يعرض 1 - 10 نتائج من 22 نتيجة بحث عن '"Nicolas Boutard"', وقت الاستعلام: 1.06s تنقيح النتائج
  1. 1
    Abstract 449: Discovery of novel MTA-cooperative PRMT5 inhibitors as targeted therapeutics for MTAP-deleted cancers

    المؤلفون: Anna Bartosik, Adam Radzimierski, Aneta Bobowska, Oleksandr Levenets, Agata Stachowicz, Kamil Kuś, Kinga Michalik, Katarzyna Banaszak, Monika Madej, Marta Skoda, Kamila Kozłowska-Tomczyk, Igor Tomczyk, Karolina Pyziak, Dobrosława Krzemień, Mirosława Gładysz, Paulina Podkalicka, Aniela Gołas, Karolina Gluza, Grzegorz Satała, Andrzej Gondela, Marta Sowińska, Nicolas Boutard, Agata Chłopek, Aleksandra Więckowska, Daria Szukiel, Grzegorz Ćwiertnia, Iana Levenets, Karol Zuchowicz, Klara Korta-Piątek, Marcin Nowogródzki, Marek Wronowski, Marianna Girardi, Mateusz Świrski, Oleksandr Popika, Paulina Niedziejko-Ćwiertnia, Pierpaolo Cordone, Przemysław Wyrębek, Quỳnh Vũ, Sujit Sasmal, Svitlana Sukhomlinova, Magdalena Miodek, Jacek Faber, Anna Kowal-Chwast, Róża Starczak, Sanja Novak Ratajczak, Agnieszka Świrska, Dawid Gogola, Paweł Guzik, Martin Swarbrick, Mateusz Nowak

    المصدر: Cancer Research. 83:449-449

    مصطلحات موضوعية: Cancer Research, Oncology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::34a1d4e4d42d7129c59897d226cd1a8b
    https://doi.org/10.1158/1538-7445.am2023-449

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  2. 2
    5-Keto-3-cyano-2,4-diaminothiophenes as selective maternal embryonic leucine zipper kinase inhibitors

    المؤلفون: Charles-Henry Fabritius, Paulina Węgrzyn, Agata Stasiowska, Marta Bugaj, Andrzej Mazan, Monika Dobrzańska, Karolina Gluza, Piotr Kowalczyk, Ewa Kolasińska, Adrian Zarebski, Przemyslaw Zawadzki, Karolina Krawczynska, Aneta Bobowska, Anna Cierpich, Małgorzata Żurawska, Nicolas Boutard, Mariusz Milik, Katarzyna Wiklik, Anna Buda, Małgorzata Jarosz, Krzysztof Brzózka, Aleksandra Sabiniarz, Mariusz Galek, Edyta Palacz, Klaudia Czerwińska, Claude Commandeur

    المصدر: Bioorganic & Medicinal Chemistry Letters. 29:607-613

    مصطلحات موضوعية: Molecular model, Clinical Biochemistry, Pharmaceutical Science, Apoptosis, Ovary, Thiophenes, Protein Serine-Threonine Kinases, 01 natural sciences, Biochemistry, Maternal embryonic leucine zipper kinase, Inhibitory Concentration 50, Prostate, Cell Line, Tumor, Drug Discovery, medicine, Humans, Protein kinase A, Molecular Biology, IC50, Cell Proliferation, 010405 organic chemistry, Chemistry, Kinase, Organic Chemistry, Cancer, medicine.disease, High-Throughput Screening Assays, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, Cancer research, Molecular Medicine, Female, Drug Screening Assays, Antitumor

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0811d2cb5e37f7797b44a0953a2ff63
    https://doi.org/10.1016/j.bmcl.2018.12.051

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  3. 3
    Abstract 1806: Discovery of novel MTA-cooperative PRMT5 inhibitors as a targeted therapeutics for MTAP deleted cancers

    المؤلفون: Oleksandr Levenets, Anna Bartosik, Marta Sowińska, Karol Zuchowicz, Sujit Sasmal, Klara Korta-Piątek, Adam Radzimierski, Paulina Niedziejko, Oleksandr Popika, Mateusz Świrski, Agata Stachowicz, Maciej Mikulski, Magdalena Sieprawska-Lupa, Katarzyna Banaszak, Kinga Michalik, Kamil Kuś, Monika Madej, Adrian Podkowa, Karolina Gluza, Grzegorz Satała, Ewelina Cieluch, Dobrosława Krzemień, Andrzej Gondela, Grzegorz Ćwiertnia, Marek Wronowski, Nicolas Boutard, Aleksandra Więckowska, Joanna Zezula, Justyna Jabłońska, Mirosława Gładysz, Igor Tomczyk, Jacek Faber, Marcin Serocki, Eliza Drwal, Kamila Kozłowska-Tomczyk, Marta Skoda, Martin Swarbrick, Krzysztof Brzózka, Mateusz Nowak

    المصدر: Cancer Research. 82:1806-1806

    مصطلحات موضوعية: Cancer Research, Oncology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::08f276f2b9f1991124155b5824fbe3fb
    https://doi.org/10.1158/1538-7445.am2022-1806

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  4. 4
    Discovery of a series of ester-substituted NLRP3 inflammasome inhibitors

    المؤلفون: Krzysztof Brzózka, Alan P. Watt, Michal Galezowski, Magdalena Mroczkowska, Stefan Chmielewski, Grzegorz Witold Topolnicki, Christopher A. Gabel, David J. Schultz, John R. Doedens, Charles-Henry Fabritius, Oleksandr Levenets, Piotr Kowalczyk, Piotr Urbanski, Katarzyna Palica, Nicolas Boutard, Anna Cierpich, Roderick A. Porter, Marta Bugaj, Jakub Woyciechowski, Marta Sowinska, David G. Harrison

    المصدر: Bioorganicmedicinal chemistry letters. 30(23)

    مصطلحات موضوعية: Inflammasomes, THP-1 Cells, Clinical Biochemistry, Pharmaceutical Science, Inflammation, Pharmacology, 01 natural sciences, Biochemistry, Heterocyclic Compounds, 4 or More Rings, Proinflammatory cytokine, Carboxylesterase, Mice, Structure-Activity Relationship, Drug Stability, Drug Discovery, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Animals, Humans, Urea, Sulfones, Furans, Molecular Biology, chemistry.chemical_classification, Sulfonamides, Innate immune system, integumentary system, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Rational design, Inflammasome, Esters, Prodrug, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, Blood, chemistry, Indenes, Drug Design, Molecular Medicine, medicine.symptom, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9b9567b37c2ffb77ffeec192329547
    https://pubmed.ncbi.nlm.nih.gov/32956781

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  5. 5
    Abstract 1281: Development and characterization of small molecule HPK1 inhibitors

    المؤلفون: Kinga Michalik, Karol Zuchowicz, Karolina Gluza, Anna Bartosik, Magdalena Zastawna, Wojciech Jasnosz, Nicolas Boutard, Andrzej Gondela, Eliza Zimoląg, Patryk Kret, Marta Bugaj, Aneta Bobowska, Sylwia Sudoł, Pawel Guzik, Maciej Kujawa, Peter Littlewood, Aleksandra Więckowska, Sujit Sasmal, David Synak, Katarzyna Banaszak, Przemysław Wyrębek, Joanna Szeremeta-Spisak, Wojciech Schonemann, Agnieszka Gibas, Mateusz Świrski, Marianna Girardi, Monika Dobrzańska, Michal Galezowski, Kostiantyn Krolenko, Marcin Nowogrodzki, Agata Dudek, Urszula Kulesza, Mateusz Ogórek, Krzysztof Brzózka, Katarzyna Wnuk-Lipinska, Oleksandr Leventes, Adrian Podkowa, Stefan Chmielewski

    المصدر: Cancer Research. 81:1281-1281

    مصطلحات موضوعية: Cancer Research, Oncology, Chemistry, Small molecule, Combinatorial chemistry, Characterization (materials science)

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1d5e702c70b2fb184d24629734608dc8
    https://doi.org/10.1158/1538-7445.am2021-1281

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  6. 6
    Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties

    المؤلفون: Nicolas Boutard, Arkadiusz Białas, Aleksandra Sabiniarz, Paweł Guzik, Katarzyna Banaszak, Artur Biela, Marcin Bień, Anna Buda, Barbara Bugaj, Ewelina Cieluch, Anna Cierpich, Łukasz Dudek, Hans-Michael Eggenweiler, Joanna Fogt, Monika Gaik, Andrzej Gondela, Krzysztof Jakubiec, Mirek Jurzak, Agata Kitlińska, Piotr Kowalczyk, Maciej Kujawa, Katarzyna Kwiecińska, Marcin Leś, Ralph Lindemann, Monika Maciuszek, Maciej Mikulski, Paulina Niedziejko, Alicja Obara, Henryk Pawlik, Tomasz Rzymski, Magdalena Sieprawska-Lupa, Marta Sowińska, Joanna Szeremeta-Spisak, Agata Stachowicz, Mateusz M. Tomczyk, Katarzyna Wiklik, Łukasz Włoszczak, Sylwia Ziemiańska, Adrian Zarębski, Krzysztof Brzózka, Mateusz Nowak, Charles-Henry Fabritius

    مصطلحات موضوعية: Sulfonamides, Phosphofructokinase-2, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, HCT116 Cells, Biochemistry, Amides, Kinetics, Solubility, Quinoxalines, Drug Discovery, Molecular Medicine, Humans, Molecular Biology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef37f4c1c80edce81f72f55d3f7931e
    https://ruj.uj.edu.pl/xmlui/handle/item/252764

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  7. 7
    Discovery and Structure-Activity Relationships of N-Aryl 6-Aminoquinoxalines as Potent PFKFB3 Kinase Inhibitors

    المؤلفون: K. Banaszak, M. Gaik, M. Maciuszek, A. Gondela, A. Stachowicz, A. Bialas, A. Kitlinska, K. Kwiecinska, H.M. Eggenweiler, M. Bien, L. Wloszczak, Mateusz Michał Tomczyk, P. Guzik, Magdalena Sieprawska-Lupa, Piotr Kowalczyk, M. Jurzak, Marta Sowinska, M. Les, Mateusz Nowak, Aleksandra Sabiniarz, S. Ziemianska, B. Bugaj, Maciej Mikulski, Nicolas Boutard, L. Dudek, Anna Cierpich, A. Biela, R. Lindemann, Adrian Zarebski, H. Pawlik, J. Fogt, E. Cieluch, Joanna Szeremeta-Spisak, Krzysztof Brzózka, T. Rzymski, M. Kujawa, K. Jakubiec, C.H. Fabritius, Katarzyna Wiklik, A. Obara, Anna Buda, P. Niedziejko

    المصدر: ChemMedChem. 14(1)

    مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Cell Survival, Phosphofructokinase-2, enzymes, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Quinoxalines, inhibitors, Drug Discovery, cancer, Humans, Glycolysis, Lactic Acid, General Pharmacology, Toxicology and Pharmaceutics, Enzyme Inhibitors, Pharmacology, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Kinase, Organic Chemistry, glycolysis, HCT116 Cells, Warburg effect, 030104 developmental biology, Enzyme, chemistry, Docking (molecular), Anaerobic glycolysis, 030220 oncology & carcinogenesis, Cancer cell, Molecular Medicine, metabolism, Phosphofructokinase

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4e2e375f345b45513bf24c44f0ee4c
    https://pubmed.ncbi.nlm.nih.gov/30378281

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  8. 8
    Synthetic Lethality Triggered by Combining Olaparib with BRCA2-Rad51 Disruptors

    المؤلفون: Tiziana Masini, Janet Robertson, Giuseppina Di Stefano, Andrea Cavalli, Federico Falchi, Saverio Minucci, Elisa Giacomini, Marinella Roberti, Roberto Pellicciari, Marcella Manerba, Isabella Pallavicini, Fulvia Farabegoli, Lorenza Di Ianni, Nicolas Boutard, Lara Rossini

    المساهمون: Falchi, Federico, Giacomini, Elisa, Masini, Tiziana, Boutard, Nicola, Di Ianni, Lorenza, Manerba, Marcella, Farabegoli, Fulvia, Rossini, Lara, Robertson, Janet, Minucci, Saverio, Pallavicini, Isabella, Di Stefano, Giuseppina, Roberti, Marinella, Pellicciari, Roberto, Cavalli, Andrea

    المصدر: ACS chemical biology. 12(10)

    مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, DNA Repair, DNA repair, Protein Conformation, RAD51, Antineoplastic Agents, Synthetic lethality, Pharmacology, Biochemistry, Piperazines, Olaparib, Antineoplastic Agent, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Gene silencing, Humans, Gene Silencing, Piperazine, Polymerase, Phthalazine, BRCA2 Protein, biology, General Medicine, Molecular biology, Gene Expression Regulation, Neoplastic, Adenosine diphosphate, 030104 developmental biology, chemistry, Cell culture, 030220 oncology & carcinogenesis, Mutation, biology.protein, Molecular Medicine, Phthalazines, Rad51 Recombinase, Human

    وصف الملف: ELETTRONICO

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140415f3064e0bf0136b2916c785959b
    https://pubmed.ncbi.nlm.nih.gov/28841282

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  9. 9
    Peptide Scanning for Studying Structure-Activity Relationships in Drug Discovery

    المؤلفون: Nicolas Boutard, David Sabatino, Andrew G. Jamieson, William D. Lubell

    المصدر: Chemical Biology & Drug Design. 81:148-165

    مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, Peptidomimetic, Sequence analysis, Drug discovery, Chemistry, Organic Chemistry, Biological activity, Peptide, Biochemistry, Chemical space, Molecular recognition, Drug development, Drug Discovery, Molecular Medicine

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fa5e73cf96c36fc48be5e32e3cb296f0
    https://doi.org/10.1111/cbdd.12042

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  10. 10
    New C-Glycosylated α-Amino Acid Synthesis by Addition Reaction of an Amino Acid Organozinc Reagent on Carbohydrate-Derived Aldehydes

    المؤلفون: Nicolas Boutard, Frédéric Labéguère, Y. Vidal, J.-P. Lavergne, Jean Martinez

    المصدر: Synthetic Communications. 42:1461-1471

    مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, Addition reaction, Trimethylsilyl chloride, chemistry, Reagent, Organic Chemistry, Organic chemistry, Lewis acids and bases, Organozinc compound, Aldehyde, Amino acid synthesis, Amino acid

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6737afc73227f4b1393e629d3964e7cf
    https://doi.org/10.1080/00397911.2010.540698

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