نتائج البحث - "Nicola Flaum"

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دورية أكاديمية

Is Reflex Germline BRCA1/2 Testing Necessary in Women Diagnosed with Non-Mucinous High-Grade Epithelial Ovarian Cancer Aged 80 Years or Older?

المؤلفون: Robert D. Morgan, George J. Burghel, Nicola Flaum, Michael Bulman, Philip Smith, Andrew R. Clamp, Jurjees Hasan, Claire L. Mitchell, Zena Salih, Emma R. Woodward, Fiona Lalloo, Emma J. Crosbie, Richard J. Edmondson, Helene Schlecht, Gordon C. Jayson, D. Gareth R. Evans

المصدر: Cancers, Vol 15, Iss 3, p 730 (2023)

مصطلحات موضوعية: epithelial ovarian cancer, germline, somatic, BRCA1, BRCA2, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2072-6694/15/3/730; https://doaj.org/toc/2072-6694

URL الوصول: https://doaj.org/article/226d8028d5794a148682355578cb1be9

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MSH2is the very young onset ovarian cancer predisposition gene, notBRCA1

المؤلفون: Nicola Flaum, Emma J Crosbie, Emma Roisin Woodward, Fiona Lalloo, Robert Morgan, Neil Ryan, D Gareth Evans

المصدر: Flaum, N, Crosbie, E J, Lalloo, F, Morgan, R, Ryan, N & Evans, D G 2023, ' MSH2is the very young onset ovarian cancer predisposition gene, notBRCA1 ', Journal of Medical Genetics . https://doi.org/10.1136/jmg-2022-109055
Flaum, N, Crosbie, E J, Woodward, E R, Lalloo, F, Morgan, R, Ryan, N & Evans, D G 2023, ' MSH2 is the very young onset ovarian cancer predisposition gene, not BRCA1 ', Journal of Medical Genetics . https://doi.org/10.1136/jmg-2022-109055

مصطلحات موضوعية: Manchester Cancer Research Centre, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, ResearchInstitutes_Networks_Beacons/mcrc, gynaecology, Genetics, Genetic Counselling, Genetic Predisposition to Disease, Genetic Testing, Genetics (clinical)

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4d90271983fca89dabf9fd560449d6
https://research.manchester.ac.uk/en/publications/50ac61ae-4138-490d-9f61-a3e60aba67e0

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BRCA1/2 in non-mucinous epithelial ovarian cancer: tumour with or without germline testing?

المؤلفون: Robert D. Morgan, George J. Burghel, Nicola Flaum, Michael Bulman, Philip Smith, Andrew R. Clamp, Jurjees Hasan, Claire L. Mitchell, Zena Salih, Emma R. Woodward, Fiona Lalloo, Emma J. Crosbie, Richard J. Edmondson, Andrew J. Wallace, Gordon C. Jayson, D. Gareth R. Evans

المصدر: Br J Cancer

مصطلحات موضوعية: BRCA2 Protein, Ovarian Neoplasms, Cancer Research, Germ Cells, Oncology, BRCA1 Protein, Humans, Female, Genetic Testing, Carcinoma, Ovarian Epithelial, Germ-Line Mutation, Article, Aged

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db2b4ec442f0132dbfe163461a01eb74
https://doi.org/10.1038/s41416-022-01773-y

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4

Dominant‐negative pathogenic variant BRIP1 c. 1045G >C is a high‐risk allele for non‐mucinous epithelial ovarian cancer: A case‐control study

المؤلفون: Stephanie Amico, Nicola Flaum, Olivia Smith, Emma J Crosbie, Richard J. Edmondson, D. Gareth Evans, Elke M van Veen, William G. Newman, Miriam J. Smith

المصدر: Flaum, N, van Veen, E M, Smith, O, Amico, S, Newman, W, Crosbie, E, Edmondson, R, Smith, M J & Evans, D G 2022, ' Dominant-negative pathogenic variant BRIP1 c.1045G >C is a high-risk allele for non-mucinous epithelial ovarian cancer: a case-control study ', Clin Genet, vol. 101, no. 1, pp. 48-54 . https://doi.org/10.1111/cge.14068

مصطلحات موضوعية: Oncology, medicine.medical_specialty, endocrine system diseases, Carcinoma, Ovarian Epithelial, symbols.namesake, Breast cancer, Gene Frequency, Internal medicine, Genetics, medicine, Humans, Missense mutation, Genetic Predisposition to Disease, Epithelial ovarian cancer, Family history, Gene, Alleles, Genetic Association Studies, Genetics (clinical), Aged, Genes, Dominant, Ovarian Neoplasms, Sanger sequencing, Manchester Cancer Research Centre, business.industry, ResearchInstitutes_Networks_Beacons/mcrc, BRIP1, Case-control study, Sequence Analysis, DNA, Middle Aged, medicine.disease, Fanconi Anemia Complementation Group Proteins, female genital diseases and pregnancy complications, Case-Control Studies, symbols, Female, business, RNA Helicases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146d8c0e1ed43161af45d79e6e126add
https://doi.org/10.1111/cge.14068

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Predicting the likelihood of a BRCA1/2 pathogenic variant being somatic by testing only tumour DNA in non-mucinous high-grade epithelial ovarian cancer

المؤلفون: Robert D Morgan, George J Burghel, Nicola Flaum, Michael Bulman, Philip Smith, Andrew R Clamp, Jurjees Hasan, Claire Mitchell, Zena Salih, Emma R Woodward, Fiona Lalloo, Joseph Shaw, Sudha Desai, Emma J Crosbie, Richard J Edmondson, Helene Schlecht, Andrew J Wallace, Gordon C Jayson, D Gareth R Evans

المصدر: Morgan, R D, Burghel, G J, Flaum, N, Bulman, M, Smith, P, Clamp, A R, Hasan, J, Mitchell, C, Salih, Z, Woodward, E R, Lalloo, F, Shaw, J, Desai, S, Crosbie, E J, Edmondson, R J, Schlecht, H, Wallace, A J, Jayson, G C & Evans, D G R 2022, ' Predicting the likelihood of a BRCA1/2 pathogenic variant being somatic by testing only tumour DNA in non-mucinous high-grade epithelial ovarian cancer ', Journal Of Clinical Pathology . https://doi.org/10.1136/jcp-2022-208369
Burghel, GJ, Flaum, N, Bulman, M, Clamp, AR, Hasan, J, Salih, Z, Lalloo, F, Shaw, J, Desai, S & Crosbie, EJ 2022, ' Predicting the likelihood of a BRCA1/2 pathogenic variant being somatic by testing only tumour DNA in non-mucinous high-grade epithelial ovarian cancer ', Journal Of Clinical Pathology . https://doi.org/10.1136/jcp-2022-208369

مصطلحات موضوعية: Ovarian Neoplasms, GENETICS, Manchester Cancer Research Centre, ResearchInstitutes_Networks_Beacons/mcrc, Biomarkers, Tumor, General Medicine, Pathology and Forensic Medicine

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76400a7c00ab211c13628e824ace32a4
https://www.mendeley.com/catalogue/f0b4bc28-8cbb-3b9b-a445-022fcc539057/

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Optimisation of polygenic risk scores in BRCA1/2 pathogenic variant heterozygotes in epithelial ovarian cancer

المؤلفون: Nicola Flaum, John Bowes, Miriam J. Smith, Emma J. Crosbie, Richard Edmondson, Artitaya Lophatananon, D. Gareth Evans

المصدر: Genetics in Medicine. :100898

مصطلحات موضوعية: Genetics (clinical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::856a847034c771b3256513a0b8bd51c6
https://doi.org/10.1016/j.gim.2023.100898

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Predicting the likelihood of a

المؤلفون: Robert D, Morgan, George J, Burghel, Nicola, Flaum, Michael, Bulman, Philip, Smith, Andrew R, Clamp, Jurjees, Hasan, Claire, Mitchell, Zena, Salih, Emma R, Woodward, Fiona, Lalloo, Joseph, Shaw, Sudha, Desai, Emma J, Crosbie, Richard J, Edmondson, Helene, Schlecht, Andrew J, Wallace, Gordon C, Jayson, D Gareth R, Evans

المصدر: Journal of clinical pathology.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::1e535daae7f9e63db4d16f9e91368235
https://pubmed.ncbi.nlm.nih.gov/35738887

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8

High detection rate from genetic testing in BRCA-negative women with familial epithelial ovarian cancer

المؤلفون: Nicola Flaum, Emma J. Crosbie, Richard Edmondson, Emma R. Woodward, Fiona Lalloo, Miriam J. Smith, Helene Schlecht, D. Gareth Evans

المصدر: Flaum, N, Crosbie, E J, Edmondson, R, Woodward, E R, Lalloo, F, Smith, M J, Schlecht, H & Evans, D G 2022, ' High detection rate from genetic testing in BRCA-negative women with familial epithelial ovarian cancer ', Genetics in Medicine, vol. 24, no. 12, pp. 2578-2586 . https://doi.org/10.1016/j.gim.2022.08.022
Flaum, N, Crosbie, E J, Edmondson, R, Woodward, E R, Lalloo, F, Smith, M J, Schlecht, H & Evans, D G 2022, ' High detection rate from genetic testing in BRCA-negative women with familial epithelial ovarian cancer ', Genetics in medicine : official journal of the American College of Medical Genetics, vol. 24, no. 12, pp. 2578-2586 . https://doi.org/10.1016/j.gim.2022.08.022

مصطلحات موضوعية: Male, BRCA2 Protein, Ovarian Neoplasms, Ovarian Neoplasms/diagnosis, Manchester Cancer Research Centre, BRCA1 Protein, ResearchInstitutes_Networks_Beacons/mcrc, Genes, BRCA2, Carcinoma, Ovarian Epithelial, BRCA2 Protein/genetics, Carcinoma, Ovarian Epithelial/genetics, Exome Sequencing, BRCA1 Protein/genetics, Humans, Female, Genetic Predisposition to Disease, Genetic Testing, Genetics (clinical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2b68712b95d6ac7121c4d44f512146
https://pubmed.ncbi.nlm.nih.gov/36169650

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Specialist oncological surgery for removal of the ovaries and fallopian tubes in BRCA1 and BRCA2 pathogenic variant carriers may reduce primary peritoneal cancer risk to very low levels

المؤلفون: Richard J. Edmondson, Nicola Flaum, Pierre L. Martin-Hirsch, Elaine F. Harkness, D. Gareth Evans, Richard D Clayton, Nicholas J Wood, Fiona Lalloo, Emma R. Woodward, Emma J Crosbie, Cathrine Holland, Patrick J. Keating, P. Donnai

المصدر: International Journal of Cancer. 148:1155-1163

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::25ada7f994f22711ae864a995042d5c4
https://doi.org/10.1002/ijc.33378

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Mainstreaming germline BRCA1/2 testing in non-mucinous epithelial ovarian cancer in the North West of England

المصدر: Eur J Hum Genet

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fde76bae880cf2e9e8baf636fc4a23f
https://doi.org/10.1038/s41431-020-0692-y

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