المؤلفون: Saverio Minucci, Carleen Cullinane, Christopher J. Clarke, Ailsa J. Christiansen, Joey L. Methot, Leonie A. Cluse, Michael Bots, Geoffrey M. Matthews, Andrea Newbold, Ricky W. Johnstone, Astrid M. Kral, Victoria M. Richon, Susanna Chiocca, J. Paul Secrist, Nicole Ozerova, Kellie M. Banks, Thomas A. Miller, Jessica E. Bolden, Ross A. Dickins, Claudia Miccolo

المصدر: Molecular Cancer Therapeutics. 12:2709-2721

مصطلحات موضوعية: Cancer Research, Lymphoma, Cell Survival, Fusion Proteins, bcr-abl, Histone Deacetylase 2, Antineoplastic Agents, Apoptosis, Histone Deacetylase 1, Biology, Histone Deacetylase 6, Hydroxamic Acids, Histone Deacetylases, Chromatin remodeling, Romidepsin, Mice, Cell Line, Tumor, medicine, Animals, Humans, HSP90 Heat-Shock Proteins, Vorinostat, Histone deacetylase 5, Histone deacetylase 2, Acetylation, HDAC6, Xenograft Model Antitumor Assays, Enzyme Activation, Histone Deacetylase Inhibitors, Histone, Oncology, Cancer research, biology.protein, Histone deacetylase, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5abb5dc70b4048447dbe3dfe2cc4aa
https://doi.org/10.1158/1535-7163.mct-13-0626

المؤلفون: Fanyu Meng, Jonathan C. Cruz, Astrid M. Kral, Robert E. Settlage, Victoria M. Richon, Cloud P. Paweletz, Ronald C. Hendrickson, J. Paul Secrist, Roy M. Pollock, Thomas A. Miller, Nathan A. Yates, Anita Y. H. Lee, Nicole Ozerova, Matthew G. Stanton

المصدر: Journal of Proteome Research. 7:5177-5186

مصطلحات موضوعية: Proteomics, Spectrometry, Mass, Electrospray Ionization, animal structures, Proteome, Antineoplastic Agents, Biochemistry, Gene Expression Regulation, Enzymologic, Histone Deacetylases, Mass Spectrometry, Histones, Histone H3, In vivo, Cell Line, Tumor, Histone H2B, Humans, Protein Isoforms, False Positive Reactions, Regulation of gene expression, biology, Chemistry, General Chemistry, HDAC1, enzymes and coenzymes (carbohydrates), Histone, ROC Curve, embryonic structures, biology.protein, Histone deacetylase, biological phenomena, cell phenomena, and immunity, Peptides, Chromatography, Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb7d272e344e421759a4a6a246ad557
https://doi.org/10.1021/pr800510p

المؤلفون: Brian B. Haines, Judith C. Fleming, Joon Jung, Paul Secrist, Hongmei Wang, Thomas A. Miller, Richard W. Heidebrecht, Paul Harrington, Joshua Close, Nicole Ozerova, John Maclean, Melissa Chenard, Astrid M. Kral

المصدر: Biochemistry. 53(4)

مصطلحات موضوعية: Gene isoform, Models, Molecular, Conformational change, Protein Conformation, Cell, Histone Deacetylase 2, Mice, Nude, Antineoplastic Agents, Histone Deacetylase 1, Biology, Hydroxamic Acids, Biochemistry, Benzoates, Substrate Specificity, Mice, Cell Line, Tumor, medicine, Animals, Humans, Fluorescent Dyes, Vorinostat, Mechanism (biology), Ligand binding assay, HDAC1, Histone Deacetylase Inhibitors, Kinetics, Histone, medicine.anatomical_structure, Mechanism of action, Xanthenes, biology.protein, Heterografts, Female, medicine.symptom, Fluorescein-5-isothiocyanate, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f01bb6ef22781c47856b23fb31baf7
https://pubmed.ncbi.nlm.nih.gov/24450491

المؤلفون: Matthew G. Stanton, David J. Witter, Christopher Hamblett, Nicole Ozerova, Brian B. Haines, Richard E. Middleton, Judith C. Fleming, Phieng Siliphaivanh, Dawn Marie Mampreian Hoffman, Hongmei Wang, Alexander A. Szewczak, Jed L. Hubbs, Melissa Chenard, Astrid M. Kral, Bethany Hughes, Kevin J. Wilson, Paul Harrington, J. Paul Secrist, Richard W. Heidebrecht, Joey L. Methot, Thomas A. Miller, Jonathan C. Cruz, Andreas Harsch, Candia M. Kenific

مصطلحات موضوعية: biology, Histone deacetylase 2, medicine.drug_class, Organic Chemistry, Histone deacetylase inhibitor, Pharmacology, Biochemistry, In vitro, HDAC1, Histone, In vivo, Acetylation, Drug Discovery, Gene expression, biology.protein, medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe238132473cf3e20a702fe00be4018
https://europepmc.org/articles/PMC4027730/

المؤلفون: Julie E. Hamill, Nicole Ozerova, Hongmei Wang, David J. Witter, Alexander A. Szewczak, Richard W. Heidebrecht, Brian B. Haines, Andreas Harsch, Richard E. Middleton, Judith C. Fleming, Chandrasekhar Mushti, Joshua Close, Jonathan B. Grimm, Melissa Chenard, Astrid M. Kral, Kevin J. Wilson, J. Paul Secrist, Thomas A. Miller, William K. Dahlberg, Bethany Hughes

المصدر: Bioorganicmedicinal chemistry letters. 19(7)

مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Transplantation, Heterologous, Organophosphonates, Pharmaceutical Science, Administration, Oral, Histone Deacetylase 2, Mice, Nude, Carboxamide, Antineoplastic Agents, Histone Deacetylase 1, Biochemistry, Histone Deacetylases, Mice, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Enzyme Inhibitors, Molecular Biology, Vorinostat, biology, Chemistry, Organic Chemistry, Histone deacetylase inhibitor, In vitro, Histone Deacetylase Inhibitors, Repressor Proteins, Enzyme inhibitor, biology.protein, Molecular Medicine, Histone deacetylase, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa642b59d8b61f88f3049ae790ef4f45
https://pubmed.ncbi.nlm.nih.gov/19268585

المؤلفون: Scott C. Berk, Candia M. Kenific, Julie E. Hamill, Paul Secrist, Paul Tempest, Jonathan C. Cruz, Andreas Harsch, Judith C. Fleming, Solomon Kattar, Bethany Hughes, Laura Surdi, Hongmei Wang, William K. Dahlberg, Nicole Ozerova, Thomas A. Miller, Melissa Chenard, Astrid M. Kral, Richard E. Middleton, Joey L. Methot, Alexander A. Szewczak, Anna A. Zabierek

المصدر: Bioorganicmedicinal chemistry letters. 19(4)

مصطلحات موضوعية: Library design, Clinical Biochemistry, Pharmaceutical Science, Histone Deacetylase 2, Histone Deacetylase 1, Biochemistry, Medicinal chemistry, Structure-Activity Relationship, Dogs, Drug Discovery, Structure–activity relationship, Animals, Combinatorial Chemistry Techniques, Humans, Molecular Biology, Molecular Structure, Chemistry, Organic Chemistry, Combinatorial chemistry, Solution phase, Xenograft Model Antitumor Assays, Rats, Histone Deacetylase Inhibitors, Repressor Proteins, Drug Design, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6736fa6f80ff62046ee78a0cd980c774
https://pubmed.ncbi.nlm.nih.gov/19138845

المؤلفون: Melissa Chenard, Christopher Hamblett, Astrid M. Kral, J. Paul Secrist, Andreas Harsch, Jonathan C. Cruz, Joon Jung, Thomas A. Miller, Brian B. Haines, Joey L. Methot, Candia M. Kenific, Judith C. Fleming, Bethany Hughes, Dawn M. Mampreian, Richard E. Middleton, William K. Dahlberg, Hongmei Wang, Nicole Ozerova, Alexander A. Szewczak

المصدر: Bioorganicmedicinal chemistry letters. 18(23)

مصطلحات موضوعية: Niacinamide, ERG1 Potassium Channel, Stereochemistry, medicine.drug_class, Clinical Biochemistry, hERG, Pharmaceutical Science, Mice, Nude, Antineoplastic Agents, Biochemistry, Histone Deacetylases, Polar surface area, Histones, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Combinatorial Chemistry Techniques, Humans, Protein Isoforms, Spiro Compounds, Molecular Biology, chemistry.chemical_classification, Nicotinamide, biology, Molecular Structure, Histone deacetylase 2, Organic Chemistry, Histone deacetylase inhibitor, Aromatic amine, HCT116 Cells, Xenograft Model Antitumor Assays, Ether-A-Go-Go Potassium Channels, Histone Deacetylase Inhibitors, chemistry, Enzyme inhibitor, Benzamides, biology.protein, Molecular Medicine, Histone deacetylase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc645ca36b7042b171a7922b573f536b
https://pubmed.ncbi.nlm.nih.gov/18951790

المؤلفون: David J. Witter, Richard E. Middleton, David L. Sloman, Candia M. Kenific, Bethany Hughes, Joon Jung, Peter T. Meinke, Melissa Chenard, Astrid M. Kral, William K. Dahlberg, Joshua Close, J. Paul Secrist, Jonathan C. Cruz, Alexander A. Szewczak, Christopher Hamblett, Prasun K. Chakravarty, Andreas Harsch, Nicole Ozerova, Matthew G. Stanton, Richard W. Heidebrecht, Joey L. Methot, Paul Harrington, Thomas A. Miller, Sriram Tyagarajan, Judith C. Fleming, Julie E. Hamill

المصدر: Bioorganicmedicinal chemistry letters. 18(3)

مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Histone Deacetylase 2, Histone Deacetylase 1, Biochemistry, Histone Deacetylases, Structure-Activity Relationship, Drug Discovery, medicine, Benzene Derivatives, Humans, Protein Isoforms, Molecular Biology, Binding Sites, biology, Molecular Structure, Histone deacetylase 2, Chemistry, fungi, Organic Chemistry, Histone deacetylase inhibitor, HDAC3, HDAC1, Cell biology, Histone Deacetylase Inhibitors, Repressor Proteins, Enzyme inhibitor, biology.protein, Molecular Medicine, Histone deacetylase, Pharmacophore, Binding domain

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdaa486e283fee48981ca5ca5efb9fd8
https://pubmed.ncbi.nlm.nih.gov/18182289

المؤلفون: Jonathan C. Cruz, Nicole Ozerova, Richard E. Middleton, Joey L. Methot, Sujal V. Deshmukh, Christopher Hamblett, Andreas Harsch, Anna M. Hitz, Judith C. Fleming, Naim Nazef, Bethany Hughes, Melissa Chenard, Astrid M. Kral, David L. Sloman, Thomas A. Miller, William K. Dahlberg, J. Paul Secrist, Matthew G. Stanton, Ralph T. Mosley, Hongmei Wang, Dawn M. Mampreian, Alex A. Szewczak

المصدر: Bioorganicmedicinal chemistry letters. 17(19)

مصطلحات موضوعية: Models, Molecular, Cell Membrane Permeability, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Biological Availability, Biochemistry, Substrate Specificity, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Enzyme Inhibitors, Benzamide, Molecular Biology, Nicotinamide, biology, Organic Chemistry, Histone deacetylase inhibitor, In vitro, Rats, Histone Deacetylase Inhibitors, Isoenzymes, 6-Aminonicotinamide, chemistry, Enzyme inhibitor, Area Under Curve, Drug Design, Benzamides, biology.protein, Molecular Medicine, Histone deacetylase, Drug Screening Assays, Antitumor, Neoplasm Transplantation, Half-Life, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa399415c2ed87e3206d1c0265918a5
https://pubmed.ncbi.nlm.nih.gov/17761416

المؤلفون: Paul Harrington, David L. Sloman, Richard W. Heidebrecht, Candia M. Kenific, Joey L. Methot, Nicole Ozerova, Hamill Julie, Melissa Chenard, Astrid M. Kral, David J. Witter, Kevin J. Wilson, Chris Hamblett, Andreas Harsch, Richard G. Middleton, Close Joshua, Thomas A. Miller, Bethany Hughes, Joon Jung, Cruz Jonathan, Alexander A. Szewczak, Matthew G. Stanton, William K. Dahlberg, Judith C. Fleming, Paul Secrist

المصدر: Cancer Research. 70:5433-5433

مصطلحات موضوعية: Cancer Research, Histone deacetylase 5, Histone deacetylase 2, HDAC11, Biology, medicine.disease_cause, Molecular biology, HDAC1, Histone, Oncology, Acetylation, Cancer research, medicine, biology.protein, Histone deacetylase, Carcinogenesis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fc1148ce9c67f69de9c7a525e830a9a3
https://doi.org/10.1158/1538-7445.am10-5433