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1
المؤلفون: Edwige Lorthiois, Marc Gerspacher, Kim S. Beyer, Andrea Vaupel, Catherine Leblanc, Rowan Stringer, Andreas Weiss, Rainer Wilcken, Daniel A. Guthy, Andreas Lingel, Claudio Bomio-Confaglia, Rainer Machauer, Pascal Rigollier, Johannes Ottl, Dorothee Arz, Pascal Bernet, Gaëlle Desjonqueres, Solene Dussauge, Malika Kazic-Legueux, Marie-Anne Lozac’h, Christophe Mura, Mickaël Sorge, Milen Todorov, Nicolas Warin, Florence Zink, Hans Voshol, Frederic J. Zecri, Richard C. Sedrani, Nils Ostermann, Saskia M. Brachmann, Simona Cotesta
المصدر: Journal of Medicinal Chemistry. 65:16173-16203
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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2
المؤلفون: Christelle Stamm, Pierre Nimsgern, Thomas Knoepfel, Jasmin Wirth, Michel Niklaus, Diana Graus-Porta, Alberto Del Rio Espinola, Dario Sterker, Michael Kiffe, Nicolas Warin, Van Huy Luu, Mario Madoerin, Robert Mah, Jacqueline Kinyamu-Akunda, Robin Alec Fairhurst, Milen Todorov, Nicole Buschmann, Sebastien Ripoche, Nils Ostermann, Inga Galuba, Philippe Couttet, Catherine Leblanc, Alexandra Buhles, Jutta Blank, Flavia Adler, Wolfgang Jahnke, Chao Zou, Joerg Berghausen, Andreas Weiss, Pascal Furet, Heiko Schadt, Johannes Voshol, Markus Wartmann, Joerg Trappe
المصدر: Journal of Medicinal Chemistry. 63:12542-12573
مصطلحات موضوعية: Receptor complex, Pyridines, Sequence alignment, Molecular Dynamics Simulation, Piperazines, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Cell Line, Tumor, Drug Discovery, Animals, Structure–activity relationship, Receptor, Fibroblast Growth Factor, Type 4, Amino Acid Sequence, Cysteine, Kinase activity, Binding site, Protein Kinase Inhibitors, Cell Proliferation, Binding Sites, Liver Neoplasms, Hemithioacetal, Fibroblast growth factor receptor 4, Xenograft Model Antitumor Assays, Rats, chemistry, Biochemistry, Drug Design, Hepatocytes, Microsomes, Liver, Molecular Medicine, Half-Life
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3
المؤلفون: Christine Lambert-van der Brempt, Jean-Jacques Marcel Lohmann, Twana Saleh, Sébastien L. Degorce, Stephen Green, Rémy Morgentin, Lara Ward, Urs Hancox, Mickaël Maudet, Martina Fitzek, Barlaam Bernard Christophe, Sabina Cosulich, Patrick Ple, Nicolas Warin, Aurélien Péru
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:2318-2323
مصطلحات موضوعية: Morpholino, Clinical Biochemistry, Cell, Pharmaceutical Science, Pharmacology, 01 natural sciences, Biochemistry, Morpholinos, Mice, chemistry.chemical_compound, Pharmacokinetics, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, PTEN, Enzyme Inhibitors, Phosphorylation, Molecular Biology, IC50, Phosphoinositide-3 Kinase Inhibitors, biology, 010405 organic chemistry, Organic Chemistry, PTEN Phosphohydrolase, 0104 chemical sciences, Isoenzymes, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, chemistry, biology.protein, Molecular Medicine, Growth inhibition
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4
المؤلفون: Stephen Green, Sébastien L. Degorce, Sabina Cosulich, Martina Fitzek, Michel Vautier, Christine Lambert-van der Brempt, Lara Ward, Jean-Jacques Marcel Lohmann, Patrick Ple, Barlaam Bernard Christophe, Marie-Jeanne Pasquet, Rémy Morgentin, Michael A. Walker, Twana Saleh, Nicolas Warin, Aurélien Péru, Urs Hancox, Mickaël Maudet
المصدر: Journal of Medicinal Chemistry. 58:943-962
مصطلحات موضوعية: Male, Morpholino, medicine.drug_class, Carboxamide, Pharmacology, Mice, Structure-Activity Relationship, Dogs, Prostate, Oral administration, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, PTEN, Phosphoinositide-3 Kinase Inhibitors, Aniline Compounds, biology, Chemistry, Drug discovery, PTEN Phosphohydrolase, Neoplasms, Experimental, medicine.anatomical_structure, Chromones, Lipophilicity, biology.protein, Molecular Medicine
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5
المؤلفون: Rémy Morgentin, Martina Fitzek, Christine Lambert-van der Brempt, Stephen Green, Sébastien L. Degorce, Sabina Cosulich, Mickaël Maudet, Rebecca Ellston, Jean-Jacques Marcel Lohmann, Nicolas Warin, Urs Hancox, Patrick Ple, Lara Ward, Barlaam Bernard Christophe
المصدر: Bioorganicmedicinal chemistry letters. 27(9)
مصطلحات موضوعية: 0301 basic medicine, Male, Morpholino, medicine.drug_class, Clinical Biochemistry, Cell, Pharmaceutical Science, Mice, Nude, Carboxamide, Antineoplastic Agents, Pharmacology, 01 natural sciences, Biochemistry, Morpholinos, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Oral administration, In vivo, Cell Line, Tumor, Drug Discovery, medicine, PTEN, Animals, Humans, Benzopyrans, Molecular Biology, IC50, Protein Kinase Inhibitors, Phosphoinositide-3 Kinase Inhibitors, biology, 010405 organic chemistry, Organic Chemistry, PTEN Phosphohydrolase, Prostate, Prostatic Neoplasms, 0104 chemical sciences, Class Ia Phosphatidylinositol 3-Kinase, Molecular Docking Simulation, 030104 developmental biology, medicine.anatomical_structure, chemistry, biology.protein, Molecular Medicine, Growth inhibition, Gene Deletion
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6
المؤلفون: Simon T. Barry, A. Hughes, Craig S. Harris, Martin Pass, Benedicte Delouvrie, Jane Kendrew, Michel Vautier, David A. Jude, Hervé Germain, Myriam Didelot, Jean-Jacques Marcel Lohmann, Jean-Claude Arnould, Andrew A. Mortlock, Nicolas Warin, Jennifer L. Vincent, Katherine Al-Kadhimi, Paul R. Gavine, Morgan Ménard, Christine Lambert-van der Brempt, Darren Cross, Claire Rooney
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:4117-4121
مصطلحات موضوعية: Models, Molecular, Cell Survival, Stereochemistry, Clinical Biochemistry, Integrin, Pharmaceutical Science, Biochemistry, Collagen receptor, Structure-Activity Relationship, Drug Discovery, Cell Adhesion, Humans, Structure–activity relationship, Tyrosine, Molecular Biology, Serum Albumin, biology, Chemistry, Molecular Mimicry, Organic Chemistry, Fibrinogen, Integrin α, In vitro, Fibronectins, biology.protein, Molecular Medicine, Integrin, beta 6, K562 Cells, Oligopeptides, Linker, Integrin alpha5beta1
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7
المؤلفون: Bénédicte, Delouvrié, Katherine, Al-Kadhimi, Jean-Claude, Arnould, Simon T, Barry, Darren A E, Cross, Myriam, Didelot, Paul R, Gavine, Hervé, Germain, Craig S, Harris, Adina M, Hughes, David A, Jude, Jane, Kendrew, Christine, Lambert-van der Brempt, Jean-Jacques, Lohmann, Morgan, Ménard, Andrew A, Mortlock, Martin, Pass, Claire, Rooney, Michel, Vautier, Jennifer L, Vincent, Nicolas, Warin
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:4111-4116
مصطلحات موضوعية: Models, Molecular, Cell Survival, Molecular Mimicry, Organic Chemistry, Clinical Biochemistry, Fibrinogen, Pharmaceutical Science, Biochemistry, Fibronectins, Structure-Activity Relationship, Drug Discovery, Cell Adhesion, Humans, Tyrosine, Molecular Medicine, K562 Cells, Oligopeptides, Molecular Biology, Serum Albumin, Integrin alpha5beta1
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8
المؤلفون: Nicolas Warin, Fabrice Renaud, Hervé Germain, Craig S. Harris
المصدر: Synthetic Communications. 39:523-530
مصطلحات موضوعية: Scale (ratio), Chemistry, business.industry, Organic Chemistry, Azatyrosine, Process engineering, business, Combinatorial chemistry
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9
المؤلفون: Annie Olivier, Jason Grant Kettle, Donald J. Ogilvie, Martin Pass, Peter Ballard, Andrew G. Leach, Craig S. Harris, Nicolas Warin, Rémy Morgentin, Teresa Klinowska, Emma J. Williams, Laurent Francois Andre Hennequin, Robert Hugh Bradbury, Johnson Paul David, Mark Hickinson
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:1633-1637
مصطلحات موضوعية: Ribose, Transplantation, Heterologous, Clinical Biochemistry, Mice, Nude, Pharmaceutical Science, Antineoplastic Agents, Biochemistry, KB Cells, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Adenosine Triphosphate, Drug Discovery, Tumor Cells, Cultured, Quinazoline, Animals, Humans, Epidermal growth factor receptor, Protein Kinase Inhibitors, Molecular Biology, Cell Proliferation, Binding Sites, Molecular Structure, biology, Kinase, Chemistry, Organic Chemistry, Active site, Rats, ErbB Receptors, Enzyme inhibitor, Docking (molecular), Colonic Neoplasms, Quinazolines, biology.protein, Molecular Medicine, Female, Signal transduction
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10
المؤلفون: Michel Vautier, Nicolas Warin, Hervé Germain, Craig S. Harris
المصدر: Tetrahedron Letters. 51:554-556
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Nucleophilic aromatic substitution, Product (mathematics), Organic Chemistry, Drug Discovery, Benzoxazole, Ring (chemistry), Biochemistry, Combinatorial chemistry