يعرض 1 - 10 نتائج من 10 نتيجة بحث عن '"Nicole Housley"', وقت الاستعلام: 0.90s تنقيح النتائج
  1. 1
    Virulent Pseudomonas aeruginosa infection converts antimicrobial amyloids into cytotoxic prions

    المؤلفون: Stephen A. Moser, Kayla Madera, Jonathon P. Audia, Brant M. Wagener, Ron Balczon, Dara W. Frank, Mikhail Alexeyev, Jean-Francois Pittet, M.S. Gwin, Scott Piechocki, Michaela Crawford, S.B. Voth, C.M. Francis, Autumn Simmons, Nicole Housley, Troy Stevens

    المصدر: The FASEB Journal

    مصطلحات موضوعية: 0301 basic medicine, Male, Amyloid, Prions, tau (τ), Virulence, medicine.disease_cause, Biochemistry, Microbiology, Type three secretion system, prion, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Bacterial Proteins, exoenzyme Y (ExoY), mental disorders, Genetics, medicine, Cytotoxic T cell, Animals, Humans, Pseudomonas Infections, Molecular Biology, Lung, Research Articles, Innate immune system, biology, Effector, Pseudomonas aeruginosa, Chemistry, Cytotoxins, nosocomial pneumonia, Endothelial Cells, Rats, Inbred F344, Anti-Bacterial Agents, Rats, 030104 developmental biology, amyloid beta (Aβ), Host-Pathogen Interactions, biology.protein, Exoenzyme, Female, 030217 neurology & neurosurgery, Biotechnology, Research Article

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6392f7098e9dcda8e4f300072ba302c7
    http://europepmc.org/articles/PMC7383673

    View record at Wiley
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  2. 2
    cAMP signaling primes lung endothelial cells to activate caspase-1 during Pseudomonas aeruginosa infection

    المؤلفون: Nicole Housley, Phoibe Renema, Domenico Spadafora, Andrea L. Britain, Diego F. Alvarez, Grace Dunbar, Kierra S. Hardy, Naga S. Annamdevula, Silas J. Leavesley, Thomas C. Rich, Jonathon P. Audia

    المصدر: American Journal of Physiology-Lung Cellular and Molecular Physiology. 318:L1074-L1083

    مصطلحات موضوعية: Pulmonary and Respiratory Medicine, education.field_of_study, Innate immune system, medicine.diagnostic_test, Physiology, Chemistry, Cell, Population, Caspase 1, Priming (immunology), Cell Biology, medicine.disease, Flow cytometry, Sepsis, medicine.anatomical_structure, Physiology (medical), medicine, Cancer research, Autacoid, education

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e908c14d081cae3f0faf6d9c0575de19
    https://doi.org/10.1152/ajplung.00185.2019

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  3. 3
    cAMP signaling primes lung endothelial cells to activate caspase-1 during

    المؤلفون: Phoibe, Renema, Kierra S, Hardy, Nicole, Housley, Grace, Dunbar, Naga, Annamdevula, Andrea, Britain, Domenico, Spadafora, Silas, Leavesley, Thomas, Rich, Jonathon P, Audia, Diego F, Alvarez

    المصدر: Am J Physiol Lung Cell Mol Physiol

    مصطلحات موضوعية: Inflammasomes, Adenine, Caspase 1, Colforsin, Interleukin-1beta, Primary Cell Culture, 8-Bromo Cyclic Adenosine Monophosphate, Endothelial Cells, Dinoprostone, Rats, Gene Expression Regulation, 1-Methyl-3-isobutylxanthine, Host-Pathogen Interactions, Pseudomonas aeruginosa, Cyclic AMP, Animals, Alprostadil, Single-Cell Analysis, Cyclic GMP, Lung, Rolipram, Cell Proliferation, Signal Transduction, Research Article

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::21b0e85f391a85ba9a82fd7fb96fe023
    https://pubmed.ncbi.nlm.nih.gov/32186399

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  4. 4
    Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents

    المؤلفون: Banumathi Sankaran, Thomas E. Edwards, Jan Abendroth, James R. Horn, Bart L. Staker, Travis R. Helgren, Nicole Housley, Phumvadee Wangtrakuldee, Jonathon P. Audia, Congling Chen, Timothy J. Hagen, Peter J. Myler

    المصدر: Bioorganic & medicinal chemistry, vol 25, iss 3
    Helgren, TR; Chen, C; Wangtrakuldee, P; Edwards, TE; Staker, BL; Abendroth, J; et al.(2017). Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents. Bioorganic and Medicinal Chemistry, 25(3), 813-824. doi: 10.1016/j.bmc.2016.11.013. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/7nh0n2pb

    مصطلحات موضوعية: 0301 basic medicine, Metalloenzyme, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Epidemic typhus, Drug Discovery, MetAP, Methionyl Aminopeptidases, Enzyme Inhibitors, Rickettsia prowazekii, Pathogen, Cells, Cultured, Inhibition, chemistry.chemical_classification, Cultured, Molecular Structure, biology, Pharmacology and Pharmaceutical Sciences, AutoDock, Antimicrobial, Anti-Bacterial Agents, Molecular Docking Simulation, Lung endothelial cells, Molecular Medicine, Drug, Methionine aminopeptidase, Cell Survival, Cells, Medicinal & Biomolecular Chemistry, In silico, Microbial Sensitivity Tests, Pulmonary Artery, Article, Microbiology, Dose-Response Relationship, Medicinal and Biomolecular Chemistry, Structure-Activity Relationship, 03 medical and health sciences, Animals, Structure–activity relationship, Molecular Biology, Dose-Response Relationship, Drug, Organic Chemistry, Endothelial Cells, biology.organism_classification, In vitro, Rats, 030104 developmental biology, Enzyme, chemistry

    وصف الملف: application/pdf

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b58b8ae3e7a3b261cd77adc6bd1cbb
    https://doi.org/10.1016/j.bmc.2016.11.013

    View record from ScienceDirect
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  5. 5
    Analysis of pulmonary vascular injury and repair during Pseudomonas aeruginosa infection-induced pneumonia and acute respiratory distress syndrome

    المؤلفون: Judy A. King, Nicole Housley, Ashley S. Lindsey, Anna Koloteva, Diego F. Alvarez, Lydia M. Sullivan, Jonathon P. Audia

    المصدر: Pulmonary Circulation

    مصطلحات موضوعية: 0301 basic medicine, Pulmonary and Respiratory Medicine, medicine.medical_specialty, ARDS, Acute respiratory distress, medicine.disease_cause, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, pulmonary edema, Lung, business.industry, Pseudomonas aeruginosa, Infection induced, acute respiratory distress syndrome (ARDS), Injury and repair, respiratory system, Pulmonary edema, medicine.disease, 3. Good health, respiratory tract diseases, Pneumonia, 030104 developmental biology, medicine.anatomical_structure, 030228 respiratory system, endothelial permeability, business, pulmonary endothelial cells, Research Article

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612f221ffdf64e8e241269d6e4eea8e0
    http://europepmc.org/articles/PMC6388462

    View record at Wiley Find this article in full text from ProQuest
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  6. 6
    Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y12 receptor antagonist-treated rats provides long-term reduction in myocardial infarct size and preservation of ventricular function

    المؤلفون: X.-M. Yang, Michael V. Cohen, Nicole Housley, Diego F. Alvarez, Edward S. Crockett, James M. Downey, Ehtesham Ul Haq, Kristen O'Donnell, Jonathon P. Audia

    المصدر: Basic Research in Cardiology. 113

    مصطلحات موضوعية: Male, 0301 basic medicine, Ticagrelor, medicine.medical_specialty, Physiology, Interleukin-1beta, Myocardial Infarction, Ischemia, Infarction, Myocardial Reperfusion Injury, 030204 cardiovascular system & hematology, Article, Mitochondria, Heart, Ventricular Function, Left, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cangrelor, Physiology (medical), Internal medicine, Purinergic P2 Receptor Antagonists, para-Aminobenzoates, Animals, Medicine, Myocardial infarction, Cardioprotection, Receptors, Purinergic P2, business.industry, Myocardium, Caspase 1, Antagonist, Isolated Heart Preparation, Dipeptides, medicine.disease, Adenosine Monophosphate, Receptors, Purinergic P2Y12, Disease Models, Animal, 030104 developmental biology, chemistry, Heart failure, Cardiology, Drug Therapy, Combination, Energy Metabolism, Cardiology and Cardiovascular Medicine, business, Signal Transduction, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efefd4d179d2a43f9ec60657761fd661
    https://doi.org/10.1007/s00395-018-0692-z

    Find this article in full text from Springer Verlag. Find this article in full text from ProQuest
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  7. 7
    The Highly Selective Caspase-1 Inhibitor VX-765 Provides Additive Protection Against Myocardial Infarction in Rat Hearts When Combined With a Platelet Inhibitor

    المؤلفون: Diego F. Alvarez, Michael V. Cohen, Jonathon P. Audia, Xi-Ming Yang, James M. Downey, Nicole Housley

    المصدر: Journal of cardiovascular pharmacology and therapeutics. 22(6)

    مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, Cardiotonic Agents, Heart disease, Myocardial Infarction, CASPASE 1 INHIBITOR, 030204 cardiovascular system & hematology, Article, Rats, Sprague-Dawley, 03 medical and health sciences, Viral Proteins, 0302 clinical medicine, Platelet inhibitor, Internal medicine, medicine, para-Aminobenzoates, Animals, Pharmacology (medical), Myocardial infarction, cardiovascular diseases, Serpins, Pharmacology, business.industry, Heart, Isolated Heart Preparation, Dipeptides, medicine.disease, Highly selective, Rats, Clinical trial, 030104 developmental biology, Cardiology, Drug Therapy, Combination, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167d37f06a6d93246d01b4ec904c1146
    https://pubmed.ncbi.nlm.nih.gov/28399648

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  8. 8
    Caspase-1 Activation Protects Lung Endothelial Barrier Function during Infection-Induced Stress

    المؤلفون: Diego F. Alvarez, Kristen O'Donnell, Anna Koloteva, Jonathon P. Audia, Chun Zhou, Nicole Housley

    مصطلحات موضوعية: 0301 basic medicine, Pulmonary and Respiratory Medicine, Clinical Biochemistry, Caspase 1, Inflammation, Cell Biology, Biology, Pulmonary edema, medicine.disease, Proinflammatory cytokine, 03 medical and health sciences, 030104 developmental biology, Immune system, In vivo, Immunology, medicine, Cancer research, medicine.symptom, Molecular Biology, Barrier function, Ex vivo, Original Research

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a27ece2f239bbbc54bdae3608ebd70
    https://europepmc.org/articles/PMC5070108/

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  9. 9
    In the absence of effector proteins, the Pseudomonas aeruginosa type three secretion system needle tip complex contributes to lung injury and systemic inflammatory responses

    المؤلفون: Chun Zhou, Naga S. Annamdevula, Diego F. Alvarez, Ashley S. Lindsey, Dara W. Frank, Nicole Housley, Jonathon P. Audia, Courtney Rothrock Ochoa, Meshann Fitzgerald, Masahiko Oka, Michie Toba

    المصدر: PLoS ONE, Vol 8, Iss 11, p e81792 (2013)
    PLoS ONE

    مصطلحات موضوعية: Male, Programmed cell death, Pathology, medicine.medical_specialty, Time Factors, lcsh:Medicine, Lung injury, Biology, Type three secretion system, Sepsis, 03 medical and health sciences, Parenchyma, medicine, Animals, Pseudomonas Infections, lcsh:Science, Bacterial Secretion Systems, Lung, 030304 developmental biology, 0303 health sciences, Multidisciplinary, Cell Death, 030306 microbiology, lcsh:R, Endothelial Cells, medicine.disease, Actin cytoskeleton, Molecular biology, Systemic Inflammatory Response Syndrome, Rats, 3. Good health, medicine.anatomical_structure, Apoptosis, Microvessels, Pseudomonas aeruginosa, lcsh:Q, Research Article

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2314895de8bd126bda99d1fc2f68f31f
    http://europepmc.org/articles/PMC3842252?pdf=render

    Find this article in full text from ProQuest
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  10. 10
    Caspase 1 Activation Prevents Pulmonary Microvascular Endothelial Cell Barrier Disruption During Infection With Pseudomonas Aeruginosa

    المؤلفون: Meshann Fitzgerald, Diego F. Alvarez, Jon P. Audia, Nicole Housley

    المصدر: D27. SIGNALING MOLECULES INVOLVED IN PULMONARY ENDOTHELIAL INJURY AND REPAIR.

    مصطلحات موضوعية: Endothelial stem cell, Chemistry, Pseudomonas aeruginosa, Immunology, medicine, Caspase 1, medicine.disease_cause, Microbiology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::34203997090d6820828f347253f6fe58
    https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5519

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