المؤلفون: Nim S; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada., O'Hara DM; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Corbi-Verge C; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada., Perez-Riba A; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada., Fujisawa K; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Kapadia M; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Chau H; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Albanese F; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Pawar G; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., De Snoo ML; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Ngana SG; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada., Kim J; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada., El-Agnaf OMA; Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar., Rennella E; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Kay LE; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.; Department of Chemistry, University of Toronto, Toronto, ON, Canada.; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada., Kalia SK; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada. suneil.kalia@utoronto.ca.; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada. suneil.kalia@utoronto.ca., Kalia LV; Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada. lorraine.kalia@utoronto.ca.; Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada. lorraine.kalia@utoronto.ca.; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada. lorraine.kalia@utoronto.ca., Kim PM; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada. pi@kimlab.org.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. pi@kimlab.org.; Department of Computer Science, University of Toronto, Toronto, ON, Canada. pi@kimlab.org.

المصدر: Nature communications [Nat Commun] 2023 Apr 19; Vol. 14 (1), pp. 2150. Date of Electronic Publication: 2023 Apr 19.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Parkinson Disease*/drug therapy , Parkinson Disease*/metabolism, Male ; Female ; Animals ; Rats ; Humans ; alpha-Synuclein/genetics ; alpha-Synuclein/metabolism ; Caenorhabditis elegans/metabolism ; Dopaminergic Neurons/metabolism ; Endosomal Sorting Complexes Required for Transport/metabolism ; Peptides/pharmacology ; Peptides/metabolism

المؤلفون: McKinnon C; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada., De Snoo ML; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada., Gondard E; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada., Neudorfer C; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada., Chau H; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada., Ngana SG; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada., O'Hara DM; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada., Brotchie JM; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada., Koprich JB; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada., Lozano AM; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada.; Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada., Kalia LV; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada.; Division of Neurology, Department of Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada., Kalia SK; Krembil Research Institute, Toronto Western Hospital, University Health Network, 60 Leonard Avenue, Toronto, ON, M5T 0S8, Canada. suneil.kalia@utoronto.ca.; Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada. suneil.kalia@utoronto.ca.

المصدر: Acta neuropathologica communications [Acta Neuropathol Commun] 2020 Feb 14; Vol. 8 (1), pp. 17. Date of Electronic Publication: 2020 Feb 14.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE

مواضيع طبية MeSH: Dopaminergic Neurons/*metabolism , Pars Compacta/*metabolism , Proteasome Endopeptidase Complex/*metabolism , Ubiquitin/*metabolism , alpha-Synuclein/*metabolism, Animals ; Female ; HEK293 Cells ; Humans ; Rats, Sprague-Dawley