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المؤلفون: Suma Gopinathan, Kenneth G. Carson, Alan G. E. Wilson, Zhi-Ming Ding, Bryce Alden Harrison, Damaris S. Diaz, Angela L. Harris, Debra Bruce, Nicole Cathleen Goodwin, Emily O’Neill, David R. Powell, Melinda Smith, Eric Strobel, David B. Rawlins, Wendy Xiong, Ling Li, Andrea Y. Thompson, Mary Thiel, Faika Mseeh
المصدر: Journal of Medicinal Chemistry. 60:710-721
مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, 030209 endocrinology & metabolism, Glucose absorption, Structure-Activity Relationship, 03 medical and health sciences, Sodium-Glucose Transporter 1, 0302 clinical medicine, In vivo, Diabetes mellitus, Internal medicine, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Benzhydryl Compounds, Glycemic, Mice, Knockout, Chemistry, Glucose Tolerance Test, medicine.disease, Phenylbutyrates, In vitro, Glucose, 030104 developmental biology, Endocrinology, Intestinal Absorption, Thioglycosides, Molecular Medicine, Cotransporter, Sodium dependent
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المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Engineering, 010405 organic chemistry, business.industry, Organic Chemistry, Business model, Chemist, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Engineering management, Biocatalysis, Drug Discovery, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d99340139655fc426d94070b3d62adc
https://europepmc.org/articles/PMC6792145/ -
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المؤلفون: Arthur Shu, Yiqian Lian, Huijie Li, Curt Dale Haffner, Terry Vincent Hughes, Ami S. Lakdawala, Julie A. Cox, Pamela A. Haile, Constantine Kreatsoulas, Beth Anne Knapp-Reed, Lisa M. Shewchuk, David B. Lipshutz, John F. Mehlmann, Michael T. Ouellette, Christopher J Aquino, Mark Elban, Nicole Cathleen Goodwin, Huiqiang Zhou, Adam Kenneth Charnley, Bartholomew J. Votta, Robert W. Marquis, Joseph J. Romano, Linda N. Casillas, Peter J. Gough, Máire A. Convery, John Bertin
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Bicyclic molecule, 010405 organic chemistry, Kinase, Chemistry, Organic Chemistry, Pyrazole, 01 natural sciences, Biochemistry, 0104 chemical sciences, RIPK2, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, NOD2, Drug Discovery, NOD1, Transferase, RECEPTOR-INTERACTING PROTEIN
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4
المؤلفون: Bryce Alden Harrison, Lakshman Samala, Nita Patel, Zheng Y. Almstead, N. Andrew Whitlock, Ross Mabon, Dennis S. Rice, Nicole Cathleen Goodwin, Beth McKnight, Yulian Zhang, Jason P. Healy, Shuli Wang, Suma Gopinathan, Gardyan Michael Walter, David B. Rawlins, Alan Wilson, Terry R. Stouch, Ying Liu, Brian D. Hamman, Brett A. Marinelli, Hugh Alfred Burgoon
المصدر: ACS Medicinal Chemistry Letters. 6:84-88
مصطلحات موضوعية: Intraocular pressure, genetic structures, business.industry, Organic Chemistry, Ocular hypertension, Phases of clinical research, Glaucoma, Pharmacology, medicine.disease, Bioinformatics, Biochemistry, eye diseases, Lim kinase, chemistry.chemical_compound, chemistry, Drug Discovery, Urea, Medicine, sense organs, Dosing, business, Rho-associated protein kinase
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المؤلفون: Alan Wilson, Angela L. Harris, Brian Zambrowicz, Wendy Xiong, Christopher M. DaCosta, David R. Powell, Bryce Alden Harrison, Nicole Cathleen Goodwin, Melinda Smith, Sabrina Jeter-Jones, Andrea Y. Thompson, Eric Strobel, Faika Mseeh, David B. Rawlins, Jennifer Greer, Deon Doree, Suma Gopinathan, Kenneth G. Carson, Zhi-Ming Ding
المصدر: The Journal of pharmacology and experimental therapeutics. 362(1)
مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, medicine.medical_specialty, 030209 endocrinology & metabolism, Carbohydrate metabolism, Rats, Sprague-Dawley, 03 medical and health sciences, Mice, Random Allocation, 0302 clinical medicine, Oral administration, Glucagon-Like Peptide 1, Diabetes mellitus, Internal medicine, medicine, Animals, Hypoglycemic Agents, Benzhydryl Compounds, Glycemic, Pharmacology, Dose-Response Relationship, Drug, business.industry, medicine.disease, Glucagon-like peptide-1, Rats, Mice, Inbred C57BL, 030104 developmental biology, Postprandial, Glycemic index, Endocrinology, Glycemic Index, Thioglycosides, Sitagliptin, Molecular Medicine, business, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38140540d80f7939267c966c2d73c1da
https://pubmed.ncbi.nlm.nih.gov/28442582 -
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المؤلفون: Melanie K. Shadoan, Philip Manton Brown, Arthur T. Sands, Phillip Banks, David R. Powell, Kenny Frazier, Nicole Cathleen Goodwin, Brian Zambrowicz, Ross Mabon, Bryce Alden Harrison, J Bronner, David B. Rawlins, Joel Freiman, Faika Mseeh, Anne Turnage, D Ruff, Alan Wilson
المصدر: Clinical Pharmacology and Therapeutics
مصطلحات موضوعية: Adult, Blood Glucose, Male, medicine.medical_specialty, Administration, Oral, Type 2 diabetes, Intestinal absorption, Sodium-Glucose Transporter 1, Glucagon-Like Peptide 1, Diabetes mellitus, Internal medicine, medicine, Humans, Hypoglycemic Agents, Peptide YY, Pharmacology (medical), Glycosides, Sodium-Glucose Transporter 2 Inhibitors, Triglycerides, Glycemic, Glycated Hemoglobin, Pharmacology, Glucose tolerance test, Dose-Response Relationship, Drug, medicine.diagnostic_test, business.industry, Type 2 Diabetes Mellitus, Glucose Tolerance Test, Middle Aged, medicine.disease, Clinical Trial, Renal glucose reabsorption, Endocrinology, Diabetes Mellitus, Type 2, Intestinal Absorption, Female, SGLT2 Inhibitor, business
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المؤلفون: C. James Chou, Jie Fan, Dennis S. Rice, Phillip W. Yates, Nicole Cathleen Goodwin, Craig E. Crosson, Oday Alsarraf
المصدر: Experimental eye research. 146
مصطلحات موضوعية: 0301 basic medicine, Male, Blotting, Western, Ischemia, Pharmacology, Biology, Neuroprotection, Histone Deacetylases, Retina, Article, Histones, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, medicine, Electroretinography, Animals, Ischemic Preconditioning, Analysis of Variance, medicine.diagnostic_test, Caspase 3, Retinal, HDAC8, Acetylation, medicine.disease, Immunohistochemistry, Sensory Systems, Rats, Ophthalmology, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, chemistry, Biochemistry, Ischemic preconditioning, Histone deacetylase
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المؤلفون: Alan Wilson, Melinda Smith, Wendy Xiong, Damaris Diaz, David R. Powell, Suma Gopinathan, Faika Mseeh, Eric Strobel, Nicole Cathleen Goodwin, Brian Zambrowicz, Kenneth G. Carson, Zhi-Ming Ding, David B. Rawlins, Deon Doree, Bryce Alden Harrison, Angela L. Harris
المصدر: Pharmacology Research & Perspectives
مصطلحات موضوعية: medicine.medical_specialty, business.industry, digestive, oral, and skin physiology, Diabetes, Glucose transporter, small molecule, Original Articles, medicine.disease, SGLT2, SGLT1, Renal glucose reabsorption, Excretion, Endocrinology, Neurology, Pharmacokinetics, Internal medicine, Diabetes mellitus, Knockout mouse, medicine, urinary glucose excretion, General Pharmacology, Toxicology and Pharmaceutics, SGLT2 Inhibitor, business, IC50, knockout mice
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المؤلفون: Jason Allen, Jason P. Healy, Eric Strobel, Ross Mabon, Giovanni Cianchetta, Nicole Cathleen Goodwin, Hugh Alfred Burgoon, Brian D. Hamman, Shuli Wang, David B. Rawlins
مصطلحات موضوعية: chemistry.chemical_classification, Kinase, Organic Chemistry, Allosteric regulation, Biology, Biochemistry, Lim kinase, chemistry.chemical_compound, Enzyme, chemistry, Amide, Drug Discovery, Molecule, Hinge region, Selectivity
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c215374221823fb0362fedb2f8c1f756
https://europepmc.org/articles/PMC4291701/ -
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المؤلفون: David B. Rawlins, Qingyun Liu, Amr Nouraldeen, Yiling Xie, Nicole Cathleen Goodwin, Jennifer Bardenhagen, Zheng Y. Almstead, Faika Mseeh, Christopher M. DaCosta, S. David Kimball, Jason P. Healy, Melanie K. Shadoan, Ross Mabon, David R. Powell, Alan G. E. Wilson, Lindsey Buhring, Bryce Alden Harrison
المصدر: Journal of medicinal chemistry. 52(20)
مصطلحات موضوعية: Kidney, medicine.medical_specialty, Xylose, Chemistry, Type 2 diabetes, Carbohydrate metabolism, medicine.disease, Renal glucose reabsorption, Substrate Specificity, Mice, medicine.anatomical_structure, Endocrinology, Glucose, Diabetes Mellitus, Type 2, In vivo, Diabetes mellitus, Internal medicine, Drug Discovery, medicine, Molecular Medicine, Glucose homeostasis, Animals, Humans, Cotransporter, Sodium-Glucose Transporter 2 Inhibitors