapore, Singapore., Ang SF; Khoo Teck Puat Hospital, Singapore, Singapore., Neo CWY; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Verma CS; Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Hoon S; Molecular Engineering Lab (MEL), IMCB, A*STAR, Singapore, Singapore., Lim SC; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.; Khoo Teck Puat Hospital, Singapore, Singapore., Tai ES; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Teo AKK; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. ateo@imcb.a-star.edu.sg.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. ateo@imcb.a-star.edu.sg.

المصدر: Nature communications [Nat Commun] 2021 May 25; Vol. 12 (1), pp. 3133. Date of Electronic Publication: 2021 May 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Mutation*, Diabetes Mellitus, Type 2/*genetics , Glucose/*metabolism , Glucose Transporter Type 2/*genetics , Hepatocyte Nuclear Factor 1-alpha/*genetics , Insulin Secretion/*genetics , Insulin-Secreting Cells/*metabolism, Cells, Cultured ; Chromatin Immunoprecipitation Sequencing/methods ; Diabetes Mellitus, Type 2/metabolism ; Female ; Glucose Transporter Type 2/metabolism ; Hepatocyte Nuclear Factor 1-alpha/chemistry ; Hepatocyte Nuclear Factor 1-alpha/metabolism ; Humans ; Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/metabolism ; Insulin-Secreting Cells/cytology ; Male ; Molecular Dynamics Simulation ; Pedigree ; Protein Domains

SCR Disease Name: Mason-Type Diabetes

المؤلفون: Tan LS; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), A∗STAR, Singapore 138673, Singapore., Chew RSE; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), A∗STAR, Singapore 138673, Singapore., Ng NHJ; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), A∗STAR, Singapore 138673, Singapore., Teo AKK; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), A∗STAR, Singapore 138673, Singapore.; Department of Biochemistry and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.

المصدر: STAR protocols [STAR Protoc] 2021 Apr 19; Vol. 2 (2), pp. 100471. Date of Electronic Publication: 2021 Apr 19 (Print Publication: 2021).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101769501 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-1667 (Electronic) Linking ISSN: 26661667 NLM ISO Abbreviation: STAR Protoc

مواضيع طبية MeSH: Cell Differentiation* , Gene Expression Profiling* , Gene Expression Regulation*, Liver/*metabolism , Pluripotent Stem Cells/*metabolism, Cells, Cultured ; Humans ; Liver/cytology ; Pluripotent Stem Cells/cytology

المؤلفون: Ng NHJ; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), A*STAR, Proteos, Singapore, Singapore., Neo CWY; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), A*STAR, Proteos, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Ding SSL; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), A*STAR, Proteos, Singapore, Singapore., Teo AKK; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), A*STAR, Proteos, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Electronic address: ateo@imcb.a-star.edu.sg.

المصدر: Vitamins and hormones [Vitam Horm] 2021; Vol. 116, pp. 193-233. Date of Electronic Publication: 2021 Mar 10.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0413601 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0083-6729 (Print) Linking ISSN: 00836729 NLM ISO Abbreviation: Vitam Horm Subsets: MEDLINE

مواضيع طبية MeSH: Insulin-Secreting Cells*/metabolism , Islets of Langerhans*/metabolism , Neuroendocrine Cells* , Pluripotent Stem Cells*, Cell Differentiation ; Humans

المؤلفون: Loo LSW; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, A*STAR, Proteos, Singapore, 138673, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore., Soetedjo AAP; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, A*STAR, Proteos, Singapore, 138673, Singapore., Lau HH; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, A*STAR, Proteos, Singapore, 138673, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore., Ng NHJ; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, A*STAR, Proteos, Singapore, 138673, Singapore., Ghosh S; Computational and Statistical Systems Biology, Institute of Molecular and Cell Biology, A*STAR, Proteos, Singapore, 138673, Singapore., Nguyen L; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, A*STAR, Proteos, Singapore, 138673, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117596, Singapore., Krishnan VG; Molecular Engineering Lab, Proteos, Singapore, 138673, Singapore., Choi H; Computational and Statistical Systems Biology, Institute of Molecular and Cell Biology, A*STAR, Proteos, Singapore, 138673, Singapore., Roca X; School of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore., Hoon S; Molecular Engineering Lab, Proteos, Singapore, 138673, Singapore., Teo AKK; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, A*STAR, Proteos, Singapore, 138673, Singapore. drainteo@gmail.com.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117596, Singapore. drainteo@gmail.com.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore. drainteo@gmail.com.

المصدر: Cell death & disease [Cell Death Dis] 2020 May 18; Vol. 11 (5), pp. 378. Date of Electronic Publication: 2020 May 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis/*physiology , Pluripotent Stem Cells/*cytology , Proto-Oncogene Proteins c-bcl-2/*metabolism , bcl-X Protein/*metabolism, Caspase 3/metabolism ; Cell Differentiation/physiology ; Cell Proliferation/physiology ; Humans ; Pancreatic Neoplasms/metabolism ; Pluripotent Stem Cells/metabolism

المؤلفون: Ng NHJ; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, A*STAR, Singapore 138673, Singapore., Jasmen JB; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, A*STAR, Singapore 138673, Singapore., Lim CS; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, A*STAR, Singapore 138673, Singapore., Lau HH; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, A*STAR, Singapore 138673, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore., Krishnan VG; Molecular Engineering Lab, A*STAR, Singapore 138673, Singapore., Kadiwala J; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Anne McLaren Laboratory, Department of Surgery, University of Cambridge, Cambridge CB2 0SZ, UK., Kulkarni RN; Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Stem Cell Institute, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02215, USA., Ræder H; Department of Pediatrics, Haukeland University Hospital, 5021 Bergen, Norway; KG Jebsen Center for Diabetes Research, Department of Clinical Science, Faculty of Medicine, University of Bergen, 5020 Bergen, Norway., Vallier L; Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Anne McLaren Laboratory, Department of Surgery, University of Cambridge, Cambridge CB2 0SZ, UK; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK., Hoon S; Molecular Engineering Lab, A*STAR, Singapore 138673, Singapore., Teo AKK; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, A*STAR, Singapore 138673, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore; Department of Biochemistry and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore. Electronic address: drainteo@gmail.com.

المصدر: IScience [iScience] 2019 Jun 28; Vol. 16, pp. 192-205. Date of Electronic Publication: 2019 May 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE

المؤلفون: Lau HH; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, Proteos, Singapore 138673, Singapore., Ng NHJ; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, Proteos, Singapore 138673, Singapore., Loo LSW; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, Proteos, Singapore 138673, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore., Jasmen JB; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, Proteos, Singapore 138673, Singapore., Teo AKK; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, Proteos, Singapore 138673, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore. Electronic address: ateo@imcb.a-star.edu.sg.

المصدر: Journal of hepatology [J Hepatol] 2018 May; Vol. 68 (5), pp. 1033-1048. Date of Electronic Publication: 2017 Nov 24.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE

مواضيع طبية MeSH: Hepatocyte Nuclear Factors/*metabolism , Liver/*metabolism, Animals ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Gene Expression Regulation, Developmental ; Gene Regulatory Networks ; Hepatocyte Nuclear Factors/chemistry ; Hepatocyte Nuclear Factors/genetics ; Humans ; Kidney/metabolism ; Liver/growth & development ; Metabolic Networks and Pathways ; Mutation ; Pancreas/metabolism ; Tissue Distribution

المؤلفون: Ng NHJ; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore., Teo AKK; Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore. drainteo@gmail.com.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. drainteo@gmail.com.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. drainteo@gmail.com.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. drainteo@gmail.com.

المصدر: Cell death & disease [Cell Death Dis] 2018 Feb 14; Vol. 9 (2), pp. 222. Date of Electronic Publication: 2018 Feb 14.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

مواضيع طبية MeSH: Single-Cell Analysis* , Transcriptome*, Human Embryonic Stem Cells/*metabolism , Insulin-Secreting Cells/*metabolism , Islets of Langerhans/*metabolism, Adult ; Cell Differentiation ; Cell Lineage ; Child ; Gene Expression Regulation ; Genomics/methods ; High-Throughput Nucleotide Sequencing ; Human Embryonic Stem Cells/cytology ; Humans ; Insulin-Secreting Cells/cytology ; Islets of Langerhans/cytology