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المؤلفون: Holger Sellner, Emilie Chapeau, Pascal Furet, Markus Voegtle, Bahaa Salem, Mickaël Le Douget, Vincent Bordas, Jean‐Marc Groell, Anne‐Laure Le Goff, Christine Rouzet, Thomas Wietlisbach, Thomas Zimmermann, Joseph McKenna, Cara E. Brocklehurst, Patrick Chène, Markus Wartmann, Clemens Scheufler, Joerg Kallen, Gareth Williams, Stephanie Harlfinger, Martin Traebert, Bérengère M. Dumotier, Tobias Schmelzle, Nicolas Soldermann
المصدر: ChemMedChem.
مصطلحات موضوعية: Pharmacology, Organic Chemistry, Drug Discovery, Molecular Medicine, General Pharmacology, Toxicology and Pharmaceutics, Biochemistry
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المؤلفون: Pascal Furet, Vincent Bordas, Mickaël Le Douget, Bahaa Salem, Yannick Mesrouze, Patricia Imbach‐Weese, Holger Sellner, Markus Voegtle, Nicolas Soldermann, Emilie Chapeau, Markus Wartmann, Clemens Scheufler, Cesar Fernandez, Joerg Kallen, Vito Guagnano, Patrick Chène, Tobias Schmelzle
المصدر: ChemMedChem. 17
مصطلحات موضوعية: Pharmacology, Organic Chemistry, Drug Discovery, Molecular Medicine, General Pharmacology, Toxicology and Pharmaceutics, Biochemistry
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المؤلفون: Pascal Furet, Vincent Bordas, Mickaël Le Douget, Bahaa Salem, Yannick Mesrouze, Patricia Imbach‐Weese, Holger Sellner, Markus Voegtle, Nicolas Soldermann, Emilie Chapeau, Markus Wartmann, Clemens Scheufler, Cesar Fernandez, Joerg Kallen, Vito Guagnano, Patrick Chène, Tobias Schmelzle
المصدر: ChemMedChem. 17(19)
مصطلحات موضوعية: Pharmacology, Neoplasms, Organic Chemistry, Drug Discovery, Molecular Medicine, Humans, YAP-Signaling Proteins, General Pharmacology, Toxicology and Pharmaceutics, Biochemistry, Adaptor Proteins, Signal Transducing, Transcription Factors
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المؤلفون: Tobias Schmelzle, Emilie Chapeau, Daniel Bauer, Patrick Chene, Jason Faris, Cesar Fernandez, Pascal Furet, Giorgio Galli, Jiachang Gong, Stephanie Harlfinger, Francesco Hofmann, Eloisa Jimenez Nunez, Joerg Kallen, Thanos Mourikis, Laurent Sansregret, Paulo Santos, Clemens Scheufler, Holger Sellner, Markus Voegtle, Markus Wartmann, Peter Wessels, Frederic Zecri, Nicolas Soldermann
المصدر: Cancer Research. 83:LB319-LB319
مصطلحات موضوعية: Cancer Research, Oncology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ad77e2db1f0369ac9729c839360bd713
https://doi.org/10.1158/1538-7445.am2023-lb319 -
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المؤلفون: Nicolas Soldermann, Ian Lewis, Alexander Baxter Smith, Klemens Hoegenauer, Frédéric Zecri, Dorothea Haasen, Anette Von Matt, Gregory Hollingworth, Christoph Burkhart, Christina Hebach, Rainer Wilcken, Romain M. Wolf
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:5657-5662
مصطلحات موضوعية: 0301 basic medicine, Pyrrolidines, Class I Phosphatidylinositol 3-Kinases, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, 01 natural sciences, Biochemistry, Mice, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Quinazoline, Animals, Humans, Structure–activity relationship, Protein Kinase Inhibitors, Molecular Biology, PI3K/AKT/mTOR pathway, Enzyme Assays, Phosphoinositide-3 Kinase Inhibitors, Organic Chemistry, Combinatorial chemistry, Rats, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, chemistry, Lipophilicity, Quinazolines, Molecular Medicine, Selectivity
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المؤلفون: Danilo Guerini, Sergio D. Rosenzweig, Birgitte Sloth, Gulbu Uzel, Anuj K. Kashyap, Steven M. Holland, Virgil A. S. H. Dalm, Stefan De Buck, Aniket Joshi, Maciej Cabanski, Sharon Webster, Dhavalkumar D. Patel, V. Koneti Rao, Christoph Burkhart, Christoph Kalis, Anna Sediva, Julie Doucet, P. Martin van Hagen, Nicolas Soldermann, Michael J. Lenardo, Christ Andreas, Ilona Pylvaenaeinen, Carrie L. Lucas
المساهمون: Immunology, Internal Medicine
المصدر: Blood, 130(21), 2307-2316. American Society of Hematology
مصطلحات موضوعية: 0301 basic medicine, Male, Immunobiology and Immunotherapy, Pyridines, medicine.medical_treatment, T-Lymphocytes, medicine.disease_cause, Lymphocyte Activation, Biochemistry, Targeted therapy, Medicine, Molecular Targeted Therapy, Child, TOR Serine-Threonine Kinases, Hematology, Organ Size, Phenotype, Child, Preschool, Tumor necrosis factor alpha, Female, Chemokines, Class I Phosphatidylinositol 3-Kinases, Primary Immunodeficiency Diseases, Immunology, Naive B cell, Transfection, 03 medical and health sciences, Immune system, Animals, Humans, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Demography, Dose-Response Relationship, Drug, business.industry, Immunologic Deficiency Syndromes, Infant, Cell Biology, Immune dysregulation, Rats, stomatognathic diseases, 030104 developmental biology, Pyrimidines, Immunoglobulin M, P110δ, Mutation, Cancer research, Lymph Nodes, business, Ex vivo, Spleen
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ee11d7e47890c9ff26ab300ee6042f
https://europepmc.org/articles/PMC5701526/ -
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المؤلفون: Amanda Littlewood-Evans, Ross Strang, Nicolas Soldermann, Klemens Hoegenauer, Sascha Gutmann, Gabriele Rummel, Greg Hollingworth, Frédéric Zecri, Romain M. Wolf, Christoph Burkhart, Nigel Graham Cooke, Alexander Baxter Smith, Nadege Graveleau, Joachim Blanz
المصدر: ACS medicinal chemistry letters. 8(9)
مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Pyrimidine, T cell, Organic Chemistry, Pharmacology, Biology, Biochemistry, In vitro, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, medicine.anatomical_structure, chemistry, Drug Discovery, Lipophilicity, medicine, Structure–activity relationship, PI3K/AKT/mTOR pathway, ADME
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المؤلفون: Nicolas Soldermann, Gregory Hollingworth, Christina Hebach, Frédéric Zecri, Pascal Furet, Sascha Gutmann, Roland Feifel, Romain M. Wolf, Klemens Hoegenauer, Ian Lewis, Christoph Burkhart, Alexander Baxter Smith, Gabriele Rummel, Nadege Graveleau, Joachim Blanz, Frédéric Stauffer, Mark Knapp
مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Kinase, T cell, Organic Chemistry, Pharmacology, Biology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, chemistry, Oral administration, 030220 oncology & carcinogenesis, Drug Discovery, medicine, Quinazoline, Structure–activity relationship, Transferase, PI3K/AKT/mTOR pathway
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da9dae3e977fa85e7ce87fa0dd5426b
https://europepmc.org/articles/PMC4983741/ -
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المؤلفون: Anette Von Matt, Wilhelm Stark, Christoph Gaul, Juergen Wagner, Eric Vangrevelinghe, Lauren G. Monovich, Gabriele Rummel, Nicolas Soldermann, Walter Schuler, André Strauss, Sandra W. Cowan-Jacob, Maurice Van Eis, Jean-Pierre Evenou, Philipp Floersheim
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:7367-7372
مصطلحات موضوعية: T-Lymphocytes, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Lymphocyte proliferation, Crystallography, X-Ray, Biochemistry, Isozyme, Enterotoxins, Mice, In vivo, Drug Discovery, Animals, Computer Simulation, Naphthyridines, Binding site, Protein Kinase Inhibitors, Molecular Biology, Protein Kinase C, Protein kinase C, Whole blood, Binding Sites, Kinase, Chemistry, Organic Chemistry, Molecular biology, In vitro, Protein Structure, Tertiary, Rats, Isoenzymes, Interleukin-2, Molecular Medicine
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المؤلفون: Istvan J. Enyedy, Wanlin Yan, Vinayak Hosagrahara, Timothy A. McKinsey, Erik Meredith, Nicolas Soldermann, Keith A. Koch, Nikos Pagratis, Qingming Zhu, Robin Burgis, Olga Rozhitskaya, Michael Paul Capparelli, Richard B. Vega, Ji-Hu Zhang, Chang Rao, Lauren G. Monovich, Kimberley Beattie, Gabriel G. Gamber
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:1447-1451
مصطلحات موضوعية: Azoles, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Biochemistry, Histone Deacetylases, Rats, Sprague-Dawley, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, Animals, Structure–activity relationship, Nuclear export signal, Protein Kinase Inhibitors, Molecular Biology, Protein Kinase C, chemistry.chemical_classification, Histone deacetylase 5, Molecular Structure, biology, Kinase, Chemistry, Organic Chemistry, Rats, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine, Histone deacetylase, Signal transduction, Signal Transduction
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