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1
المؤلفون: Simon Giroux, Nigel Ewing, Youssef L. Bennani, Francoise Berlioz-Seux, Rebecca S. Shawgo, Anne-Laure Grillot, Nathalie Chauret, Kevin M. Cottrell, Laval C. Chan, Evelyne Dietrich, Francois Denis, Morris Mark A, John Maxwell, Sanjoy Kumar Das, Lucille L’Heureux, Darius Bilimoria, T. Jagadeeswar Reddy, Subajini Selliah, Caroline Cadilhac, Olivier Nicolas, Jinwang Xu, James A. Henderson, Nagraj Mani
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:936-939
مصطلحات موضوعية: Biphenyl, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Imidazoles, virus diseases, Pharmaceutical Science, Viral Nonstructural Proteins, Antiviral Agents, Biochemistry, digestive system diseases, chemistry.chemical_compound, Character (mathematics), chemistry, Genotype 1b, Drug Discovery, Molecular Medicine, NS5A, Molecular Biology, Linker
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2
المصدر: Rapid Communications in Mass Spectrometry. 26:659-669
مصطلحات موضوعية: Chromatography, Drug discovery, Electrospray ionization, Metabolite, High-throughput screening, Organic Chemistry, Glutathione, Mass spectrometry, Analytical Chemistry, Adduct, Matrix (chemical analysis), chemistry.chemical_compound, chemistry, Spectroscopy
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3
المؤلفون: Nigel Ewing, Judy Straub, Ursula A. Germann, James W. Janetka, Alex Aronov, Ernst ter Haar, Jeremy Green, Mark N. Namchuk, Guy W. Bemis, Xiaoling Xie, William Markland, Michael R. Hale, Pamella J. Ford, Gabriel Martinez-Botella, Guanjing Chen, Qing Tang, Francois Maltais, Marc Jacobs, Jingrong Cao, Srinivasu Poondru, Suganthini Nanthakumar
المصدر: Journal of Medicinal Chemistry. 52:6362-6368
مصطلحات موضوعية: Models, Molecular, chemistry.chemical_classification, MAPK/ERK pathway, Conformational change, biology, Chemistry, Cell growth, Molecular Conformation, Substrate Specificity, Cell biology, Enzyme, Antitarget, Biochemistry, Cell culture, Drug Design, Mitogen-activated protein kinase, Drug Discovery, biology.protein, Molecular Medicine, Pyrroles, Signal transduction, Extracellular Signal-Regulated MAP Kinases, Protein Kinase Inhibitors
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4
المؤلفون: Jian Wang, Anne-Laure Grillot, Carl Poisson, Simon Giroux, Nigel Ewing, Youssef L. Bennani, Rebecca S. Shawgo, Ronald Grey, Louis Vaillancourt, Nathalie Chauret, Darius Bilimoria, Olivier Nicolas, Lucille L’Heureux, Subajini Selliah, Kevin M. Cottrell, B. Govinda Rao, Constantin Yannopoulos, Guy Falardeau, Monica Bubenik, Laval C. Chan, James A. Henderson, Sanjoy Kumar Das, Francois Denis, T. Jagadeeswar Reddy, Caroline Cadilhac, Morris Mark A, Oswy Z. Pereira, Evelyne Dietrich, Nagraj Mani, John Maxwell, Francoise Berlioz-Seux, Bingcan Liu
المصدر: Bioorganicmedicinal chemistry letters. 25(4)
مصطلحات موضوعية: Benzimidazole, Pyrrolidines, Genotype, Hepatitis C virus, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biology, Viral Nonstructural Proteins, medicine.disease_cause, Biochemistry, Antiviral Agents, chemistry.chemical_compound, Genotype 1b, chemistry, Drug Discovery, medicine, Molecular Medicine, Potency, Benzimidazoles, NS5A, Molecular Biology
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5
المؤلفون: Anne-Laure Grillot, Nigel Ewing, Youssef L. Bennani, Simon Giroux, Nathalie Chauret, Caroline Cadilhac, Kevin M. Cottrell, Olivier Nicolas, T. Jagadeeswar Reddy, Evelyne Dietrich, Lucille L’Heureux, Francois Denis, Oswy Z. Pereira, Rebecca S. Shawgo, Jinwang Xu, Nagraj Mani, Francoise Berlioz-Seux, Jian Wang, Sanjoy Kumar Das, John Maxwell, Bingcan Liu, James A. Henderson, Louis Vaillancourt, Subajini Selliah, Guy Falardeau, Laval C. Chan, Morris Mark A, Carl Poisson, Darius Bilimoria, Monica Bubenik
المصدر: Bioorganicmedicinal chemistry letters. 25(4)
مصطلحات موضوعية: Ledipasvir, Daclatasvir, viruses, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Biochemistry, Antiviral Agents, chemistry.chemical_compound, Structure-Activity Relationship, Amide, Drug Discovery, medicine, Structure–activity relationship, NS5A, Molecular Biology, Organic Chemistry, virus diseases, biochemical phenomena, metabolism, and nutrition, Combinatorial chemistry, digestive system diseases, Ombitasvir, chemistry, Molecular Medicine, Pharmacophore, medicine.drug
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6
المؤلفون: John Maxwell, Francois Denis, Kevin M. Cottrell, Francoise Berlioz-Seux, Subajini Selliah, Rebecca S. Shawgo, Nigel Ewing, Youssef L. Bennani, Morris Mark A, Anne-Laure Grillot, Laval C. Chan, Simon Giroux, Darius Bilimoria, Nagraj Mani, Caroline Cadilhac, T. Jagadeeswar Reddy, James A. Henderson, Olivier Nicolas, Sanjoy Kumar Das, Nathalie Chauret, Jinwang Xu, Lucille L’Heureux, Evelyne Dietrich
المصدر: Bioorganicmedicinal chemistry letters. 25(4)
مصطلحات موضوعية: Genotype, Clinical Biochemistry, Non symmetric, Pharmaceutical Science, Hepacivirus, Pharmacology, Viral Nonstructural Proteins, Biochemistry, Antiviral Agents, Genotype 1b, Drug Discovery, Potency, Animals, Humans, NS5A, Molecular Biology, Chemistry, Organic Chemistry, Imidazoles, virus diseases, Aromaticity, digestive system diseases, Rats, Molecular Medicine, Linker
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7
المؤلفون: Marc Jacobs, Hardwin O'dowd, Shannon Dean, Paul S. Charifson, Tim Doyle, Trudy H. Grossman, Vaishali Dixit, Brian Boucher, Pan Li, Nigel Ewing, Youssef L. Bennani, Emanuele Perola, Yusheng Liao, Anne-Laure Grillot, Emmanuelle Sizensky, Tiansheng Wang, Lauffer David J, Arnaud Le Tiran, Brian L. Hanzelka, Elaine Krueger, Waal Nathan D, Jerry Tanoury, Shengkai Liao, Steve Ronkin, Qing Tang, Jones Steven
المصدر: Journal of medicinal chemistry. 57(21)
مصطلحات موضوعية: DNA Topoisomerase IV, Benzimidazole, Topoisomerase IV, Microbial Sensitivity Tests, DNA gyrase, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Drug Discovery, Structure–activity relationship, Moiety, Animals, Humans, Topoisomerase II Inhibitors, Urea, Enzyme Inhibitors, biology, Chemistry, Anti-Bacterial Agents, Biochemistry, DNA Gyrase, Drug Design, biology.protein, Microsomes, Liver, Molecular Medicine, Benzimidazoles, Antibacterial activity
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8
المؤلفون: Melissa DeFilippo, Chuanliang Liu, Nigel Ewing
المصدر: Methods. 32:32-37
مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Chromatography, Protein mass spectrometry, Chemistry, Protein database, Mass spectrometry, Tandem mass tag, Tandem mass spectrometry, Peptide Fragments, General Biochemistry, Genetics and Molecular Biology, Characterization (materials science), Mice, Antigens, Neoplasm, Neoplasms, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Animals, Indicators and Reagents, Bottom-up proteomics, Shotgun proteomics, Molecular Biology, Chromatography, High Pressure Liquid, Heat-Shock Proteins
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9
المؤلفون: Nathalie Chauret, Francoise Berlioz-Seux, Anne-Laure Grillot, Nigel Ewing, Sanjoy Kumar Das, Jinwang Xu, Oliver Nicolas, James A. Henderson, Youssef L. Bennani, Darius Bilimoria, Simon Giroux, Francois Denis, John Maxwell, Caroline Cadilhac, Morris Mark A, Mark N. Namchuk, Nagraj Mani, Laval C. Chan, Lucille L’Heureux, Subajini Selliah, T. Jagadeeswar Reddy, Rebecca S. Shawgo, Kevin M. Cottrell
مصطلحات موضوعية: Stereochemistry, business.industry, Organic Chemistry, HCV genotypes, Sonogashira coupling, Bioinformatics, Biochemistry, Genotype 1b, Drug Discovery, Potency, Common key, Medicine, Replicon, business, NS5A, Linker
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6659bdfa639f80381f726c3da883bd65
https://europepmc.org/articles/PMC4027595/