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1
المؤلفون: Christine F. Gelin, Brice Stenne, Heather Coate, Afton Hiscox, Akinola Soyode-Johnson, Jessica L. Wall, Brian Lord, Jeffrey Schoellerman, Kevin J. Coe, Kai Wang, Jesus Alcázar, Christa C. Chrovian, Curt A. Dvorak, Nicholas I. Carruthers, Tatiana Koudriakova, Bartosz Balana, Michael A. Letavic
المصدر: Journal of Medicinal Chemistry. 66:2877-2892
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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2
المؤلفون: Anne E. Fitzgerald, Tatiana Koudriakova, Kevin J. Coe, Anthony Ndifor, Cathy Preville, Christine Dugovic, Neelakandha S. Mani, Nicholas I. Carruthers, Michele C. Rizzolio, Timothy W. Lovenberg, Brock T. Shireman, Diane Nepomuceno, Coate Heather R, Daniel J. Pippel, Brian Lord, Allison Brett Douglas, Curt A. Dvorak, Pascal Bonaventure
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: 010405 organic chemistry, Chemistry, Sleep wake, digestive, oral, and skin physiology, Organic Chemistry, Antagonist, Neuropeptide, Pharmacology, 01 natural sciences, Biochemistry, Orexin receptor, 0104 chemical sciences, Orexin, 010404 medicinal & biomolecular chemistry, nervous system, mental disorders, Drug Discovery, Receptor, Mode of action, hormones, hormone substitutes, and hormone antagonists, psychological phenomena and processes
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3
المؤلفون: Nicholas I. Carruthers, Stefan J. McCarver, Chi Chip Le, Shireman Brock T, Russell T. Smith, Xiaheng Zhang, David W. C. MacMillan
المصدر: Nature
مصطلحات موضوعية: chemistry.chemical_classification, Sulfonyl, Biological Products, Multidisciplinary, Trifluoromethyl, Bicyclic molecule, 010405 organic chemistry, Radical, Heteroatom, Chemistry Techniques, Synthetic, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Article, 0104 chemical sciences, Propellane, chemistry.chemical_compound, chemistry, Nucleophile, Pharmaceutical Preparations, Cyclization, Pentanes, Alkyl, Copper
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4دورية أكاديمية
المؤلفون: Xiaheng Zhang, Russell T. Smith, Chip Le, Stefan J. McCarver, Brock T. Shireman, Nicholas I. Carruthers, David W. C. MacMillan
المصدر: Nature, Nature. 580(7802):220-226
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5
المؤلفون: Akinola Soyode-Johnson, Michael A. Letavic, Kevin J. Coe, Christa C. Chrovian, Brian Lord, Nicholas I. Carruthers, Wall Jessica L, Bartosz Balana, Xiaohui Jiang, Tatiana Koudriakova, Leslie Nguyen, Jason C. Rech, Jeff Schoellerman
المصدر: ACS Medicinal Chemistry Letters. 10:261-266
مصطلحات موضوعية: biology, 010405 organic chemistry, Stereochemistry, Organic Chemistry, Allosteric regulation, hERG, Cytochrome P450, 01 natural sciences, Biochemistry, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, Pyridine, biology.protein, Potency, Receptor
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6
المؤلفون: Tatiana Koudriakova, Devin M. Swanson, Dongpei Wu, Nicholas I. Carruthers, Kevin J. Coe, Timothy W. Lovenberg, Michael K. Ameriks, Mark Seierstad, Beatriz García Olmos, Jorge Vives Martinez, Nyantsz Wu, Brian Lord, Michael P. Maher, Brad M. Savall
المصدر: ACS Medicinal Chemistry Letters. 10:267-272
مصطلحات موضوعية: 010405 organic chemistry, medicine.medical_treatment, Organic Chemistry, Glutamate receptor, AMPA receptor, Glutathione, Pharmacology, 01 natural sciences, Biochemistry, Pyrazolopyrimidine, Transmembrane protein, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Anticonvulsant, chemistry, Drug Discovery, medicine, Efflux, Receptor
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7
المؤلفون: Curt A, Dvorak, Dale A, Rudolph, Diane, Nepomuceno, Lisa, Dvorak, Brian, Lord, Ian, Fraser, Pascal, Bonaventure, Timothy, Lovenberg, Nicholas I, Carruthers
المصدر: Bioorganicmedicinal chemistry letters. 31
مصطلحات موضوعية: Dose-Response Relationship, Drug, Molecular Structure, Azepines, Haplorhini, Rats, Mice, Structure-Activity Relationship, Dogs, Receptors, Serotonin, Drug Discovery, Animals, Humans, Serotonin Antagonists, Receptors, Serotonin, 5-HT2
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8
المؤلفون: Brad M. Savall, Perry Leung, Suchitra Ravula, Brian Lord, Ray Rynberg, Kevin J. Coe, Michael P. Maher, Nicholas I. Carruthers, Kai Wang, David La, Devin M. Swanson, Mark Seierstad, Minh Nguyen, Tatiana Koudriakova, Michael K. Ameriks, Nyantsz Wu, Ziff Jeannie M, Daniel J. Pippel, Timothy W. Lovenberg
المصدر: ACS Medicinal Chemistry Letters. 9:821-826
مصطلحات موضوعية: 0301 basic medicine, Organic Chemistry, Glutamate receptor, Gating, AMPA receptor, Neurotransmission, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, nervous system, chemistry, Drug Discovery, Biophysics, Excitatory postsynaptic potential, Oxindole, Receptor, 030217 neurology & neurosurgery, Ionotropic effect
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9
المؤلفون: Leah Aluisio, Jan-Sebastian Grigoleit, Michael A. Letavic, Ian Fraser, Timothy W. Lovenberg, Natalie Taylor, Nicholas I. Carruthers, Jason C. O'Connor, Brian Lord, Anindya Bhattacharya, Shannon N. Campbell, Yingbo He, Mariusz Papp, Christa C. Chrovian
المصدر: Neuropsychopharmacology. 43:2586-2596
مصطلحات موضوعية: Lipopolysaccharides, Male, 0301 basic medicine, Anhedonia, Purinergic P2X Receptor Antagonists, Pyridines, Interleukin-1beta, Drug Evaluation, Preclinical, Pharmacology, Article, Rats, Sprague-Dawley, Mice, 03 medical and health sciences, Drug Delivery Systems, 0302 clinical medicine, medicine, Animals, Chronic stress, Rats, Wistar, Cells, Cultured, Neuropharmacology, ED50, Neuroinflammation, Inflammation, Dose-Response Relationship, Drug, Microglia, business.industry, Antagonist, Rats, Mice, Inbred C57BL, Disease Models, Animal, Psychiatry and Mental health, Pyrimidines, 030104 developmental biology, medicine.anatomical_structure, Neuroimmunology, Receptors, Purinergic P2X7, Inflammation Mediators, medicine.symptom, business, 030217 neurology & neurosurgery
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10
المؤلفون: Alan D. Wickenden, Monicah A. Otieno, Jimmy T. Liang, Stewart Bryant, Michael A. Letavic, Ian Fraser, Derek A. Beauchamp, Nicholas I. Carruthers, Devin M. Swanson, Christine F. Gelin, Curt A. Dvorak, Meri De Angelis, Ceusters Marc Andre, Hong Ao, Anindya Bhattacharya, Brian Lord, Tatiana Koudriakova, Allison Brett Douglas, Pascal Bonaventure, Brad M. Savall, Kevin J. Coe, Leah Aluisio, Freddy Schoetens, Qi Wang, José Ignacio Andrés, Timothy W. Lovenberg
المصدر: Journal of Medicinal Chemistry. 60:4559-4572
مصطلحات موضوعية: 0301 basic medicine, Purinergic P2X Receptor Antagonists, Pyridines, Drug discovery, Stereochemistry, Target engagement, Biological Availability, Metabolic stability, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, Pharmacokinetics, In vivo, Drug Discovery, Pyridine, Animals, Humans, Molecular Medicine, Receptors, Purinergic P2X7, P2x7 receptor, 030217 neurology & neurosurgery