المؤلفون: Hu F; Penn Statistics in Imaging and Visualization Endeavor (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Lucas A; Center for Neuroengineering and Therapeutics, Department of Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Chen AA; Penn Statistics in Imaging and Visualization Endeavor (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Coleman K; Statistical Center for Single-Cell and Spatial Genomics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Horng H; Penn Statistics in Imaging and Visualization Endeavor (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Ng RWS; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Tustison NJ; Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia, USA., Davis KA; Center for Neuroengineering and Therapeutics, Department of Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Shou H; Penn Statistics in Imaging and Visualization Endeavor (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Center for Biomedical Image Computing and Analytics (CBICA), Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Li M; Statistical Center for Single-Cell and Spatial Genomics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Shinohara RT; Penn Statistics in Imaging and Visualization Endeavor (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Center for Biomedical Image Computing and Analytics (CBICA), Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

مؤلفون مشاركون: Alzheimer's Disease Neuroimaging Initiative

المصدر: Human brain mapping [Hum Brain Mapp] 2024 Aug 01; Vol. 45 (11), pp. e26708.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 9419065 Publication Model: Print Cited Medium: Internet ISSN: 1097-0193 (Electronic) Linking ISSN: 10659471 NLM ISO Abbreviation: Hum Brain Mapp Subsets: MEDLINE

مواضيع طبية MeSH: Deep Learning* , Neuroimaging*/methods , Neuroimaging*/standards , Image Processing, Computer-Assisted*/methods , Image Processing, Computer-Assisted*/standards, Humans ; Magnetic Resonance Imaging/standards ; Magnetic Resonance Imaging/methods ; Cerebral Cortex/diagnostic imaging ; Aged ; Male ; Female

المؤلفون: Ng RWS, Shaffer SM

المصدر: Nature [Nature] 2023 Jun; Vol. 618 (7965), pp. 464-465.

نوع المنشور: News

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms*, Humans ; Transcriptome

المؤلفون: Hu F; Penn Statistics in Imaging and Visualization Endeavor (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania., Lucas A; Center for Neuroengineering and Therapeutics, Department of Engineering, University of Pennsylvania., Chen AA; Penn Statistics in Imaging and Visualization Endeavor (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania., Coleman K; Statistical Center for Single-Cell and Spatial Genomics, Perelman School of Medicine, University of Pennsylvania., Horng H; Penn Statistics in Imaging and Visualization Endeavor (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania., Ng RWS; Perelman School of Medicine, University of Pennsylvania., Tustison NJ; Department of Radiology and Medical Imaging, University of Virginia., Davis KA; Center for Neuroengineering and Therapeutics, Department of Engineering, University of Pennsylvania.; Department of Neurology, Perelman School of Medicine, University of Pennsylvania., Shou H; Penn Statistics in Imaging and Visualization Endeavor (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania.; Center for Biomedical Image Computing and Analytics (CBICA), Perelman School of Medicine., Li M; Statistical Center for Single-Cell and Spatial Genomics, Perelman School of Medicine, University of Pennsylvania., Shinohara RT; Penn Statistics in Imaging and Visualization Endeavor (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania.; Center for Biomedical Image Computing and Analytics (CBICA), Perelman School of Medicine.

مؤلفون مشاركون: Alzheimer’s Disease Neuroimaging Initiative

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2023 Apr 24. Date of Electronic Publication: 2023 Apr 24.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Raghavan S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Winter PS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: pswinter@mit.edu., Navia AW; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Williams HL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA., DenAdel A; Center for Computational Molecular Biology, Brown University, Providence, RI 02912, USA; Division of Applied Mathematics, Brown University, Providence, RI 02912, USA., Lowder KE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Galvez-Reyes J; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Kalekar RL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Mulugeta N; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Kapner KS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Raghavan MS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Borah AA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Liu N; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Väyrynen SA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA., Costa AD; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA., Ng RWS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Wang J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Hill EK; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Ragon DY; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Brais LK; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Jaeger AM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Spurr LF; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Li YY; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Cherniack AD; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA., Booker MA; Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Cohen EF; Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Tolstorukov MY; Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Wakiro I; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Rotem A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Johnson BE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02215, USA., McFarland JM; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Sicinska ET; Harvard Medical School, Boston, MA 02115, USA; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Jacks TE; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Sullivan RJ; Harvard Medical School, Boston, MA 02115, USA; Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA., Shapiro GI; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Clancy TE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA., Perez K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Rubinson DA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Ng K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Cleary JM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Crawford L; Center for Computational Molecular Biology, Brown University, Providence, RI 02912, USA; Department of Biostatistics, Brown University, Providence, RI 02912, USA; Microsoft Research New England, Cambridge, MA 02142, USA., Manalis SR; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Nowak JA; Harvard Medical School, Boston, MA 02115, USA; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA., Wolpin BM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Hahn WC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Aguirre AJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: andrew_aguirre@dfci.harvard.edu., Shalek AK; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. Electronic address: shalek@mit.edu.

المصدر: Cell [Cell] 2021 Dec 09; Vol. 184 (25), pp. 6119-6137.e26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Tumor Microenvironment*, Biomarkers, Tumor/*metabolism , Carcinoma, Pancreatic Ductal/*metabolism , Pancreatic Neoplasms/*metabolism, Adult ; Aged ; Cell Line, Tumor ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Middle Aged ; Single-Cell Analysis

المؤلفون: Ferguson FM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Nabet B; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Raghavan S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Liu Y; Departments of Biochemistry and Radiation Oncology, the University of Texas Southwestern Medical Center, Dallas, TX, USA., Leggett AL; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Kuljanin M; Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Kalekar RL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Yang A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., He S; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Wang J; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Ng RWS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sulahian R; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Li L; Departments of Biochemistry and Radiation Oncology, the University of Texas Southwestern Medical Center, Dallas, TX, USA., Poulin EJ; Cancer Research Institute and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Huang L; Cancer Research Institute and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Koren J; Department of Molecular and Human Genetics, Therapeutic Innovation Center Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA., Dieguez-Martinez N; Departament de Bioquímica i Biologia Molecular & Institut de Neurociencies, Facultat de Medicina. Universitat Autonoma de Barcelona, Bellaterra, Spain., Espinosa S; Departament de Bioquímica i Biologia Molecular & Institut de Neurociencies, Facultat de Medicina. Universitat Autonoma de Barcelona, Bellaterra, Spain., Zeng Z; Promega Corporation, Madison, WI, USA., Corona CR; Promega Corporation, Madison, WI, USA., Vasta JD; Promega Corporation, Madison, WI, USA., Ohi R; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA., Sim T; Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea and KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, Republic of Korea., Kim ND; NDBio Therapeutics Inc, Incheon, Republic of Korea., Harshbarger W; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; GSK Vaccines, Rockville, MD, USA., Lizcano JM; Departament de Bioquímica i Biologia Molecular & Institut de Neurociencies, Facultat de Medicina. Universitat Autonoma de Barcelona, Bellaterra, Spain., Robers MB; Promega Corporation, Madison, WI, USA., Muthaswamy S; Cancer Research Institute and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Departments of Medicine and Pathology, Harvard Medical School, Boston, MA, USA., Lin CY; Department of Molecular and Human Genetics, Therapeutic Innovation Center Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA., Look AT; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA., Haigis KM; Cancer Research Institute and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Harvard Digestive Disease Center, Harvard Medical School, Boston, MA, USA., Mancias JD; Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Wolpin BM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Aguirre AJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Hahn WC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Westover KD; Departments of Biochemistry and Radiation Oncology, the University of Texas Southwestern Medical Center, Dallas, TX, USA., Gray NS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. nathanael_gray@dfci.harvard.edu.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. nathanael_gray@dfci.harvard.edu.

المصدر: Nature chemical biology [Nat Chem Biol] 2020 Jun; Vol. 16 (6), pp. 635-643. Date of Electronic Publication: 2020 Apr 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Pancreatic Ductal/*drug therapy , Intracellular Signaling Peptides and Proteins/*antagonists & inhibitors , Pancreatic Neoplasms/*drug therapy , Protein Kinase Inhibitors/*chemistry , Protein Serine-Threonine Kinases/*antagonists & inhibitors, Animals ; Cell Line, Tumor ; Cell Movement ; Doublecortin Protein ; Doublecortin-Like Kinases ; Drug Screening Assays, Antitumor ; Gene Expression Regulation ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; Mice ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors/pharmacokinetics ; Proteomics ; Rats ; Structure-Activity Relationship ; Zebrafish ; Pancreatic Neoplasms

المؤلفون: Hobbs GA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Baker NM; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Miermont AM; Thoracic and GI Oncology Branch, NCI, Bethesda, Maryland., Thurman RD; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Pierobon M; Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia., Tran TH; NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland., Anderson AO; Thoracic and GI Oncology Branch, NCI, Bethesda, Maryland., Waters AM; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Diehl JN; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Papke B; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Hodge RG; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Klomp JE; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Goodwin CM; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., DeLiberty JM; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Wang J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Ng RWS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Gautam P; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Bryant KL; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Esposito D; NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland., Campbell SL; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Petricoin EF 3rd; Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, Virginia., Simanshu DK; NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland., Aguirre AJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Wolpin BM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Wennerberg K; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark., Rudloff U; Thoracic and GI Oncology Branch, NCI, Bethesda, Maryland. cjder@med.unc.edu rudloffu@mail.nih.gov.; Rare Tumor Initiative, Pediatric Oncology Branch, NCI, Bethesda, Maryland., Cox AD; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Der CJ; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. cjder@med.unc.edu rudloffu@mail.nih.gov.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

المصدر: Cancer discovery [Cancer Discov] 2020 Jan; Vol. 10 (1), pp. 104-123. Date of Electronic Publication: 2019 Oct 24.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Mutation* , Pinocytosis*, Carcinoma, Pancreatic Ductal/*pathology , Class I Phosphatidylinositol 3-Kinases/*metabolism , Pancreatic Neoplasms/*pathology , Proto-Oncogene Proteins p21(ras)/*genetics, Animals ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/metabolism ; Cell Proliferation ; Class I Phosphatidylinositol 3-Kinases/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays

المؤلفون: Sulahian R; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Kwon JJ; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Walsh KH; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Pailler E; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Bosse TL; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Thaker M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Almanza D; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Dempster JM; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Pan J; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Piccioni F; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Dumont N; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Gonzalez A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Rennhack J; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Nabet B; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA., Bachman JA; Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Ave., Boston, MA 02115, USA., Goodale A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Lee Y; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Bagul M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Liao R; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Navarro A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Yuan TL; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Ng RWS; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Raghavan S; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA., Gray NS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA., Tsherniak A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Vazquez F; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Root DE; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Firestone AJ; Calico Life Sciences, South San Francisco, CA 94080, USA., Settleman J; Calico Life Sciences, South San Francisco, CA 94080, USA., Hahn WC; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, MA. Electronic address: william_hahn@dfci.harvard.edu., Aguirre AJ; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, MA. Electronic address: andrew_aguirre@dfci.harvard.edu.

المصدر: Cell reports [Cell Rep] 2019 Oct 01; Vol. 29 (1), pp. 118-134.e8.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Intracellular Signaling Peptides and Proteins/*metabolism , MAP Kinase Signaling System/*physiology , Mitogen-Activated Protein Kinases/*metabolism , Neoplasms/*metabolism , ras Proteins/*metabolism, A549 Cells ; Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/physiology ; HCT116 Cells ; Humans ; MAP Kinase Signaling System/drug effects ; Mice ; Mice, Hairless ; Mice, SCID ; Neoplasms/drug therapy ; Protein Kinase Inhibitors/pharmacology ; Signal Transduction/drug effects ; Signal Transduction/physiology

المؤلفون: Goyal L; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Shi L; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Liu LY; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Fece de la Cruz F; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Lennerz JK; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Raghavan S; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts., Leschiner I; Broad Institute of Harvard and MIT, Cambridge, Massachusetts., Elagina L; Broad Institute of Harvard and MIT, Cambridge, Massachusetts., Siravegna G; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Torino, Italy.; Department of Oncology, University of Torino, Candiolo, Torino, Italy., Ng RWS; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts., Vu P; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Patra KC; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Saha SK; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Uppot RN; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Arellano R; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Reyes S; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Sagara T; Tsukuba Research Institute, Taiho Pharmaceutical Co., Ltd., Japan., Otsuki S; Tsukuba Research Institute, Taiho Pharmaceutical Co., Ltd., Japan., Nadres B; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Shahzade HA; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Dey-Guha I; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Fetter IJ; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Baiev I; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Van Seventer EE; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Murphy JE; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Ferrone CR; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Tanabe KK; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Deshpande V; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Harding JJ; Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York., Yaeger R; Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York., Kelley RK; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California., Bardelli A; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Torino, Italy.; Department of Oncology, University of Torino, Candiolo, Torino, Italy., Iafrate AJ; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Hahn WC; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts., Benes CH; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Ting DT; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Hirai H; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Getz G; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts., Juric D; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts., Zhu AX; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. bardeesy.nabeel@mgh.harvard.edu azhu@partners.org rbcorcoran@partners.org., Corcoran RB; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. bardeesy.nabeel@mgh.harvard.edu azhu@partners.org rbcorcoran@partners.org., Bardeesy N; Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. bardeesy.nabeel@mgh.harvard.edu azhu@partners.org rbcorcoran@partners.org.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts.

المصدر: Cancer discovery [Cancer Discov] 2019 Aug; Vol. 9 (8), pp. 1064-1079. Date of Electronic Publication: 2019 May 20.

نوع المنشور: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Adenosine Triphosphate/*metabolism , Cholangiocarcinoma/*genetics , Cholangiocarcinoma/*metabolism , Drug Resistance, Neoplasm/*genetics , Protein Kinase Inhibitors/*pharmacology , Receptor, Fibroblast Growth Factor, Type 2/*antagonists & inhibitors , Receptor, Fibroblast Growth Factor, Type 2/*genetics, Adult ; Aged ; Cell Line, Tumor ; Cholangiocarcinoma/diagnosis ; Circulating Tumor DNA ; Female ; Humans ; Male ; Middle Aged ; Mutation ; Oncogene Proteins, Fusion/antagonists & inhibitors ; Oncogene Proteins, Fusion/genetics ; Phenylurea Compounds/pharmacology ; Protein Kinase Inhibitors/chemistry ; Pyrimidines/pharmacology ; Receptor, Fibroblast Growth Factor, Type 2/chemistry ; Receptor, Fibroblast Growth Factor, Type 2/metabolism ; Signal Transduction/drug effects ; Structure-Activity Relationship ; Tomography, X-Ray Computed

المؤلفون: Dirice E; Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Kahraman S; Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., De Jesus DF; Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Graduate Program in Areas of Basic and Applied Biology (GABBA), Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal., El Ouaamari A; Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Basile G; Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Baker RL; Department of Immunology, School of Medicine, University of Colorado, Aurora, CO, USA., Yigit B; Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Piehowski PD; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Kim MJ; Section for Immunobiology, Joslin Diabetes Center, Boston, MA, USA., Dwyer AJ; University of Minnesota, Center for Immunology, Department of Medicine, Minneapolis, MN, USA., Ng RWS; Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Schuster C; Section for Immunobiology, Joslin Diabetes Center, Boston, MA, USA., Vethe H; Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA., Martinov T; University of Minnesota, Center for Immunology, Department of Medicine, Minneapolis, MN, USA., Ishikawa Y; Section for Immunobiology, Joslin Diabetes Center, Boston, MA, USA., Teo AKK; Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Smith RD; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Hu J; Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Haskins K; Department of Immunology, School of Medicine, University of Colorado, Aurora, CO, USA., Serwold T; Section for Immunobiology, Joslin Diabetes Center, Boston, MA, USA., Qian WJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Fife BT; University of Minnesota, Center for Immunology, Department of Medicine, Minneapolis, MN, USA., Kissler S; Section for Immunobiology, Joslin Diabetes Center, Boston, MA, USA., Kulkarni RN; Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Harvard Stem Cell Institute, Boston, MA, USA.

المصدر: Nature metabolism [Nat Metab] 2019 May; Vol. 1 (5), pp. 509-518. Date of Electronic Publication: 2019 May 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab

مواضيع طبية MeSH: Cell Proliferation*, Diabetes Mellitus, Type 1/*pathology , Immune System/*immunology , Insulin-Secreting Cells/*pathology, Animals ; Diabetes Mellitus, Type 1/immunology ; Diabetes Mellitus, Type 1/metabolism ; Disease Progression ; Humans ; Mice

المؤلفون: Chan EM; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Shibue T; Broad Institute of Harvard and MIT, Cambridge, MA, USA., McFarland JM; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Gaeta B; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Ghandi M; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Dumont N; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Gonzalez A; Broad Institute of Harvard and MIT, Cambridge, MA, USA., McPartlan JS; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Li T; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Zhang Y; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Bin Liu J; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Lazaro JB; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Gu P; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA., Piett CG; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Apffel A; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Ali SO; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Deasy R; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Keskula P; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Ng RWS; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Roberts EA; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Reznichenko E; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Leung L; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Alimova M; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Schenone M; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Islam M; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Maruvka YE; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Liu Y; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Roper J; Department of Medicine, Division of Gastroenterology, Duke University, Durham, NC, USA., Raghavan S; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Giannakis M; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Tseng YY; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Nagel ZD; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA., D'Andrea A; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Root DE; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Boehm JS; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Getz G; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Massachusetts General Hospital Cancer Center, Boston, MA, USA., Chang S; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA.; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT, USA., Golub TR; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Tsherniak A; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Vazquez F; Broad Institute of Harvard and MIT, Cambridge, MA, USA. vazquez@broadinstitute.org.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. vazquez@broadinstitute.org., Bass AJ; Broad Institute of Harvard and MIT, Cambridge, MA, USA. adam_bass@dfci.harvard.edu.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. adam_bass@dfci.harvard.edu.

المصدر: Nature [Nature] 2019 Apr; Vol. 568 (7753), pp. 551-556. Date of Electronic Publication: 2019 Apr 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Microsatellite Instability*, Microsatellite Repeats/*genetics , Neoplasms/*genetics , Synthetic Lethal Mutations/*genetics , Werner Syndrome Helicase/*genetics, Apoptosis/genetics ; CRISPR-Cas Systems/genetics ; Cell Cycle Checkpoints/genetics ; Cell Line, Tumor ; DNA Breaks, Double-Stranded ; Humans ; Models, Genetic ; Neoplasms/pathology ; RNA Interference ; Tumor Suppressor Protein p53/metabolism ; Werner Syndrome Helicase/deficiency